Abstract:
:Syncollin is a small protein that is abundantly expressed in pancreatic acinar cells and that is tightly associated with the lumenal side of the zymogen granule membrane. To shed light on the hitherto unknown function of syncollin, we have generated syncollin-deficient mice. The mice are viable and show a normal pancreatic morphology as well as normal release kinetics in response to secretagogue stimulation. Although syncollin is highly enriched in zymogen granules, no change was found in the overall protein content and in the levels of chymotrypsin, trypsin, and amylase. However, syncollin-deficient mice reacted to caerulein hyperstimulation with a more severe pancreatitis. Furthermore, the rates of both protein synthesis and intracellular transport of secretory proteins were reduced. We conclude that syncollin plays a role in maturation and/or concentration of zymogens in zymogen granules.
journal_name
Mol Cell Bioljournal_title
Molecular and cellular biologyauthors
Antonin W,Wagner M,Riedel D,Brose N,Jahn Rdoi
10.1128/mcb.22.5.1545-1554.2002subject
Has Abstractpub_date
2002-03-01 00:00:00pages
1545-54issue
5eissn
0270-7306issn
1098-5549journal_volume
22pub_type
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