Abstract:
:The development and differentiation of oligodendrocytes (OC) in developing mouse spinal cord (MSC) were investigated by correlative analysis of light and electron microscopy (EM), and immunoperoxidase studies for glial fibrillary acidic protein (GFAP) and myelin basic protein (MBP). The sequential development of glial cells within the subpial region of the MSC bears a striking resemblance to the developing human fetal spinal cord. A rise in the level of mitotic activity among subpial astrocytes just prior to the onset of myelination was followed by the appearance of OC within the same region. The finding of "transitional" cells with the cytological and ultrastructural features of both astrocytes and OC and the finding of GFAP within the immature OC strongly support the hypothesis that OC in the developing central nervous system may arise from astroglial precursors. These observations also suggest that the MSC may be a suitable model for the study of OC differentiation and myelinogenesis in man.
journal_name
J Neuropathol Exp Neuroljournal_title
Journal of neuropathology and experimental neurologyauthors
Choi BHdoi
10.1097/00005072-198609000-00003subject
Has Abstractpub_date
1986-09-01 00:00:00pages
513-24issue
5eissn
0022-3069issn
1554-6578journal_volume
45pub_type
杂志文章abstract::Defects in synaptic development and plasticity may lead to autism. Brain-derived neurotrophic factor (BDNF) plays a critical role in synaptogenesis and synaptic plasticity. BDNF is synthesized as a precursor, pro-BDNF, which can be processed into either a truncated form or into mature BDNF. Previous studies reported i...
journal_title:Journal of neuropathology and experimental neurology
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doi:10.1097/NEN.0b013e31824b27e4
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journal_title:Journal of neuropathology and experimental neurology
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journal_title:Journal of neuropathology and experimental neurology
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journal_title:Journal of neuropathology and experimental neurology
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journal_title:Journal of neuropathology and experimental neurology
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journal_title:Journal of neuropathology and experimental neurology
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journal_title:Journal of neuropathology and experimental neurology
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journal_title:Journal of neuropathology and experimental neurology
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doi:10.1097/00005072-199411000-00008
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journal_title:Journal of neuropathology and experimental neurology
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journal_title:Journal of neuropathology and experimental neurology
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journal_title:Journal of neuropathology and experimental neurology
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journal_title:Journal of neuropathology and experimental neurology
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journal_title:Journal of neuropathology and experimental neurology
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journal_title:Journal of neuropathology and experimental neurology
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journal_title:Journal of neuropathology and experimental neurology
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journal_title:Journal of neuropathology and experimental neurology
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journal_title:Journal of neuropathology and experimental neurology
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journal_title:Journal of neuropathology and experimental neurology
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journal_title:Journal of neuropathology and experimental neurology
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journal_title:Journal of neuropathology and experimental neurology
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journal_title:Journal of neuropathology and experimental neurology
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