Chloroquine aggravates the arsenic trioxide (As2O3)-induced apoptosis of acute promyelocytic leukemia NB4 cells via inhibiting lysosomal degradation in vitro.

Abstract:

OBJECTIVE:Acute promyelocytic leukemia (APL) is a distinct subtype of acute myeloid leukemia (AML), as standing out for its distinguished sensitivity to all-trans retinoic acid and arsenic trioxide (ATO, As2O3). The As2O3-mediated degradation of PML-RARA (promyelocytic leukemia-retinoic acid receptor-α) oncoprotein via the proteasome pathway appears to be critical for such distinguished sensitivity. MATERIALS AND METHODS:The present study was to evaluate the influence by chloroquine (CQ), an inhibitor to the release of lysosomal enzymes, on the sensitivity of APL cells to As2O3. APL-derived NB4 cell line was treated with As2O3 or/and CQ in vitro. Then, the cell viability, the induction of apoptosis, and autophagy were examined with MTT assay, with TUNEL staining or with enhanced green fluorescence protein (EGFP)-light Chain 3 (LC3) reporter. The apoptosis- or autophagy-associated proteins were quantified with Western blotting assay. RESULTS:Our results demonstrated that the As2O3 treatment promoted either apoptosis or autophagy in APL NB4 cells and upregulated both apoptosis- and autophagy-associated proteins. However, additional CQ treatment deteriorated the As2O3-induced NB4 cell apoptosis, whereas aggravated the As2O3-induced accumulation of acidic vesicular organelles (AVOs) and blocked the lysosomal degradation in NB4 cells. CONCLUSIONS:Chloroquine aggravates the arsenic trioxide-induced apoptosis of APL NB4 cells via inhibiting lysosomal degradation in vitro. It implies that chloroquine might be adjuvant to sensitize APL cells to arsenic trioxide.

authors

Liu DM,Zhang XD,Yang L

doi

10.26355/eurrev_201810_16054

subject

Has Abstract

pub_date

2018-10-01 00:00:00

pages

6412-6421

issue

19

eissn

1128-3602

issn

2284-0729

journal_volume

22

pub_type

杂志文章
  • The protective effects of Berberine and Hesperidin on inflammatory factor-stimulating cardiac fibroblasts.

    abstract:OBJECTIVE:The previous work has shown that Berberine and Hesperidin have beneficial effects on cardiovascular diseases. However, the underlying mechanisms remain unknown. This study aimed to investigate the effect of Berberine and Hesperidin on inflammatory cytokine secretion, proliferation, differentiation, and collag...

    journal_title:European review for medical and pharmacological sciences

    pub_type: 杂志文章

    doi:10.26355/eurrev_201906_18216

    authors: Yu XH,Wang YF,Dai FY,Zhao JH,Li P

    更新日期:2019-06-01 00:00:00

  • Unpredictable behavior of breast phyllodes tumors.

    abstract:OBJECTIVE:Phyllodes Tumor is a rare fibroepithelial breast tumor with variable malignant potential. These tumors that currently accepted nomenclature are benign, borderline and malignant according to the World Health Organization. It tends to behave in a benign way but it may undergo a malignant transformation. The pur...

    journal_title:European review for medical and pharmacological sciences

    pub_type: 杂志文章

    doi:

    authors: Akcakaya A,Koc B,Erozgen F,Memmi N,Hot S,Yildiz MK,Gucin Z,Adas G,Kemik O

    更新日期:2014-01-01 00:00:00

  • Chest and breast MRI: the added value of a fast imaging for a new diagnostic approach in the planning of augmentation surgery in patients with thoracic asymmetries.

    abstract:OBJECTIVE:In breast augmentation surgery, breast symmetry depends on the breast tissue, implants and chest wall. Any asymmetry of the anterior thoracic wall can influence the breast shape. If breast asymmetry is detected in the preoperative evaluation, a chest wall deformity should be suspected. Until now, very few rep...

    journal_title:European review for medical and pharmacological sciences

    pub_type: 杂志文章

    doi:

    authors: Rinaldi P,Parapatt GK,Giuliani M,Borelli C,Giardina GG,Fubelli R,Buccheri C,Tambasco D,Belli P,Salgarello M,Bonomo L

    更新日期:2015-07-01 00:00:00

  • Wnt3a promotes human umbilical cord mesenchymal stem cells to differentiate into epidermal-like cells.

    abstract:OBJECTIVE:Mesenchymal stem cells are a population of pluripotent cells that can differentiate into epidermal-like cells under certain conditions. Wnt3a can promote the proliferation and differentiation of stem cells. However, the role of Wnt3a in the differentiation of human umbilical cord mesenchymal stem cells (hUCMS...

