Domains of human c-myc protein required for autosuppression and cooperation with ras oncogenes are overlapping.

Abstract:

:Amino acids 106 to 143 and 354 to 433 of the human c-myc protein (439 amino acids) were shown to be required for the protein to suppress c-myc gene transcription and were found to exactly overlap with those necessary for c-myc to cooperate with ras oncogenes in the transformation of rat embryo fibroblasts. The essential carboxyl-terminal region harbors structural motifs (a basic region, a helix-loop-helix motif, and a "leucine zipper"), which, in other proteins, can mediate dimerization and sequence-specific DNA binding.

journal_name

Mol Cell Biol

authors

Penn LJ,Brooks MW,Laufer EM,Littlewood TD,Morgenstern JP,Evan GI,Lee WM,Land H

doi

10.1128/mcb.10.9.4961

subject

Has Abstract

pub_date

1990-09-01 00:00:00

pages

4961-6

issue

9

eissn

0270-7306

issn

1098-5549

journal_volume

10

pub_type

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