Microinjection of ras p21 induces a rapid rise in intracellular pH.

abstract：:ADR1 is a yeast transcription factor that contains two zinc fingers of the Cys-2-His-2 (C2H2) class. Mutations that change the specificity of DNA binding of ADR1 to its target site, upstream activation sequence 1 (UAS1), have been identified at three positions in the first zinc finger. Mutations Arg-115 to Gln, His-11...

journal_title：Molecular and cellular biology

authors： Thukral SK,Morrison ML,Young ET

更新日期：1992-06-01 00:00:00

abstract：:Streptozotocin (STZ) is widely used to induce diabetic rodent models. It is specifically toxic to pancreatic beta cells and causes severe destruction and dysfunction. We investigated the effect of 1-palmitoyl-2-linoleoyl-3-acetyl-rac-glycerol (PLAG) on an STZ-induced diabetic mouse model. PLAG attenuated the glucose i...

journal_title：Molecular and cellular biology

authors： Kim J,Kim JH,Sohn KY,Yoon SY,Kim JW

更新日期：2019-10-11 00:00:00

abstract：:Mutation in the REC2 gene of Ustilago maydis leads to defects in DNA repair, recombination, and meiosis. Analysis of the primary sequence of the Rec2 protein reveals a region with significant homology to bacterial RecA protein and to the yeast recombination proteins Dmc1, Rad51, and Rad57. This homologous region in th...

journal_title：Molecular and cellular biology

authors： Rubin BP,Ferguson DO,Holloman WK

更新日期：1994-09-01 00:00:00

abstract：:Endonuclease decay of nonsense-containing beta-globin mRNA in erythroid cells generates 5'-truncated products that were reported previously to have a cap or caplike structure. We confirmed that this 5' modification is indistinguishable from the cap on full-length mRNA, and Western blotting, immunoprecipitation, and ac...

journal_title：Molecular and cellular biology

authors： Otsuka Y,Kedersha NL,Schoenberg DR

更新日期：2009-04-01 00:00:00

abstract：:We previously identified a set of transcription regulators, referred to as TIPs (tension-induced/inhibited proteins), with a role in myogenic versus adipogenic differentiation. Here we report that the TIP family comprises eight isoforms, all bearing a SANT (switching-defective protein 3, adaptor 2, nuclear receptor co...

journal_title：Molecular and cellular biology

authors： Badri KR,Zhou Y,Dhru U,Aramgam S,Schuger L

更新日期：2008-10-01 00:00:00

abstract：:CTCFL, a paralog of CTCF, also known as BORIS (brother of regulator of imprinted sites), is a testis-expressed gene whose function is largely unknown. Its product is a cancer testis antigen (CTA), and it is often expressed in tumor cells and also seen in two benign human vascular malformations, juvenile angiofibromas ...

journal_title：Molecular and cellular biology

authors： Sati L,Zeiss C,Yekkala K,Demir R,McGrath J

更新日期：2015-10-01 00:00:00

abstract：:Net, Elk-1, and Sap-1 are members of the ternary complex factor (TCF) subfamily of Ets transcription factors. They form ternary complexes with serum response factor (SRF) on serum response elements of immediate early genes such as c-fos and egr-1 and mediate responses to growth factors and mitogen-activated protein ki...

journal_title：Molecular and cellular biology

authors： Buchwalter G,Gross C,Wasylyk B

更新日期：2005-12-01 00:00:00

abstract：:We previously purified and characterized functionally the Escherichia coli-expressed product of the human subgroup C adenovirus E1A 13S mRNA (B. Ferguson, N. Jones, J. Richter, and M. Rosenberg, Science 224:1343-1346, 1984; B. Krippl, B. Ferguson, M. Rosenberg, and H. Westphal, Proc. Natl. Acad. Sci. USA 81:6988-6992,...

journal_title：Molecular and cellular biology

authors： Ferguson B,Krippl B,Andrisani O,Jones N,Westphal H,Rosenberg M

更新日期：1985-10-01 00:00:00

abstract：:EYA1 is known to be overexpressed in human breast cancer, in which the Myc protein is also accumulated in association with decreased phospho-T58 (pT58) levels. We have recently reported that EYA1 functions as a unique protein phosphatase to dephosphorylate Myc at pT58 to regulate Myc levels. However, it remains unclea...

journal_title：Molecular and cellular biology

authors： Li J,Rodriguez Y,Cheng C,Zeng L,Wong EYM,Xu CY,Zhou MM,Xu PX

更新日期：2016-12-19 00:00:00

abstract：:The Drosophila Hrb98DE locus encodes proteins that are highly homologous to the mammalian A1 protein, a major component of heterogeneous nuclear ribonucleoprotein (RNP) particles. The Hrb98DE locus is transcribed throughout development, with the highest transcript levels found in ovaries, early embryos, and pupae. Eig...