    journal_title:European review for medical and pharmacological sciences

    pub_type: 杂志文章

    doi:

    authors: Sun TJ,Tao R,Han YQ,Xu G,Liu J,Han YF

    更新日期:2015-01-01 00:00:00

  • A new predicting model of preeclampsia based on peripheral blood test value.

    abstract:OBJECTIVE:To identify laboratory markers among platelet indices, coagulation parameters, blood lipid parameters, and liver/kidney function variables that can be used to predict preeclampsia. PATIENTS AND METHODS:We studied records of 568 women with preeclampsia, gestational hypertension (GH), or normal term pregnancie...

    journal_title:European review for medical and pharmacological sciences

    pub_type: 杂志文章

    doi:10.26355/eurrev_202007_21874

    authors: Han Q,Zheng W,Guo XD,Zhang D,Liu HF,Yu L,Yan JY

    更新日期:2020-07-01 00:00:00

  • Evaluation of in vitro antileishmanial activity of curcumin and its derivatives "gallium curcumin, indium curcumin and diacethyle curcumin".

    abstract:BACKGROUND AND OBJECTIVES:Leishmania parasites are intracellular haemoflagellates that infect macrophages of the skin and viscera to produce diseases in their vertebrates hosts. Antileishmania therapy is based on pentavalent antimony compounds which toxicity of these agents and the persistence of side effects are sever...

    journal_title:European review for medical and pharmacological sciences

    pub_type: 杂志文章

    doi:

    authors: Fouladvand M,Barazesh A,Tahmasebi R

    更新日期:2013-12-01 00:00:00

  • Cystic thymoma coexisting with vascular dysplasia.

    abstract::We report the case of a 23-year-old female patient, who was admitted to our hospital because of aggravating pain in the right shoulder, right chest and ear accompanied by cough and dyspnea. Imaging revealed a soft tissue mass in the mediastinum in close relation with an additional large mass extending in the right upp...

    journal_title:European review for medical and pharmacological sciences

    pub_type: 杂志文章

    doi:

    authors: Papadas T,Dimopoulos PA,Sampsonas F,Mastronikolis N,Spiropoulos K,Goumas PD

    更新日期:2008-09-01 00:00:00

  • Predictors of major adverse cardiovascular events; results of population based MELEN study with prospective follow-up.

    abstract:OBJECTIVE:In healthy persons, cardiovascular risk is the result of multiple interacting risk associates including demographic, clinical, genetic and environmental factors. Several non-invasive tools such as echocardiography, ultrasonography and electrocardiography as well as new biochemical markers were shown to be app...

    journal_title:European review for medical and pharmacological sciences

    pub_type: 杂志文章

    doi:

    authors: Albayrak S,Ozhan H,Aslantas Y,Ekinozu I,Tibilli H,Kayapinar O,Melen Study Investigators.

    更新日期:2015-04-01 00:00:00

  • Clinical features, imaging findings, treatment aspects of elastofibroma dorsi and long-term outcomes after surgical resection.

    abstract:OBJECTIVE:We aim to present clinical features, imaging findings, treatment aspects of the elastofibroma dorsi (ED), which is a benign tumor arising from connective tissue at the scapular region, and long-term outcomes after surgical resection. PATIENTS AND METHODS:We evaluated retrospectively 82 patients (55 females, ...

    journal_title:European review for medical and pharmacological sciences

    pub_type: 杂志文章

    doi:

    authors: Bartocci M,Dell'Atti C,Meacci E,Congedo MT,Magarelli N,Bonomo L,Leone A

    更新日期:2017-05-01 00:00:00

  • A study on regulatory mechanism of miR-223 in ulcerative colitis through PI3K/Akt-mTOR signaling pathway.

    abstract:OBJECTIVE:The aim of this study was to explore the regulatory mechanism of micro ribonucleic acid (miR)-223 in ulcerative colitis (UC) through the phosphatidylinositol 3-kinase (PI3K)/protein kinase B (Akt)-mammalian target of rapamycin (mTOR) signaling pathway. MATERIALS AND METHODS:A total of 36 Sprague-Dawley (SD) ...

    journal_title:European review for medical and pharmacological sciences

    pub_type: 杂志文章

    doi:10.26355/eurrev_201906_18074

    authors: Jiang W,Han YP,Hu M,Bao XQ,Yan Y,Chen G

    更新日期:2019-06-01 00:00:00

  • Increased HSPG2 expression independently predicts poor survival in patients with oligoastrocytoma and oligodendroglioma.

