The genome of Shope fibroma virus, a tumorigenic poxvirus, contains a growth factor gene with sequence similarity to those encoding epidermal growth factor and transforming growth factor alpha.


:Degenerate oligonucleotide probes corresponding to a highly conserved region common to epidermal growth factor, transforming growth factor alpha, and vaccinia growth factor were used to identify a novel growth factor gene in the Shope fibroma virus genome. Sequence analysis indicates that the Shope fibroma growth factor is a distinct new member of this family of growth factors.


Mol Cell Biol


Chang W,Upton C,Hu SL,Purchio AF,McFadden G




Has Abstract


1987-01-01 00:00:00












  • Ubiquitin metabolism affects cellular response to volatile anesthetics in yeast.

    abstract::To investigate the mechanism of action of volatile anesthetics, we are studying mutants of the yeast Saccharomyces cerevisiae that have altered sensitivity to isoflurane, a widely used clinical anesthetic. Several lines of evidence from these studies implicate a role for ubiquitin metabolism in cellular response to vo...

    journal_title:Molecular and cellular biology

    pub_type: 杂志文章


    authors: Wolfe D,Reiner T,Keeley JL,Pizzini M,Keil RL

    更新日期:1999-12-01 00:00:00

  • Loss of the zymogen granule protein syncollin affects pancreatic protein synthesis and transport but not secretion.

    abstract::Syncollin is a small protein that is abundantly expressed in pancreatic acinar cells and that is tightly associated with the lumenal side of the zymogen granule membrane. To shed light on the hitherto unknown function of syncollin, we have generated syncollin-deficient mice. The mice are viable and show a normal pancr...

    journal_title:Molecular and cellular biology

    pub_type: 杂志文章


    authors: Antonin W,Wagner M,Riedel D,Brose N,Jahn R

    更新日期:2002-03-01 00:00:00

  • Influence of intron length on alternative splicing of CD44.

    abstract::Although the splicing of transcripts from most eukaryotic genes occurs in a constitutive fashion, some genes can undergo a process of alternative splicing. This is a genetically economical process which allows a single gene to give rise to several protein isoforms by the inclusion or exclusion of sequences into or fro...

    journal_title:Molecular and cellular biology

    pub_type: 杂志文章


    authors: Bell MV,Cowper AE,Lefranc MP,Bell JI,Screaton GR

    更新日期:1998-10-01 00:00:00

  • HTL1 encodes a novel factor that interacts with the RSC chromatin remodeling complex in Saccharomyces cerevisiae.

    abstract::RSC is an essential chromatin remodeling complex in Saccharomyces cerevisiae that performs central roles in transcriptional regulation and cell cycle progression. Here we identify Htl1 as a novel factor that associates with the RSC complex both physically and functionally. We isolated HTL1 through a genetic screen for...

    journal_title:Molecular and cellular biology

    pub_type: 杂志文章


    authors: Romeo MJ,Angus-Hill ML,Sobering AK,Kamada Y,Cairns BR,Levin DE

    更新日期:2002-12-01 00:00:00

  • The C proteins of HeLa 40S nuclear ribonucleoprotein particles exist as anisotropic tetramers of (C1)3 C2.

    abstract::The C proteins (C1 and C2) of HeLa 40S heterogeneous nuclear ribonucleoprotein particles copurify under native conditions as a stable complex with a fixed molar protein ratio (S.F. Barnett, W.M. LeStourgeon, and D.L. Friedman, J. Biochem. Biophys. Methods 16:87-97, 1988). Gel filtration chromatography and velocity sed...

    journal_title:Molecular and cellular biology

    pub_type: 杂志文章


    authors: Barnett SF,Friedman DL,LeStourgeon WM

    更新日期:1989-02-01 00:00:00

  • Binding of myc proteins to canonical and noncanonical DNA sequences.

