当前位置： SCI文献检索 > European Review for Medical and Pharmacological Sciences期刊下所有文献 > Relationship between miR-375 regulating Ndrg2/IL-6/STAT3 signaling pathway and diabetic retinopathy in rats.

Relationship between miR-375 regulating Ndrg2/IL-6/STAT3 signaling pathway and diabetic retinopathy in rats.

Abstract：

OBJECTIVE:To explore the relationship between micro ribonucleic acid (miR)-375 in regulating the N-Myc downstream-regulated gene 2 (Ndrg2)/interleukin-6 (IL-6)/signal transducer and activator of transcription 3 (STAT3) signaling pathway and diabetic retinopathy (DR) in rats. MATERIALS AND METHODS:Thirty Sprague- Dawley rats were randomly divided into Control group (n=10), Model group (n=10), and miR-375 inhibitor group [miR-375 small interfering RNA (siRNA) group, n=10]. The rats in Model group were injected with streptozotocin (STZ) via the tail vein to prepare into rat models of diabetes. The body weight, fasting blood glucose, and retinal barrier permeability of rats in each group were detected. The levels of malondialdehyde (MDA) and superoxide dismutase (SOD) in rat serum were measured using kits. Terminal deoxynucleotidyl transferase-mediated deoxyuridine triphosphate-biotin nick end labeling (TUNEL) assay was performed to determine the apoptosis of optic ganglion cells in rat retinal tissues. Additionally, the messenger RNA (mRNA) and protein levels of Ndrg2, IL-6 and STAT3 in rat retinal tissues were detected via reverse transcription-polymerase chain reaction (RT-PCR) and Western blotting, respectively. RESULTS:Compared with Control group, Model group had reduced body weight of rats, increased blood glucose and retinal permeability of rats, raised serum MDA content, decreased SOD activity, up-regulated apoptotic rate of optic ganglia, and notably elevated mRNA and protein levels of Ndrg2, IL-6 and STAT3 in retinal tissues. Compared with those in Model group, the body weight of rats declined, the blood glucose of rats rose, the retinal permeability of rats was decreased significantly, the serum MDA content was reduced, the SOD activity was raised, the apoptotic rate of optic ganglia was decreased, and the mRNA and protein levels of Ndrg2, IL-6 and STAT3 in retinal tissues were also decreased significantly in miR-375 siRNA group. CONCLUSIONS:MiR-375 inhibitors are able to reduce blood glucose, retinal permeability, and optic ganglion apoptosis in rats with DR, and the mechanism of action may be related to the regulation on the Ndrg2/IL-6/STAT3 signaling pathway.

journal_name

Eur Rev Med Pharmacol Sci

journal_title

European review for medical and pharmacological sciences

authors

Pu LJ,Chen W,Liu QH,Huang AP,Zhao Q,Gu HH

doi

10.26355/eurrev_202003_20484

subject

Has Abstract

pub_date

2020-03-01 00:00:00

pages

2189-2195

issue

5

eissn

1128-3602

issn

2284-0729

journal_volume

24

pub_type

杂志文章

相关文献

European Review for Medical and Pharmacological Sciences文献大全
  • A new walker with upper trunk suspension system for severely disabled patients.

    abstract：:We have recently designed a new type of walker for those severely disabled patients who cannot walk with commonly used medical walkers. A drawing and the description of this new walker is reported in order to permit the worldwide companies as well as artisans to develop and produce it for the people affected from seve...

    journal_title：European review for medical and pharmacological sciences

    pub_type： 杂志文章

    doi：

    authors： Scoppetta C,Scoppetta M

    更新日期：2013-10-01 00:00:00

  • Effect of melatonin and n-acetylcysteine on hepatic injury in rat induced by methanol intoxication: a comparative study.

    abstract：BACKGROUND:Methanol intoxication leads liver injury; in contrast melatonin and n-acetyl cysteine (NAC) are known to have protective effects on liver. AIM:We aimed to investigate the ultrastructural effects of melatonin and NAC on livers of methanol intoxicated rats and compare potential protective effects of melatonin...

