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Characterization of novel VIM carbapenemase, VIM-38, and first detection of GES-5 carbapenem-hydrolyzing β-lactamases in Pseudomonas aeruginosa in Turkey.

Abstract：

:Pseudomonas aeruginosa isolates were collected form a Turkish hospital. Antimicrobial susceptibility was performed using the Vitek 2 Compact system, and 24 isolates were categorized as multidrug resistant (n = 18), extensively-drug resistant (n = 5), or pan-drug resistant (n = 1). PCR and DNA sequence analysis revealed that 1 strain possessed the blaGES-5 and another carried a novel blaVIM variant, named VIM-38. This new gene exhibited 1 amino acid substitution (Ala265Val) in comparison to its closest variant, VIM-5. Both VIM encoding genes were clones and demonstrated similar susceptibility profile when expressed in identical background. The presence of VIM-38 increases the diversity of carbapenemases in Turkey.

journal_name

Diagn Microbiol Infect Dis

journal_title

Diagnostic microbiology and infectious disease

authors

Iraz M,Duzgun AO,Cicek AC,Bonnin RA,Ceylan A,Saral A,Nordmann P,Sandalli C

doi

10.1016/j.diagmicrobio.2013.12.003

subject

Has Abstract

pub_date

2014-03-01 00:00:00

pages

292-4

issue

3

eissn

0732-8893

issn

1879-0070

pii

S0732-8893(13)00645-7

journal_volume

78

pub_type

杂志文章

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