    abstract::Using an in vitro binding-site selection assay, we have demonstrated that c-Myc-Max complexes bind not only to canonical CACGTG or CATGTG motifs that are flanked by variable sequences but also to noncanonical sites that consist of an internal CG or TG dinucleotide in the context of particular variations in the CA--TG ...

    journal_title:Molecular and cellular biology

    pub_type: 杂志文章


    authors: Blackwell TK,Huang J,Ma A,Kretzner L,Alt FW,Eisenman RN,Weintraub H

    更新日期:1993-09-01 00:00:00

  • Novel splicing factor RBM25 modulates Bcl-x pre-mRNA 5' splice site selection.

    abstract::RBM25 has been shown to associate with splicing cofactors SRm160/300 and assembled splicing complexes, but little is known about its splicing regulation. Here, we characterize the functional role of RBM25 in alternative pre-mRNA splicing. Increased RBM25 expression correlated with increased apoptosis and specifically ...

    journal_title:Molecular and cellular biology

    pub_type: 杂志文章


    authors: Zhou A,Ou AC,Cho A,Benz EJ Jr,Huang SC

    更新日期:2008-10-01 00:00:00

  • Characterization of a positive regulatory gene, LAC9, that controls induction of the lactose-galactose regulon of Kluyveromyces lactis: structural and functional relationships to GAL4 of Saccharomyces cerevisiae.

    abstract::Lactose or galactose induces the expression of the lactose-galactose regulon in Kluyveromyces lactis. We show here that the regulon is not induced in strains defective in LAC9. We demonstrate that this gene codes for a regulatory protein that acts in a positive manner to induce transcription. The LAC9 gene was isolate...

    journal_title:Molecular and cellular biology

    pub_type: 杂志文章


    authors: Wray LV Jr,Witte MM,Dickson RC,Riley MI

    更新日期:1987-03-01 00:00:00

  • Concerted action of the transcriptional activators REB1, RAP1, and GCR1 in the high-level expression of the glycolytic gene TPI.

    abstract::In Saccharomyces cerevisiae, the TPI gene product, triosephosphate isomerase, makes up about 2% of the soluble cellular protein. Using in vitro and in vivo footprinting techniques, we have identified four binding sites for three factors in the 5' noncoding region of TPI: a REB1-binding site located at positions -401 t...

    journal_title:Molecular and cellular biology

    pub_type: 杂志文章


    authors: Scott EW,Baker HV

    更新日期:1993-01-01 00:00:00

  • IME4, a gene that mediates MAT and nutritional control of meiosis in Saccharomyces cerevisiae.

    abstract::In the yeast Saccharomyces cerevisiae, sporulation occurs in response to nutritional and genetic signals. The process is initiated when nutrient availability limits mitotic growth, but only in MATa/MAT alpha diploid cells. Under these conditions, the cells express an activator of meiosis (IME1), which is required for ...

    journal_title:Molecular and cellular biology

    pub_type: 杂志文章


    authors: Shah JC,Clancy MJ

    更新日期:1992-03-01 00:00:00

  • Mutations in the yeast KEX2 gene cause a Vma(-)-like phenotype: a possible role for the Kex2 endoprotease in vacuolar acidification.

    abstract::Mutants of Saccharomyces cerevisiae that lack vacuolar proton-translocating ATPase (V-ATPase) activity show a well-defined set of Vma- (stands for vacuolar membrane ATPase activity) phenotypes that include pH-conditional growth, increased calcium sensitivity, and the inability to grow on nonfermentable carbon sources....

    journal_title:Molecular and cellular biology

    pub_type: 杂志文章


    authors: Oluwatosin YE,Kane PM

    更新日期:1998-03-01 00:00:00

  • Induction of neuronal differentiation in PC12 cells by B-cell stimulatory factor 2/interleukin 6.

    abstract::B-cell stimulatory factor 2 (BSF-2) is a lymphokine which induces the final maturation of B cells. BSF-2 acts on a variety of cells other than B cells, and moreover, expression of BSF-2 mRNA is detected in interleukin-1 beta-stimulated glioblastoma and astrocytoma cell lines. Here, we studied the function of BSF-2 on ...

