Multiple properties of the splicing repressor SRp38 distinguish it from typical SR proteins.

abstract：:3'-end processing of nucleus-encoded mRNAs includes the addition of a poly(A) tail that is important for translation initiation. Since the vast majority of chloroplast mRNAs acquire their 3' termini by processing yet are not polyadenylated, we asked whether 3' end maturation plays a role in chloroplast translation. A ...

journal_title：Molecular and cellular biology

authors： Rott R,Levy H,Drager RG,Stern DB,Schuster G

更新日期：1998-08-01 00:00:00

abstract：:Reaper (RPR), HID, and GRIM activate apoptosis in cells programmed to die during Drosophila development. We have previously shown that transient overexpression of RPR in the lepidopteran SF-21 cell line induces apoptosis and that members of the inhibitor of apoptosis (IAP) family of antiapoptotic proteins can inhibit ...

journal_title：Molecular and cellular biology

authors： Vucic D,Kaiser WJ,Miller LK

更新日期：1998-06-01 00:00:00

abstract：:JUN transcription factors bind DNA as part of the AP-1 complex, regulate many cellular processes, and play a key role in oncogenesis. The three JUN proteins (c-JUN, JUNB, and JUND) can have both redundant and unique functions depending on the biological phenotype and cell type assayed. Mechanisms that allow this dynam...

journal_title：Molecular and cellular biology

authors： Selvaraj N,Budka JA,Ferris MW,Plotnik JP,Hollenhorst PC

更新日期：2015-01-01 00:00:00

abstract：:The function of the p53 tumor suppressor to inhibit proliferation or initiate apoptosis is often abrogated in tumor cells. Mdm2 and its homolog, Mdm4, are critical inhibitors of p53 that are often overexpressed in human tumors. In mice, loss of Mdm2 or Mdm4 leads to embryonic lethal phenotypes that are completely resc...

journal_title：Molecular and cellular biology

authors： Grier JD,Xiong S,Elizondo-Fraire AC,Parant JM,Lozano G

更新日期：2006-01-01 00:00:00

abstract：:The transcription of meiosis-specific genes, as well as the initiation of meiosis, in the budding yeast Saccharomyces cerevisiae depends on IME1. IME1 encodes a transcriptional activator which lacks known DNA binding motifs. In this study we have determined the mode by which Ime1 specifically activates the transcripti...

journal_title：Molecular and cellular biology

authors： Rubin-Bejerano I,Mandel S,Robzyk K,Kassir Y

更新日期：1996-05-01 00:00:00

abstract：:Chronic myelogenous leukemia (CML) is a clonal myeloproliferative disorder resulting from the neoplastic transformation of a hematopoietic stem cell. The majority of cases of CML are associated with the (9;22) chromosome translocation that generates the bcr-abl chimeric gene. Alpha interferon (IFN-alpha) treatment ind...

journal_title：Molecular and cellular biology

authors： Hao SX,Ren R

更新日期：2000-02-01 00:00:00

abstract：:We have studied the mechanism by which 5'-flanking sequences modulate the in vitro transcription of eucaryotic tRNA genes. Using deletion and linker substitution mutagenesis, we have found that the 5'-flanking sequences responsible for the different in vitro transcription levels of three Drosophila tRNA5Asn genes are ...

journal_title：Molecular and cellular biology

authors： Lofquist AK,Garcia AD,Sharp SJ

更新日期：1988-10-01 00:00:00

abstract：:Human myeloid leukemia cells respond to 12-O-tetradecanoylphorbol-13-acetate (TPA) and other activators of protein kinase C (PKC) with induction of monocytic differentiation. The present studies demonstrated that treatment of U-937 and HL-60 myeloid leukemia cells with TPA, phorbol-12,13-dibutyrate, or bryostatin 1 wa...

journal_title：Molecular and cellular biology

authors： Kaneki M,Kharbanda S,Pandey P,Yoshida K,Takekawa M,Liou JR,Stone R,Kufe D

更新日期：1999-01-01 00:00:00

abstract：:Tyrosine phosphorylation of CAS (Crk-associated substrate, p130(Cas)) has been implicated as a key signaling step in integrin control of normal cellular behaviors, including motility, proliferation, and survival. Aberrant CAS tyrosine phosphorylation may contribute to cell transformation by certain oncoproteins, inclu...

journal_title：Molecular and cellular biology

authors： Ruest PJ,Shin NY,Polte TR,Zhang X,Hanks SK

更新日期：2001-11-01 00:00:00

abstract：:Protein kinase activities were measured in Rous sarcoma virus-infected baby hamster kidney (BHK) cells that express v-src (BHK [v-src]) and compared with those of revertant and control BHK cells. We observed about a fivefold-higher tyrosine phosphorylating activity in BHK (v-src) cell extracts, which was due to src bu...

