c-erbA encodes multiple proteins in chicken erythroid cells.

abstract：:A culture system was developed which permitted the differentiation of chicken lens epithelial cells to lentoid bodies which contained several cell layers, accumulated high levels of delta-crystallin, and produced extensive gap junctions. This differentiation process was prevented when the cells were infected with a te...

journal_title：Molecular and cellular biology

authors： Menko AS,Boettiger D

更新日期：1988-04-01 00:00:00

abstract：:E6-AP is a 100-kDa cellular protein that mediates the interaction of the human papillomavirus type 16 and 18 E6 proteins with p53. The association of p53 with E6 and E6-AP promotes the specific ubiquitination and subsequent proteolytic degradation of p53 in vitro. We recently isolated a cDNA encoding E6-AP and have no...

journal_title：Molecular and cellular biology

authors： Huibregtse JM,Scheffner M,Howley PM

更新日期：1993-08-01 00:00:00

abstract：:Flap endonuclease 1 (FEN1) has been shown to remove 5' overhanging flap intermediates during base excision repair and to process the 5' ends of Okazaki fragments during lagging-strand DNA replication in vitro. To assess the in vivo role of the mammalian enzyme in repair and replication, we used a gene-targeting approa...

journal_title：Molecular and cellular biology

authors： Larsen E,Gran C,Saether BE,Seeberg E,Klungland A

更新日期：2003-08-01 00:00:00

abstract：:With v-yes DNA as the probe, a human cDNA library made from placental RNA was screened under relaxed conditions, and DNA clones derived from a novel genetic locus, termed lyn, were obtained. Nucleotide sequencing revealed that lyn could encode a novel tyrosine kinase that was very similar to mouse T-lymphocyte-specifi...

journal_title：Molecular and cellular biology

authors： Yamanashi Y,Fukushige S,Semba K,Sukegawa J,Miyajima N,Matsubara K,Yamamoto T,Toyoshima K

更新日期：1987-01-01 00:00:00

abstract：:Nuclear receptor corepressors (N-CoR) and silencing mediator for retinoid and thyroid receptors (SMRT) have both been implicated in thyroid hormone receptor (TR)-mediated repression. Here we show that endogenous N-CoR, TBL1, and histone deacetylase 3 (HDAC3), but not HDAC1, -2, or -4, are recruited to a stably integra...

journal_title：Molecular and cellular biology

authors： Ishizuka T,Lazar MA

更新日期：2003-08-01 00:00:00

abstract：:The GCN4 gene encodes a positive effector of amino acid biosynthetic genes in Saccharomyces cerevisiae. Genetic analysis has suggested that GCN4 is regulated by a hierarchy of interacting positive and negative effectors in response to amino acid starvation. Results presented here for a GCN4-lacZ gene fusion support th...

journal_title：Molecular and cellular biology

authors： Hinnebusch AG

更新日期：1985-09-01 00:00:00

abstract：:Tetraspanins are clustered in specific microdomains (named tetraspanin-enriched microdomains, or TERM) in the plasma membrane and regulate the functions of associated transmembrane receptors, including integrins and receptor tyrosine kinases. We have identified syntenin-1, a PDZ domain-containing protein, as a new com...

journal_title：Molecular and cellular biology

authors： Latysheva N,Muratov G,Rajesh S,Padgett M,Hotchin NA,Overduin M,Berditchevski F

更新日期：2006-10-01 00:00:00

abstract：:Matrix metalloproteinases (MMPs) exert both pro- and antiangiogenic functions by the release of cytokines or proteolytically generated angiogenic inhibitors from extracellular matrix and basement membrane remodeling. In the Mmp2-/- mouse neovascularization is greatly reduced, but the mechanistic aspects of this remain...

journal_title：Molecular and cellular biology

authors： Dean RA,Butler GS,Hamma-Kourbali Y,Delbé J,Brigstock DR,Courty J,Overall CM

更新日期：2007-12-01 00:00:00

abstract：:The ETS transcription factor complex GABP consists of the GABPalpha protein, containing an ETS DNA binding domain, and an unrelated GABPbeta protein, containing a transactivation domain and nuclear localization signal. GABP has been shown in vitro to regulate the expression of nuclear genes involved in mitochondrial r...

journal_title：Molecular and cellular biology

authors： Ristevski S,O'Leary DA,Thornell AP,Owen MJ,Kola I,Hertzog PJ

更新日期：2004-07-01 00:00:00

abstract：:The Werner syndrome protein (WRN) suppresses the loss of telomeres replicated by lagging-strand synthesis by a yet to be defined mechanism. Here, we show that whereas either WRN or the Bloom syndrome helicase (BLM) stimulates DNA polymerase δ progression across telomeric G-rich repeats, only WRN promotes sequential st...

