p53 mediates senescence-like arrest induced by chronic replicational stress.

abstract：:The histone H1(0)-encoding gene is expressed in vertebrates in differentiating cells during the arrest of proliferation. In the H1(0) promoter, a specific regulatory element, which we named the H4 box, exhibits features which implicate a role in mediating H1(0) gene expression in response to both differentiation and c...

journal_title：Molecular and cellular biology

authors： Lemercier C,Duncliffe K,Boibessot I,Zhang H,Verdel A,Angelov D,Khochbin S

更新日期：2000-09-01 00:00:00

abstract：:Streptozotocin (STZ) is widely used to induce diabetic rodent models. It is specifically toxic to pancreatic beta cells and causes severe destruction and dysfunction. We investigated the effect of 1-palmitoyl-2-linoleoyl-3-acetyl-rac-glycerol (PLAG) on an STZ-induced diabetic mouse model. PLAG attenuated the glucose i...

journal_title：Molecular and cellular biology

authors： Kim J,Kim JH,Sohn KY,Yoon SY,Kim JW

更新日期：2019-10-11 00:00:00

abstract：:PEX genes encode peroxins, which are required for the biogenesis of peroxisomes. The Yarrowia lipolytica PEX17 gene encodes the peroxin Pex17p, which is 671 amino acids in length and has a predicted molecular mass of 75,588 Da. Pex17p is peripherally associated with the peroxisomal membrane. The carboxyl-terminal trip...

journal_title：Molecular and cellular biology

authors： Smith JJ,Szilard RK,Marelli M,Rachubinski RA

更新日期：1997-05-01 00:00:00

abstract：:NIH 3T3 cells infected with Moloney murine leukemia virus (MoMLV) express high levels of virus-specific RNA. To inhibit replication of the virus, we stably introduced chimeric tRNA genes encoding antisense templates into NIH 3T3 cells via a retroviral vector. Efficient expression of hybrid tRNA-MoMLV antisense transcr...

journal_title：Molecular and cellular biology

authors： Sullenger BA,Lee TC,Smith CA,Ungers GE,Gilboa E

更新日期：1990-12-01 00:00:00

abstract：:The treatment of cells with histone deacetylase inhibitors (HDACi) was reported to reveal the acetylation of STAT1 at lysine 410 and lysine 413 (O. H. Krämer et al., Genes Dev. 20:473-485, 2006). STAT1 acetylation was proposed to regulate apoptosis by facilitating binding to NF-κB and to control immune responses by su...

journal_title：Molecular and cellular biology

authors： Antunes F,Marg A,Vinkemeier U

更新日期：2011-07-01 00:00:00

abstract：:Osteoclasts are bone-resorbing cells essential for skeletal development, homeostasis, and regeneration. They derive from hematopoietic progenitors in the monocyte/macrophage lineage and differentiate in response to RANKL. However, the precise nature of osteoclast progenitors is a longstanding and important question. U...

journal_title：Molecular and cellular biology

authors： Wei W,Zeve D,Wang X,Du Y,Tang W,Dechow PC,Graff JM,Wan Y

更新日期：2011-12-01 00:00:00

abstract：:The Ran binding protein RanBP1 is localized to the cytosol of interphase cells. A leucine-rich nuclear export signal (NES) near the C terminus of RanBP1 is essential to maintain this distribution. We now show that RanBP1 accumulates in nuclei of cells treated with the export inhibitor, leptomycin B, and collapse of th...

journal_title：Molecular and cellular biology

authors： Plafker K,Macara IG

更新日期：2000-05-01 00:00:00

abstract：:Myocyte enhancer factor 2 (MEF2) transcription factors cooperate with the MyoD family of basic helix-loop-helix (bHLH) transcription factors to drive skeletal muscle development during embryogenesis, but little is known about the potential functions of MEF2 factors in postnatal skeletal muscle. Here we show that skele...

