Abstract:
:Deregulated signaling by the four members of the epidermal growth factor receptor tyrosine kinase family (erbB family) is implicated in the genesis or progression of human cancers. However, efforts to analyze signaling by these receptors have been hampered by the diversity of ligands and extensive interreceptor cross talk. We have expressed the four human erbB family receptors, singly and in pairwise combinations, in a pro-B-lymphocyte cell line (Ba/F3) and investigated the range of interactions activated by the epidermal growth factor homology domain of the agonist neuregulin beta. The results provide the first comprehensive analysis of the response of this receptor family to a single peptide agonist. This peptide induced complex patterns of receptor tyrosine phosphorylation and regulation of Ba/F3 cell survival and proliferation. These data demonstrate the existence of several previously undocumented receptor interactions driven by neuregulin.
journal_name
Mol Cell Bioljournal_title
Molecular and cellular biologyauthors
Riese DJ 2nd,van Raaij TM,Plowman GD,Andrews GC,Stern DFdoi
10.1128/mcb.15.10.5770subject
Has Abstractpub_date
1995-10-01 00:00:00pages
5770-6issue
10eissn
0270-7306issn
1098-5549journal_volume
15pub_type
杂志文章abstract::Tmprss2 encodes an androgen-regulated type II transmembrane serine protease (TTSP) expressed highly in normal prostate epithelium and has been implicated in prostate carcinogenesis. Although in vitro studies suggest protease-activated receptor 2 may be a substrate for TMPRSS2, the in vivo biological activities of TMPR...
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pub_type: 杂志文章
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pub_type: 杂志文章
doi:10.1128/mcb.20.5.1526-1536.2000
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pub_type: 杂志文章
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更新日期:2003-11-01 00:00:00
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journal_title:Molecular and cellular biology
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pub_type: 杂志文章
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journal_title:Molecular and cellular biology
pub_type: 杂志文章
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更新日期:1999-12-01 00:00:00
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pub_type: 杂志文章
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更新日期:2004-07-01 00:00:00