    journal_title：European review for medical and pharmacological sciences

    pub_type： 杂志文章

    doi：

    authors： Koksal M,Kurcer Z,Erdogan D,Iraz M,Tas M,Eren MA,Aydogan T,Ulas T

    更新日期：2012-04-01 00:00:00

  • 124 cases of clinical analysis of children with viral myocarditis.

    abstract：OBJECTIVE:A study on clinical characteristics, diagnostic methods of children's viral myocarditis (VMC) and analysis of the effect of VMC is carried out. PATIENTS AND METHODS:A retrospective analysis of the clinical data of 124 cases of children with VMC from January 2008 to March 2011 in Xuzhou Children's Hospital is...

    journal_title：European review for medical and pharmacological sciences

    pub_type： 杂志文章

    doi：

    authors： Niu L,An XJ,Tian J,Wang Y

    更新日期：2015-08-01 00:00:00

  • Comparison of minimal residual disease (MRD) monitoring by WT1 quantification between childhood acute myeloid leukemia and acute lymphoblastic leukemia.

    abstract：OBJECTIVE:Wilms tumor gene 1 (WT1) has been identified as an independent risk prognostic factor in acute leukemia. However, there exists a controversy that WT1 as a marker for minimal residual disease (MRD) monitoring in acute leukemias. We detected WT1-RNA transcript level to estimate the diagnostic value of monitorin...

    journal_title：European review for medical and pharmacological sciences

    pub_type： 杂志文章

    doi：

    authors： Zhang R,Yang JY,Sun HQ,Jia H,Liao J,Shi YJ,Li G

    更新日期：2015-01-01 00:00:00

  • LncRNA CASC15 promotes migration and invasion in prostate cancer via targeting miR-200a-3p.

    abstract：OBJECTIVE:Prostate cancer (PC) is one of the most ordinary malignant cancers. Recent researches have proved that long noncoding RNAs (lncRNAs) act as an important role in cancers. Our study aims to explore the function of lncRNA CASC15 in the tumor metastasis of PC. PATIENTS AND METHODS:Real Time-quantitative Polymera...

    journal_title：European review for medical and pharmacological sciences

    pub_type： 杂志文章

    doi：10.26355/eurrev_201910_19141

    authors： Zhang C,Wang GX,Fu B,Zhou XC,Li Y,Li YY

    更新日期：2019-10-01 00:00:00

  • Long noncoding RNA ROR1-AS1 induces tumor metastasis and epithelial-mesenchymal transition by sponging miR-375 in nasopharyngeal carcinoma.

    abstract：OBJECTIVE:The vital role of long noncoding RNAs (lncRNAs) in tumor progression has been identified in numerous studies. Nasopharyngeal carcinoma (NPC) is one of the most ordinary malignant tumors. This study aims to explore the role of lncRNA ROR1-AS1 in the metastasis of NPC. PATIENTS AND METHODS:Real Time-quantitati...

    journal_title：European review for medical and pharmacological sciences

    pub_type： 杂志文章,收录出版

    doi：10.26355/eurrev_202001_19909

    authors： Hou J,Yan J,Ren XY,Zhu K,Du XY,Li JJ,Xu M

    更新日期：2020-01-01 00:00:00

  • Composite artificial semi-knee joint system.

    abstract：OBJECTIVES:The purpose of the study was to investigate the clinical implantation protocol of custom-made artificial semi-knee joint based on computer-aided design so as to improve the limb salvage efficiency. MATERIALS AND METHODS:The custom-made artificial semi-knee joint was designed and manufactured based on rapid ...

    journal_title：European review for medical and pharmacological sciences

    pub_type： 杂志文章

    doi：

    authors： Li Z,Xu SF,Li DC,Sun Z,Zhang T,Lu JX,Wang Z

    更新日期：2014-01-01 00:00:00

  • Intraosseous lipoma presenting as a sphenoid sinus mass.

