Two distinct phosphorylation pathways have additive effects on Abl family kinase activation.

abstract：:Tissue-specific gene expression requires modulation of nucleosomes, allowing transcription factors to occupy cis elements that are accessible only in selected tissues. Master transcription factors control cell-specific genes and define cellular identities, but it is unclear if they possess special abilities to regulat...

journal_title：Molecular and cellular biology

authors： Verzi MP,Shin H,San Roman AK,Liu XS,Shivdasani RA

更新日期：2013-01-01 00:00:00

abstract：:MOT1 is an essential Saccharomyces cerevisiae protein and a member of the SNF2/SWI2 family of ATPases. MOT1 functions by removing TATA-binding protein (TBP) from DNA, and as a consequence, MOT1 can regulate transcription both in vitro and in vivo. Here we describe the in vivo and in vitro activities of MOT1 deletion a...

journal_title：Molecular and cellular biology

authors： Auble DT,Wang D,Post KW,Hahn S

更新日期：1997-08-01 00:00:00

abstract：:Mouse neuroblastoma Neuro-2A cells produce transforming growth factors during exponential growth in a defined hormone-free medium, which, on Bio-Gel columns in 1 M HAc, elute at a molecular size of 15 to 20 kilodaltons (kDa). These neuroblastoma-derived transforming growth factors have strong mitogenic activity, but t...

journal_title：Molecular and cellular biology

authors： van Zoelen EJ,van de Ven WJ,Franssen HJ,van Oostwaard TM,van der Saag PT,Heldin CH,de Laat SW

更新日期：1985-09-01 00:00:00

abstract：:The small subunit of ribonucleotide reductase in Saccharomyces cerevisiae (RNR2) was induced 3- to 20-fold by a variety of DNA-damaging agents. Induction of the RNR2 transcript by at least one of these agents, methyl methanesulfonate, did not require protein synthesis. To identify sequences involved in the regulation ...

journal_title：Molecular and cellular biology

authors： Hurd HK,Roberts JW

更新日期：1989-12-01 00:00:00

abstract：:F9 embryonic teratocarcinoma stem cells differentiate into an epithelial cell type called extraembryonic endoderm when treated with retinoic acid (RA), a derivative of retinol (vitamin A). This differentiation is presumably mediated through the actions of retinoid receptors, the RARs and RXRs. To delineate the functio...

journal_title：Molecular and cellular biology

authors： Boylan JF,Lufkin T,Achkar CC,Taneja R,Chambon P,Gudas LJ

更新日期：1995-02-01 00:00:00

abstract：:YY1 is a multifunctional transcription factor that acts as an activator or repressor in different contexts. YY1 binds to multiple sites in the mouse c-fos promoter, inducing at each site a sharp DNA bend. Binding of YY1 to a site situated between the cyclic AMP response element (CRE) and the TATA box bends the DNA in ...

journal_title：Molecular and cellular biology

authors： Natesan S,Gilman M

更新日期：1995-11-01 00:00:00

abstract：:The coordinated expression of CD4 and CD8 during T-cell development is tightly coupled with the maturation state of the T cell. Additionally, the mutually exclusive expression of these receptors in mature T cells is representative of the functional T-cell subclasses (CD4+ helper T cells versus CD8+ cytotoxic T cells)....

journal_title：Molecular and cellular biology

authors： Wurster AL,Siu G,Leiden JM,Hedrick SM

更新日期：1994-10-01 00:00:00

abstract：:The yeast protein Spa2p localizes to growth sites and is important for polarized morphogenesis during budding, mating, and pseudohyphal growth. To better understand the role of Spa2p in polarized growth, we analyzed regions of the protein important for its function and proteins that interact with Spa2p. Spa2p interact...

journal_title：Molecular and cellular biology

authors： Sheu YJ,Santos B,Fortin N,Costigan C,Snyder M

更新日期：1998-07-01 00:00:00

abstract：:We provide evidence that the human DNA ligase III gene encodes a mitochondrial form of this enzyme. First, the DNA ligase III cDNA contains an in-frame ATG located upstream from the putative translation initiation start site. The DNA sequence between these two ATG sites encodes an amphipathic helix similar to previous...

journal_title：Molecular and cellular biology

authors： Lakshmipathy U,Campbell C

更新日期：1999-05-01 00:00:00

abstract：:Substitution of phenylalanine for tyrosine at codon 809 (Y809F) of the human colony-stimulating factor 1 (CSF-1) receptor (CSF-1R) impairs ligand-stimulated tyrosine kinase activity, prevents induction of c-MYC and cyclin D1 genes, and blocks CSF-1-dependent progression through the G1 phase of the cell cycle. We devis...