journal_title：Molecular and cellular biology

authors： Potthoff MJ,Arnold MA,McAnally J,Richardson JA,Bassel-Duby R,Olson EN

更新日期：2007-12-01 00:00:00

abstract：:The mouse cytochrome P1450 (CYP1A1) gene is responsible for the metabolism of numerous carcinogens and toxic chemicals. Induction by the environmental contaminant tetrachlorodibenzo-p-dioxin (TCDD) requires a functional aromatic hydrocarbon (Ah) receptor. We examined the 5'-flanking region of the CYP1A1 gene in mouse ...

journal_title：Molecular and cellular biology

authors： Neuhold LA,Shirayoshi Y,Ozato K,Jones JE,Nebert DW

更新日期：1989-06-01 00:00:00

abstract：:In cystic fibrosis (CF), epithelial cells are unable to normally up-regulate apical membrane Cl- secretion in response to agents which increase cyclic AMP, but they do increase Cl- secretion in response to increases in intracellular Ca2+. Since intracellular divalent cations regulate the expression of many genes, we h...

journal_title：Molecular and cellular biology

authors： Bargon J,Trapnell BC,Chu CS,Rosenthal ER,Yoshimura K,Guggino WB,Dalemans W,Pavirani A,Lecocq JP,Crystal RG

更新日期：1992-04-01 00:00:00

abstract：:Cells of Candida albicans WO-1 spontaneously switch between a white and opaque CFU, and this phase transition involves a dramatic change in cellular phenotype. By using a differential hybridization screen, an opaque-specific cDNA, Op1a, which represents the transcript of a gene regulated by switching, has been isolate...

journal_title：Molecular and cellular biology

authors： Morrow B,Srikantha T,Soll DR

更新日期：1992-07-01 00:00:00

abstract：:Inactivation of the TATA-binding protein-containing complex TFIIIB contributes to the mitotic repression of RNA polymerase III transcription, both in frogs and in humans (J. M. Gottesfeld, V. J. Wolf, T. Dang, D. J. Forbes, and P. Hartl, Science 263:81-84, 1994; R. J. White, T. M. Gottlieb, C. S. Downes, and S. P. Jac...

journal_title：Molecular and cellular biology

authors： White RJ,Gottlieb TM,Downes CS,Jackson SP

更新日期：1995-12-01 00:00:00

abstract：:The onc gene (v-fes) of the acutely transforming feline sarcoma virus (Snyder-Theilen strain) has homologous cellular sequences (c-fes) in all vertebrate species, including humans. We isolated from a human DNA library recombinant phages containing overlapping c-fes sequences. The human c-fes locus spans a region of 3....

journal_title：Molecular and cellular biology

authors： Franchini G,Gelmann EP,Dalla-Favera R,Gallo RC,Wong-Staal F

更新日期：1982-08-01 00:00:00

abstract：:TDP-43, or TAR DNA-binding protein 43, is a pathological marker of a spectrum of neurodegenerative disorders, including amyotrophic lateral sclerosis and frontotemporal lobar degeneration with ubiquitin-positive inclusions. TDP-43 is an RNA/DNA-binding protein implicated in transcriptional and posttranscriptional regu...

journal_title：Molecular and cellular biology

authors： Dewey CM,Cenik B,Sephton CF,Dries DR,Mayer P 3rd,Good SK,Johnson BA,Herz J,Yu G

更新日期：2011-03-01 00:00:00

abstract：:We report here the isolation of a novel, highly tissue-restricted member of the ets transcription factor/oncogene family, ESE-1 (for epithelium-specific Ets), which has features distinct from those of any other ets-related factor. ESE-1 contains two putative DNA binding domains: an ETS domain, which is unique in that ...

journal_title：Molecular and cellular biology

authors： Oettgen P,Alani RM,Barcinski MA,Brown L,Akbarali Y,Boltax J,Kunsch C,Munger K,Libermann TA

