Abstract:
PURPOSE:This study evaluated the usefulness of the maximum standardized uptake value (SUVmax) as a measure of histologic response to neoadjuvant chemotherapy in patients with extremity osteosarcoma. The correlation between [(18) F]FDG PET SUVmax values and histologic response to preoperative chemotherapy was also assessed prospectively using PET/MRI. METHODS:A total of 26 consecutive patients with high-grade osteosarcoma were prospectively enrolled. All patients underwent parallel PET and MRI scans before and after neoadjuvant chemotherapy. Using the PET and MRI images and pathologic mapping, we assessed the percentage necrosis by histology at the highest metabolic activity point in the tumors. This was defined as the minimum histologic response. The predictive values of SUVmax before (SUV1) and after (SUV2) chemotherapy and the SUV change ratio were determined. Correlations were also investigated among SUV2, minimum histologic response and histologic response. RESULTS:Histologically, 13 patients were classified as good responders and 13 as poor responders. Patients with an SUV2 of >5 showed a poor histologic response. A significant correlation was found between SUV2 and histologic response (Spearman's rho -0.642; P < 0.001), and SUV2 and histologic response were both found to be significantly correlated with minimum histologic response (Spearman's rho -0.515 and 0.911; P = 0.007 and P < 0.001, respectively). CONCLUSION:A SUVmax of more than 5 after neoadjuvant chemotherapy identified the majority of histologic nonresponders (sensitivity 61.3 %, PPV 88.9 %). Tumor necrosis at the point of maximum metabolic activity was found to be significantly correlated with the histologic response of entire resected specimen.
journal_name
Eur J Nucl Med Mol Imagingauthors
Kong CB,Byun BH,Lim I,Choi CW,Lim SM,Song WS,Cho WH,Jeon DG,Koh JS,Yoo JY,Lee SYdoi
10.1007/s00259-013-2344-8subject
Has Abstractpub_date
2013-05-01 00:00:00pages
728-36issue
5eissn
1619-7070issn
1619-7089journal_volume
40pub_type
临床试验,杂志文章abstract:PURPOSE:The aims of this study were (1) to evaluate FDG PET/CT and CT for the detection of axillary lymph node metastases in breast cancer (BC) patients and (2) to evaluate FDG PET/CT as a pre-test for the triage to sentinel lymph node biopsy (SLNB) versus axillary lymph node dissection (ALND). METHODS:The sensitivity...
journal_title:European journal of nuclear medicine and molecular imaging
pub_type: 杂志文章
doi:10.1007/s00259-009-1145-6
更新日期:2009-10-01 00:00:00
abstract:PURPOSE:Standardized uptake value ratio (SUVr) used to quantify amyloid-β burden from amyloid-PET scans can be biased by variations in the tracer's nonspecific (NS) binding caused by the presence of cerebrovascular disease (CeVD). In this work, we propose a novel amyloid-PET quantification approach that harnesses the i...
journal_title:European journal of nuclear medicine and molecular imaging
pub_type: 杂志文章
doi:10.1007/s00259-020-05131-z
更新日期:2021-01-07 00:00:00
abstract::Inflammation plays a major role in the development of many diseases. This review article summarizes recent research in the field of in vivo imaging of inflammation. Novel methodologies using PET with (68)Ga peptides targeting, for example, vascular adhesion protein 1 are discussed. ...
journal_title:European journal of nuclear medicine and molecular imaging
pub_type: 杂志文章,评审
doi:10.1007/s00259-011-1987-6
更新日期:2012-02-01 00:00:00
abstract:PURPOSE:The study aims to investigate the role of 18F-alfatide positron emission tomography/computed tomography (PET/CT) in predicting the short-term outcome of concurrent chemoradiotherapy (CCRT) in patients with advanced non-small cell lung cancer (NSCLC). METHODS:Eighteen patients with advanced NSCLC had undergone ...
journal_title:European journal of nuclear medicine and molecular imaging
pub_type: 杂志文章
doi:10.1007/s00259-016-3505-3
更新日期:2016-12-01 00:00:00
abstract:PURPOSE:The purpose of this study was to assess whether digital photon counting technology in digital PET/CT influences the quantification of SUVmax in target lesions and regions of reference compared to analog PET/CT before an interchangeable use of either system in follow up studies. METHODS:From January to June of ...
journal_title:European journal of nuclear medicine and molecular imaging
pub_type: 杂志文章
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更新日期:2019-07-01 00:00:00
abstract:PURPOSE:To analyse the diagnostic value of (18)F-FDG PET and MRI for the evaluation of active lesions in paediatric Langerhans cell histiocytosis. METHODS:We compared 21 (18)F-FDG PET scans with 21 MRI scans (mean time interval 17 days) in 15 patients (11 male, 4 female, age range 4 months to 19 years) with biopsy-pro...
