Properties of the DNA-binding domain of the simian virus 40 large T antigen.

abstract：:TDP-43, or TAR DNA-binding protein 43, is a pathological marker of a spectrum of neurodegenerative disorders, including amyotrophic lateral sclerosis and frontotemporal lobar degeneration with ubiquitin-positive inclusions. TDP-43 is an RNA/DNA-binding protein implicated in transcriptional and posttranscriptional regu...

journal_title：Molecular and cellular biology

authors： Dewey CM,Cenik B,Sephton CF,Dries DR,Mayer P 3rd,Good SK,Johnson BA,Herz J,Yu G

更新日期：2011-03-01 00:00:00

abstract：:The conserved RECQ5 DNA helicase is a tumor suppressor in mammalian cells. Defects in RECQ5 lead to the accumulation of spontaneous DNA double-stranded breaks (DSBs) during replication, despite the fact that these cells are proficient in DSB repair by homologous recombination (HR). The reason for this is unknown. Here...

journal_title：Molecular and cellular biology

authors： Li M,Xu X,Liu Y

更新日期：2011-05-01 00:00:00

abstract：:Mutations in the SRA1 or SRA3 gene eliminate the requirement for either RAS gene (RAS1 or RAS2) in Saccharomyces cerevisiae. We cloned SRA1 and SRA3 and determined their DNA sequences. SRA1 encodes the regulatory subunit of the cyclic AMP (cAMP)-dependent protein kinase and therefore is identical to REG1 and BCY1. Thi...

journal_title：Molecular and cellular biology

authors： Cannon JF,Tatchell K

更新日期：1987-08-01 00:00:00

abstract：:The Surf-3 gene of the unusually tight mouse Surfeit locus gene cluster has been identified as the highly conserved ribosomal protein gene L7a (rpL7a). The topography and juxtaposition of the Surfeit locus genes are conserved for the 600 million years of divergent evolution between mammals and birds. This suggests cis...

journal_title：Molecular and cellular biology

authors： Armes N,Fried M

更新日期：1995-05-01 00:00:00

abstract：:Selective and accurate transcription of purified genes by RNA polymerase II requires multiple factors. The factor designated TFIID was purified extensively from HeLa cell nuclear extracts by using a simple and novel complementation assay. Thus, TFIID was preferentially inactivated by mild heat treatment of a nuclear e...

journal_title：Molecular and cellular biology

authors： Nakajima N,Horikoshi M,Roeder RG

更新日期：1988-10-01 00:00:00

abstract：:Growth factor independence 1B (GFI1B) coordinates assembly of transcriptional repressor complexes comprised of corepressors and histone-modifying enzymes to control gene expression programs governing lineage allocation in hematopoiesis. Enforced expression of GFI1B in K562 erythroleukemia cells favors erythroid over m...

journal_title：Molecular and cellular biology

authors： McClellan D,Casey MJ,Bareyan D,Lucente H,Ours C,Velinder M,Singer J,Lone MD,Sun W,Coria Y,Mason CC,Engel ME

更新日期：2019-06-13 00:00:00

abstract：:Transcription from the Moloney murine leukemia virus (Mo-MuLV) long terminal repeat (LTR) is inhibited in murine stem cells and induced during maturation of these cells. We have investigated whether alterations in the activity of this viral regulatory element also occur during differentiation of human myeloid leukemia...

journal_title：Molecular and cellular biology

authors： Reisman D,Rotter V

更新日期：1989-08-01 00:00:00

abstract：:The v-myb oncogene of avian myeloblastosis virus causes acute myelomonocytic leukemia in chickens and transforms avian myeloid cells in vitro. Its protein product p48v-myb is a nuclear, sequence-specific, DNA-binding protein which activates gene expression in transient DNA transfection studies. To investigate the rela...

journal_title：Molecular and cellular biology

authors： Lane T,Ibanez C,Garcia A,Graf T,Lipsick J

更新日期：1990-06-01 00:00:00

abstract：:Podocytes are highly differentiated and polarized epithelial cells located on the visceral side of the glomerulus. They form an indispensable component of the glomerular filter, the slit diaphragm, formed by several transmembrane proteins and adaptor molecules. Disruption of the slit diaphragm can lead to massive prot...

journal_title：Molecular and cellular biology

authors： Tossidou I,Niedenthal R,Klaus M,Teng B,Worthmann K,King BL,Peterson KJ,Haller H,Schiffer M

更新日期：2012-03-01 00:00:00

abstract：:CD146, an endothelial biomarker, has been shown to be aberrantly upregulated during pathological angiogenesis and functions as a coreceptor for vascular endothelial growth factor receptor 2 (VEGFR-2) to promote disease progression. However, the regulatory mechanisms of CD146 expression during angiogenesis remain uncle...