更新日期：1997-08-01 00:00:00

abstract：:MAP2K4 encodes a dual-specificity kinase (mitogen-activated protein kinase kinase 4, or MKK4) that is mutated in a variety of human malignancies, but the biochemical properties of the mutant kinases and their roles in tumorigenesis have not been fully elucidated. Here we showed that 8 out of 11 cancer-associated MAP2K...

journal_title：Molecular and cellular biology

authors： Ahn YH,Yang Y,Gibbons DL,Creighton CJ,Yang F,Wistuba II,Lin W,Thilaganathan N,Alvarez CA,Roybal J,Goldsmith EJ,Tournier C,Kurie JM

更新日期：2011-11-01 00:00:00

abstract：:Human platelet-derived endothelial cell growth factor (hPD-ECGF) is a novel angiogenic factor which stimulates endothelial cell growth in vitro and promotes angiogenesis in vivo. We report here the cloning and sequencing of the gene for hPD-ECGF and its flanking regions. This gene is composed of 10 exons dispersed ove...

journal_title：Molecular and cellular biology

authors： Hagiwara K,Stenman G,Honda H,Sahlin P,Andersson A,Miyazono K,Heldin CH,Ishikawa F,Takaku F

更新日期：1991-04-01 00:00:00

abstract：:Adaptive immune signaling can be coupled to stress-activated protein kinase (SAPK)/c-Jun N-terminal kinase (JNK) and NF-kappaB activation by the hematopoietic progenitor kinase 1 (HPK1), a mammalian hematopoiesis-specific Ste20 kinase. To gain insight into the regulation of leukocyte signal transduction, we investigat...

journal_title：Molecular and cellular biology

authors： Arnold R,Patzak IM,Neuhaus B,Vancauwenbergh S,Veillette A,Van Lint J,Kiefer F

更新日期：2005-03-01 00:00:00

abstract：:A mutation (K38R) which specifically eliminates kinase activity was created in the Drosophila melanogaster ckI gene (doubletime [dbt]). In vitro, DBT protein carrying the K38R mutation (DBT(K/R)) interacted with Period protein (PER) but lacked kinase activity. In cell culture and in flies, DBT(K/R) antagonized the pho...

journal_title：Molecular and cellular biology

authors： Muskus MJ,Preuss F,Fan JY,Bjes ES,Price JL

更新日期：2007-12-01 00:00:00

abstract：:Here, we demonstrate that elevation of intracellular cyclic AMP (cAMP) in vascular endothelial cells (ECs) by either a direct activator of adenylyl cyclase or endogenous cAMP-mobilizing G protein-coupled receptors inhibited the tyrosine phosphorylation of STAT proteins by an interleukin 6 (IL-6) receptor trans-signali...

journal_title：Molecular and cellular biology

authors： Sands WA,Woolson HD,Milne GR,Rutherford C,Palmer TM

更新日期：2006-09-01 00:00:00

abstract：:In the cell cycle of the budding yeast Saccharomyces cerevisiae, expression of the histone genes H2A and H2B of the TRT1 and TRT2 loci is regulated by the performance of "start," the step that also regulates the cell cycle. Here we show that histone production is also subject to an additional form of regulation that i...

journal_title：Molecular and cellular biology

authors： Drebot MA,Veinot-Drebot LM,Singer RA,Johnston GC

更新日期：1990-12-01 00:00:00

abstract：:Wnt signaling is critical to many aspects of development, and aberrant activation of the Wnt signaling pathway can cause cancer. Dishevelled (Dvl) protein plays a central role in this pathway by transducing the signal from the Wnt receptor complex to the beta-catenin destruction complex. Dvl also plays a pivotal role ...

