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Distribution of AdeABC efflux system genes in genotypically diverse strains of clinical Acinetobacter baumannii.

Abstract：

:Acinetobacter baumannii has emerged as a highly problematic hospital-associated pathogen. Different mechanisms contribute to the formation of multidrug resistance in A. baumannii, including the AdeABC efflux system. Distribution of the structural and regulatory genes encoding the AdeABC efflux system among genetically diverse clinical A. baumannii strains was achieved by using PCR and pulsed-field gel electrophoresis techniques. The distribution of adeABRS genes is extremely high among our A. baumannii strains, except the adeC gene. We have observed a large proportion of strains presenting multidrug-resistance phenotype for several years. The efflux pump could be an important mechanism in these strains in resistance to antibiotics.

journal_name

Diagn Microbiol Infect Dis

journal_title

Diagnostic microbiology and infectious disease

authors

Wieczorek P,Sacha P,Czaban S,Hauschild T,Ojdana D,Kowalczuk O,Milewski R,Poniatowski B,Nikliński J,Tryniszewska E

doi

10.1016/j.diagmicrobio.2013.06.017

subject

Has Abstract

pub_date

2013-10-01 00:00:00

pages

106-9

issue

2

eissn

0732-8893

issn

1879-0070

pii

S0732-8893(13)00349-0

journal_volume

77

pub_type

杂志文章

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