A unifying model of concurrent spatial and temporal modularity in muscle activity.

Abstract:

:Modularity in the central nervous system (CNS), i.e., the brain capability to generate a wide repertoire of movements by combining a small number of building blocks ("modules"), is thought to underlie the control of movement. Numerous studies reported evidence for such a modular organization by identifying invariant muscle activation patterns across various tasks. However, previous studies relied on decompositions differing in both the nature and dimensionality of the identified modules. Here, we derive a single framework that encompasses all influential models of muscle activation modularity. We introduce a new model (named space-by-time decomposition) that factorizes muscle activations into concurrent spatial and temporal modules. To infer these modules, we develop an algorithm, referred to as sample-based nonnegative matrix trifactorization (sNM3F). We test the space-by-time decomposition on a comprehensive electromyographic dataset recorded during execution of arm pointing movements and show that it provides a low-dimensional yet accurate, highly flexible and task-relevant representation of muscle patterns. The extracted modules have a well characterized functional meaning and implement an efficient trade-off between replication of the original muscle patterns and task discriminability. Furthermore, they are compatible with the modules extracted from existing models, such as synchronous synergies and temporal primitives, and generalize time-varying synergies. Our results indicate the effectiveness of a simultaneous but separate condensation of spatial and temporal dimensions of muscle patterns. The space-by-time decomposition accommodates a unified view of the hierarchical mapping from task parameters to coordinated muscle activations, which could be employed as a reference framework for studying compositional motor control.

journal_name

J Neurophysiol

authors

Delis I,Panzeri S,Pozzo T,Berret B

doi

10.1152/jn.00245.2013

subject

Has Abstract

pub_date

2014-02-01 00:00:00

pages

675-93

issue

3

eissn

0022-3077

issn

1522-1598

pii

jn.00245.2013

journal_volume

111

pub_type

杂志文章
  • Stance- and locomotion-dependent processing of vibration-induced proprioceptive inflow from multiple muscles in humans.

    abstract::We performed a whole-body mapping study of the effect of unilateral muscle vibration, eliciting spindle Ia firing, on the control of standing and walking in humans. During quiet stance, vibration applied to various muscles of the trunk-neck system and of the lower limb elicited a significant tilt in whole body postura...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00764.2006

    authors: Courtine G,De Nunzio AM,Schmid M,Beretta MV,Schieppati M

    更新日期:2007-01-01 00:00:00

  • Role of cAMP in the short-term modulation of a neuromuscular system in aplysia.

    abstract::Neuromuscular synapses in buccal muscle I3a of Aplysia are modulated by the small cardioactive peptide (SCP), a peptide cotransmitter that is intrinsic to the motor neurons, and by serotonin (5-HT) released from modulatory neurons that are extrinsic to the motor circuit. Although the modulation of excitatory junction ...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.2000.83.3.1567

    authors: Fox LE,Lloyd PE

    更新日期:2000-03-01 00:00:00

  • Effects of ventrobasal lesion and cortical cooling on fast oscillations (>200 Hz) in rat somatosensory cortex.

    abstract::High-frequency oscillatory activity (>200 Hz) termed "fast oscillations" (FO) have been recorded in the rodent somatosensory cortex and may reflect very rapid integration of vibrissal information in sensory cortex. Yet, while electrophysiological correlates suggest that FO is generated within intracortical networks, c...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.01098.2002

    authors: Staba RJ,Brett-Green B,Paulsen M,Barth DS

    更新日期:2003-05-01 00:00:00

  • Encoding of probabilistic rewarding and aversive events by pallidal and nigral neurons.

    abstract::Previous studies have rarely tested whether the activity of high-frequency discharge (HFD) neurons of the basal ganglia (BG) is modulated by expectation, delivery, and omission of aversive events. Therefore the full value domain encoded by the BG network is still unknown. We studied the activity of HFD neurons of the ...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.90764.2008

    authors: Joshua M,Adler A,Rosin B,Vaadia E,Bergman H

    更新日期:2009-02-01 00:00:00

  • Responses of lumbosacral spinal units to mechanical stimuli related to analysis of lordosis reflex in female rats.