journal_title：Molecular and cellular biology

authors： Haynes SR,Raychaudhuri G,Beyer AL

更新日期：1990-01-01 00:00:00

abstract：:Using chromatin immunoprecipitation assays, we studied the 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-mediated recruitment of the aryl hydrocarbon receptor (AhR) and several co-regulators to the CYP1A1 promoter. AhR displayed a time-dependent recruitment, reaching a peak at 75 min and maintaining promoter occupancy fo...

journal_title：Molecular and cellular biology

authors： Matthews J,Wihlén B,Thomsen J,Gustafsson JA

更新日期：2005-07-01 00:00:00

abstract：:T antigen (Tag) from simian virus 40 binds specifically to two distinct sites in the viral origin of replication and to single-stranded DNA. Analysis of the protein domain responsible for these activities revealed the following. (i) The C-terminal boundary of the origin-specific and single-strand-specific DNA-binding ...

journal_title：Molecular and cellular biology

authors： McVey D,Strauss M,Gluzman Y

更新日期：1989-12-01 00:00:00

abstract：:We have constructed a genomic DNA library from a methotrexate-resistant Chinese hamster ovary cell line (CHOC 400) in the cosmid vector pHC79. By utilizing a murine dihydrofolate reductase (DHFR) cDNA clone, we have identified 66 DHFR+ clones among the 11,000 colonies screened by colony hybridization. To isolate a rec...

journal_title：Molecular and cellular biology

authors： Milbrandt JD,Azizkhan JC,Greisen KS,Hamlin JL

更新日期：1983-07-01 00:00:00

abstract：:We have analyzed the fine structure of DNA repair in Chinese hamster ovary (CHO) cells within the G1 and G2 phases of the cell cycle. Repair of inactive regions of the genome has been suggested to increase in the G2 phase of the cell cycle compared with other phases. However, detailed studies of DNA repair in the G2 p...

journal_title：Molecular and cellular biology

authors： Petersen LN,Orren DK,Bohr VA

更新日期：1995-07-01 00:00:00

abstract：:Despite the identification of PBC proteins as cofactors that provide DNA affinity and binding specificity for the HOX homeodomain proteins, HOX proteins do not demonstrate robust activity in transient-transcription assays and few authentic downstream targets have been identified for these putative transcription factor...

journal_title：Molecular and cellular biology

authors： Shen WF,Krishnan K,Lawrence HJ,Largman C

更新日期：2001-11-01 00:00:00

abstract：:Up to 70% of human genes are associated with regions of nonmethylated DNA called CpG islands (S. Saxonov, P. Berg, and D. L. Brutlag, Proc. Natl. Acad. Sci. U. S. A. 103:1412-1417, 2006). Usually associated with the 5' end of genes, CpG islands are thought to impact gene expression. We previously demonstrated that the...

journal_title：Molecular and cellular biology

authors： Zhou JC,Blackledge NP,Farcas AM,Klose RJ

更新日期：2012-01-01 00:00:00

abstract：:RNA editing occurs in two higher-plant organelles, chloroplasts and mitochondria. Because chloroplasts and mitochondria exhibit some similarity in editing site selection, we investigated whether mitochondrial RNA sequences could be edited in chloroplasts. We produced transgenic tobacco plants that contained chimeric g...

journal_title：Molecular and cellular biology

authors： Sutton CA,Zoubenko OV,Hanson MR,Maliga P

更新日期：1995-03-01 00:00:00

abstract：:A new retrovirus vector containing the gene for hygromycin B resistance (hyg) as a selectable marker under the control of an internal simian virus 40 promoter was constructed. It was used, together with an analogous previously described vector, DO1, which contains the gene for G418 resistance, to introduce and express...

journal_title：Molecular and cellular biology

authors： Yang Z,Korman AJ,Cooper J,Pious D,Accolla RS,Mulligan RC,Strominger JL

更新日期：1987-11-01 00:00:00

abstract：:The SR protein SRp38 is a general splicing repressor that is activated by dephosphorylation during mitosis and in response to heat shock. Here we describe experiments that provide insights into the mechanism by which SRp38 functions in splicing repression. We first show that SRp38 redistributes and colocalizes with sn...

journal_title：Molecular and cellular biology

authors： Shin C,Kleiman FE,Manley JL

更新日期：2005-09-01 00:00:00

abstract：:We investigated two phenotypically distinct types of diphtheria toxin-resistant mutants of Chinese hamster cells and compared their resistance with that of naturally resistant mouse cells. All are resistant due to a defect in the process of internalization and delivery of toxin to its target in the cytosol, elongation...

