Regulatory role of MEF2D in serum induction of the c-jun promoter.

abstract：:Glucocorticoid production in the adrenal cortex is activated in response to an increase in cyclic AMP (cAMP) signaling. The nuclear protein p54(nrb)/NONO belongs to the Drosophila behavior/human splicing (DBHS) family and has been implicated in several nuclear processes, including transcription, splicing, and RNA expo...

journal_title：Molecular and cellular biology

authors： Lu JY,Sewer MB

更新日期：2015-04-01 00:00:00

abstract：:The DNA-binding hemopoietic zinc finger transcription factor GATA1 promotes terminal megakaryocyte differentiation and restrains abnormal immature megakaryocyte expansion. How GATA1 coordinates these fundamental processes is unclear. Previous studies of synthetic and naturally occurring mutant GATA1 molecules demonstr...

journal_title：Molecular and cellular biology

authors： Kuhl C,Atzberger A,Iborra F,Nieswandt B,Porcher C,Vyas P

更新日期：2005-10-01 00:00:00

abstract：:The M double-stranded RNA component of type 1 killer strains of the yeast Saccharomyces cerevisiae contains an internal 200-base pair adenine- and uracil-rich region. The plus strands of this viral genomic RNA contain an internal adenine-rich region which allows these strands to bind to polyuridylate-Sepharose as tigh...

journal_title：Molecular and cellular biology

authors： Hannig EM,Thiele DJ,Leibowitz MJ

更新日期：1984-01-01 00:00:00

abstract：:We have analyzed the structures and locations of small nuclear RNA (snRNA) precursors at various stages in their synthesis and maturation. In the nuclei of pulse-labeled Xenopus laevis oocytes, we detected snRNAs that were longer than their mature forms at their 3' ends by up to 10 nucleotides. Analysis of the 5' caps...

journal_title：Molecular and cellular biology

authors： Neuman de Vegvar HE,Dahlberg JE

更新日期：1990-07-01 00:00:00

abstract：:The pluripotent factor Oct4 is a key transcription factor that maintains embryonic stem (ES) cell self-renewal and is down-regulated upon the differentiation of ES cells and silenced in somatic cells. A combination of cis elements, transcription factors, and epigenetic modifications, such as DNA methylation, are invol...

journal_title：Molecular and cellular biology

authors： Gu P,Le Menuet D,Chung AC,Cooney AJ

更新日期：2006-12-01 00:00:00

abstract：:Nucleocytoplasmic shuttling of class IIa of histone deacetylases (HDACs) is a key mechanism that controls cell fate and animal development. We have identified the filamin B (FLNB) as a novel HDAC7-interacting protein that is required for temporal and spatial regulation of vascular endothelial growth factor (VEGF)-medi...

journal_title：Molecular and cellular biology

authors： Su YT,Gao C,Liu Y,Guo S,Wang A,Wang B,Erdjument-Bromage H,Miyagi M,Tempst P,Kao HY

更新日期：2013-04-01 00:00:00

abstract：:The scid mouse mutation affects V(D)J rearrangement and double-strand break repair. scid V(D)J rearrangement is characterized by defective coding joint formation which prevents the development of mature B and T cells. Hairpin DNA has been implicated in the formation of V(D)J coding joints. We found scid cells to be pr...

journal_title：Molecular and cellular biology

authors： Staunton JE,Weaver DT

更新日期：1994-06-01 00:00:00

abstract：:A Dictyostelium discoideum cDNA encoding an alpha-type subunit of casein kinase II was isolated, and its cDNA was used to study developmental expression of casein kinase II during the Dictyostelium life cycle. The 1.3-kb cDNA insert contained an open reading frame of 337 amino acids (M(r) 39,900). The deduced amino ac...

journal_title：Molecular and cellular biology

authors： Kikkawa U,Mann SK,Firtel RA,Hunter T

更新日期：1992-12-01 00:00:00

abstract：:The large T antigen of simian virus 40 (SV40) is a multifunctional protein that is essential in both the virus lytic cycle and the oncogenic transformation of cells by SV40. To investigate the role of the numerous biochemical and physiological activities of T antigen in the lytic and transformation processes, we have ...

journal_title：Molecular and cellular biology

authors： Manos MM,Gluzman Y

更新日期：1984-06-01 00:00:00

abstract：:Although the essential involvement of the progesterone receptor (PR) in female reproductive tissues is firmly established, the coregulators preferentially enlisted by PR to mediate its physiological effects have yet to be fully delineated. To further dissect the roles of members of the steroid receptor coactivator (SR...

journal_title：Molecular and cellular biology

authors： Mukherjee A,Soyal SM,Fernandez-Valdivia R,Gehin M,Chambon P,Demayo FJ,Lydon JP,O'Malley BW