    abstract：:Intraosseous lipoma is an uncommon mesenchymal tumor that is frequently found in appendecular skeleton. In extremely rare conditions, it can appear in sphenoid bone, and only 2 cases have been described in literature until now. We present a case of lipoma in the body of the sphenoid bone mimicking sphenoid sinus tumor...

    journal_title：European review for medical and pharmacological sciences

    pub_type： 杂志文章

    doi：

    authors： Dogan M,Kahraman AS,Firat C,Kahraman B,Karatas E,Kizilay A

    更新日期：2011-11-01 00:00:00

  • Hypoxic markers in non-small cell lung cancer (NSCLC) - A review.

    abstract：:Surgery, chemotherapy and radiotherapy have been the main pillars of cancer treatment. Some of the recent improvements in survival of other cancers can be attributed to novel treatment therapies. Such therapies mostly target specific molecules involved in cancer progression and metastasis. Development and clinical int...

    journal_title：European review for medical and pharmacological sciences

    pub_type： 杂志文章,评审

    doi：

    authors： Xu FX,Zhang YL,Liu JJ,Zhang DD,Chen HB

    更新日期：2016-03-01 00:00:00

  • Effects of polymorphisms of serotonin transporter promoter (5-HTTLPR) and brain derived neurotrophic factor gene (G196A rs6265) on the risk of major depressive disorder in the Chinese Han population.

    abstract：OBJECTIVE:The etiology of Major depressive disorder (MDD) is multifactorial but the genetic risk is an important factor. Previous studies have shown a significant interaction between serotonin and brain-derived neurotrophic factor (BDNF) in brain function. The serotonin transporter protein promoter polymorphism (5-HTTL...

    journal_title：European review for medical and pharmacological sciences

    pub_type： 杂志文章

    doi：

    authors： Sun N,Yang CX,Liu ZF,Li XR,Xu Y,Zhang KR

    更新日期：2016-05-01 00:00:00

  • Surgical management of pyogenic liver abscess.

    abstract：BACKGROUND AND AIM:Although Pyogenic Liver Abscess (PLA) has lower mortality rate in recent years due to the broad spectrum antibiotic usage, developed imaging techniques and improved intensive care services, it is still a potentially fatal disease. The objective of this study is to examine the treatment methods and ou...

    journal_title：European review for medical and pharmacological sciences

    pub_type： 杂志文章

    doi：

    authors： Onder A,Kapan M,Böyük A,Gümüş M,Tekbaş G,Girgin S,Tacyildiz IH

    更新日期：2011-10-01 00:00:00

  • Synovial mesenchymal stem cells effectively alleviate osteoarthritis through promoting the proliferation and differentiation of meniscus chondrocytes.

    abstract：OBJECTIVE:To investigate the relationship between the meniscal defect area and OA progression and explore the effect and mechanism of SMSCs cell therapy in knee osteoarthritis (OA) rat model. MATERIALS AND METHODS:For animal experiments, knee osteoarthritis (OA) model was constructed in Sprague Dawley (SD) rats by rem...

    journal_title：European review for medical and pharmacological sciences

    pub_type： 杂志文章

    doi：10.26355/eurrev_202002_20338

    authors： Qiong J,Xia Z,Jing L,Haibin W

    更新日期：2020-02-01 00:00:00

  • Downregulation of miR-145-5p correlates with poor prognosis in gastric cancer.

    abstract：OBJECTIVE:The aim of this study was to explore the clinical significance of miR-145-5p expression in gastric cancer (GC). PATIENTS AND METHODS:Expression of miR-145-5p was evaluated by qRT- PCR in tumor and normal gastric tissues in 145 GC patients. The correlation between the miR-145-5p expression and clinicopatholog...