    journal_title:Molecular and cellular biology

    pub_type: 杂志文章


    authors: Satoh T,Nakamura S,Taga T,Matsuda T,Hirano T,Kishimoto T,Kaziro Y

    更新日期:1988-08-01 00:00:00

  • Disruption of the c/ebp alpha gene in adult mouse liver.

    abstract::The liver-enriched transcription factor C/EBP alpha has been implicated in the regulation of numerous liver-specific genes. It was previously reported that mice carrying a homozygous null mutation at the c/ebp alpha locus died as neonates due to the absence of hepatic glycogen and the resulting hypoglycemia. However, ...

    journal_title:Molecular and cellular biology

    pub_type: 杂志文章


    authors: Lee YH,Sauer B,Johnson PF,Gonzalez FJ

    更新日期:1997-10-01 00:00:00

  • Telomerase- and Rad52-independent immortalization of budding yeast by an inherited-long-telomere pathway of telomeric repeat amplification.

    abstract::In the absence of telomerase, telomeres erode, provoking accumulation of DNA damage and death by senescence. Rare survivors arise, however, due to Rad52-based amplification of telomeric sequences by homologous recombination. The present study reveals that in budding yeast cells, postsenescence survival relying on ampl...

    journal_title:Molecular and cellular biology

    pub_type: 杂志文章


    authors: Grandin N,Charbonneau M

    更新日期:2009-02-01 00:00:00

  • CIF150, a human cofactor for transcription factor IID-dependent initiator function.

    abstract::The transcription factor IID (TFIID) complex is highly conserved between the Drosophila and mammalian systems. A mammalian homolog has been described for all the Drosophila TATA box-binding protein-associated factors (TAFs), with the exception of dTAF(II)150. We previously reported the identification of CIF, an essent...

    journal_title:Molecular and cellular biology

    pub_type: 杂志文章


    authors: Kaufmann J,Ahrens K,Koop R,Smale ST,Müller R

    更新日期:1998-01-01 00:00:00

  • Two distinct mechanisms of transcriptional control operate on c-myc during differentiation of HL60 cells.

    abstract::We examined the mechanisms that control the downregulation of the c-myc mRNA during differentiation of HL60 cells. On treatment with dimethyl sulfoxide, HL60 cells downmodulated their steady-state c-myc message levels, ceased to proliferate, and underwent terminal differentiation. In nuclear run-on assays in which dis...

    journal_title:Molecular and cellular biology

    pub_type: 杂志文章


    authors: Siebenlist U,Bressler P,Kelly K

    更新日期:1988-02-01 00:00:00

  • Cross talk between beta-adrenergic and bradykinin B(2) receptors results in cooperative regulation of cyclic AMP accumulation and mitogen-activated protein kinase activity.

    abstract::Costimulation of G protein-coupled receptors (GPCRs) may result in cross talk interactions between their downstream signaling pathways. Stimulation of GPCRs may also lead to cross talk regulation of receptor tyrosine kinase signaling and thereby to activation of mitogen-activated protein kinase (MAPK). In COS-7 cells,...

    journal_title:Molecular and cellular biology

    pub_type: 杂志文章


    authors: Hanke S,Nürnberg B,Groll DH,Liebmann C

    更新日期:2001-12-01 00:00:00

  • Mutant mouse models reveal the relative roles of E2F1 and E2F3 in vivo.

    abstract::The E2F1, -2, and -3 transcription factors are key downstream targets of the retinoblastoma protein (pRB) tumor suppressor that drive expression of proliferation-associated genes. Here we use mutant mouse strains to investigate E2F3's role in vivo. We show that E2F3 is essential for embryonic viability in the pure 129...

    journal_title:Molecular and cellular biology

    pub_type: 杂志文章


    authors: Cloud JE,Rogers C,Reza TL,Ziebold U,Stone JR,Picard MH,Caron AM,Bronson RT,Lees JA