journal_title：Molecular and cellular biology

authors： Clinton GM,Roskoski R Jr

更新日期：1984-05-01 00:00:00

abstract：:Welander distal myopathy (WDM) is a muscle dystrophy characterized by adult-onset distal muscle weakness, prevalently impacting the distal long extensors of the hands and feet. WDM is an autosomal dominant disorder caused by a missense mutation (c.1362G>A; p.E384K) in the TIA1 (T-cell intracellular antigen 1) gene, wh...

journal_title：Molecular and cellular biology

authors： Carrascoso I,Sánchez-Jiménez C,Silion E,Alcalde J,Izquierdo JM

更新日期：2018-12-11 00:00:00

abstract：:Telomerase synthesizes tandem repeats of the sequence d(TTGGGG) onto input d(TTGGGG)n primer oligonucleotides (C. W. Greider and E. H. Blackburn, Cell 43:405-413). An intrinsic RNA component of the enzyme provides the template for d(TTGGGG)n repeat synthesis [C. W. Greider and E. H. Blackburn, Nature (London) 337:331-...

journal_title：Molecular and cellular biology

authors： Greider CW

更新日期：1991-09-01 00:00:00

abstract：:Hydroxyurea (HU) is a DNA replication inhibitor that negatively affects both the elongation and initiation phases of replication and triggers the "intra-S phase checkpoint." Previous work with budding yeast has shown that, during a short exposure to HU, MEC1/RAD53 prevent initiation at some late S phase origins. In th...

journal_title：Molecular and cellular biology

authors： Alvino GM,Collingwood D,Murphy JM,Delrow J,Brewer BJ,Raghuraman MK

更新日期：2007-09-01 00:00:00

abstract：:The retinoblastoma tumor suppressor protein (RB) is a negative regulator of the cell cycle that inhibits both G(1) and S-phase progression. While RB-mediated G(1) inhibition has been extensively studied, the mechanism utilized for S-phase inhibition is unknown. To delineate the mechanism through which RB inhibits DNA ...

journal_title：Molecular and cellular biology

authors： Sever-Chroneos Z,Angus SP,Fribourg AF,Wan H,Todorov I,Knudsen KE,Knudsen ES

更新日期：2001-06-01 00:00:00

abstract：:The Saccharomyces cerevisiae Srs2 protein is involved in DNA repair and recombination. In order to gain better insight into the roles of Srs2, we performed a screen to identify mutations that are synthetically lethal with an srs2 deletion. One of them is a mutated allele of the ULP1 gene that encodes a protease specif...

journal_title：Molecular and cellular biology

authors： Soustelle C,Vernis L,Fréon K,Reynaud-Angelin A,Chanet R,Fabre F,Heude M

更新日期：2004-06-01 00:00:00

abstract：:Using an expression cDNA cloning approach, we examined human tumor cell lines for novel oncogenes that might evade detection by conventional techniques. We isolated a transforming sequence that was highly efficient in transforming NIH 3T3 mouse fibroblasts. DNA sequence analysis identified the gene as the human homolo...

journal_title：Molecular and cellular biology

authors： Chan AM,Fleming TP,McGovern ES,Chedid M,Miki T,Aaronson SA

更新日期：1993-02-01 00:00:00

abstract：:To determine whether regulation of c-myc proteins occurs during the differentiation of murine erythroleukemia cells, we examined c-myc protein synthesis and accumulation throughout dimethyl sulfoxide (DMSO)- or hypoxanthine-induced differentiation. c-myc protein expression exhibited an overall biphasic reduction, with...

journal_title：Molecular and cellular biology

authors： Spotts GD,Hann SR

更新日期：1990-08-01 00:00:00

abstract：:WW domains are protein modules that mediate protein-protein interactions through recognition of proline-rich peptide motifs and phosphorylated serine/threonine-proline sites. To pursue the functional properties of WW domains, we employed mass spectrometry to identify 148 proteins that associate with 10 human WW domain...

journal_title：Molecular and cellular biology

authors： Ingham RJ,Colwill K,Howard C,Dettwiler S,Lim CS,Yu J,Hersi K,Raaijmakers J,Gish G,Mbamalu G,Taylor L,Yeung B,Vassilovski G,Amin M,Chen F,Matskova L,Winberg G,Ernberg I,Linding R,O'donnell P,Starostine A,Keller W

更新日期：2005-08-01 00:00:00

abstract：:We report that the genes for the homologous Saccharomyces cerevisiae RAD10 and human ERCC-1 DNA excision repair proteins harbor overlapping antisense transcription units in their 3' regions. Since naturally occurring antisense transcription is rare in S. cerevisiae and humans (this is the first example in human cells)...

journal_title：Molecular and cellular biology

authors： van Duin M,van Den Tol J,Hoeijmakers JH,Bootsma D,Rupp IP,Reynolds P,Prakash L,Prakash S

更新日期：1989-04-01 00:00:00

abstract：:Even though endothelin is recognized as an important vasoregulatory molecule, the roles of endothelin receptors in specific cell types are not yet fully understood. Mice with a null mutation in endothelin A receptor gene (ET(A)) or in the gene of its ligand (endothelin 1) die neonatally due to craniofacial and cardiac...