    journal_title：European review for medical and pharmacological sciences

    pub_type： 杂志文章

    doi：

    authors： Zhang Y,Wen X,Hu XL,Cheng LZ,Yu JY,Wei ZB

    更新日期：2016-07-01 00:00:00

  • Pharmacokinetics study of ferulic acid in rats after oral administration of γ-oryzanol under combined use of Tween 80 by LC/MS/MS.

    abstract：AIM:γ-oryzanol (OZ) is a rich source of commercially-important bioactive phytochemicals, most of them of interest in nutrition, pharmacy and cosmetics. However, the poor solubility of OZ limited the use. In the paper, ultraviolet-visible (UV-Vis) analysis was conducted to analysis the solubilization of OZ under combine...

    journal_title：European review for medical and pharmacological sciences

    pub_type： 杂志文章

    doi：

    authors： Pan Y,Cai L,He S,Zhang Z

    更新日期：2014-01-01 00:00:00

  • Serum and exosomal hsa_circ_0000907 and hsa_circ_0057362 as novel biomarkers in the early diagnosis of diabetic foot ulcer.

    abstract：OBJECTIVE:Diabetic foot ulcer (DFU) is a serious chronic complication leading to disability and death in patients suffering from diabetes. Currently, there is no effective marker for its early diagnosis. The aim of this study is to analyze the difference of circRNA expression profiles between DFU and normal human wound...

    journal_title：European review for medical and pharmacological sciences

    pub_type： 杂志文章

    doi：10.26355/eurrev_202008_22498

    authors： Chen ZJ,Shi XJ,Fu LJ,Liu J,Shi K,Zhang WB,Su PK

    更新日期：2020-08-01 00:00:00

  • Comparative effects of zinc, selenium and vitamin E or their combination on carbohydrate metabolizing enzymes and oxidative stress in streptozotocin induced-diabetic rats.

    abstract：OBJECTIVE:It is well documented that oxidative stress is a basic mechanism behind the development of diabetic state. The current study was undertaken to elucidate the hypoglycemic role of zinc, selenium and vitamin E and their mixture in comparison with the antidiabetic drug glibenclamide. MATERIALS AND METHODS:Male W...

    journal_title：European review for medical and pharmacological sciences

    pub_type： 杂志文章

    doi：

    authors： Aly HF,Mantawy MM

    更新日期：2012-01-01 00:00:00

  • Architecture of enteric neural circuits involved in intestinal motility.

    abstract：:This short review describes the conceptual development in the search for the enteric neural circuits with the initial identifications of the classes of enteric neurons on the bases of their morphology, neurochemistry, biophysical properties, projections and connectivity. The discovery of the presence of multiple neuro...

    journal_title：European review for medical and pharmacological sciences

    pub_type： 杂志文章,评审

    doi：

    authors： Costa M,Brookes SH

    更新日期：2008-08-01 00:00:00

  • Butorphanol protects on myocardial ischemia/reperfusion injury in rats through MAPK signaling pathway.

    abstract：OBJECTIVE:To explore the influence of butorphanol on myocardial ischemia/reperfusion (I/R) injury in rats through the mitogen-activated protein kinase (MAPK) signaling pathway. MATERIALS AND METHODS:The I/R model in Sprague-Dawley rats was established. The rats were randomly divided into normal group (n=20), myocardia...

    journal_title：European review for medical and pharmacological sciences

    pub_type： 杂志文章

    doi：10.26355/eurrev_201912_19695

    authors： Wang H,Wang JL,Ren HW,He WF,Sun M

    更新日期：2019-12-01 00:00:00

  • Ambroxol alleviates ventilator-induced lung injury by inhibiting c-Jun expression.

    abstract：OBJECTIVE:Ventilator-induced lung injury (VILI) remains a challenge. This study was designed to investigate the effects of ambroxol on VILI and the underlying mechanisms in a rodent model. MATERIALS AND METHODS:Male Wistar rats weighing 310-380 g were divided into four groups (n=8 per group): 1) saline only, 2) ventil...