更新日期：2006-09-01 00:00:00

abstract：:Negative-feedback loops between transcription factors and repressors in responses to xenobiotics, oxidants, heat, hypoxia, DNA damage, and infection have been described. Although common, the function of feedback is largely unstudied. Here, we define a negative-feedback loop between the Caenorhabditis elegans detoxific...

journal_title：Molecular and cellular biology

authors： Leung CK,Wang Y,Deonarine A,Tang L,Prasse S,Choe KP

更新日期：2013-09-01 00:00:00

abstract：:Two alpha-tubulin genes from the budding yeast Saccharomyces cerevisiae were identified and cloned by cross-species DNA homology. Nucleotide sequencing studies revealed that the two genes, named TUB1 and TUB3, encoded gene products of 447 and 445 amino acids, respectively, that are highly homologous to alpha-tubulins ...

journal_title：Molecular and cellular biology

authors： Schatz PJ,Pillus L,Grisafi P,Solomon F,Botstein D

更新日期：1986-11-01 00:00:00

abstract：:Changes in chromatin composition are often a prerequisite for gene induction. Nonallelic histone variants have recently emerged as key players in transcriptional control and chromatin modulation. While the changes in chromatin accessibility and histone posttranslational modification (PTM) distribution that accompany g...

journal_title：Molecular and cellular biology

authors： Sutcliffe EL,Parish IA,He YQ,Juelich T,Tierney ML,Rangasamy D,Milburn PJ,Parish CR,Tremethick DJ,Rao S

更新日期：2009-04-01 00:00:00

abstract：:SR proteins are essential for pre-mRNA splicing in vitro, act early in the splicing pathway, and can influence alternative splice site choice. Here we describe the isolation of both dominant and loss-of-function alleles of B52, the gene for a Drosophila SR protein. The allele B52ED was identified as a dominant second-...

journal_title：Molecular and cellular biology

authors： Peng X,Mount SM

更新日期：1995-11-01 00:00:00

abstract：:A transgenic gpt+ Chinese hamster cell line (G12) was found to be susceptible to carcinogenic nickel-induced inactivation of gpt expression without mutagenesis or deletion of the transgene. Many nickel-induced 6-thioguanine-resistant variants spontaneously reverted to actively express gpt, as indicated by both reversi...

journal_title：Molecular and cellular biology

authors： Lee YW,Klein CB,Kargacin B,Salnikow K,Kitahara J,Dowjat K,Zhitkovich A,Christie NT,Costa M

更新日期：1995-05-01 00:00:00

abstract：:The tetraspanins are a family of integral membrane proteins with four transmembrane domains. These molecules form multimolecular networks on the surfaces of many different cell types. Gene-targeting studies have revealed a role for tetraspanins in B- and T-lymphocyte function. We have isolated and deleted a novel tetr...

journal_title：Molecular and cellular biology

authors： Tarrant JM,Groom J,Metcalf D,Li R,Borobokas B,Wright MD,Tarlinton D,Robb L

更新日期：2002-07-01 00:00:00

abstract：:Thrombospondins are a family of stress-inducible secreted glycoproteins that underlie tissue remodeling. We recently reported that thrombospondin-4 (Thbs4) has a critical intracellular function, regulating the adaptive endoplasmic reticulum (ER) stress pathway through activating transcription factor 6α (Atf6α). In the...

journal_title：Molecular and cellular biology

authors： Brody MJ,Schips TG,Vanhoutte D,Kanisicak O,Karch J,Maliken BD,Blair NS,Sargent MA,Prasad V,Molkentin JD

更新日期：2015-10-12 00:00:00

abstract：:Growth, patterning, and apoptosis are mutually interactive during development. For example, cells that select an abnormal fate in a developing field are frequently removed by apoptosis. An important issue in this process that needs to be resolved is the mechanism used by cells to discern their correct fate from an abn...

journal_title：Molecular and cellular biology

authors： Adachi-Yamada T,Harumoto T,Sakurai K,Ueda R,Saigo K,O'Connor MB,Nakato H

更新日期：2005-04-01 00:00:00

abstract：:ING1 is a type II tumor suppressor that affects cell growth, stress signaling, apoptosis, and DNA repair by altering chromatin structure and regulating transcription. Decreased ING1 expression is seen in several human cancers, and mislocalization has been noted in diverse types of cancer cells. Aberrant targeting may,...

journal_title：Molecular and cellular biology

authors： Gong W,Russell M,Suzuki K,Riabowol K

更新日期：2006-04-01 00:00:00

abstract：:We have isolated new histone H3 mutants in Saccharomyces cerevisiae that confer phenotypes indicative of transcriptional defects. Here we describe the characterization of one such mutant, encoded by the hht2-11 allele, which contains the single amino acid change L61W in the globular domain of H3. Whole-genome expressi...

