Control of the replicative life span of human fibroblasts by p16 and the polycomb protein Bmi-1.

abstract：:Thrombin stimulation of platelets induces a transient increase in the specific activity of pp60c-src followed by a redistribution of pp60c-src to the Triton X-100-insoluble, cytoskeleton-rich fraction. Concomitant with the observed increase in pp60c-src activity was a rapid dephosphorylation of tyrosine 527 in 10 to 1...

journal_title：Molecular and cellular biology

authors： Clark EA,Brugge JS

更新日期：1993-03-01 00:00:00

abstract：:The RNA-binding protein (RBP) nucleolin promotes the expression of several proliferative proteins. Nucleolin levels are high in cancer cells, but the mechanisms that control nucleolin expression are unknown. Here, we show that nucleolin abundance is controlled posttranscriptionally via factors that associate with its ...

journal_title：Molecular and cellular biology

authors： Tominaga K,Srikantan S,Lee EK,Subaran SS,Martindale JL,Abdelmohsen K,Gorospe M

更新日期：2011-10-01 00:00:00

abstract：:Signaling via the pre-T-cell receptor (pre-TCR), along with associated signals from Notch and chemokine receptors, regulates the β-selection checkpoint that operates on CD4(-) CD8(-) doubly negative (DN) thymocytes. Since many hematopoietic malignancies arise at the immature developmental stages of lymphocytes, unders...

journal_title：Molecular and cellular biology

authors： Trampont PC,Zhang L,Giles AJ,Walk SF,Gu JJ,Pendergast AM,Ravichandran KS

更新日期：2015-04-01 00:00:00

abstract：:Entry into mitosis depends upon activation of the dual-specificity phosphatase Cdc25C, which dephosphorylates and activates the cyclin B-Cdc2 complex. Previous work has shown that the Xenopus polo-like kinase Plx1 can phosphorylate and activate Cdc25C in vitro. In the work presented here, we demonstrate that Plx1 is a...

journal_title：Molecular and cellular biology

authors： Qian YW,Erikson E,Li C,Maller JL

更新日期：1998-07-01 00:00:00

abstract：:The 3' noncoding region element (AUUUA)n specifically targets many short-lived mRNAs for degradation. Although the mechanism by which this sequence functions is not yet understood, a potential link between facilitated mRNA turnover and translation has been implied by the stabilization of cellular mRNAs in the presence...

journal_title：Molecular and cellular biology

authors： Aharon T,Schneider RJ

更新日期：1993-03-01 00:00:00

abstract：:A missense mutation within the histone acetyltransferase (HAT) domain of the TATA binding protein-associated factor TAF1 induces ts13 cells to undergo a late G(1) arrest and decreases cyclin D1 transcription. We have found that TAF1 mutants (Delta844-850 and Delta848-850, from which amino acids 844 through 850 and 848...

journal_title：Molecular and cellular biology

authors： Hilton TL,Li Y,Dunphy EL,Wang EH

更新日期：2005-05-01 00:00:00

abstract：:SMYD lysine methyltransferases target histones and nonhistone proteins for methylation and are critical regulators of muscle development and implicated in neoplastic transformation. They are characterized by a split catalytic SET domain and an intervening MYND zinc finger domain, as well as an extended C-terminal doma...

journal_title：Molecular and cellular biology

authors： Jaiswal D,Turniansky R,Moresco JJ,Ikram S,Ramaprasad G,Akinwole A,Wolf J,Yates JR 3rd,Green EM

更新日期：2020-01-03 00:00:00

abstract：:We reported the identification of a new family of DNA-binding proteins from our characterization of the dead ringer (dri) gene of Drosophila melanogaster. We show that dri encodes a nuclear protein that contains a sequence-specific DNA-binding domain that bears no similarity to known DNA-binding domains. A number of p...

journal_title：Molecular and cellular biology

authors： Gregory SL,Kortschak RD,Kalionis B,Saint R

更新日期：1996-03-01 00:00:00

abstract：:Hybridization-complementation studies indicated that mutations in multiple genes can render Chinese hamster cells resistant to the alkaloid translation inhibitor emetine. Two of the genes, emtA and emtB, recognized in Chinese hamster lung and ovary cell lines, respectively, are known to affect the ribosomes of the cel...

journal_title：Molecular and cellular biology

authors： Nielsen-Smith K,McGill S,Frahm M,Roufa DJ

更新日期：1983-02-01 00:00:00

abstract：:A sequence-specific DNA-binding protein from skeletal-muscle extracts that binds to probes of three muscle gene DNA elements is identified. This protein, referred to as muscle factor 3, forms the predominant nucleoprotein complex with the MCAT gene sequence motif in an electrophoretic mobility shift assay. This protei...

