Myelin-forming oligodendrocytes of developing mouse spinal cord: immunocytochemical and ultrastructural studies.


:The development and differentiation of oligodendrocytes (OC) in developing mouse spinal cord (MSC) were investigated by correlative analysis of light and electron microscopy (EM), and immunoperoxidase studies for glial fibrillary acidic protein (GFAP) and myelin basic protein (MBP). The sequential development of glial cells within the subpial region of the MSC bears a striking resemblance to the developing human fetal spinal cord. A rise in the level of mitotic activity among subpial astrocytes just prior to the onset of myelination was followed by the appearance of OC within the same region. The finding of "transitional" cells with the cytological and ultrastructural features of both astrocytes and OC and the finding of GFAP within the immature OC strongly support the hypothesis that OC in the developing central nervous system may arise from astroglial precursors. These observations also suggest that the MSC may be a suitable model for the study of OC differentiation and myelinogenesis in man.


Choi BH




Has Abstract


1986-09-01 00:00:00












  • TDP-43 in the ubiquitin pathology of frontotemporal dementia with VCP gene mutations.

    abstract::Frontotemporal dementia with inclusion body myopathy and Paget disease of bone is a rare, autosomal-dominant disorder caused by mutations in the gene valosin-containing protein (VCP). The CNS pathology is characterized by a novel pattern of ubiquitin pathology distinct from sporadic and familial frontotemporal lobar d...

    journal_title:Journal of neuropathology and experimental neurology

    pub_type: 杂志文章


    authors: Neumann M,Mackenzie IR,Cairns NJ,Boyer PJ,Markesbery WR,Smith CD,Taylor JP,Kretzschmar HA,Kimonis VE,Forman MS

    更新日期:2007-02-01 00:00:00

  • Primitive neuroectodermal tumors of the cerebral hemispheres in two siblings with TP53 germline mutation.

    abstract::AWe report on two siblings (brother and sister) who developed cerebral PNETs at the age of 5 years and 6 months, respectively. Both children were treated by operation followed by polychemotherapy. The brother also received cranio-spinal irradiation. Nevertheless, the children died about 12 months and 24 months post-op...

    journal_title:Journal of neuropathology and experimental neurology

    pub_type: 杂志文章


    authors: Reifenberger J,Janssen G,Weber RG,Boström J,Engelbrecht V,Lichter P,Borchard F,Göbel U,Lenard HG,Reifenberger G

    更新日期:1998-02-01 00:00:00

  • Natalizumab-associated progressive multifocal leukoencephalopathy in a patient with multiple sclerosis: a postmortem study.

    abstract::Natalizumab, a monoclonal antibody directed against α4 integrins, has, to date, been associated with 399 cases of progressive multifocal leukoencephalopathy (PML) worldwide in patients receiving treatment for multiple sclerosis (MS). Because of the limited number of histologic studies, the possible interplay between M...

    journal_title:Journal of neuropathology and experimental neurology

    pub_type: 杂志文章


    authors: Wüthrich C,Popescu BF,Gheuens S,Marvi M,Ziman R,Denq SP,Tham M,Norton E,Parisi JE,Dang X,Lucchinetti CF,Koralnik IJ

    更新日期:2013-11-01 00:00:00

  • Erythropoietin is neuroprotective in a preterm ovine model of endotoxin-induced brain injury.

    abstract::Intrauterine infection and inflammation have been linked to preterm birth and brain damage. We hypothesized that recombinant human erythropoietin (rhEPO) would ameliorate brain damage in anovine model of fetal inflammation. At 107 +/- 1 day of gestational age (DGA), chronically catheterized fetal sheep received on 3 c...

    journal_title:Journal of neuropathology and experimental neurology

    pub_type: 杂志文章


    authors: Rees S,Hale N,De Matteo R,Cardamone L,Tolcos M,Loeliger M,Mackintosh A,Shields A,Probyn M,Greenwood D,Harding R

    更新日期:2010-03-01 00:00:00

  • Early pathologic changes in hereditary diffuse leukoencephalopathy with spheroids.

    abstract::Hereditary diffuse leukoencephalopathy with spheroids (HDLS) is a familial neurodegenerative disease clinically characterized by progressive cognitive and motor dysfunction. Mutations in the colony-stimulating factor 1 receptor (CSF1R) gene have recently been identified in HDLS patients. The presence of diffuse axonal...

    journal_title:Journal of neuropathology and experimental neurology

    pub_type: 杂志文章


    authors: Riku Y,Ando T,Goto Y,Mano K,Iwasaki Y,Sobue G,Yoshida M

    更新日期:2014-12-01 00:00:00

  • Cortical Remyelination Is Heterogeneous in Multiple Sclerosis.

    abstract::Cortical lesions (CLs) are an important component of multiple sclerosis (MS) pathology; they correlate better with physical disability and cognitive impairment than white matter lesions (WMLs). Because remyelination can be extensive in CLs, we quantified remyelination in gray matter (GM) and white matter (WM), address...