    abstract:OBJECTIVE:Perlecan, which is also called heparan sulfate proteoglycan 2 (HSPG2), is a protein encoded by the HSPG2 gene that maps to 1p36.12 in the human genome. In this study, we assessed the independent prognostic value of HSPG2 in terms of overall survival (OS) and recurrence-free survival (RFS) in patients with LGG...

    journal_title:European review for medical and pharmacological sciences

    pub_type: 杂志文章

    doi:10.26355/eurrev_201810_16154

    authors: Ma XL,Shang F,Ni W,Zhu J,Luo B,Zhang YQ

    更新日期:2018-10-01 00:00:00

  • PFNA vs. DHS helical blade for elderly patients with osteoporotic femoral intertrochanteric fractures.

    abstract:OBJECTIVE:This study sought to compare the effects of proximal femoral nail anti-rotation (PFNA) and dynamic hip screw (DHS) helical blade treatments in patients with osteoporotic femoral intertrochanteric fractures. PATIENTS AND METHODS:Eighty elderly osteoporosis patients with femoral intertrochanteric fracture comp...

    journal_title:European review for medical and pharmacological sciences

    pub_type: 杂志文章

    doi:10.26355/eurrev_201807_15346

    authors: Li H,Wang Q,Dai GG,Peng H

    更新日期:2018-07-01 00:00:00

  • Effects of low dose pre-irradiation on hepatic damage and genetic material damage caused by cyclophosphamide.

    abstract:OBJECTIVE:Cyclophosphamide (CTX) can attack tumour cells, but can also damage the other cells and microstructures of an organism at different levels, such as haematopoietic cells, liver cells, peripheral lymphocyte DNA, and genetic materials. Low dose radiation (LDR) can induce general adaptation reaction. In this stud...

    journal_title:European review for medical and pharmacological sciences

    pub_type: 杂志文章

    doi:

    authors: Yu HS,Song AQ,Liu N,Wang H

    更新日期:2014-01-01 00:00:00

  • Serum cytokine and pro-brain natriuretic peptide (BNP) levels in patients with migraine.

    abstract:OBJECTIVE:Although migraine has been related with an increased risk for ischemic stroke and cardiovascular events, there is insufficient data for role of pro-brain natriuretic peptide (pro-BNP) in migraine. In present case-control study, serum levels of pro-inflammatory (TNF-alpha, IL-1beta and IL-6) and anti-inflammat...

    journal_title:European review for medical and pharmacological sciences

    pub_type: 杂志文章

    doi:

    authors: Uzar E,Evliyaoglu O,Yucel Y,Ugur Cevik M,Acar A,Guzel I,Islamoglu Y,Colpan L,Tasdemir N

    更新日期:2011-10-01 00:00:00

  • Correlations of serum homocysteine, VEGF and gastrin 17 with gastric cancer and precancerous lesions.

    abstract:OBJECTIVE:To investigate the correlations of Homocysteine (Hcy), vascular endothelial growth factor (VEGF), and serum gastrin 17 (G17) with gastric cancer and precancerous lesions. PATIENTS AND METHODS:A total of 56 patients with gastric cancer (gastric cancer group) and 53 patients with precancerous lesions (precance...

    journal_title:European review for medical and pharmacological sciences

    pub_type: 杂志文章

    doi:10.26355/eurrev_201905_17922

    authors: Zhao WX,Liu ZF,Li XL,Li Z

    更新日期:2019-05-01 00:00:00

  • The pure effects of obstructive sleep apnea syndrome on cardiac autonomic functions: heart rate turbulence analysis.

    abstract:OBJECTIVES:To demonstrate the pure effect of obstructive sleep apnea syndrome (OSAS) on cardiac autonomic function (CAF) using heart rate turbulence (HRT) parameters. PATIENTS AND METHODS:A total of 64 patients with OSAS and 30 age- and gender-matched healthy subjects were enrolled. All subjects had normal coronary ar...

    journal_title:European review for medical and pharmacological sciences

    pub_type: 杂志文章

    doi:

    authors: Erdem A,Dogan OT,Yontar OC,Epozturk K,Ozlu MF,Ozturk S,Ayhan SS,Erdem FH,Yazici M,Akkurt I,Talay F

    更新日期:2013-10-01 00:00:00

  • Apigenin inhibits indoxyl sulfate-induced endoplasmic reticulum stress and anti-proliferative pathways, CHOP and IL-6/p21, in human renal proximal tubular cells.

    abstract:OBJECTIVE:Indoxyl sulfate (IS) has been reported to induce endoplasmic reticulum (ER) stress in tubular cells and to inhibit the cell proliferation via ER stress and ERK/IL-6/p21 pathways. This study has investigated the effect of apigenin on IS-induced ER stress in immortalized human renal proximal tubular HK-2 cells....

