Abstract:
:Two-dimensional electrophoretograms of newly synthesized polypeptides from low-metastatic (P29) and high-metastatic (D6) Lewis lung carcinoma cells were compared. The results showed that the synthesis of tropomyosin 2 (TM2) was significantly less in D6 cells than in P29 cells. Furthermore, suppression of TM2 synthesis was induced in P29 cells during incubation in medium containing dimethyl sulfoxide or butyric acid, which induced the metastatic phenotype of P29 cells. These results suggest that the suppression of TM2 synthesis is linked to the metastatic potential of Lewis lung carcinoma cells.
journal_name
Mol Cell Bioljournal_title
Molecular and cellular biologyauthors
Takenaga K,Nakamura Y,Sakiyama Sdoi
10.1128/mcb.8.9.3934subject
Has Abstractpub_date
1988-09-01 00:00:00pages
3934-7issue
9eissn
0270-7306issn
1098-5549journal_volume
8pub_type
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