    journal_title:Journal of neuropathology and experimental neurology

    pub_type: 杂志文章


    authors: Strijbis EMM,Kooi EJ,van der Valk P,Geurts JJG

    更新日期:2017-05-01 00:00:00

  • Biological evaluation of biopsies from adult cerebral astrocytomas: cell-growth/cell-suicide ratios and their relationship to patient survival.

    abstract::In adult cerebral astrocytomas, the more anaplasia that is present, the more malignancy that occurs. Cell proliferation antigen staining (MIB-1) and DNA labeling methods for apoptosis using paraffin sections from 39 cases were compared with histopathological grading systems for predicting patient survival. Cases were ...

    journal_title:Journal of neuropathology and experimental neurology

    pub_type: 临床试验,杂志文章


    authors: Rhodes RH

    更新日期:1998-08-01 00:00:00

  • Qualitative and quantitative studies on human myelin basic protein in situ with respect to time interval between death and autopsy.

    abstract::Normal human frontal lobe white matter obtained at autopsy was used to determine the extent of in situ post-mortem degradation of myelin basic protein (BP). Effects of the following two factors were studied: 1) time interval between death and autopsy, and 2) freezing and thawing the tissue. Quantitative extraction of...

    journal_title:Journal of neuropathology and experimental neurology

    pub_type: 杂志文章


    authors: Ansari KA,Rand A,Hendrickson H,Bentley MD

    更新日期:1976-03-01 00:00:00

  • Abeta species removal after abeta42 immunization.

    abstract::Neuropathologic examination of 3 patients with Alzheimer disease in the Elan Pharmaceuticals trial using antibodies specific for different Abeta species showed in one case, 4 months after the immunization, evidence of a stage of active plaque clearance with "moth-eaten" plaques and abundant Abeta phagocytosis by micro...

    journal_title:Journal of neuropathology and experimental neurology

    pub_type: 杂志文章,多中心研究


    authors: Nicoll JA,Barton E,Boche D,Neal JW,Ferrer I,Thompson P,Vlachouli C,Wilkinson D,Bayer A,Games D,Seubert P,Schenk D,Holmes C

    更新日期:2006-11-01 00:00:00

  • Identification of inter-species transmission of prion strains.

    abstract::The concern of the potential transmission of animal spongiform encephalopathies to humans, which arose as soon as the interspecies transmission of these diseases was recognized, has been reinforced with the emergence of bovine spongiform encephalopathy (BSE) in cattle. Recent experimental findings suggest that the inf...

    journal_title:Journal of neuropathology and experimental neurology

    pub_type: 杂志文章,评审


    authors: Baron T

    更新日期:2002-05-01 00:00:00

  • Examination of the clinicopathologic continuum of Alzheimer disease in the autopsy cohort of the National Alzheimer Coordinating Center.

    abstract::To test the hypothesis that Alzheimer disease (AD) is a clinical and pathologic continuum between normal aging and end-stage dementia, we selected a convenience sample of subjects from the National Alzheimer Coordinating Center 2005 to 2012 autopsy cohort (n = 2,083) with the last clinical evaluation within 2 years be...

    journal_title:Journal of neuropathology and experimental neurology

    pub_type: 杂志文章


    authors: Serrano-Pozo A,Qian J,Monsell SE,Frosch MP,Betensky RA,Hyman BT

    更新日期:2013-12-01 00:00:00

  • Localized Hypertrophic Neuropathy as a Neoplastic Manifestation of KRAS-Mediated RASopathy.

    abstract::Localized hypertrophic neuropathy is a rare Schwann cell proliferation that usually affects single nerves from the extremities, and it is of unclear etiology in its pure form. RASopathies are a defined group of genetic diseases with overlapping clinical features, usually secondary to germline mutations in genes encodi...

    journal_title:Journal of neuropathology and experimental neurology

    pub_type: 杂志文章


    authors: Vizcaino MA,Belzberg A,Ahlawat S,Belakhoua S,Chen L,Staedtke V,Rodriguez FJ

    更新日期:2020-06-01 00:00:00

  • Atypical progressive supranuclear palsy with corticospinal tract degeneration.

    abstract::Progressive supranuclear palsy (PSP), corticobasal degeneration (CBD), sporadic multisystem tauopathy, and some forms of frontotemporal dementia with Parkinsonism linked to chromosome 17 are characterized by neuronal and glial lesions accumulating tau protein containing 4 conserved repeats in microtubule-binding domai...

    journal_title:Journal of neuropathology and experimental neurology

    pub_type: 杂志文章


    authors: Josephs KA,Katsuse O,Beccano-Kelly DA,Lin WL,Uitti RJ,Fujino Y,Boeve BF,Hutton ML,Baker MC,Dickson DW

    更新日期:2006-04-01 00:00:00

  • c-Jun, JNK/SAPK kinases and transcription factor NF-kappa B are selectively activated in astrocytes, but not motor neurons, in amyotrophic lateral sclerosis.