journal_title：Molecular and cellular biology

authors： Santoro IM,Yi TM,Walsh K

更新日期：1991-04-01 00:00:00

abstract：:The metabolic lifetime of mRNA can be specified by specific cis-acting elements within mRNA. One type of element is an adenylate- and uridylate-rich element (ARE) found in the 3' untranslated region of many highly unstable mRNAs for mammalian early-response genes (ERGs). Among the better-characterized members of the E...

journal_title：Molecular and cellular biology

authors： Chen CY,Shyu AB

更新日期：1994-12-01 00:00:00

abstract：:As a subunit of a ubiquitin ligase, Skp2 is implicated in facilitating cell cycle progression via degradation of various protein targets. We report here that Skp2 is rapidly degraded following cellular stimulation by the cytokine transforming growth factor beta (TGF-beta) and that this degradation stabilizes the cell ...

journal_title：Molecular and cellular biology

authors： Liu W,Wu G,Li W,Lobur D,Wan Y

更新日期：2007-04-01 00:00:00

abstract：:The E2A-HLF fusion gene, formed by the t(17;19)(q22;p13) translocation in childhood acute pro-B-cell leukemia, encodes a hybrid protein that contains the paired trans-activation domains of E2A (E12/E47) linked to the basic region/leucine zipper DNA-binding and dimerization domain of hepatic leukemia factor (HLF). To a...

journal_title：Molecular and cellular biology

authors： Yoshihara T,Inaba T,Shapiro LH,Kato JY,Look AT

更新日期：1995-06-01 00:00:00

abstract：:We investigated various parameters associated with the initial selection of mouse 3T6 cells for resistance to single concentrations of methotrexate and characterized resistant colonies for the presence of additional (amplified) copies of the dihydrofolate reductase gene. Our results indicate that the frequency of occu...

journal_title：Molecular and cellular biology

authors： Brown PC,Tlsty TD,Schimke RT

更新日期：1983-06-01 00:00:00

abstract：:Thyroid hormone (T3) is critical for growth, differentiation, and maintenance of metabolic homeostasis. Mice with a knock-in mutation in the thyroid hormone receptor alpha gene (TRalpha1PV) were created previously to explore the roles of mutated TRalpha1 in vivo. TRalpha1PV is a dominant negative mutant with a framesh...

journal_title：Molecular and cellular biology

authors： Ying H,Araki O,Furuya F,Kato Y,Cheng SY

更新日期：2007-03-01 00:00:00

abstract：:Cells construct a number of plasma membrane structures to meet a range of physiological demands. Driven by juxtamembrane actin machinery, these actin-based membrane protrusions are essential for the operation and maintenance of cellular life. They are required for diverse cellular functions, such as directed cell moti...

journal_title：Molecular and cellular biology

authors： Hoon JL,Wong WK,Koh CG

更新日期：2012-11-01 00:00:00

abstract：:clk-1 encodes a demethoxyubiquinone (DMQ) hydroxylase that is necessary for ubiquinone biosynthesis. When Caenorhabditis elegans clk-1 mutants are grown on bacteria that synthesize ubiquinone (UQ), they are viable but have a pleiotropic phenotype that includes slowed development, behaviors, and aging. However, when gr...

journal_title：Molecular and cellular biology

authors： Branicky R,Nguyen PA,Hekimi S

更新日期：2006-05-01 00:00:00

abstract：:The SLP-76 family of immune cell-specific adaptors is composed of three distinct members named SLP-76, Blnk, and Clnk. They have been implicated in the signaling pathways coupled to immunoreceptors such as the antigen receptors and Fc receptors. Previous studies using gene-targeted mice and deficient cell lines showed...

journal_title：Molecular and cellular biology

authors： Utting O,Sedgmen BJ,Watts TH,Shi X,Rottapel R,Iulianella A,Lohnes D,Veillette A

更新日期：2004-07-01 00:00:00

abstract：:Thyroid hormone receptor (TR) functions as part of multiprotein complexes that also include retinoid X receptor (RXR) and transcriptional coregulators. We have found that both the TR CoR box and ninth heptad are required for RXR interaction and in turn for interaction with corepressor proteins N-CoR and SMRT. Remarkab...

journal_title：Molecular and cellular biology

authors： Zhang J,Zamir I,Lazar MA

更新日期：1997-12-01 00:00:00

abstract：:Histone H1 is an abundant and essential component of chromatin whose precise role in regulating gene expression is poorly understood. Here, we report that a major target of H1-mediated regulation in embryonic stem (ES) cells is the X-linked Rhox homeobox gene cluster. To address the underlying mechanism, we examined t...

journal_title：Molecular and cellular biology

authors： Maclean JA,Bettegowda A,Kim BJ,Lou CH,Yang SM,Bhardwaj A,Shanker S,Hu Z,Fan Y,Eckardt S,McLaughlin KJ,Skoultchi AI,Wilkinson MF