journal_title：Molecular and cellular biology

authors： Wang P,Luo Y,Duan H,Xing S,Zhang J,Lu D,Feng J,Yang D,Song L,Yan X

更新日期：2013-09-01 00:00:00

abstract：:alpha 1-Antitrypsin (AT), the major elastase inhibitor in mammalian serum, is produced primarily in the liver. We have characterized AT gene structure and expression in the mouse species Mus caroli, which expresses high levels of AT in the kidneys as well as in the liver. Analysis of cDNA and genomic clones showed tha...

journal_title：Molecular and cellular biology

authors： Latimer JJ,Berger FG,Baumann H

更新日期：1990-02-01 00:00:00

abstract：:The accumulation of misfolded proteins stresses the endoplasmic reticulum (ER) and triggers cell death through activation of the multidomain proapoptotic BCL-2 proteins BAX and BAK at the outer mitochondrial membrane. The signaling events that connect ER stress with the mitochondrial apoptotic machinery remain unclear...

journal_title：Molecular and cellular biology

authors： Upton JP,Austgen K,Nishino M,Coakley KM,Hagen A,Han D,Papa FR,Oakes SA

更新日期：2008-06-01 00:00:00

abstract：:The E2F transcription factors are key downstream targets of the retinoblastoma protein (pRB) tumor suppressor. We have previously shown that E2F3 plays a critical role in mediating the mitogen-induced activation of E2F-responsive genes and contributes to both the inappropriate proliferation and the p53-dependent apopt...

journal_title：Molecular and cellular biology

authors： Ziebold U,Lee EY,Bronson RT,Lees JA

更新日期：2003-09-01 00:00:00

abstract：:Sirtuins are a family of protein deacetylases, deacylases, and ADP-ribosyltransferases that regulate life span, control the onset of numerous age-associated diseases, and mediate metabolic homeostasis. We have uncovered a novel role for the mitochondrial sirtuin SIRT4 in the regulation of hepatic lipid metabolism duri...

journal_title：Molecular and cellular biology

authors： Laurent G,de Boer VC,Finley LW,Sweeney M,Lu H,Schug TT,Cen Y,Jeong SM,Li X,Sauve AA,Haigis MC

更新日期：2013-11-01 00:00:00

abstract：:To investigate the transcriptional program underlying thyroid hormone (T3)-induced cell proliferation, cDNA microarrays were used to survey the temporal expression profiles of 4,400 genes. Of 358 responsive genes identified, 88% had not previously been reported to be transcriptionally or functionally modulated by T3. ...

journal_title：Molecular and cellular biology

authors： Miller LD,Park KS,Guo QM,Alkharouf NW,Malek RL,Lee NH,Liu ET,Cheng SY

更新日期：2001-10-01 00:00:00

abstract：:The response to amino acid starvation involves the global decrease of protein synthesis and an increase in the translation of some mRNAs that contain an internal ribosome entry site (IRES). It was previously shown that translation of the mRNA for the arginine/lysine amino acid transporter Cat-1 increases during amino ...

journal_title：Molecular and cellular biology

authors： Majumder M,Yaman I,Gaccioli F,Zeenko VV,Wang C,Caprara MG,Venema RC,Komar AA,Snider MD,Hatzoglou M

更新日期：2009-05-01 00:00:00

abstract：:We previously identified a small basic leucine zipper (bZIP) protein, Jun dimerization protein 2 (JDP-2), that acts as a coregulator of the N-terminal transcriptional activation domain of progesterone receptor (PR). We show here that JDP-2, through interaction with the DNA binding domain (DBD), induces or stabilizes s...

journal_title：Molecular and cellular biology

authors： Wardell SE,Kwok SC,Sherman L,Hodges RS,Edwards DP

更新日期：2005-10-01 00:00:00

abstract：:To study the relationship between oncogenesis by v-src and normal cellular signalling pathways, we determined the effects of v-src on 3T3-TNR9 cells, a Swiss 3T3 variant which does not respond mitogenically to tumor promoters such as 12-O-tetradecanoyl-phorbol-13-acetate (TPA). We found that src was unable to transfor...

journal_title：Molecular and cellular biology

authors： Nori M,Shawver LK,Weber MJ

更新日期：1990-08-01 00:00:00

abstract：:KIF14 is a microtubule motor protein whose elevated expression is associated with poor-prognosis breast cancer. Here we demonstrate KIF14 accumulation in mitotic cells, where it associated with developing spindle poles and spindle microtubules. Cells at later stages of mitosis were characterized by the concentration o...

journal_title：Molecular and cellular biology

authors： Carleton M,Mao M,Biery M,Warrener P,Kim S,Buser C,Marshall CG,Fernandes C,Annis J,Linsley PS

更新日期：2006-05-01 00:00:00

abstract：:Our previous studies of Saccharomyces cerevisiae described a gene repression mechanism where the transcription of intergenic noncoding DNA (ncDNA) (SRG1) assembles nucleosomes across the promoter of the adjacent SER3 gene that interfere with the binding of transcription factors. To investigate the role of histones in ...