    journal_title：European review for medical and pharmacological sciences

    pub_type： 杂志文章

    doi：10.26355/eurrev_201906_18092

    authors： Cao DW,Hou MX,Zhang XR

    更新日期：2019-06-01 00:00:00

  • The cyclic hexapeptide AcF attenuates sepsis-induced acute lung injury and mortality in rats.

    abstract：OBJECTIVE:The purpose of this study was to elucidate the possible beneficial effects of AcF on acute lung injury (ALI) in a rat model of sepsis. MATERIALS AND METHODS:Male Sprague-Dawley rats were randomly divided into the following four experimental groups (n = 10 per group): animals undergoing a sham cecal ligature ...

    journal_title：European review for medical and pharmacological sciences

    pub_type： 杂志文章

    doi：

    authors： Dong H,Shan F,Sun Q,Yang BX,Li CP

    更新日期：2014-01-01 00:00:00

  • The effect of low dosage of procaine on lung cancer cell proliferation.

    abstract：OBJECTIVE:Non-small cell lung cancer (NSCLC) is the most common type of human lung cancer leading cause of cancer death worldwide. However, first-line drugs such as gefitinib and erlotinib showed great drug resistance in the clinical. MATERIALS AND METHODS:The cell proliferation was evaluated by MTT assay; gene expres...

    journal_title：European review for medical and pharmacological sciences

    pub_type： 杂志文章

    doi：

    authors： Ma XW,Li Y,Han XC,Xin QZ

    更新日期：2016-11-01 00:00:00

  • Gastrointestinal tract duplications in children.

    abstract：AIM:Gastrointestinal tract duplications (GTD) are rare congenital abnormalities that can occur anywhere along the gastrointestinal tract. These anomalies may present as a single, multiple, or a vague pathologies. Diagnosing and treating these diseases may be difficult in some patients. We aimed to present 32 patients w...

    journal_title：European review for medical and pharmacological sciences

    pub_type： 杂志文章

    doi：

    authors： Okur MH,Arslan MS,Arslan S,Aydogdu B,Türkçü G,Goya C,Uygun I,Cigdem MK,Önen A,Otcu S

    更新日期：2014-01-01 00:00:00

  • Influence of MiR-154 on myocardial apoptosis in rats with acute myocardial infarction through Wnt/β-catenin signaling pathway.

    abstract：OBJECTIVE:To explore the influence of micro ribonucleic acid (miR)-154 on myocardial apoptosis in rats with acute myocardial infarction (AMI), and to analyze whether Wnt/β-catenin signaling pathway was involved in the regulation. MATERIALS AND METHODS:The Sprague-Dawley (SD) rat model of AMI was established via ligati...

    journal_title：European review for medical and pharmacological sciences

    pub_type： 杂志文章

    doi：10.26355/eurrev_201901_16896

    authors： Sun HY,Wang XL,Ma LC,Yang M,Yang HJ,Huang HW,Zhao GA

    更新日期：2019-01-01 00:00:00

  • Beware of the dog - Capnocytophga Canimorsus septic shock: a case report.

    abstract：:Capnocytophaga canimorsus is a Gram-negative rods frequently isolated as commensal in the saliva of pets that can be transmitted to humans. We report a case of septic shock caused by this pathogen. A 78-year-old man affected by diabetes and hypertension was admitted for fever in our Emergency Department. He reported f...

    journal_title：European review for medical and pharmacological sciences

    pub_type： 杂志文章

    doi：10.26355/eurrev_201909_18866

    authors： Sabia L,Marchesini D,Pignataro G,Navarra SM,Saviano A,Giuliano G,De Luca G,Covino M,Franceschi F,Candelli M

    更新日期：2019-09-01 00:00:00

  • MiR-182 affects renal cancer cell proliferation, apoptosis, and invasion by regulating PI3K/AKT/mTOR signaling pathway.

    abstract：:Since this article has been suspected of research misconduct and the corresponding authors did not respond to our request to prove originality of data and figures, "MiR-182 affects renal cancer cell proliferation, apoptosis, and invasion by regulating PI3K/AKT/mTOR signaling pathway, by J.-H. Fu, S. Yang, C.-J. Nan, C...