journal_title：Molecular and cellular biology

authors： Davis JN,Rock CO,Cheng M,Watson JB,Ashmun RA,Kirk H,Kay RJ,Roussel MF

更新日期：1997-12-01 00:00:00

abstract：:Telomere maintenance is required for chromosome stability, and telomeres are typically replicated by the action of the reverse transcriptase telomerase. In both tumor and yeast cells that lack telomerase, telomeres are maintained by an alternative recombination mechanism. Genetic studies have led to the identification...

journal_title：Molecular and cellular biology

authors： Tsai YL,Tseng SF,Chang SH,Lin CC,Teng SC

更新日期：2002-08-01 00:00:00

abstract：:A Dictyostelium discoideum cDNA encoding an alpha-type subunit of casein kinase II was isolated, and its cDNA was used to study developmental expression of casein kinase II during the Dictyostelium life cycle. The 1.3-kb cDNA insert contained an open reading frame of 337 amino acids (M(r) 39,900). The deduced amino ac...

journal_title：Molecular and cellular biology

authors： Kikkawa U,Mann SK,Firtel RA,Hunter T

更新日期：1992-12-01 00:00:00

abstract：:Although mitogenic and differentiating factors often activate a number of common signaling pathways, the mechanisms leading to their distinct cellular outcomes have not been elucidated. In a previous report, we demonstrated that mitogen-activated protein (MAP) kinase (ERK) activation by the neurogenic agents fibroblas...

journal_title：Molecular and cellular biology

authors： Corbit KC,Soh JW,Yoshida K,Eves EM,Weinstein IB,Rosner MR

更新日期：2000-08-01 00:00:00

abstract：:While wild-type p53 is normally a rapidly degraded protein, mutant forms of p53 are stabilized and accumulate to high levels in tumor cells. In this study, we show that mutant and wild-type p53 proteins are ubiquitinated and degraded through overlapping but distinct pathways. While Mdm2 can drive the degradation of bo...

journal_title：Molecular and cellular biology

authors： Lukashchuk N,Vousden KH

更新日期：2007-12-01 00:00:00

abstract：:The mammalian ABL1 gene encodes the ubiquitously expressed nonreceptor tyrosine kinase ABL. In response to growth factors, cytokines, cell adhesion, DNA damage, oxidative stress, and other signals, ABL is activated to stimulate cell proliferation or differentiation, survival or death, retraction, or migration. ABL als...

journal_title：Molecular and cellular biology

authors： Wang JY

更新日期：2014-04-01 00:00:00

abstract：:In the budding yeast Saccharomyces cerevisiae, Cdc37 is required for the productive formation of Cdc28-cyclin complexes. The cdc37-1 mutant arrests at Start with low levels of Cdc28 protein, which is predominantly unphosphorylated at Thr169, fails to bind cyclin, and has little protein kinase activity. We show here th...

journal_title：Molecular and cellular biology

authors： Farrell A,Morgan DO

更新日期：2000-02-01 00:00:00

abstract：:We have studied the patterns of expression of four B-type cyclins (Clbs), Clb1, Clb2, Clb3, and Clb4, and their ability to activate p34cdc28 during the mitotic and meiotic cell cycles of Saccharomyces cerevisiae. During the mitotic cell cycle, Clb3 and Clb4 were expressed and induced a kinase activity in association w...

journal_title：Molecular and cellular biology

authors： Grandin N,Reed SI

更新日期：1993-04-01 00:00:00

abstract：:During V(D)J recombination, the coding ends to be joined are extensively modified. Those modifications, termed coding-end processing, consist of removal and addition of various numbers of nucleotides. We previously showed in vivo that coding-end processing is specific for each coding end, suggesting that specific moti...

journal_title：Molecular and cellular biology

authors： Nadel B,Feeney AJ

更新日期：1997-07-01 00:00:00

abstract：:Mouse mammary tumor virus (MMTV) promoter-driven transcription is induced by glucocorticoid hormone via binding of the glucocorticoid receptor (GR). The MMTV promoter also harbors a binding site for nuclear factor 1 (NF1). NF1 and GR were expressed in Xenopus oocytes; this revealed GR-NF1 cooperativity both in terms o...

journal_title：Molecular and cellular biology

authors： Belikov S,Astrand C,Holmqvist PH,Wrange O

更新日期：2004-04-01 00:00:00

abstract：:By injecting the appropriately constructed plasmids into one-cell Xenopus embryos, we determined that the 3' region of the maternal Xenopus Eg2 mRNA confers instability on the chimeric mRNA transcribed from these plasmids. This instability, like that of the maternal Eg2 transcript, was abolished by treatment of the em...