journal_title：Molecular and cellular biology

authors： Cong F,Schweizer L,Varmus H

更新日期：2004-03-01 00:00:00

abstract：:Regulation of the activity of N-methyl-d-aspartate receptors (NMDARs) at glutamatergic synapses is essential for certain forms of synaptic plasticity underlying learning and memory and is also associated with neurotoxicity and neurodegenerative diseases. In this report, we investigate the role of Src-like adaptor prot...

journal_title：Molecular and cellular biology

authors： Semerdjieva S,Abdul-Razak HH,Salim SS,Yáñez-Muñoz RJ,Chen PE,Tarabykin V,Alifragis P

更新日期：2013-04-01 00:00:00

abstract：:F9 embryonic teratocarcinoma stem cells differentiate into an epithelial cell type called extraembryonic endoderm when treated with retinoic acid (RA), a derivative of retinol (vitamin A). This differentiation is presumably mediated through the actions of retinoid receptors, the RARs and RXRs. To delineate the functio...

journal_title：Molecular and cellular biology

authors： Boylan JF,Lufkin T,Achkar CC,Taneja R,Chambon P,Gudas LJ

更新日期：1995-02-01 00:00:00

abstract：:We isolated cDNA clones corresponding to the normal human Ki-ras2 gene and to the transforming allele of the Ki-ras2 gene present in the human colon carcinoma cell line SW480. These two cDNAs encode p21 proteins which differ only at the amino acid at position 12. The normal cDNA encodes a glycine at this position, and...

journal_title：Molecular and cellular biology

authors： McCoy MS,Bargmann CI,Weinberg RA

更新日期：1984-08-01 00:00:00

abstract：:While it is well appreciated that receptors for secreted cytokines transmit ligand-induced signals, little is known about additional roles for cytokine receptor components in the control of ligand transport and secretion. Here, we show that interleukin-15 (IL-15) translocation into the endoplasmic reticulum occurs ind...

journal_title：Molecular and cellular biology

authors： Duitman EH,Orinska Z,Bulanova E,Paus R,Bulfone-Paus S

更新日期：2008-08-01 00:00:00

abstract：:First characterized in Trypanosoma brucei, the spliced leader-associated (SLA) RNA gene locus has now been isolated from the kinetoplastids Leishmania tarentolae and Trypanosoma cruzi. In addition to the T. brucei SLA RNA, both L. tarentolae and T. cruzi SLA RNA repeat units also yield RNAs of 75 or 76 nucleotides (nt...

journal_title：Molecular and cellular biology

authors： Roberts TG,Sturm NR,Yee BK,Yu MC,Hartshorne T,Agabian N,Campbell DA

更新日期：1998-08-01 00:00:00

abstract：:The single-copy gene encoding the alpha subunit of glycoprotein hormones is expressed in the pituitaries of all mammals and in the placentas of only primates and horses. We have systematically analyzed the promoter-regulatory elements of the human and bovine alpha-subunit genes to elucidate the molecular mechanisms un...

journal_title：Molecular and cellular biology

authors： Bokar JA,Keri RA,Farmerie TA,Fenstermaker RA,Andersen B,Hamernik DL,Yun J,Wagner T,Nilson JH

更新日期：1989-11-01 00:00:00

abstract：:Deregulated signaling by the four members of the epidermal growth factor receptor tyrosine kinase family (erbB family) is implicated in the genesis or progression of human cancers. However, efforts to analyze signaling by these receptors have been hampered by the diversity of ligands and extensive interreceptor cross ...

journal_title：Molecular and cellular biology

authors： Riese DJ 2nd,van Raaij TM,Plowman GD,Andrews GC,Stern DF

更新日期：1995-10-01 00:00:00

abstract：:Endothelial cells differentiate from mesoderm-derived precursors to initiate the earliest events in vascular development. Although the signaling events that regulate the successive steps of vascular development are known in some detail, the transcriptional processes that regulate the first steps in vasculogenesis are ...

journal_title：Molecular and cellular biology

authors： Wu Y,Moser M,Bautch VL,Patterson C

更新日期：2003-08-01 00:00:00