    journal_title：European review for medical and pharmacological sciences

    pub_type： 杂志文章

    doi：10.26355/eurrev_202007_21852

    authors： Fu JH,Yang S,Nan CJ,Zhou CC,Lu DQ,Li S,Mu HQ

    更新日期：2020-07-01 00:00:00

  • MiR-146a regulates the development of ulcerative colitis via mediating the TLR4/MyD88/NF-κB signaling pathway.

    abstract：OBJECTIVE:To study the effect of micro ribonucleic acid (miR)-146a on the development of ulcerative colitis (UC) and to explore its regulatory effect on the Toll-like receptor 4 (TLR4)/myeloid differentiation factor 88 (MyD88) and nuclear factor-kappa B (NF-κB) signaling pathways. MATERIALS AND METHODS:The UC model in...

    journal_title：European review for medical and pharmacological sciences

    pub_type： 杂志文章

    doi：10.26355/eurrev_201903_17260

    authors： Wang JP,Dong LN,Wang M,Guo J,Zhao YQ

    更新日期：2019-03-01 00:00:00

  • MiR-4429 suppresses the malignant development of ovarian cancer by targeting YOD1.

    abstract：OBJECTIVE:The purpose of this study was to assess the clinical significance of microRNA-4429 (miR-4429) in the development and prognosis of ovarian cancer, and to explore the regulatory role of miR-4429 in migratory potential of ovarian cancer cells. PATIENTS AND METHODS:MiR-4429 levels in paired ovarian cancer specie...

    journal_title：European review for medical and pharmacological sciences

    pub_type： 杂志文章

    doi：10.26355/eurrev_202009_22809

    authors： Zhu YM,Chen P,Shi L,Zhu T,Chen X

    更新日期：2020-09-01 00:00:00

  • Gastric emptying time in cyclic vomiting syndrome in children.

    abstract：:Pathogenesis of cyclic vomiting syndrome (CVS) is still uncertain. Aim of our study has been to verify the role of gastric emptying time in children affected by CVS. We studied 9 children with CVS who underwent measurement of gastric emptying time by real-time ultrasonography after administration of a mixed, solid-liq...

    journal_title：European review for medical and pharmacological sciences

    pub_type： 杂志文章

    doi：

    authors： Turchetti A,Guglielmi S,Fossati C,Matrunola M,Corrado G

    更新日期：2004-11-01 00:00:00

  • Expression of long non-coding RNA MAGI2‑AS3 in human gliomas and its prognostic significance.

    abstract：OBJECTIVE:It has been confirmed that the dysregulation of long noncoding RNAs (lncRNAs) is associated with various diseases, especially cancer. LncRNA MAGI2 antisense RNA 3 (MAGI2-AS3) has been reported to be involved in the progression of bladder cancer and breast cancer. In this study, we aimed to explore its express...

    journal_title：European review for medical and pharmacological sciences

    pub_type： 杂志文章

    doi：10.26355/eurrev_201904_17710

    authors： Chen XD,Zhu MX,Wang SJ

    更新日期：2019-04-01 00:00:00

  • Perindopril inhibits myocardial apoptosis in mice with acute myocardial infarction through TLR4/NF-κB pathway.

    abstract：OBJECTIVE:To explore the anti-apoptotic effect of perindopril on myocardial cells in mice with acute myocardial infarction (AMI). MATERIALS AND METHODS:A total of 48 mice were randomly divided into 4 groups before intervention, namely sham operation group (Sham group, n=12), AMI group (n=12), 1.5 mg/kg perindopril tre...

    journal_title：European review for medical and pharmacological sciences

    pub_type： 杂志文章

    doi：10.26355/eurrev_201908_18558

    authors： Wang XZ,Yu ZX,Nie B,Chen DM

    更新日期：2019-08-01 00:00:00