更新日期：2011-03-01 00:00:00

abstract：:HIRA-like (Hir) proteins are evolutionarily conserved and are implicated in the assembly of repressive chromatin. In Saccharomyces cerevisiae, Hir proteins contribute to the function of centromeres. However, S. cerevisiae has point centromeres that are structurally different from the complex centromeres of metazoans. ...

journal_title：Molecular and cellular biology

authors： Blackwell C,Martin KA,Greenall A,Pidoux A,Allshire RC,Whitehall SK

更新日期：2004-05-01 00:00:00

abstract：:Tissue-specific gene expression requires modulation of nucleosomes, allowing transcription factors to occupy cis elements that are accessible only in selected tissues. Master transcription factors control cell-specific genes and define cellular identities, but it is unclear if they possess special abilities to regulat...

journal_title：Molecular and cellular biology

authors： Verzi MP,Shin H,San Roman AK,Liu XS,Shivdasani RA

更新日期：2013-01-01 00:00:00

abstract：:Lactoperoxidase was used to selectively radiolabel endocytic membrane. CHO cells were incubated with enzyme at 37 degrees C for 10 min to permit lactoperoxidase internalization. Radioiodination was done at 4 degrees C. About 90% of the radioiodinated products pelleted at 100,000 X g. From 12 to 15 different electropho...

journal_title：Molecular and cellular biology

authors： Storrie B,Dreesen TD,Maurey KM

更新日期：1981-03-01 00:00:00

abstract：:Deletion analysis was used to identify sequences upstream of the ADH2 gene of Saccharomyces cerevisiae that are required for its regulation. 5' and 3' internal deletions of the ADH2 control region were created in vitro, and the fragments were ligated adjacent to the ADH1 promoter and structural gene. Hybrid genes with...

journal_title：Molecular and cellular biology

authors： Beier DR,Sledziewski A,Young ET

更新日期：1985-07-01 00:00:00

abstract：:The extracellular signal-regulated kinase 1 and 2 (ERK1/2) mitogen-activated protein (MAP) kinase signaling pathway plays an important role in the proliferative response of mammalian cells to mitogens. However, the individual contribution of the isoforms ERK1 and ERK2 to cell proliferation control is unclear. The two ...

journal_title：Molecular and cellular biology

authors： Voisin L,Saba-El-Leil MK,Julien C,Frémin C,Meloche S

更新日期：2010-06-01 00:00:00

abstract：:For proper male sexual differentiation, anti-Müllerian hormone (AMH) must be tightly regulated during embryonic development to promote regression of the Müllerian duct. However, the molecular mechanisms specifying the onset of AMH in male mammals are not yet clearly defined. A DNA-binding element for the steroidogenic...

journal_title：Molecular and cellular biology

authors： De Santa Barbara P,Bonneaud N,Boizet B,Desclozeaux M,Moniot B,Sudbeck P,Scherer G,Poulat F,Berta P

更新日期：1998-11-01 00:00:00

abstract：:The Fanconi anemia (FA) pathway is a DNA damage-activated signaling pathway which regulates cellular resistance to DNA cross-linking agents. Cloned FA genes and proteins cooperate in this pathway, and monoubiquitination of FANCD2 is a critical downstream event. The cell cycle checkpoint kinase ATR is required for the ...

journal_title：Molecular and cellular biology

authors： Ho GP,Margossian S,Taniguchi T,D'Andrea AD

更新日期：2006-09-01 00:00:00

abstract：:All inbred strains of mice carry the Ren-1 structural gene, which encodes the renin-1 isozyme, the classical renin activity found in kidneys. In addition, some strains carry a second renin structural gene, Ren-2, which encodes the predominantly expressed submaxillary gland renin isozyme, renin-2. Ren-1 and Ren-2 exhib...

journal_title：Molecular and cellular biology

authors： Field LJ,Philbrick WM,Howles PN,Dickinson DP,McGowan RA,Gross KW

更新日期：1984-11-01 00:00:00

abstract：:The Rex protein of human T-cell leukemia virus type 1, like the functionally equivalent Rev protein of human immunodeficiency virus type 1, contains a leucine-rich activation domain that specifically interacts with the human nucleoporin-like Rab/hRIP cofactor. Here, this Rex sequence is shown to function also as a pro...

journal_title：Molecular and cellular biology

authors： Bogerd HP,Fridell RA,Benson RE,Hua J,Cullen BR

更新日期：1996-08-01 00:00:00

abstract：:Both systemic insulin resistance and tissue-specific insulin resistance have been described in Drosophila and are accompanied by many indicators of metabolic disease. The downstream mediators of insulin-resistant pathophysiology remain unclear. We analyzed insulin signaling in the fat body studying loss and gain of fu...

journal_title：Molecular and cellular biology

authors： Musselman LP,Fink JL,Grant AR,Gatto JA,Tuthill BF 2nd,Baranski TJ

更新日期：2017-12-29 00:00:00