Abstract:
:A culture system was developed which permitted the differentiation of chicken lens epithelial cells to lentoid bodies which contained several cell layers, accumulated high levels of delta-crystallin, and produced extensive gap junctions. This differentiation process was prevented when the cells were infected with a temperature-sensitive src mutant of Rous sarcoma virus and maintained at the permissive temperature. These transformed cells continued to proliferate and also synthesized the major lens gap junction protein, MP28, at near-normal rates. However, this MP28 was not assembled to produce gap junctions. Cultures shifted to the nonpermissive temperature formed lentoid bodies similar to those in uninfected lens cultures, including the establishment of gap junctions containing MP28.
journal_name
Mol Cell Bioljournal_title
Molecular and cellular biologyauthors
Menko AS,Boettiger Ddoi
10.1128/mcb.8.4.1414subject
Has Abstractpub_date
1988-04-01 00:00:00pages
1414-20issue
4eissn
0270-7306issn
1098-5549journal_volume
8pub_type
杂志文章abstract::TIN2 is a negative regulator of telomere elongation that interacts with telomeric DNA repeat binding factor 1 (TRF1) and affects telomere length by a telomerase-dependent mechanism. Here we show that inactivation of the mouse TRF1-interacting protein 2 (TIN2) gene results in early embryonic lethality. We further obser...
journal_title:Molecular and cellular biology
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pub_type: 杂志文章,收录出版
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pub_type: 杂志文章
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pub_type: 杂志文章
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更新日期:1982-11-01 00:00:00
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pub_type: 杂志文章
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pub_type: 杂志文章
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更新日期:2014-01-01 00:00:00
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journal_title:Molecular and cellular biology
pub_type: 杂志文章
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更新日期:1991-10-01 00:00:00
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pub_type: 杂志文章
doi:10.1128/mcb.8.10.4557
更新日期:1988-10-01 00:00:00
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journal_title:Molecular and cellular biology
pub_type: 杂志文章
doi:10.1128/mcb.5.8.2090
更新日期:1985-08-01 00:00:00
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journal_title:Molecular and cellular biology
pub_type: 杂志文章
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更新日期:2013-12-01 00:00:00
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pub_type: 杂志文章
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journal_title:Molecular and cellular biology
pub_type: 杂志文章
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更新日期:1997-12-01 00:00:00
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journal_title:Molecular and cellular biology
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pub_type: 杂志文章
doi:10.1128/mcb.11.12.6139
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