journal_title：Molecular and cellular biology

authors： Hainer SJ,Martens JA

更新日期：2011-09-01 00:00:00

abstract：:Two cDNAs derived from Xenopus laevis calmodulin mRNA have been cloned. Both cDNAs contain the complete protein-coding region and various lengths of untranslated segments. The two cDNAs encode an identical protein but differ from each other by 5% nucleotide substitutions. The 5' and 3' untranslated regions, to the ext...

journal_title：Molecular and cellular biology

authors： Chien YH,Dawid IB

更新日期：1984-03-01 00:00:00

abstract：:beta-Site beta-amyloid precursor protein (APP)-cleaving enzyme 1 (BACE1) is the beta-secretase in vivo for processing APP to generate amyloid beta protein (Abeta). Abeta deposition in the brain is the hallmark of Alzheimer's disease (AD) neuropathology. Inhibition of BACE1 activity has major pharmaceutical potential f...

journal_title：Molecular and cellular biology

authors： Zhou W,Song W

更新日期：2006-05-01 00:00:00

abstract：:The location in the mouse genome of the 149-base pair MES-1 element, previously isolated by its ability to restore expression to an enhancerless selectable gene, was analyzed. The active moiety of the single-copy MES-1 element is located between the 5' ends of two divergent transcription units, SURF-1 and SURF-2, both...

journal_title：Molecular and cellular biology

authors： Williams TJ,Fried M

更新日期：1986-12-01 00:00:00

abstract：:Sensing of extracellular glucose is necessary for cells to adapt to glucose variation in their environment. In the respiratory yeast Kluyveromyces lactis, extracellular glucose controls the expression of major glucose permease gene RAG1 through a cascade similar to the Saccharomyces cerevisiae Snf3/Rgt2/Rgt1 glucose s...

journal_title：Molecular and cellular biology

authors： Cairey-Remonnay A,Deffaud J,Wésolowski-Louvel M,Lemaire M,Soulard A

更新日期：2015-02-01 00:00:00

abstract：:Expression of the reaper gene (rpr) correlates with the initiation of apoptosis in Drosophila melanogaster. Transient expression of rpr in the lepidopteran SF-21 cell line induced apoptosis displaying nuclear condensation and fragmentation, oligonucleosomal ladder formation, cell surface blebbing, and apoptotic body f...

journal_title：Molecular and cellular biology

authors： Vucic D,Seshagiri S,Miller LK

更新日期：1997-02-01 00:00:00

abstract：:The activities of the related Abl and Arg nonreceptor tyrosine kinases are kept under tight control in cells, but exposure to several different stimuli results in a two- to fivefold stimulation of kinase activity. Following the breakdown of inhibitory intramolecular interactions, Abl activation requires phosphorylatio...

journal_title：Molecular and cellular biology

authors： Tanis KQ,Veach D,Duewel HS,Bornmann WG,Koleske AJ

更新日期：2003-06-01 00:00:00

abstract：:Studies ex vivo have shown that phosphoinositide 3-kinase (PI3K) activity is necessary but not sufficient for insulin-stimulated glucose uptake. Unexpectedly, mice lacking either of the PI3K regulatory subunits p85alpha or p85beta exhibit increased insulin sensitivity. The insulin hypersensitivity is particularly unex...

journal_title：Molecular and cellular biology

authors： Brachmann SM,Ueki K,Engelman JA,Kahn RC,Cantley LC

更新日期：2005-03-01 00:00:00

abstract：:Pancreatic beta-cell-type-specific transcription of the insulin gene is principally regulated by a single cis-acting DNA sequence element, termed the insulin control element (ICE), which is found within the 5'-flanking region of the gene. The ICE activator is a heteromeric complex composed of an islet alpha/beta-cell-...

journal_title：Molecular and cellular biology

authors： Robinson GL,Cordle SR,Henderson E,Weil PA,Teitelman G,Stein R

更新日期：1994-10-01 00:00:00

abstract：:The androgen receptor (AR) is a ligand-activated transcription factor that interacts with coregulatory proteins during androgen-dependent gene regulation. Melanoma antigen gene protein 11 (MAGE-11) is an AR coregulator that specifically binds the AR NH(2)-terminal FXXLF motif and modulates the AR NH(2)- and carboxyl-t...

journal_title：Molecular and cellular biology

authors： Bai S,Wilson EM

更新日期：2008-03-01 00:00:00

abstract：:The DNA damage checkpoint is tightly controlled. After its activation, the checkpoint machinery is inactivated once lesions are repaired or undergoes adaptation if the DNA damage is unable to be repaired. Protein acetylation has been shown to play an important role in DNA damage checkpoint activation. However, the rol...

journal_title：Molecular and cellular biology

authors： Tao R,Xue H,Zhang J,Liu J,Deng H,Chen YG

更新日期：2013-11-01 00:00:00