Ethnic differences in the link between insulin resistance and elevated ALT.


BACKGROUND:Nonalcoholic fatty liver disease (NAFLD) exhibits tight links with insulin resistance (IR) and the metabolic syndrome (MetS), a cluster of cardiovascular risk factors. Compared with non-Hispanic whites, non-Hispanic black adolescents have more IR but a lower prevalence of NAFLD and MetS. Our hypothesis was that IR would be a better predictor of alanine aminotransferase (ALT) elevations than is MetS among non-Hispanic blacks. METHODS:We analyzed data from 4124 adolescents aged 12 to 19 years in the 1999 to 2010 NHANES, using unexplained elevations in ALT (>30 U/L) to characterize presumed NAFLD and using a pediatric adaptation of the Adult Treatment Panel III definition of MetS. RESULTS:Prevalence of elevated ALT varied by race/ethnicity (Hispanics 13.7%, non-Hispanic white 8.6%, non-Hispanic blacks 5.4%, P < .0001). Among non-Hispanic whites and Hispanics, a classification of MetS performed well in identifying adolescents with elevated ALT (odds ratios [ORs] 9.53 and 5.56, respectively), as did MetS-related indices. However, among non-Hispanic blacks, the association between MetS and ALT elevations was smaller in magnitude and technically nonsignificant (OR = 3.24, P = .051). Furthermore, among non-Hispanic blacks, the presence of IR and elevated waist circumference performed more poorly at identifying ALT elevations (ORs 3.93 and 2.28, respectively: significantly smaller than ORs for non-Hispanic whites, P < .05), with triglyceride elevations being a better predictor (OR = 4.44). CONCLUSIONS:Non-Hispanic black adolescents exhibit a lower relationship between IR and elevated ALT, supporting racial/ethnic differences in the link between MetS and NAFLD. These data may have implications regarding triggers for screening for NAFLD among non-Hispanic black adolescents, focusing particularly on those with triglyceride elevations.






Deboer MD,Wiener RC,Barnes BH,Gurka MJ




Has Abstract


2013-09-01 00:00:00














  • Mental Health and Antiretroviral Adherence Among Youth Living With HIV in Rwanda.

    abstract:BACKGROUND AND OBJECTIVES:In Rwanda, significant progress has been made in advancing access to antiretroviral therapy (ART) among youth. As availability of ART increases, adherence is critical for preventing poor clinical outcomes and transmission of HIV. The goals of the study are to (1) describe ART adherence and men...


    pub_type: 杂志文章


    authors: Smith Fawzi MC,Ng L,Kanyanganzi F,Kirk C,Bizimana J,Cyamatare F,Mushashi C,Kim T,Kayiteshonga Y,Binagwaho A,Betancourt TS

    更新日期:2016-10-01 00:00:00

  • Vaccination and Risk of Childhood IgA Vasculitis.

    abstract:BACKGROUND AND OBJECTIVES:Immunoglobulin A vasculitis (IgAV) might develop after vaccination. However, this potential relationship is essentially based on case reports, and robust pharmaco-epidemiologic data are scarce. We aimed to investigate the effect of vaccination on short-term risk of IgAV in children. METHODS:W...


    pub_type: 杂志文章


    authors: Piram M,Gonzalez Chiappe S,Madhi F,Ulinski T,Mahr A

    更新日期:2018-11-01 00:00:00

  • Febrile exudative tonsillitis: viral or streptococcal?

    abstract::A prospective 1-year study of acute febrile exudative tonsillitis in 110 children was carried out. Viral infection was associated with 42% of the cases, beta-hemolytic streptococci with 31% (12% group A), Mycoplasma pneumoniae with 5%, and unknown cause with 35%. More than one agent was implicated in 14% of the cases....


    pub_type: 杂志文章


    authors: Putto A

    更新日期:1987-07-01 00:00:00

  • Summary of workgroup meeting on use of family history information in pediatric primary care and public health.

    abstract::A workgroup meeting on the use of family history information in pediatric primary care and public health sponsored by the National Center on Birth Defects and Developmental Disabilities at the Centers for Disease Control and Prevention was held February 24 to 25, 2006. The workgroup participants met to discuss how to ...




    authors: Green RF

    更新日期:2007-09-01 00:00:00

  • Birth weight and hearing impairment in norwegians born from 1967 to 1993.

    abstract:OBJECTIVES:To estimate the association between birth weight and hearing impairment among Norwegians born between 1967 and 1993, taking other pregnancy-related conditions into consideration. METHODS:A cohort study was conducted of all Norwegian live births from 1967 to 1993 (n = 1 548 429) linking information of the Me...


