Abstract:
OBJECTIVE:Asthma is the most common chronic airway inflammatory disease. Sirtuin 1 (SIRT1) exerts a crucial effect on regulating chronic inflammatory responses. Therefore, this study aims to explore the effect of SIRT1 on the pathogenesis of asthma. MATERIALS AND METHODS:Serum level of SIRT1 in asthma patients and healthy controls was detected by Western blot. Correlation between SIRT1 level and pulmonary function in asthma patients was analyzed. Subsequently, asthma model in mouse was established. Primary airway epithelial cells were extracted from asthma mice and control mice to detect SIRT1 level. Furthermore, relative levels of Akt and interleukin 6 (IL-6) were detected in 16HBE cells. Regulatory effects of Akt on SIRT1 in 16HBE cells were determined as well. RESULTS:SIRT1 was highly expressed in serum of asthma patients, which was negatively correlated with FEV1/FVC (r=-0.27, **p<0.01). Both mRNA and protein levels of SIRT1 were downregulated in primary airway epithelial cells extracted from asthma mice compared with those from controls. SIRT1 knockdown in 16HBE cells upregulated IL-6 expression, which was reversed by Akt inhibitors. CONCLUSIONS:SIRT1 regulates IL-6 level via Akt pathway, thereafter affecting pulmonary function in asthma patients.
journal_name
Eur Rev Med Pharmacol Scijournal_title
European review for medical and pharmacological sciencesauthors
Zhang YZ,Wu QJ,Yang X,Xing XX,Chen YY,Wang Hdoi
10.26355/eurrev_201906_18085subject
Has Abstractpub_date
2019-06-01 00:00:00pages
4948-4953issue
11eissn
1128-3602issn
2284-0729journal_volume
23pub_type
杂志文章abstract:OBJECTIVE:In healthy persons, cardiovascular risk is the result of multiple interacting risk associates including demographic, clinical, genetic and environmental factors. Several non-invasive tools such as echocardiography, ultrasonography and electrocardiography as well as new biochemical markers were shown to be app...
journal_title:European review for medical and pharmacological sciences
pub_type: 杂志文章
doi:
更新日期:2015-04-01 00:00:00
abstract:OBJECTIVES:The diagnosis of lung cancer remains a clinical challenge. Many studies have assessed the diagnostic potential of anti-p53 antibody in lung cancer patients but with controversial results. This study aims to summarize the overall diagnostic performance of anti-p53 antibody in lung cancer. MATERIALS AND METHO...
journal_title:European review for medical and pharmacological sciences
pub_type: 杂志文章,meta分析
doi:
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doi:10.26355/eurrev_202008_22641
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journal_title:European review for medical and pharmacological sciences
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doi:10.26355/eurrev_202002_20338
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journal_title:European review for medical and pharmacological sciences
pub_type: 杂志文章
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doi:10.26355/eurrev_201803_14486
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doi:10.26355/eurrev_201806_15268
更新日期:2018-06-01 00:00:00
abstract:OBJECTIVE:This study investigates whether microRNA-599 can inhibit the progression of Parkinson's disease (PD) by regulating the LRRK2 expression. We aim to search for a new therapeutic target for PD. MATERIALS AND METHODS:A mouse model of PD was first established. A relative amount of TH+ neurons in the mouse brain w...
journal_title:European review for medical and pharmacological sciences
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更新日期:2018-11-01 00:00:00
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journal_title:European review for medical and pharmacological sciences
pub_type: 杂志文章,随机对照试验
doi:
更新日期:2017-05-01 00:00:00
abstract::The coronavirus disease 2019 (COVID-19) is declared as an international emergency in 2020. Its prevalence and fatality rate are rapidly increasing but the medication options are still limited for this perilous disease. The emergent outbreak of COVID-19 triggered by severe acute respiratory syndrome coronavirus 2 (SARS...
journal_title:European review for medical and pharmacological sciences
pub_type: 杂志文章,评审
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更新日期:2020-12-01 00:00:00
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doi:10.26355/eurrev_202001_19934
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doi:10.26355/eurrev_202003_20667
更新日期:2020-03-01 00:00:00
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journal_title:European review for medical and pharmacological sciences
pub_type: 杂志文章
doi:10.26355/eurrev_201910_19302
更新日期:2019-10-01 00:00:00
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journal_title:European review for medical and pharmacological sciences
pub_type: 杂志文章,评审
doi:
更新日期:2017-10-01 00:00:00
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更新日期:2020-11-01 00:00:00
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更新日期:2018-04-01 00:00:00
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journal_title:European review for medical and pharmacological sciences
pub_type: 杂志文章
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journal_title:European review for medical and pharmacological sciences
pub_type: 杂志文章
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更新日期:2014-01-01 00:00:00
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pub_type: 杂志文章,多中心研究
doi:
更新日期:2007-03-01 00:00:00
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doi:10.26355/eurrev_201906_18184
更新日期:2019-06-01 00:00:00
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更新日期:2018-02-01 00:00:00