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Evaluation of antibiotic releasing porous polymethylmethacrylate space maintainers in an infected composite tissue defect model.

Abstract：

:This study evaluated the in vitro and in vivo performance of antibiotic-releasing porous polymethylmethacrylate (PMMA)-based space maintainers comprising a gelatin hydrogel porogen and a poly(dl-lactic-co-glycolic acid) (PLGA) particulate carrier for antibiotic delivery. Colistin was released in vitro from either gelatin or PLGA microparticle loaded PMMA constructs, with gelatin-loaded constructs releasing colistin over approximately 7 days and PLGA microparticle-loaded constructs releasing colistin for up to 8 weeks. Three formulations with either burst release or extended release at different doses were tested in a rabbit mandibular defect inoculated with Acinetobacter baumannii (2×10(7) colony forming units ml(-1)). In addition, one material control that released antibiotic but was not inoculated with A. baumannii was tested. A. baumannii was not detectable in any animal after 12 weeks on culture of the defect, saliva, or blood. Defects with high dose extended release implants had greater soft tissue healing compared with defects with burst release implants, with 8 of 10 animals showing healed mucosae compared with 2 of 10 respectively. Extended release of locally delivered colistin via a PLGA microparticle carrier improved soft tissue healing compared with implants with burst release of colistin from a gelatin carrier.

journal_name

Acta Biomater

journal_title

Acta biomaterialia

authors

Spicer PP,Shah SR,Henslee AM,Watson BM,Kinard LA,Kretlow JD,Bevil K,Kattchee L,Bennett GN,Demian N,Mende K,Murray CK,Jansen JA,Wong ME,Mikos AG,Kasper FK

doi

10.1016/j.actbio.2013.07.018

subject

Has Abstract

pub_date

2013-11-01 00:00:00

pages

8832-9

issue

11

eissn

1742-7061

issn

1878-7568

pii

S1742-7061(13)00357-7

journal_volume

9

pub_type

杂志文章

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