journal_title：Molecular and cellular biology

authors： Duina AA,Winston F

更新日期：2004-01-01 00:00:00

abstract：:The v-vis gene encodes p28sis, the transforming protein of simian sarcoma virus. This gene resulted from a fusion of the env gene of simian sarcoma-associated virus and the woolly monkey gene for the B chain of platelet-derived growth factor (PDGF). Previous work has shown that the v-sis gene product undergoes signal ...

journal_title：Molecular and cellular biology

authors： Lee BA,Maher DW,Hannink M,Donoghue DJ

更新日期：1987-10-01 00:00:00

abstract：:A transcriptional initiator (Inr) for mammalian RNA polymerase II can be defined as a DNA sequence element that overlaps a transcription start site and is sufficient for (i) determining the start site location in a promoter that lacks a TATA box and (ii) enhancing the strength of a promoter that contains a TATA box. W...

journal_title：Molecular and cellular biology

authors： Javahery R,Khachi A,Lo K,Zenzie-Gregory B,Smale ST

更新日期：1994-01-01 00:00:00

abstract：:V(D)J recombination requires binding and synapsis of a complementary (12/23) pair of recombination signal sequences (RSSs) by the RAG1 and RAG2 proteins, aided by a high-mobility group protein, HMG1 or HMG2. Double-strand DNA cleavage within this synaptic, or paired, complex is thought to involve DNA distortion or mel...

journal_title：Molecular and cellular biology

authors： Ciubotaru M,Schatz DG

更新日期：2004-10-01 00:00:00

abstract：:Various stresses activate the c-Jun N-terminal kinase (JNK), which is involved in the regulation of many aspects of cellular physiology, including apoptosis. Here we demonstrate that in contrast to UV irradiation, heat shock causes little or no stimulation of the JNK-activating kinase SEK1, while knocking out the SEK1...

journal_title：Molecular and cellular biology

authors： Meriin AB,Yaglom JA,Gabai VL,Zon L,Ganiatsas S,Mosser DD,Zon L,Sherman MY

更新日期：1999-04-01 00:00:00

abstract：:EGL-15 is a fibroblast growth factor receptor in the nematode Caenorhabditis elegans. Components that mediate EGL-15 signaling have been identified via mutations that confer a Clear (Clr) phenotype, indicative of hyperactivity of this pathway, or a suppressor-of-Clr (Soc) phenotype, indicative of reduced pathway activ...

journal_title：Molecular and cellular biology

authors： Schutzman JL,Borland CZ,Newman JC,Robinson MK,Kokel M,Stern MJ

更新日期：2001-12-01 00:00:00

abstract：:A strong block to the elongation of nascent RNA transcripts by RNA polymerase II occurs in the 5' part of the mammalian c-fos proto-oncogene. In addition to the control of initiation, this mechanism contributes to transcriptional regulation of the gene. In vitro transcription experiments using nuclear extracts and pur...

journal_title：Molecular and cellular biology

authors： Mechti N,Piechaczyk M,Blanchard JM,Jeanteur P,Lebleu B

更新日期：1991-05-01 00:00:00

abstract：:Quiescent mouse NIH 3T3 cells responded to microinjection of activated ras p21 with a rapid and sustained rise in intracellular pH (approximately 0.17 pH units). The p21-induced pH change was inhibited by amiloride treatment or growth of cells in medium low in sodium, suggesting a role for the Na+/H+ antiporter. Amilo...

journal_title：Molecular and cellular biology

authors： Hagag N,Lacal JC,Graber M,Aaronson S,Viola MV

更新日期：1987-05-01 00:00:00

abstract：:EYA1 is known to be overexpressed in human breast cancer, in which the Myc protein is also accumulated in association with decreased phospho-T58 (pT58) levels. We have recently reported that EYA1 functions as a unique protein phosphatase to dephosphorylate Myc at pT58 to regulate Myc levels. However, it remains unclea...

journal_title：Molecular and cellular biology

authors： Li J,Rodriguez Y,Cheng C,Zeng L,Wong EYM,Xu CY,Zhou MM,Xu PX

更新日期：2016-12-19 00:00:00

abstract：:p63 is a member of the p53 tumor suppressor gene family, which regulates downstream target gene expression by binding to sequence-specific response elements similar to those of p53. By using oligonucleotide expression microarray analysis and analyzing the promoters of p63-induced genes, we have identified novel p63-sp...

journal_title：Molecular and cellular biology

authors： Osada M,Park HL,Nagakawa Y,Yamashita K,Fomenkov A,Kim MS,Wu G,Nomoto S,Trink B,Sidransky D

更新日期：2005-07-01 00:00:00

abstract：:A novel protein, p55CDC, has been identified in cycling mammalian cells. This transcript is readily detectable in all exponentially growing cell lines but disappears when cells are chemically induced to fall out of the cell cycle and differentiate. The p55CDC protein appears to be essential for cell division, since tr...

journal_title：Molecular and cellular biology

authors： Weinstein J,Jacobsen FW,Hsu-Chen J,Wu T,Baum LG

更新日期：1994-05-01 00:00:00