The genome of Shope fibroma virus, a tumorigenic poxvirus, contains a growth factor gene with sequence similarity to those encoding epidermal growth factor and transforming growth factor alpha.

Abstract:

:Degenerate oligonucleotide probes corresponding to a highly conserved region common to epidermal growth factor, transforming growth factor alpha, and vaccinia growth factor were used to identify a novel growth factor gene in the Shope fibroma virus genome. Sequence analysis indicates that the Shope fibroma growth factor is a distinct new member of this family of growth factors.

journal_name

Mol Cell Biol

authors

Chang W,Upton C,Hu SL,Purchio AF,McFadden G

doi

10.1128/mcb.7.1.535

subject

Has Abstract

pub_date

1987-01-01 00:00:00

pages

535-40

issue

1

eissn

0270-7306

issn

1098-5549

journal_volume

7

pub_type

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