    abstract::1. To analyze further the sensory mechanisms for triggering the lordosis reflex, single-unit (n = 345) activity was recorded extracellularly from spinal segments L5-S1 of urethan-anesthetized female rats. Unit responses to pressure on the skin (necessary and sufficient for evoking lordosis) and other mechanical stimul...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1980.43.1.27

    authors: Kow LM,Zemlan FP,Pfaff DW

    更新日期:1980-01-01 00:00:00

  • On the origin of event-related potentials indexing covert attentional selection during visual search: timing of selection by macaque frontal eye field and event-related potentials during pop-out search.

    abstract::Event-related potentials (ERPs) have provided crucial data concerning the time course of psychological processes, but the neural mechanisms producing ERP components remain poorly understood. This study continues a program of research in which we investigated the neural basis of attention-related ERP components by simu...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00549.2012

    authors: Purcell BA,Schall JD,Woodman GF

    更新日期:2013-01-01 00:00:00

  • Responses of spinothalamic tract neurons to mechanical and thermal stimuli in an experimental model of peripheral neuropathy in primates.

    abstract::1. An experimental peripheral neuropathy (EPN) was induced in three monkeys (Macaca fascicularis) by ligation of spinal nerve L7. Behavioral responses to innocuous mechanical stimuli were tested before and after the surgery. Two weeks after the nerve ligation, the activity of spinothalamic tract (STT) neurons was reco...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1992.68.6.1951

    authors: Palecek J,Dougherty PM,Kim SH,Palecková V,Lekan H,Chung JM,Carlton SM,Willis WD

    更新日期:1992-12-01 00:00:00

  • The effects of expectancy on corticospinal excitability: passively preparing to observe a movement.

    abstract::The corticospinal tract excitability is modulated when preparing movements. Earlier to movement execution, the excitability of the spinal cord increases waiting for supraspinal commands to release the movement. Movement execution and movement observation share processes within the motor system, although movement obser...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00353.2013

    authors: Arias P,Robles-García V,Espinosa N,Corral-Bergantiños Y,Mordillo-Mateos L,Grieve K,Oliviero A,Cudeiro J

    更新日期:2014-04-01 00:00:00

  • Contributions of optostatic and optokinetic cues to the perception of vertical.

    abstract::While it has been well established that optostatic and optokinetic cues contribute to the perception of vertical, it is unclear how the brain processes their combined presence with the nonvisual vestibular cues. Using a psychometric approach, we examined the percept of vertical in human participants (n = 17) with thei...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00740.2018

    authors: Niehof N,Perdreau F,Koppen M,Medendorp WP

    更新日期:2019-08-01 00:00:00

  • Anticipatory postural adjustments and spatial organization of motor cortex: evidence of adaptive compensations in healthy older adults.

    abstract::During anticipated postural perturbations induced by limb movement, the central nervous system generates anticipatory postural adjustments (APAs) in the trunk and hip musculature to minimize disturbances to equilibrium. Age-related changes in functional organization of the nervous system may contribute to changes in A...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00428.2018

    authors: Smith JA,Fisher BE

    更新日期:2018-12-01 00:00:00

  • N-methyl-D-aspartate receptors of ganglion cells in rabbit retina.

    abstract::1. Intracellular and extracellular recordings were obtained from ganglion cells in the rabbit retina. The effect of N-methyl-DL-aspartate (NMDLA) and N-methyl-D-aspartate (NMDA) antagonists were studied with the use of a perfusion method for drug application. 2. NMDLA excited all ganglion cell types and caused a chara...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1990.63.1.16

    authors: Massey SC,Miller RF

    更新日期:1990-01-01 00:00:00

  • Bidirectional synaptic plasticity correlated with the magnitude of dendritic calcium transients above a threshold.

    abstract::The magnitude of postsynaptic Ca(2+) transients is thought to affect activity-dependent synaptic plasticity associated with learning and memory. Large Ca(2+) transients have been implicated in the induction of long-term potentiation (LTP), while smaller Ca(2+) transients have been associated with long-term depression ...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.2001.85.1.399

    authors: Cormier RJ,Greenwood AC,Connor JA

    更新日期:2001-01-01 00:00:00

  • Single-unit activity in bulbar reticular formation during food ingestion in chronic cats.

    abstract::1. Single-unit activity was recorded from 215 neurons in the medial bulbar reticular formation during the masticatory sequence, from intake to deglutition, of 3 kinds of food (cat food pellets, canned fish, and milk) in 8 chronically prepared, unanesthetized, spontaneously respiring cats with their head fixed to a ste...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1988.60.4.1333

    authors: Hiraba K,Taira M,Sahara Y,Nakamura Y

    更新日期:1988-10-01 00:00:00

  • Transformation of temporal discharge patterns in a ventral cochlear nucleus stellate cell model: implications for physiological mechanisms.

