Evaluation of the application of high volume hemofiltration in sepsis combined with acute kidney injury.

Abstract:

OBJECTIVE:To investigate the safety and effectiveness of the application of high-volume hemofiltration (HVHF) in children with sepsis combined with acute kidney injury. PATIENTS AND METHODS:A total of 76 child patients were enrolled and randomly divided equally (n=38) into control and the observation groups respectively. The control group received conventional volume hemofiltration (the ultrafiltration rate of 35-50 ml/kg/h), and the observation group received HVHF (50-100 ml/kg/h). RESULTS:The serum Interleukin-6 (IL-6), Tumor Necrosis Factor-a (TNF-α) and creatinine levels were significantly lower in the observation group than the control group at 6 h, 12 h, 24 h and 48 h of hemofiltration (p<0.05). The efficacy rate of treatment was improved. The mortality rate and incidence rate of complications were decreased, and the treatment course was significantly shortened (p<0.05). CONCLUSIONS:The application of HVHF in children with sepsis combined with acute kidney injury has a better safety and effectiveness.

authors

Meng SQ,Yang WB,Liu JG,Yuan JY,Zhang K,Ding WY,Yang SQ,Liu JH

doi

10.26355/eurrev_201802_14298

subject

Has Abstract

pub_date

2018-02-01 00:00:00

pages

715-720

issue

3

eissn

1128-3602

issn

2284-0729

journal_volume

22

pub_type

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