    pub_type: 杂志文章


    authors: Nafstad P,Samuelsen SO,Irgens LM,Bjerkedal T

    更新日期:2002-09-01 00:00:00

  • Prepubertal female genitalia: examination for evidence of sexual abuse.

    abstract::Experience with more than 375 cases of possible sexual abuse has taught us that much work still needs to be done in understanding normal prepubertal female anatomy and interpreting findings in sexual abuse cases. Because pediatric clinicians are often called upon to assess possible sexual abuse victims, knowledge of w...


    pub_type: 杂志文章


    authors: Herman-Giddens ME,Frothingham TE

    更新日期:1987-08-01 00:00:00

  • First case of human infection caused by Pasteurella gallinarum causing infective endocarditis in an adolescent 10 years after surgical correction for truncus arteriosus.

    abstract:OBJECTIVE:To report the first case of human infection (infective endocarditis [IE]) caused by Pasteurella gallinarum and to review the literature regarding IE caused by the genus Pasteurella. SETTING:University hospital based. PATIENT:An adolescent boy who underwent successful correction for truncus arteriosus 10 yea...


    pub_type: 杂志文章,评审


    authors: al Fadel Saleh M,al-Madan MS,Erwa HH,Defonseka I,Sohel SZ,Sanyal SK

    更新日期:1995-06-01 00:00:00

  • Congenital malignant melanoma.

    abstract::A 6-week-old girl with congenital melanoma of the skin is reported and the literature is reviewed. We believe this to be the first case of congenital melanoma in a black infant who had no underlying giant melanocytic nevus. Because of the significant relationship between the early treatment and prognosis of malignant ...


    pub_type: 杂志文章


    authors: Prose NS,Laude TA,Heilman ER,Coren C

    更新日期:1987-06-01 00:00:00

  • The effect of instituting a prehospital-discharge newborn bilirubin screening program in an 18-hospital health system.

    abstract:OBJECTIVE:Kernicterus is a rare but devastating condition. The prevention of bilirubin-induced brain injury is based on the detection of infants at risk for developing severe hyperbilirubinemia. In an 18-hospital health system, Intermountain Health Care (IHC), we initiated a program of predischarge bilirubin screening ...


    pub_type: 杂志文章,多中心研究


    authors: Eggert LD,Wiedmeier SE,Wilson J,Christensen RD

    更新日期:2006-05-01 00:00:00

  • Regulatory barriers to clinical trial enrollment of adolescent and young adult oncology patients.

    abstract::Adolescent and young adult (AYA) patients with cancer may face unique challenges if they and their families wish to participate in clinical oncology trials. Regulatory guidelines and funding requirements put in place to protect patients may actually raise barriers to enrollment in clinical trials. Hospital age guideli...


    pub_type: 杂志文章


    authors: Felgenhauer J,Hooke MC

    更新日期:2014-06-01 00:00:00

  • Neural tube defects: knowledge and preconceptional prevention practices in minority young women.

    abstract:OBJECTIVE:To assess 1) knowledge of neural tube defect (NTD) prevention by folic acid, 2) frequency of intake of multivitamins and folate- and folic acid-fortified food, and 3) factors associated with knowledge and prevention practices among sexually active minority adolescent and young adult women. METHODS:Young mino...


    pub_type: 杂志文章


    authors: Chacko MR,Anding R,Kozinetz CA,Grover JL,Smith PB

    更新日期:2003-09-01 00:00:00

  • Childhood Assets and Cardiometabolic Health in Adolescence.

    abstract:BACKGROUND:Research shows that the development of cardiometabolic disease can begin early in life with risk factors accumulating over time, but less is known about protective pathways to positive health. In this study, we use prospective data to test whether childhood assets predict a greater likelihood of being in opt...


    pub_type: 杂志文章


    authors: Qureshi F,Koenen KC,Tiemeier H,Williams MA,Misra S,Kubzansky LD

    更新日期:2019-03-01 00:00:00

  • Recognition of sleep-disordered breathing in children.

    abstract:OBJECTIVE:To determine whether upper airway resistance syndrome (UARS) can be recognized and distinguished from obstructive sleep apnea syndrome (OSAS) in prepubertal children based on clinical evaluations, and, in a subgroup of the population, to compare the efficacy of esophageal pressure (Pes) monitoring to that of ...