    journal_title:European review for medical and pharmacological sciences

    pub_type: 杂志文章

    doi:

    authors: Jeon BJ,Yang HM,Lyu YS,Pae HO,Ju SM,Jeon BH

    更新日期:2015-06-01 00:00:00

  • MiR-4429 suppresses the malignant development of ovarian cancer by targeting YOD1.

    abstract:OBJECTIVE:The purpose of this study was to assess the clinical significance of microRNA-4429 (miR-4429) in the development and prognosis of ovarian cancer, and to explore the regulatory role of miR-4429 in migratory potential of ovarian cancer cells. PATIENTS AND METHODS:MiR-4429 levels in paired ovarian cancer specie...

    journal_title:European review for medical and pharmacological sciences

    pub_type: 杂志文章

    doi:10.26355/eurrev_202009_22809

    authors: Zhu YM,Chen P,Shi L,Zhu T,Chen X

    更新日期:2020-09-01 00:00:00

  • Mesenchymal stem cell-based FGF2 gene therapy for acute lung injury induced by lipopolysaccharide in mice.

    abstract:OBJECTIVE:Bone marrow-derived mesenchymal stem cells (MSCs) can serve as a vehicle for gene therapy. FGF2 (basic fibroblast growth factor) is a multifunctional growth factor and exhibits diverse function in different cell types, it also has pleiotropic effects in different tissues and organs, including potent angiogeni...

    journal_title:European review for medical and pharmacological sciences

    pub_type: 杂志文章

    doi:

    authors: Zhao YF,Luo YM,Xiong W,Ding W,Li YR,Zhao W,Zeng HZ,Gao HC,Wu XL

    更新日期:2015-01-01 00:00:00

  • Radiofrequency Y-V anoplasty in the treatment of anal stenosis.

    abstract:BACKGROUND:Anal stenosis is a common proctologic disease often caused from hemorrhoids surgery. Treatments adopted are many and varied. In this study we applied radiofrequencies to the classic Y-V anoplasty operation and reported results obtained. METHODS:Eligibility criteria consisted of patients affected by anal ste...

    journal_title:European review for medical and pharmacological sciences

    pub_type: 杂志文章

    doi:

    authors: Filingeri V,Gravante G,Cassisa D

    更新日期:2006-09-01 00:00:00

  • MicroRNA-383 suppresses pancreatic carcinoma development via inhibition of GAB1 expression.

    abstract:OBJECTIVE:Pancreatic carcinoma (PC) is a serious malignancy associated with high morbidity and mortality rates. Previous studies have identified various microRNAs (miRNAs) involved in the development of PC; however, the role of miR-383 still remains unclear. This study investigates the role of miR-383 in the malignant ...

    journal_title:European review for medical and pharmacological sciences

    pub_type: 杂志文章

    doi:10.26355/eurrev_201912_19774

    authors: Su QL,Zhao HJ,Song CF,Zhao S,Tian ZS,Zhou JJ

    更新日期:2019-12-01 00:00:00

  • Is the pepper spray a triggering factor in myocardial infarction? A case report.

    abstract::Forty-year-old man was admitted to emergency department with complains of chest pain and dispnea after exposure the pepper gas that sprayed to environment during a social event. Physical examination and electrocardiogram was revealed acute myocardial infarction. ...

    journal_title:European review for medical and pharmacological sciences

    pub_type: 杂志文章

    doi:

    authors: Cil H,Atilgan ZA,Islamoğlu Y,Tekbaş EO,Dostbil Z

    更新日期:2012-03-01 00:00:00

  • Circular RNA_LARP4 inhibits cell proliferation and invasion of nasopharyngeal carcinoma by repressing ROCK1.

    abstract:OBJECTIVE:Nasopharyngeal carcinoma (NPC) is one of the most ordinary malignant tumors. Recent studies have revealed that circular RNAs play an important role in the progression of tumorigenesis. This study aims to identify how circular RNA_LARP4 functions in the progression of NPC. PATIENTS AND METHODS:We performed Re...

    journal_title:European review for medical and pharmacological sciences

    pub_type: 杂志文章

    doi:10.26355/eurrev_201911_19557

    authors: Pan JY,Bao XL,Zhu K

    更新日期:2019-11-01 00:00:00

  • Effect of pioglitazone combined with simvastatin on the CD40-CD40 ligand system in rabbits with atherosclerosis.

    abstract:OBJECTIVE:This paper aims to investigate the interaction mechanism between pioglitazone/simvastatin and the CD40-CD40 ligand (CD40-CD40L) system and to determine their interaction effects on atherosclerosis in rabbits. MATERIALS AND METHODS:Forty rabbits were randomly divided into five groups of eight: normal control,...