journal_title：Molecular and cellular biology

authors： Li B,Reddy S,Comai L

更新日期：2017-01-19 00:00:00

abstract：:Cellular differentiation is governed by changes in gene expression, but at the same time, a cell's identity needs to be maintained through multiple cell divisions during maturation. In myeloid cell lines, retinoids induce gene expression and a well-characterized two-step lineage-specific differentiation. To identify m...

journal_title：Molecular and cellular biology

authors： Balint BL,Szanto A,Madi A,Bauer UM,Gabor P,Benko S,Puskás LG,Davies PJ,Nagy L

更新日期：2005-07-01 00:00:00

abstract：:SLC5A8 is a putative tumor suppressor that is inactivated in more than 10 different types of cancer, but neither the oncogenic signaling responsible for SLC5A8 inactivation nor the functional relevance of SLC5A8 loss to tumor growth has been elucidated. Here, we identify oncogenic HRAS (HRAS(G12V)) as a potent mediato...

journal_title：Molecular and cellular biology

authors： Elangovan S,Pathania R,Ramachandran S,Ananth S,Padia RN,Srinivas SR,Babu E,Hawthorn L,Schoenlein PV,Boettger T,Smith SB,Prasad PD,Ganapathy V,Thangaraju M

更新日期：2013-10-01 00:00:00

abstract：:The CDC8 gene, whose product is required for DNA replication in Saccharomyces cerevisiae, has been isolated on recombinant plasmids. The yeast vector YCp50 bearing the yeast ARS1, CEN4, and URA3 sequences, to provide for replication, stability, and selection, respectively, was used to prepare a recombinant plasmid poo...

journal_title：Molecular and cellular biology

authors： Kuo CL,Campbell JL

更新日期：1983-10-01 00:00:00

abstract：:The mouse Surfeit locus, which contains a cluster of at least four genes (Surf-1 to Surf-4), is unusual in that adjacent genes are separated by no more than 73 base pairs (bp). The heterogeneous 5' ends of Surf-1 and Surf-2 are separated by only 15 to 73 bp, the 3' ends of Surf-1 and Surf-3 are only 70 bp apart, and t...

journal_title：Molecular and cellular biology

authors： Giallongo A,Yon J,Fried M

更新日期：1989-01-01 00:00:00

abstract：:Throughout life, intestinal Lgr5+ stem cells give rise to proliferating transient amplifying cells in crypts, which subsequently differentiate into one of the five main cell types and migrate along the crypt-villus axis. These dynamic processes are coordinated by a relatively small number of evolutionarily conserved s...

journal_title：Molecular and cellular biology

authors： van Es JH,Haegebarth A,Kujala P,Itzkovitz S,Koo BK,Boj SF,Korving J,van den Born M,van Oudenaarden A,Robine S,Clevers H

更新日期：2012-05-01 00:00:00

abstract：:Simultaneous resistance to an array of drugs with different cytotoxic activities is a property of Saccharomyces cerevisiae, in which the protein Pdr3p has recently been shown to play a role as a transcriptional regulator. We provide evidence that the yeast PDR3 gene, which encodes a zinc finger transcription factor im...

journal_title：Molecular and cellular biology

authors： Delahodde A,Delaveau T,Jacq C

更新日期：1995-08-01 00:00:00

abstract：:Prostaglandins, pleiotropic immune modulators that induce protein kinase A (PKA), inhibit gamma interferon induction of class II major histocompatibility complex (MHC) genes. We show that phosphorylation of CIITA by PKA accounts for this inhibition. Treatment with prostaglandin E or 8-bromo-cyclic AMP or transfection ...

journal_title：Molecular and cellular biology

authors： Li G,Harton JA,Zhu X,Ting JP

更新日期：2001-07-01 00:00:00

abstract：:Amino acids 106 to 143 and 354 to 433 of the human c-myc protein (439 amino acids) were shown to be required for the protein to suppress c-myc gene transcription and were found to exactly overlap with those necessary for c-myc to cooperate with ras oncogenes in the transformation of rat embryo fibroblasts. The essenti...

journal_title：Molecular and cellular biology

authors： Penn LJ,Brooks MW,Laufer EM,Littlewood TD,Morgenstern JP,Evan GI,Lee WM,Land H

更新日期：1990-09-01 00:00:00

abstract：:The existence of torsional stress in eukaryotic chromatin has been controversial. To determine whether it could be detected, we probed the structure of an alternating AT tract. These sequences adopt cruciform geometry when the DNA helix is torsionally strained by negative supercoiling. The single-strand-specific nucle...

journal_title：Molecular and cellular biology

authors： Leonard MW,Patient RK

更新日期：1991-12-01 00:00:00

abstract：:CREB binding protein (CBP) is a 270-kDa nuclear protein required for activated transcription of a large number of cellular genes. Although CBP was originally discovered through its interaction with phosphorylated CREB (pCREB), it is utilized by a multitude of cellular transcription factors and viral oncoproteins. Both...