journal_title：Molecular and cellular biology

authors： Bouvet P,Paris J,Phillippe M,Osborne HB

更新日期：1991-06-01 00:00:00

abstract：:Chemical carcinogenesis in mouse skin has been useful in delineating the molecular events that underlie squamous cell carcinoma progression. A late event in this progression, the epithelial-to-mesenchymal transition (EMT), is characterized by the loss of epithelial markers and the presence of mesenchymal markers. One ...

journal_title：Molecular and cellular biology

authors： Hulboy DL,Matrisian LM,Crawford HC

更新日期：2001-08-01 00:00:00

abstract：:Generally, histone deacetylase (HDAC) inhibitor-induced p21(Waf1/Cip1) expression is thought to be p53 independent. Here we found that an inhibitor of HDAC, depsipeptide (FR901228), but not trichostatin A (TSA), induces p21(Waf1/Cip1) expression through both p53 and Sp1/Sp3 pathways in A549 cells (which retain wild-ty...

journal_title：Molecular and cellular biology

authors： Zhao Y,Lu S,Wu L,Chai G,Wang H,Chen Y,Sun J,Yu Y,Zhou W,Zheng Q,Wu M,Otterson GA,Zhu WG

更新日期：2006-04-01 00:00:00

abstract：:We previously identified a sequence-specific erythroid cell-enriched endoribonuclease (ErEN) activity involved in the turnover of the stable alpha-globin mRNA. We now demonstrate that ErEN activity is regulated by the poly(A) tail. The unadenylated alpha-globin 3' untranslated region (3'UTR) was an efficient substrate...

journal_title：Molecular and cellular biology

authors： Wang Z,Kiledjian M

更新日期：2000-09-01 00:00:00

abstract：:The simian virus 40 large T antigen (T antigen) inactivates tumor suppressor proteins and therefore has been used in numerous studies to probe the mechanisms that control cellular growth and to generate immortalized cell lines. Binding of T antigen to the Rb family of growth-regulatory proteins is necessary but not su...

journal_title：Molecular and cellular biology

authors： Sullivan CS,Cantalupo P,Pipas JM

更新日期：2000-09-01 00:00:00

abstract：:Interleukin-6 (IL-6) is one of the major mediators of inflammation, and its expression is inducible by the other inflammatory lymphokines, interleukin-1 (IL-1) and tumor necrosis factor alpha (TNF-alpha). We demonstrate that a common IL-6 promoter element, termed inflammatory lymphokine-responsive element (ILRE), is i...

journal_title：Molecular and cellular biology

authors： Shimizu H,Mitomo K,Watanabe T,Okamoto S,Yamamoto K

更新日期：1990-02-01 00:00:00

abstract：:Transcription of Xenopus laevis mitochondrial DNA (xl-mtDNA) by the mitochondrial RNA polymerase requires a dissociable factor. This factor was purified to near homogeneity and identified as a 40-kDa protein. A second protein implicated in the transcription of mtDNA, the Xenopus homolog of the HMG box protein mtTFA, w...

journal_title：Molecular and cellular biology

authors： Antoshechkin I,Bogenhagen DF

更新日期：1995-12-01 00:00:00

abstract：:During aging, cellular plasticity and senescence play important roles in tissue regeneration and the pathogenesis of different diseases, including cancer. We have recently shown that senescent breast luminal cells can activate their adjacent stromal fibroblasts. In the present report, we present clear evidence that th...

journal_title：Molecular and cellular biology

authors： Al-Khalaf HH,Ghebeh H,Wakil SM,Al-Mohanna F,Aboussekhra A

更新日期：2020-04-13 00:00:00

abstract：:Alternative mRNA splicing is an important means of diversifying function in higher eukaryotes. Notably, both NCoR and SMRT corepressors are subject to alternative mRNA splicing, yielding a series of distinct corepressor variants with highly divergent functions. Normal adipogenesis is associated with a switch in corepr...

journal_title：Molecular and cellular biology

authors： Goodson ML,Young BM,Snyder CA,Schroeder AC,Privalsky ML

更新日期：2014-11-15 00:00:00

abstract：:In Blastocladiella emersonii zoospores, a set of proteins was found associated with the ribosomes and free ribonucleoprotein particles distinct from the ribosomes and polyribosomes. These proteins were designated P120, P105, P64, P56, and P42 based on their molecular weights determined by gel electrophoresis. Synthesi...

journal_title：Molecular and cellular biology

authors： Jaworski AJ,Stumhofer P

更新日期：1981-04-01 00:00:00

abstract：:Signal transducer and activator of transcription 6 (Stat6) and NF-kappaB are widely distributed transcription factors which are induced by different stimuli and bind to distinct DNA sequence motifs. Interleukin-4 (IL-4), which activates Stat6, synergizes with activators of NF-kappaB to induce IL-4-responsive genes, bu...

journal_title：Molecular and cellular biology

authors： Shen CH,Stavnezer J

更新日期：1998-06-01 00:00:00