journal_title：Molecular and cellular biology

authors： Kedzierski RM,Grayburn PA,Kisanuki YY,Williams CS,Hammer RE,Richardson JA,Schneider MD,Yanagisawa M

更新日期：2003-11-01 00:00:00

abstract：:CD40, a tumor necrosis factor (TNF) receptor (TNFR) family member, conveys signals regulating diverse cellular responses, ranging from proliferation and differentiation to growth suppression and cell death. The ability of CD40 to mediate apoptosis in carcinoma cells is intriguing given the fact that the CD40 cytoplasm...

journal_title：Molecular and cellular biology

authors： Eliopoulos AG,Davies C,Knox PG,Gallagher NJ,Afford SC,Adams DH,Young LS

更新日期：2000-08-01 00:00:00

abstract：:The extracellular signal-regulated kinase 1 and 2 (ERK1/2) mitogen-activated protein (MAP) kinase signaling pathway plays an important role in the proliferative response of mammalian cells to mitogens. However, the individual contribution of the isoforms ERK1 and ERK2 to cell proliferation control is unclear. The two ...

journal_title：Molecular and cellular biology

authors： Voisin L,Saba-El-Leil MK,Julien C,Frémin C,Meloche S

更新日期：2010-06-01 00:00:00

abstract：:Serum induction of c-jun expression in HeLa cells requires a MEF2 site at -59 in the c-jun promoter. MEF2 sites, found in many muscle-specific enhancers, are bound by a family of transcription factors, MEF2A through -D, which are related to serum response factor in their DNA binding domains. We have found that MEF2D i...

journal_title：Molecular and cellular biology

authors： Han TH,Prywes R

更新日期：1995-06-01 00:00:00

abstract：:We measured the content and metabolism of histone mRNA in mouse 3T6 fibroblasts during a serum-induced transition from the resting to growing state. The content of several histone H3 and H2b mRNAs was measured by an S1 nuclease procedure. All of these increase in parallel by a factor of about 50 during S phase. Howeve...

journal_title：Molecular and cellular biology

authors： DeLisle AJ,Graves RA,Marzluff WF,Johnson LF

更新日期：1983-11-01 00:00:00

abstract：:The Wnt-1 proto-oncogene is essential for proper development of the midbrain and is expressed in a spatially and temporally restricted manner during central nervous system development in mice. In vitro, the gene is specifically transcribed during the retinoic acid (RA)-induced neuroectodermal differentiation of the P1...

journal_title：Molecular and cellular biology

authors： St-Arnaud R,Moir JM

更新日期：1993-03-01 00:00:00

abstract：:The human genome contains a number of methyl CpG binding proteins that translate DNA methylation into a physiological response. To gain insight into the function of MBD2 and MBD3, we first applied protein tagging and mass spectrometry. We show that MBD2 and MBD3 assemble into mutually exclusive distinct Mi-2/NuRD-like...

journal_title：Molecular and cellular biology

authors： Le Guezennec X,Vermeulen M,Brinkman AB,Hoeijmakers WA,Cohen A,Lasonder E,Stunnenberg HG

更新日期：2006-02-01 00:00:00

abstract：:We utilized the human 4F2 heavy-chain (4F2HC) gene as a model system to study the regulation of inducible gene expression during normal human T-cell activation. Previous studies have demonstrated that 4F2HC gene expression is induced during normal T-cell activation and that the activity of the gene is regulated, at le...

journal_title：Molecular and cellular biology

authors： Karpinski BA,Yang LH,Cacheris P,Morle GD,Leiden JM

更新日期：1989-06-01 00:00:00

abstract：:ADR1 is a yeast transcription factor that contains two zinc fingers of the Cys-2-His-2 (C2H2) class. Mutations that change the specificity of DNA binding of ADR1 to its target site, upstream activation sequence 1 (UAS1), have been identified at three positions in the first zinc finger. Mutations Arg-115 to Gln, His-11...

journal_title：Molecular and cellular biology

authors： Thukral SK,Morrison ML,Young ET

更新日期：1992-06-01 00:00:00

abstract：:A mouse adenine phosphoribosyltransferase (aprt) pseudogene that had previously been recovered from a BALB/c sperm DNA library possessed several unusual features. Its nucleotide sequence, like that of other processed pseudogenes, was colinear with its corresponding mRNA, but it was truncated at its 3' end and lacked a...

journal_title：Molecular and cellular biology

authors： Dush MK,Tischfield JA,Khan SA,Feliciano E,Sikela JM,Kozak CA,Stambrook PJ

更新日期：1986-12-01 00:00:00

abstract：:The int-1 proto-oncogene is a target for insertional activation of transcription by mouse mammary tumor virus in many murine mammary tumors. Whereas no expression of int-1 is seen in normal mammary tissue, int-1 RNA can be detected in normal mice in the neural tubes of midgestation embryos and in postmeiotic spermatoc...

journal_title：Molecular and cellular biology

authors： Papkoff J

更新日期：1989-08-01 00:00:00