journal_title：Molecular and cellular biology

authors： Giebler HA,Lemasson I,Nyborg JK

更新日期：2000-07-01 00:00:00

abstract：:The Gfi-1 proto-oncogene encodes a zinc finger protein with six C2H2-type, C-terminal zinc finger motifs and is activated by provirus integration in T-cell lymphoma lines selected for interleukin-2 independence in culture and in primary retrovirus-induced thymomas. Gfi-1 expression in adult animals is restricted to th...

journal_title：Molecular and cellular biology

authors： Zweidler-Mckay PA,Grimes HL,Flubacher MM,Tsichlis PN

更新日期：1996-08-01 00:00:00

abstract：:We have characterized the mechanism by which coactivator p300 facilitates transcriptional activation mediated by the heterodimer of thyroid hormone (T3) receptor and 9-cis retinoid acid receptor (TR-RXR) in the context of chromatin. We demonstrate that, while p300 can enhance the transcriptional activation mediated by...

journal_title：Molecular and cellular biology

authors： Li J,O'Malley BW,Wong J

更新日期：2000-03-01 00:00:00

abstract：:The Epstein-Barr virus BRLF1 and BZLF1 genes are the first viral genes transcribed upon induction of the viral lytic cycle. The protein products of both genes (referred to here as Rta and Zta, respectively) activate expression of other viral genes, thereby initiating the lytic cascade. Among the viral antigens express...

journal_title：Molecular and cellular biology

authors： Flemington EK,Lytle JP,Cayrol C,Borras AM,Speck SH

更新日期：1994-05-01 00:00:00

abstract：:Loss of p53 sensitizes to antimicrotubule agents in human tumor cells, but little is known about its role during mitosis. We have identified the Polo-like kinase family member serum inducible kinase (Snk/Plk2) as a novel p53 target gene. Snk/Plk2 mutagenesis demonstrated that its kinase activity is negatively regulate...

journal_title：Molecular and cellular biology

authors： Burns TF,Fei P,Scata KA,Dicker DT,El-Deiry WS

更新日期：2003-08-01 00:00:00

abstract：:We have isolated new histone H3 mutants in Saccharomyces cerevisiae that confer phenotypes indicative of transcriptional defects. Here we describe the characterization of one such mutant, encoded by the hht2-11 allele, which contains the single amino acid change L61W in the globular domain of H3. Whole-genome expressi...

journal_title：Molecular and cellular biology

authors： Duina AA,Winston F

更新日期：2004-01-01 00:00:00

abstract：:A monoclonal antibody (MAb 30B6) was recently described by Rogalski and Singer (J. Cell Biol. 101:785-801, 1985) which identified an integral membrane glycoprotein of chicken cells that was associated with a wide variety of sites of actin microfilament attachments to membranes. In this report, we present a further cha...

journal_title：Molecular and cellular biology

authors： Maher PA,Singer SJ

更新日期：1988-02-01 00:00:00

abstract：:Ubiquitin is a multifunctional 76-amino-acid protein which plays critical roles in many aspects of cellular metabolism. In Caenorhabditis elegans, the major source of ubiquitin RNA is the polyubiquitin locus, UbiA. UbiA is transcribed as a polycistronic mRNA which contains 11 tandem repeats of ubiquitin sequence and p...

journal_title：Molecular and cellular biology

authors： Graham RW,Jones D,Candido EP

更新日期：1989-01-01 00:00:00

abstract：:A transcriptional enhancer has been mapped to a region 5.5 kilobases 3' of the C beta 2 gene in the human T-cell receptor (TCR) beta-chain locus. Transient transfections allowed localization of enhancer activity to a 480-base-pair HincII-XbaI restriction enzyme fragment. The TCR beta enhancer was active on both the mi...

journal_title：Molecular and cellular biology

authors： Gottschalk LR,Leiden JM

更新日期：1990-10-01 00:00:00

abstract：:An interferon-alpha-like sequence was isolated from a human genomic library by hybridization with a 15-base oligonucleotide. The sequence also showed homology to alpha-interferon and was most closely related to the leukocyte interferon-M gene fragment. The original isolate cross-hybridized to a family of sequences, 10...

journal_title：Molecular and cellular biology

authors： Feinstein SI,Mory Y,Chernajovsky Y,Maroteaux L,Nir U,Lavie V,Revel M

更新日期：1985-03-01 00:00:00

abstract：:We investigated two phenotypically distinct types of diphtheria toxin-resistant mutants of Chinese hamster cells and compared their resistance with that of naturally resistant mouse cells. All are resistant due to a defect in the process of internalization and delivery of toxin to its target in the cytosol, elongation...

journal_title：Molecular and cellular biology

authors： Didsbury JR,Moehring JM,Moehring TJ

更新日期：1983-07-01 00:00:00