当前位置： SCI文献检索 > EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING期刊下所有文献 > Diagnostic value of full-dose FDG PET/CT for axillary lymph node staging in breast cancer patients.

Diagnostic value of full-dose FDG PET/CT for axillary lymph node staging in breast cancer patients.

Abstract：

PURPOSE:The aims of this study were (1) to evaluate FDG PET/CT and CT for the detection of axillary lymph node metastases in breast cancer (BC) patients and (2) to evaluate FDG PET/CT as a pre-test for the triage to sentinel lymph node biopsy (SLNB) versus axillary lymph node dissection (ALND). METHODS:The sensitivity, specificity, positive and negative predictive value (PPV, NPV), and accuracy of FDG PET/CT and CT for axillary lymph node metastases were determined in 61 patients (gold standard: histopathology). According to the equation "NPV = specificity (1-prevalence) / [specificity (1-prevalence) + (1-sensitivity) prevalence]" FDG PET/CT was evaluated as a triage tool for SLNB versus ALND. RESULTS:The sensitivity, specificity, PPV, NPV and accuracy of FDG PET/CT was 58, 92, 82, 77 and 79% and of CT 46, 89, 72, 71 and 72%, respectively. Patients with an up to approximately 60% risk for axillary lymph node metastases appear to be candidates for SLNB provided that the axilla is unremarkable on FDG PET/CT. CONCLUSION:FDG PET/CT cannot replace invasive approaches for axillary staging but may extend the indication for SLNB.

journal_name

Eur J Nucl Med Mol Imaging

journal_title

European journal of nuclear medicine and molecular imaging

authors

Heusner TA,Kuemmel S,Hahn S,Koeninger A,Otterbach F,Hamami ME,Kimmig KR,Forsting M,Bockisch A,Antoch G,Stahl A

doi

10.1007/s00259-009-1145-6

subject

Has Abstract

pub_date

2009-10-01 00:00:00

pages

1543-50

issue

10

eissn

1619-7070

issn

1619-7089

journal_volume

36

pub_type

杂志文章

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