    pub_type: 杂志文章


    authors: Guilleminault C,Pelayo R,Leger D,Clerk A,Bocian RC

    更新日期:1996-11-01 00:00:00

  • Is moderate drinking during pregnancy associated with an increased risk for malformations?

    abstract::The relationship between heavy drinking during pregnancy and congenital malformations is well known; however, whether moderate or light drinking is teratogenic is controversial. This prospective birth defects study collected information from 32,870 women about alcohol consumption during the first trimester of pregnanc...


    pub_type: 杂志文章


    authors: Mills JL,Graubard BI

    更新日期:1987-09-01 00:00:00

  • Protection Versus Progress: The Challenge of Research on Cannabis Use During Pregnancy.

    abstract::A central tension in pediatric research ethics arises from our desire to protect children from harm while also allowing progress toward discoveries that could improve child health. A prime example of this tension is research on a controversial yet increasingly common practice: the use of cannabis by women to treat nau...


    pub_type: 杂志文章


    authors: MacDuffie KE,Kleinhans NM,Stout K,Wilfond BS

    更新日期:2020-08-01 00:00:00

  • Growth of children with Down's syndrome: birth to age 3 years.

    abstract::A sample of 90 children with Down's syndrome were measured for recumbent length and weight from birth to age 36 months at the Children's Hospital Medical Center in Boston. At birth, means for both length and weight were reduced by about 0.5 SDs from the control group means. By 36 months, mean recumbent length was grea...


    pub_type: 杂志文章


    authors: Cronk CE

    更新日期:1978-04-01 00:00:00

  • Prenatal cocaine exposure and child behavior.

    abstract:OBJECTIVE:The aim of this study was to evaluate previous teacher reports that children exposed to cocaine prenatally have more problem behaviors. METHODS:A historical, prospective design was used. Maternal subjects (n = 116) of 6-year-old singleton, term (>/=36 weeks) children, and the children's first-grade teachers ...


    pub_type: 杂志文章


    authors: Delaney-Black V,Covington C,Templin T,Ager J,Martier S,Sokol R

    更新日期:1998-10-01 00:00:00

  • Fatal and nonfatal farm injuries to children and adolescents in the United States.

    abstract::Agriculture is the second most dangerous occupation in the United States, and unlike other occupations, children make up a significant portion of the work force. This study presents national data on the morbidity and mortality due to farm injuries to children and adolescents less than or equal to 19 years of age. Data...


    pub_type: 杂志文章


    authors: Rivara FP

    更新日期:1985-10-01 00:00:00

  • Effect of donor-specific transfusions on renal transplantation in children.

    abstract::Most family members who are evaluated as kidney donors for children have high reactivity in a mixed lymphocyte culture test and are thus excluded from donation. Fifty children, most of whom had highly reactive mixed lymphocyte cultures with their donors, were challenged with three blood transfusions from their donors ...


    pub_type: 杂志文章


    authors: Potter D,Garovoy M,Hopper S,Terasaki P,Salvatierra O Jr

    更新日期:1985-09-01 00:00:00

  • Utility of symptoms to predict treatment outcomes in obstructive sleep apnea syndrome.

    abstract:BACKGROUND AND OBJECTIVES:Polysomnography defines the pathophysiology of obstructive sleep apnea syndrome (OSAS) but does not predict some important comorbidities or their response to adenotonsillectomy. We assessed whether OSAS symptoms, as reflected on the Sleep-Related Breathing Disorders Scale of the Pediatric Slee...


    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Rosen CL,Wang R,Taylor HG,Marcus CL,Katz ES,Paruthi S,Arens R,Muzumdar H,Garetz SL,Mitchell RB,Jones D,Weng J,Ellenberg S,Redline S,Chervin RD

    更新日期:2015-03-01 00:00:00

  • Philosophic objection to vaccination as a risk for tetanus among children younger than 15 years.

    abstract:OBJECTIVES:Although safe and effective vaccines are available to protect against tetanus in the United States and vaccination rates are high, cases of tetanus among children continue to occur. The objectives of this article are to describe reported cases of tetanus in children in the United States and to identify the r...


    pub_type: 杂志文章


    authors: Fair E,Murphy TV,Golaz A,Wharton M

    更新日期:2002-01-01 00:00:00

  • Trends in Referrals to a Pediatric Transgender Clinic.

    abstract:OBJECTIVES:We characterized referral trends over time at a transgender clinic within an integrated health system in Northern California. We identified the transition-related requests of pediatric transgender and gender-nonconforming patients and evaluated differences in referrals by age group. METHODS:Medical records ...