journal_title：Molecular and cellular biology

authors： Didsbury JR,Moehring JM,Moehring TJ

更新日期：1983-07-01 00:00:00

abstract：:X-linked inhibitor of apoptosis (XIAP) is an inhibitor of apoptotic cell death that protects cells by caspase-dependent and independent mechanisms. In a screen for molecules that participate with XIAP in regulating cellular activities, we identified apoptosis-inducing factor (AIF) as an XIAP binding protein. Baculovir...

journal_title：Molecular and cellular biology

authors： Wilkinson JC,Wilkinson AS,Galbán S,Csomos RA,Duckett CS

更新日期：2008-01-01 00:00:00

abstract：:The v-vis gene encodes p28sis, the transforming protein of simian sarcoma virus. This gene resulted from a fusion of the env gene of simian sarcoma-associated virus and the woolly monkey gene for the B chain of platelet-derived growth factor (PDGF). Previous work has shown that the v-sis gene product undergoes signal ...

journal_title：Molecular and cellular biology

authors： Lee BA,Maher DW,Hannink M,Donoghue DJ

更新日期：1987-10-01 00:00:00

abstract：:The expression of the Drosophila segmentation gene fushi tarazu (ftz) is controlled at the level of transcription. The proximal enhancer, located approximately 3.4 kb upstream of the transcription start site, directs lacZ fusion gene expression in a ftz-like seven-stripe pattern in transgenic fly embryos. We have take...

journal_title：Molecular and cellular biology

authors： Han W,Yu Y,Altan N,Pick L

更新日期：1993-09-01 00:00:00

abstract：:Transcription of Xenopus laevis mitochondrial DNA (xl-mtDNA) by the mitochondrial RNA polymerase requires a dissociable factor. This factor was purified to near homogeneity and identified as a 40-kDa protein. A second protein implicated in the transcription of mtDNA, the Xenopus homolog of the HMG box protein mtTFA, w...

journal_title：Molecular and cellular biology

authors： Antoshechkin I,Bogenhagen DF

更新日期：1995-12-01 00:00:00

abstract：:Glutamine is the preferred source of nitrogen of Neurospora crassa. In its presence and that of the gene product of MS5 (nmr-1), the fungus represses the assimilation of less preferred forms of nitrogen, such as nitrate. In the absence of glutamine and the presence of the product of gene nit-2, less preferred forms of...

journal_title：Molecular and cellular biology

authors： Sorger GJ,Brown D,Farzannejad M,Guerra A,Jonathan M,Knight S,Sharda R

更新日期：1989-09-01 00:00:00

abstract：:Poliovirus polysomal RNA is naturally uncapped, and as such, its translation must bypass any 5' cap-dependent ribosome recognition event. To elucidate the manner by which poliovirus mRNA is translated, we have determined the translational efficiencies of a series of deletion mutants within the 5' noncoding region of t...

journal_title：Molecular and cellular biology

authors： Pelletier J,Kaplan G,Racaniello VR,Sonenberg N

更新日期：1988-03-01 00:00:00

abstract：:Cells of Candida albicans WO-1 spontaneously switch between a white and opaque CFU, and this phase transition involves a dramatic change in cellular phenotype. By using a differential hybridization screen, an opaque-specific cDNA, Op1a, which represents the transcript of a gene regulated by switching, has been isolate...

journal_title：Molecular and cellular biology

authors： Morrow B,Srikantha T,Soll DR

更新日期：1992-07-01 00:00:00

abstract：:Hox11 is a homeobox gene essential for spleen formation in mice, since atrophy of the anlage of a developing spleen occurs in early embryonic development in Hox11 null mice. HOX11 is also expressed in a subset of T-cell acute leukemias after specific chromosomal translocations. Since the protein has a homeodomain and ...

journal_title：Molecular and cellular biology

authors： Greene WK,Bahn S,Masson N,Rabbitts TH

更新日期：1998-12-01 00:00:00

abstract：:Both cyclin D1 and the transcription factor C/EBPβ are required for mammary epithelial cell differentiation; however, the pathway in which they operate is uncertain. Previous analyses of the patterns of gene expression in human tumors suggested a connection between cyclin D1 overexpression and C/EBPβ, but whether this...

journal_title：Molecular and cellular biology

authors： Liu Q,Boudot A,Ni J,Hennessey T,Beauparlant SL,Rajabi HN,Zahnow C,Ewen ME

更新日期：2014-08-01 00:00:00

abstract：:In a gene trap screen for genes expressed in the primitive streak and tail bud during mouse embryogenesis, we isolated a mutation in Jade1, a gene encoding a PHD zinc finger protein previously shown to interact with the tumor suppressor pVHL. Expressed sequence tag analysis indicates that Jade1 is subject to posttrans...

journal_title：Molecular and cellular biology

authors： Tzouanacou E,Tweedie S,Wilson V

更新日期：2003-12-01 00:00:00