    更新日期:2002-04-01 00:00:00

  • Mitochondrial import and processing of mutant human ornithine transcarbamylase precursors in cultured cells.

    abstract::We have investigated mitochondrial import and processing of the precursor for human ornithine transcarbamylase (OTC; carbamoylphosphate:L-ornithine carbamoyltransferase, EC in HeLa cells stably transformed with cDNA sequences encoding OTC precursors carrying mutations in their leader peptides. The mutant prec...

    journal_title:Molecular and cellular biology

    pub_type: 杂志文章


    authors: Isaya G,Fenton WA,Hendrick JP,Furtak K,Kalousek F,Rosenberg LE

    更新日期:1988-12-01 00:00:00

  • RAP30/74: a general initiation factor that binds to RNA polymerase II.

    abstract::We have previously shown by affinity chromatography that RAP30 and RAP74 are the mammalian proteins that have the highest affinity for RNA polymerase II. Here we show that RAP30 binds to RAP74 and that the RAP30-RAP74 complex (RAP30/74) is required for accurate initiation by RNA polymerase II. RAP30/74 is required for...

    journal_title:Molecular and cellular biology

    pub_type: 杂志文章


    authors: Burton ZF,Killeen M,Sopta M,Ortolan LG,Greenblatt J

    更新日期:1988-04-01 00:00:00

  • Cardiomyocyte-specific endothelin A receptor knockout mice have normal cardiac function and an unaltered hypertrophic response to angiotensin II and isoproterenol.

    abstract::Even though endothelin is recognized as an important vasoregulatory molecule, the roles of endothelin receptors in specific cell types are not yet fully understood. Mice with a null mutation in endothelin A receptor gene (ET(A)) or in the gene of its ligand (endothelin 1) die neonatally due to craniofacial and cardiac...

    journal_title:Molecular and cellular biology

    pub_type: 杂志文章


    authors: Kedzierski RM,Grayburn PA,Kisanuki YY,Williams CS,Hammer RE,Richardson JA,Schneider MD,Yanagisawa M

    更新日期:2003-11-01 00:00:00

  • Saccharomyces cerevisiae killer virus transcripts contain template-coded polyadenylate tracts.

    abstract::The M double-stranded RNA component of type 1 killer strains of the yeast Saccharomyces cerevisiae contains an internal 200-base pair adenine- and uracil-rich region. The plus strands of this viral genomic RNA contain an internal adenine-rich region which allows these strands to bind to polyuridylate-Sepharose as tigh...

    journal_title:Molecular and cellular biology

    pub_type: 杂志文章


    authors: Hannig EM,Thiele DJ,Leibowitz MJ

    更新日期:1984-01-01 00:00:00

  • Simian virus 40 large T-antigen point mutants that are defective in viral DNA replication but competent in oncogenic transformation.

    abstract::The large T antigen of simian virus 40 (SV40) is a multifunctional protein that is essential in both the virus lytic cycle and the oncogenic transformation of cells by SV40. To investigate the role of the numerous biochemical and physiological activities of T antigen in the lytic and transformation processes, we have ...

    journal_title:Molecular and cellular biology

    pub_type: 杂志文章


    authors: Manos MM,Gluzman Y

    更新日期:1984-06-01 00:00:00

  • Three tightly linked genes encoding human type I keratins: conservation of sequence in the 5'-untranslated leader and 5'-upstream regions of coexpressed keratin genes.

    abstract::We have isolated and subcloned three separate segments of human DNA which share strong sequence homology with a previously sequenced gene encoding a type I keratin, K14 (50 kilodaltons). Restriction endonuclease mapping has demonstrated that these three genes are tightly linked chromosomally, whereas the K14 gene appe...

    journal_title:Molecular and cellular biology

    pub_type: 杂志文章


    authors: RayChaudhury A,Marchuk D,Lindhurst M,Fuchs E

    更新日期:1986-02-01 00:00:00

  • Developmental characterization and chromosomal mapping of the 5-azacytidine-sensitive fluF locus of Aspergillus nidulans.