    pub_type: 杂志文章


    authors: Handler T,Hojilla JC,Varghese R,Wellenstein W,Satre DD,Zaritsky E

    更新日期:2019-11-01 00:00:00

  • Air swallowing caused recurrent ileus in Tourette's syndrome.

    abstract::This report describes an adolescent boy who has Tourette's syndrome and developed a subtle but significant increase in vocal tics after an 8-month respite. The increase in vocal tics was associated with an acute increase in psychological stressors and resulted in recurrent air swallowing, which, in turn, caused abdomi...


    pub_type: 杂志文章


    authors: Frye RE,Hait EJ

    更新日期:2006-06-01 00:00:00

  • Toxicity of over-the-counter cough and cold medications.

    abstract::Over-the-counter (OTC) cough and cold medications are marketed widely for relief of common cold symptoms, and yet studies have failed to demonstrate a benefit of these medications for young children. In addition, OTC medications can be associated with significant morbidity and even mortality in both acute overdoses an...


    pub_type: 杂志文章


    authors: Gunn VL,Taha SH,Liebelt EL,Serwint JR

    更新日期:2001-09-01 00:00:00

  • Case Report: When an Induced Illness Looks Like a Rare Disease.

    abstract::The recognition of fabricated illness (FI) in a child represents a diagnostic challenge. The suspicion of FI often arises from the discrepancy between laboratory tests and clinical history. For instance, (unnecessary) insulin injections by caregivers has been widely described as a common cause of factitious hypoglycem...


    pub_type: 杂志文章


    authors: Rabbone I,Galderisi A,Tinti D,Ignaccolo MG,Barbetti F,Cerutti F

    更新日期:2015-11-01 00:00:00

  • National patterns of aspirin use and Reye syndrome reporting, United States, 1980 to 1985.

    abstract::The number of cases of Reye syndrome reported annually to the Centers for Disease Control declined markedly between 1980 and 1985. In this article, we present pharmaceutical marketing research data that suggest sharp decreases in the use and purchase of children's aspirin between 1980 and 1985. These trends appear to ...


    pub_type: 杂志文章


    authors: Arrowsmith JB,Kennedy DL,Kuritsky JN,Faich GA

    更新日期:1987-06-01 00:00:00

  • Common bile duct obstruction due to an intraluminal mass of candidiasis in a previously healthy child.

    abstract::A 3 6/12-year-old previously healthy girl had intermittent attacks of abdominal pain following a blunt abdominal trauma. At admission to the hospital, she had jaundice and hepatomegaly. Results of laboratory tests indicated an obstructive pattern, and ultrasonography revealed an intraluminal mass in the distal common ...


    pub_type: 杂志文章


    authors: Carstensen H,Nilsson KO,Nettelblad SC,Cederlund CG,Hildell J

    更新日期:1986-06-01 00:00:00

  • INSIGHT Responsive Parenting Intervention and Infant Sleep.

    abstract:OBJECTIVES:Inadequate sleep during infancy is associated with adverse outcomes for infants and families. We sought to improve sleep behaviors and duration through a responsive parenting (RP) intervention designed for obesity prevention. METHODS:The Intervention Nurses Start Infants Growing on Healthy Trajectories (INS...


    pub_type: 杂志文章,随机对照试验


    authors: Paul IM,Savage JS,Anzman-Frasca S,Marini ME,Mindell JA,Birch LL

    更新日期:2016-07-01 00:00:00

  • Clinical Management of Staphylococcus aureus Bacteremia in Neonates, Children, and Adolescents.

    abstract::Staphylococcus aureus is a common cause of community and health care-associated bacteremia, with authors of recent studies estimating the incidence of S aureus bacteremia (SAB) in high-income countries between 8 and 26 per 100 000 children per year. Despite this, <300 children worldwide have ever been randomly assigne...


    pub_type: 杂志文章


    authors: McMullan BJ,Campbell AJ,Blyth CC,McNeil JC,Montgomery CP,Tong SYC,Bowen AC

    更新日期:2020-09-01 00:00:00

  • The value of pulsus paradoxus in assessing the child with status asthmaticus.

    abstract::The presence of pulsus paradoxus (PP) in 13 episodes of status asthmaticus in 12 children, ages 13 months to 15 years, was compared sequentially to a clinical score, peak expiratory flow rate (PEFR), heart rate, arterialized capillary pH, carbon dioxide pressure (PCO2), and the ratio of inspired oxygen to oxygen press...


    pub_type: 杂志文章


    authors: Galant SP,Groncy CE,Shaw KC

    更新日期:1978-01-01 00:00:00