Abstract:
:The purpose of this study was to examine the protective effects of intracellular homogeneous melanin produced by Lachnum YM156 (LIM) against ultraviolet B (UVB) induced damage in mice. The possible structural formula of the LIM was concluded based on elemental analysis, ultraviolet-visible spectroscopy (UV-Vis), Fourier transform infrared spectroscopy (FTIR), nuclear magnetic resonance (NMR), and mass spectrometry (MS). The LIM was modified by arginine to improve its water solubility and biological activities. LIM and ALIM show significant anti-radiation activity in which LIM and ALIM protect the skin under UV radiation. Results indicate that activities of anti-oxidant enzymes in skin were improved after treatment of LIM or ALIM. In addition, LIM and ALIM inhibited over expression of the pro-inflammatory cytokines, including interleukin (IL)-1α, IL-1β, and IL-6 and tumor necrosis factor-α (TNF-α). The protection ability of ALIM was higher than that of LIM at the same dose. Thus, applied LIM and ALIM may be a promising radiation-protective agent.
journal_name
Appl Biochem Biotechnoljournal_title
Applied biochemistry and biotechnologyauthors
Li S,Yang L,Li J,Chen T,Ye Mdoi
10.1007/s12010-018-2898-9subject
Has Abstractpub_date
2019-06-01 00:00:00pages
555-567issue
2eissn
0273-2289issn
1559-0291pii
10.1007/s12010-018-2898-9journal_volume
188pub_type
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