    journal_title:European review for medical and pharmacological sciences

    pub_type: 杂志文章

    doi:

    authors: Xue L,Zhu XH,Yang XF,Bao XC,Gao XQ,Qiu YH,Wu Z,Ji XP,Li HW

    更新日期:2015-01-01 00:00:00

  • The effect of sequential transcatheter arterial chemoembolization (TACE) and portal venous embolizations (PVE) vs. TACE or PVE alone on rabbit VX2 liver carcinoma and on liver regeneration.

    abstract:OBJECTIVE:This study aimed to build VX2 liver tumor model in rabbits and to investigate the sequential transcatheter arterial chemoembolization (TACE) and portal vein embolizations (PVE) vs. TACE or PVE alone on rabbit VX2 liver carcinoma and liver regeneration. MATERIALS AND METHODS:VX2 liver tumor models were built ...

    journal_title:European review for medical and pharmacological sciences

    pub_type: 杂志文章

    doi:

    authors: Guo WC,He XF,Li YH,Li ZH,Mei QL,Chen Y

    更新日期:2016-07-01 00:00:00

  • Long non-coding RNA MIR503HG serves as a tumor suppressor in non-small cell lung cancer mediated by wnt1.

    abstract:OBJECTIVE:The incidence and death rate of lung cancer has been rising year by year. Non-small cell lung cancer (NSCLC) seriously affects people's health and quality of life. This study was designed to explore the functional role of long-chain non-coding RNA (LncRNA) MIR503HG in the development of NSCLC. PATIENTS AND M...

    journal_title:European review for medical and pharmacological sciences

    pub_type: 杂志文章

    doi:10.26355/eurrev_201912_19785

    authors: Lin H,Li P,Zhang N,Cao L,Gao YF,Ping F

    更新日期:2019-12-01 00:00:00

  • Predicting transcription factors in human alcoholic hepatitis from gene regulatory network.

    abstract:OBJECTIVE:Alcoholic hepatitis (AH) is a type of alcoholic liver disorder caused by overconsumption of alcohol. The involvement of several transcription factors (TF), as the main regulators of disease related gene expression has been documented previously. However, despite the importance of analysis of gene regulatory n...

    journal_title:European review for medical and pharmacological sciences

    pub_type: 杂志文章

    doi:

    authors: Mohammadnia A,Yaqubi M,Fallahi H

    更新日期:2015-06-01 00:00:00

  • Nanoscale bubble delivered YCD-TK/Cx26 gene therapeutic system suppresses tumor growth by inducing necrosis of tumor tissues in mouse Xenograft bladder cancer models.

    abstract:OBJECTIVE:Bladder cancer is considered as the fifth most common cancer in the whole world. This study aimed to investigate the anti-tumor effects of Nanoscale bubbles delivered yeast cytosine deaminase thymidine kinase/connexin 26 (YCD-TK/Cx26) on tumor cell proliferation and tumor growth. MATERIALS AND METHODS:Nanosc...

    journal_title:European review for medical and pharmacological sciences

    pub_type: 杂志文章

    doi:10.26355/eurrev_201909_18839

    authors: Fu YR,Luo Y,Xie X,Lu W,Zhang R,Xiong B,Chen F

    更新日期:2019-09-01 00:00:00

  • Current views of common pediatric cancers - an update.

    abstract::Advancements in pediatric cancers diagnostics clarity and treatments have greatly increased survival rates in the pediatric oncology population. Increased survival rates have turned new attention to studying psychosocial stressors and improvisation of the quality of life of the suffering cancer patients. The cancer tr...

    journal_title:European review for medical and pharmacological sciences

    pub_type: 杂志文章,评审

    doi:

    authors: An Q,Fan CH,Xu SM

    更新日期:2017-10-01 00:00:00

  • BNIP1 inhibits cell proliferation, migration and invasion, and promotes apoptosis by mTOR in cervical cancer cells.

    abstract:OBJECTIVE:BNIP1, a member of the BH3-only protein family, plays essential roles in a variety of biological processes. However, the mechanism and function of BNIP1 are still unknown in cervical cancer. We aim to explore the roles of BNIP1 on cervical cancer cell proliferation, apoptosis, migration, and invasion abilitie...

    journal_title:European review for medical and pharmacological sciences

    pub_type: 杂志文章

    doi:10.26355/eurrev_201902_17096

    authors: Li FH,Xiang L,Ran L,Zhou S,Huang Z,Chen M,Yu WF

    更新日期:2019-02-01 00:00:00