    abstract::In Aspergillus nidulans, a fungus that possesses negligible, if any, levels of methylation in its genome, low concentrations of 5-azacytidine (5-AC) convert a high percentage of the cell population to fluffy phenotypic variants through a heritable modification of a single nuclear gene (M. Tamame, F. Antequera, J. R. V...

    journal_title:Molecular and cellular biology

    pub_type: 杂志文章


    authors: Tamame M,Antequera F,Santos E

    更新日期:1988-08-01 00:00:00

  • Drosophila lin-52 acts in opposition to repressive components of the Myb-MuvB/dREAM complex.

    abstract::The Drosophila melanogaster Myb-MuvB/dREAM complex (MMB/dREAM) participates in both the activation and repression of developmentally regulated genes and origins of DNA replication. Mutants in MMB subunits exhibit diverse phenotypes, including lethality, eye defects, reduced fecundity, and sterility. Here, we used P-el...

    journal_title:Molecular and cellular biology

    pub_type: 杂志文章


    authors: Lewis PW,Sahoo D,Geng C,Bell M,Lipsick JS,Botchan MR

    更新日期:2012-08-01 00:00:00

  • Expression of human Hemojuvelin (HJV) is tightly regulated by two upstream open reading frames in HJV mRNA that respond to iron overload in hepatic cells.

    abstract::The gene encoding human hemojuvelin (HJV) is one of the genes that, when mutated, can cause juvenile hemochromatosis, an early-onset inherited disorder associated with iron overload. The 5' untranslated region of the human HJV mRNA has two upstream open reading frames (uORFs), with 28 and 19 codons formed by two upstr...

    journal_title:Molecular and cellular biology

    pub_type: 杂志文章


    authors: Onofre C,Tomé F,Barbosa C,Silva AL,Romão L

    更新日期:2015-04-01 00:00:00

  • The myc intron-binding polypeptide associates with RFX1 in vivo and binds to the major histocompatibility complex class II promoter region, to the hepatitis B virus enhancer, and to regulatory regions of several distinct viral genes.

    abstract::We demonstrated that MIF-1, identified initially as a binding activity that associated with the intron I element of the c-myc gene, consists of two polypeptides, the myc intron-binding peptide (MIBP1) and the major histocompatibility class II promoter-binding protein, RFX1. Using a polyclonal antiserum directed agains...

    journal_title:Molecular and cellular biology

    pub_type: 杂志文章


    authors: Reinhold W,Emens L,Itkes A,Blake M,Ichinose I,Zajac-Kaye M

    更新日期:1995-06-01 00:00:00

  • Decreased growth of Vhl-/- fibrosarcomas is associated with elevated levels of cyclin kinase inhibitors p21 and p27.

    abstract::Inactivating mutations within the von Hippel-Lindau (VHL) tumor suppressor gene predispose patients to develop a variety of highly vascularized tumors. pVHL targets alpha subunits of the heterodimeric transcription factor hypoxia-inducible factor (HIF), a critical regulator of energy metabolism, angiogenesis, hematopo...

    journal_title:Molecular and cellular biology

    pub_type: 杂志文章


    authors: Mack FA,Patel JH,Biju MP,Haase VH,Simon MC

    更新日期:2005-06-01 00:00:00

  • Regulation of c-SRC activity and function by the adapter protein CAS.

    abstract::SRC family kinases play essential roles in a variety of cellular functions, including proliferation, survival, differentiation, and apoptosis. The activities of these kinases are regulated by intramolecular interactions and by heterologous binding partners that modulate the transition between active and inactive struc...

    journal_title:Molecular and cellular biology

    pub_type: 杂志文章


    authors: Burnham MR,Bruce-Staskal PJ,Harte MT,Weidow CL,Ma A,Weed SA,Bouton AH

    更新日期:2000-08-01 00:00:00