    abstract::1. We have stimulated responses of stellate cells in the anteroventral cochlear nucleus (AVCN) to single-formant stimuli (SFSs) with the use of recorded auditory-nerve fiber (ANF) responses as inputs. In particular, two important features of temporal discharge patterns, the phase locking to best frequency (BF) tones a...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1995.73.4.1600

    authors: Wang X,Sachs MB

    更新日期:1995-04-01 00:00:00

  • Electrical coupling between Aplysia bag cell neurons: characterization and role in synchronous firing.

    abstract::In neuroendocrine cells, hormone release often requires a collective burst of action potentials synchronized by gap junctions. This is the case for the electrically coupled bag cell neurons in the reproductive system of the marine snail, Aplysia californica. These neuroendocrine cells are found in two clusters, and fi...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00494.2014

    authors: Dargaei Z,Colmers PL,Hodgson HM,Magoski NS

    更新日期:2014-12-01 00:00:00

  • Megamap: flexible representation of a large space embedded with nonspatial information by a hippocampal attractor network.

    abstract::The problem of how the hippocampus encodes both spatial and nonspatial information at the cellular network level remains largely unresolved. Spatial memory is widely modeled through the theoretical framework of attractor networks, but standard computational models can only represent spaces that are much smaller than t...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00856.2015

    authors: Hedrick KR,Zhang K

    更新日期:2016-08-01 00:00:00

  • Summation of motor unit tensions in the tibialis posterior muscle of the cat under isometric and nonisometric conditions.

    abstract::1. The tension produced by the combined stimulation of two to four single motor units of the cat tibialis posterior muscle was compared with the algebraic sum of the tensions produced by each individual motor unit. Comparisons were made under isometric conditions and during imposed changes in muscle length. 2. Under i...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1991.66.6.1838

    authors: Powers RK,Binder MD

    更新日期:1991-12-01 00:00:00

  • Synaptic transmission and hippocampal long-term potentiation in olfactory cyclic nucleotide-gated channel type 1 null mouse.

    abstract::Field potential recording was used to investigate properties of synaptic transmission and long-term potentiation (LTP) at Schaffer collateral-CA1 synapses in both hippocampal slices of mutant mice in which the alpha-subunit of the olfactory cyclic nucleotide-gated channel (alpha3/OCNC)1 was rendered null and also in s...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1998.79.6.3295

    authors: Parent A,Schrader K,Munger SD,Reed RR,Linden DJ,Ronnett GV

    更新日期:1998-06-01 00:00:00

  • Delayed excitatory connections in the flight system of the locust.

    abstract::1. Synaptic interactions between identified neurons in the flight system of the locust were investigated by the use of standard intracellular recording and staining techniques. The intent was to determine the distribution and functional significance of delayed excitatory connections, which have been previously describ...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1991.65.5.1150

    authors: Robertson RM

    更新日期:1991-05-01 00:00:00

  • Spatially selective enhancement of proprioceptive acuity following motor learning.

    abstract::It is well recognized that the brain uses sensory information to accurately produce motor commands. Indeed, most research into the relationship between sensory and motor systems has focused on how sensory information modulates motor function. In contrast, recent studies have begun to investigate the reverse: how senso...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章,随机对照试验

    doi:10.1152/jn.00949.2010

    authors: Wong JD,Wilson ET,Gribble PL

    更新日期:2011-05-01 00:00:00

  • Transcribing the connectome: roles for transcription factors and chromatin regulators in activity-dependent synapse development.

    abstract::The wiring of synaptic connections in the developing mammalian brain is shaped by both intrinsic and extrinsic signals. One point where these regulatory pathways converge is via the sensory experience-dependent regulation of new gene transcription. Recent studies have elucidated a number of molecular mechanisms that a...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章,评审

    doi:10.1152/jn.00067.2017

    authors: Chen LF,Zhou AS,West AE

    更新日期:2017-08-01 00:00:00

  • Developmental time course distinguishes changes in spontaneous and light-evoked retinal ganglion cell activity in rd1 and rd10 mice.