journal_title:European journal of nuclear medicine and molecular imaging
pub_type: 杂志文章
doi:10.1007/s00259-012-2278-6
更新日期:2013-02-01 00:00:00
abstract:PURPOSE:18-fluorodeoxyglucose positron emission tomography combined with computed tomography (FDG-PET/CT) is increasingly used to evaluate treatment response in head and neck squamous cell carcinoma (HNSCC). This analysis assessed the diagnostic value of FDG-PET/CT in detecting nodal disease within 6 months after treat...
journal_title:European journal of nuclear medicine and molecular imaging
pub_type: 杂志文章,meta分析
doi:10.1007/s00259-018-3978-3
更新日期:2018-06-01 00:00:00
abstract:PURPOSE:PET imaging has been recently introduced for investigating the type 1 angiotensin II receptor (AT(1)R) in vivo. The goal of the present study was to investigate the effects of acute and chronic exposure to angiotensin converting enzyme inhibitors (ACEI) on the AT(1)R in the dog kidney. METHODS:Animals were ima...
journal_title:European journal of nuclear medicine and molecular imaging
pub_type: 杂志文章
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更新日期:2008-06-01 00:00:00
abstract::Nuclear medicine has a central role in the diagnosis, staging, response assessment and long-term follow-up of neuroblastoma, the most common solid extracranial tumour in children. These EANM guidelines include updated information on 123I-mIBG, the most common study in nuclear medicine for the evaluation of neuroblasto...
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pub_type: 杂志文章
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journal_title:European journal of nuclear medicine and molecular imaging
pub_type: 杂志文章
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更新日期:2007-03-01 00:00:00
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journal_title:European journal of nuclear medicine and molecular imaging
pub_type: 杂志文章,多中心研究
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更新日期:2014-08-01 00:00:00
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journal_title:European journal of nuclear medicine and molecular imaging
pub_type: 临床试验,杂志文章
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更新日期:2005-04-01 00:00:00
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journal_title:European journal of nuclear medicine and molecular imaging
pub_type: 杂志文章
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更新日期:2007-08-01 00:00:00
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journal_title:European journal of nuclear medicine and molecular imaging
pub_type: 杂志文章
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更新日期:2013-01-01 00:00:00
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journal_title:European journal of nuclear medicine and molecular imaging
pub_type: 临床试验,杂志文章
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更新日期:2011-04-01 00:00:00
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journal_title:European journal of nuclear medicine and molecular imaging
pub_type: 杂志文章,评审
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abstract:PURPOSE:This study was conducted to investigate whether( 18)F-fluorodeoxyglucose (FDG) uptake, quantified by positron emission tomography (PET), correlates with histological variables including tumour grade, cell proliferation, cell cycle control integrity and glucose metabolism in patients with bone and soft tissue sa...
journal_title:European journal of nuclear medicine and molecular imaging
pub_type: 临床试验,杂志文章
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pub_type: 杂志文章
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journal_title:European journal of nuclear medicine and molecular imaging
pub_type: 杂志文章
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journal_title:European journal of nuclear medicine and molecular imaging
pub_type: 杂志文章,评审
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journal_title:European journal of nuclear medicine and molecular imaging
pub_type: 临床试验,杂志文章
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更新日期:2013-02-01 00:00:00
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journal_title:European journal of nuclear medicine and molecular imaging
pub_type: 杂志文章
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更新日期:2008-03-01 00:00:00
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journal_title:European journal of nuclear medicine and molecular imaging
pub_type: 杂志文章
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更新日期:2007-12-01 00:00:00
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journal_title:European journal of nuclear medicine and molecular imaging
pub_type: 杂志文章
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更新日期:2012-02-01 00:00:00
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journal_title:European journal of nuclear medicine and molecular imaging
pub_type: 杂志文章,评审
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journal_title:European journal of nuclear medicine and molecular imaging
pub_type: 杂志文章
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更新日期:2010-08-01 00:00:00
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journal_title:European journal of nuclear medicine and molecular imaging
pub_type: 杂志文章
doi:10.1007/s00259-008-1002-z
更新日期:2009-05-01 00:00:00
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journal_title:European journal of nuclear medicine and molecular imaging
pub_type: 杂志文章
doi:10.1007/s00259-020-05084-3
更新日期:2020-10-30 00:00:00
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journal_title:European journal of nuclear medicine and molecular imaging
pub_type: 杂志文章,meta分析,评审
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更新日期:2016-05-01 00:00:00
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journal_title:European journal of nuclear medicine and molecular imaging
pub_type: 杂志文章
doi:10.1007/s00259-018-4062-8
更新日期:2019-01-01 00:00:00