    abstract::In a subset of hereditary retinal diseases, early photoreceptor degeneration causes rapidly progressive blindness in children. To better understand how retinal development may interact with degenerative processes, we compared spontaneous and light-evoked activity among retinal ganglion cells in rd1 and rd10 mice, stra...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00704.2010

    authors: Stasheff SF,Shankar M,Andrews MP

    更新日期:2011-06-01 00:00:00

  • Role of chloride-homeostasis in the inhibitory control of neuronal network oscillators.

    abstract::1. Spontaneous synaptic activity in networks formed by dissociated neurons from embryonic rat midbrain was analyzed in tight seal whole cell recordings. 2. Application of furosemide (0.5 mM) to the cell and its surrounding area increased the frequency of spontaneous synaptic currents. Incubation of the culture with fu...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1996.75.6.2654

    authors: Jarolimek W,Brunner H,Lewen A,Misgeld U

    更新日期:1996-06-01 00:00:00

  • Spinocervical tract neurons responsive to light mechanical stimulation of the raccoon forepaw.

    abstract::1. The extracellular activity of 45 antidromically identified spinocervical tract (SCT) neurons responsive to light mechanical stimulation of the glabrous surfaces of the forepaw was examined in raccoons anesthetized with pentobarbital sodium. An additional seven neurons had peripheral receptive fields (RFs) located o...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1989.61.1.138

    authors: Hirata H,Pubols BH Jr

    更新日期:1989-01-01 00:00:00

  • Developmental regulation of whole cell capacitance and membrane current in identified interneurons in C. elegans.

    abstract::Postembryonic developmental changes in electrophysiological properties of the AIY interneuron class were investigated using whole cell voltage clamp. AIY interneurons displayed an increase in cell capacitance during larval development, whereas steady-state current amplitude did not increase. The time course of the out...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00052.2006

    authors: Faumont S,Boulin T,Hobert O,Lockery SR

    更新日期:2006-06-01 00:00:00

  • Glutamate and GABA activate different receptors and Cl(-) conductances in crab peptide-secretory neurons.

    abstract::Responses to rapid application of glutamic acid (Glu) and gamma-aminobutyric acid (GABA), 0.01-3 mM, were recorded by whole-cell patch clamp of cultured crab (Cardisoma carnifex) X-organ neurons. Responses peaked within 200 ms. Both Glu and GABA currents had reversal potentials that followed the Nernst Cl(-) potential...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.2000.83.1.31

    authors: Duan S,Cooke IM

    更新日期:2000-01-01 00:00:00

  • Role of the cerebellar flocculus region in cancellation of the VOR during passive whole body rotation.

    abstract::A series of studies were carried out to investigate the role of the cerebellar flocculus and ventral paraflocculus in the ability to voluntarily cancel the vestibuloocular reflex (VOR). Squirrel monkeys were trained to pursue moving visual targets and to fixate a head stationary or earth stationary target during passi...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.2000.84.3.1599

    authors: Belton T,McCrea RA

    更新日期:2000-09-01 00:00:00

  • Ventrolateral medullary functional connectivity and the respiratory and central chemoreceptor-evoked modulation of retrotrapezoid-parafacial neurons.

    abstract::The medullary ventral respiratory column (VRC) of neurons is essential for respiratory motor pattern generation; however, the functional connections among these cells are not well understood. A rostral extension of the VRC, including the retrotrapezoid nucleus/parafacial region (RTN-pF), contains neurons responsive to...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00262.2010

    authors: Ott MM,Nuding SC,Segers LS,Lindsey BG,Morris KF

    更新日期:2011-06-01 00:00:00

  • Enhancement of neural synchronization in the anteroventral cochlear nucleus. II. Responses in the tuning curve tail.

    abstract::1. Discharges of neurons in the peripheral auditory system contain information about the temporal features of acoustic stimuli. Phase-locking of neurons in the anteroventral cochlear nucleus (AVCN) is usually reported to be less robust than in auditory nerve (AN) fibers, which provide their major input. In a companion...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1994.71.3.1037

    authors: Joris PX,Smith PH,Yin TC

    更新日期:1994-03-01 00:00:00

  • Ca2+-induced uncoupling of Aplysia bag cell neurons.

    abstract::Electrical transmission is a dynamically regulated form of communication and key to synchronizing neuronal activity. The bag cell neurons of Aplysia are a group of electrically coupled neuroendocrine cells that initiate ovulation by secreting egg-laying hormone during a prolonged period of synchronous firing called th...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00603.2014

    authors: Dargaei Z,Standage D,Groten CJ,Blohm G,Magoski NS

    更新日期:2015-02-01 00:00:00