    abstract::There is increasing evidence that oxidative damage plays a major role in amyotrophic lateral sclerosis (ALS), but how it contributes to motor neuron degeneration and astrocytic gliosis, two pathologic hallmarks of the disease, is unknown. A few studies have suggested that ALS motor neurons die via apoptosis and show u...

    journal_title:Journal of neuropathology and experimental neurology

    pub_type: 杂志文章


    authors: Migheli A,Piva R,Atzori C,Troost D,Schiffer D

    更新日期:1997-12-01 00:00:00

  • Immunization with neurofilament light protein induces spastic paresis and axonal degeneration in Biozzi ABH mice.

    abstract::Axonal damage is the major cause of irreversible neurologic disability in patients with multiple sclerosis. Although axonal damage correlates with antibodies against neurofilament light (NF-L) protein, a major component of the axonal cytoskeleton, the possible pathogenic role of autoimmunity to axonal antigens such as...

    journal_title:Journal of neuropathology and experimental neurology

    pub_type: 杂志文章


    authors: Huizinga R,Heijmans N,Schubert P,Gschmeissner S,'t Hart BA,Herrmann H,Amor S

    更新日期:2007-04-01 00:00:00

  • The life and death of oligodendrocytes in vanishing white matter disease.

    abstract::Vanishing white matter disease (VWM) is a progressive cavitating disease of central white matter due to a deficiency of the translation initiation factor eIF2B. Oligodendrocytes appear to be numerically increased in some white matter areas, while decreased in others. We compared oligodendrocytes of cerebral, cerebella...

    journal_title:Journal of neuropathology and experimental neurology

    pub_type: 杂志文章


    authors: Van Haren K,van der Voorn JP,Peterson DR,van der Knaap MS,Powers JM

    更新日期:2004-06-01 00:00:00

  • The Serotonin Brainstem Hypothesis for the Sudden Infant Death Syndrome.

    abstract::The sudden infant death syndrome (SIDS) is the leading cause of postneonatal infant mortality in the United States today, with an overall rate of 0.39/1000 live births. It is defined as the sudden and unexpected death of an infant <12 months of age that remains unexplained after a complete autopsy, death scene investi...

    journal_title:Journal of neuropathology and experimental neurology

    pub_type: 杂志文章,评审


    authors: Kinney HC,Haynes RL

    更新日期:2019-09-01 00:00:00

  • Aggressive phenotypic and genotypic features in pediatric and NF2-associated meningiomas: a clinicopathologic study of 53 cases.

    abstract::Pediatric and NF2-associated meningiomas are uncommon and poorly characterized in comparison to sporadic adult cases. In order to elucidate their molecular features, we analyzed MIB-1, progesterone receptor (PR), NF2, merlin, DAL-1, DAL-1 protein, and chromosomal arms 1p and 14q in 53 meningiomas from 40 pediatric/NF2...

    journal_title:Journal of neuropathology and experimental neurology

    pub_type: 杂志文章


    authors: Perry A,Giannini C,Raghavan R,Scheithauer BW,Banerjee R,Margraf L,Bowers DC,Lytle RA,Newsham IF,Gutmann DH

    更新日期:2001-10-01 00:00:00

  • Modulation of hippocampal neuroplasticity by Fas/CD95 regulatory protein 2 (Faim2) in the course of bacterial meningitis.

    abstract::Fas-apoptotic inhibitory molecule 2 (Faim2) is a neuron-specific membrane protein and a member of the evolutionary conserved lifeguard apoptosis regulatory gene family. Its neuroprotective effect in acute neurological diseases has been demonstrated in an in vivo model of focal cerebral ischemia. Here we show that Faim...

    journal_title:Journal of neuropathology and experimental neurology

    pub_type: 杂志文章


    authors: Tauber SC,Harms K,Falkenburger B,Weis J,Sellhaus B,Nau R,Schulz JB,Reich A

    更新日期:2014-01-01 00:00:00

  • Glycolipid markers of astrocytomas and oligodendrogliomas.

    abstract::Neutral glycolipids and gangliosides were analyzed in 149 astrocytomas (A), 46 oligodendrogliomas (O), and 21 oligoastrocytomas (OA) to determine if specific glycolipids correlate with histologic diagnosis and grade. Positivity for asialoGM1 (GA1) and negativity for paragloboside by immuno-TLC correlated with histolog...

    journal_title:Journal of neuropathology and experimental neurology

    pub_type: 杂志文章


    authors: Yates AJ,Comas T,Scheithauer BW,Burger PC,Pearl DK

    更新日期:1999-12-01 00:00:00

  • Selective deposition of 4-repeat tau in cerebral infarcts.

    abstract::The tau deposits found in neurodegenerative diseases are classified based on their isoforms, that is, 3-repeat (3R) tau and 4-repeat (4R) tau. These isoforms are distinguishable using the antibodies RD3 and RD4, respectively, and Gallyas (Gal) and Campbell-Switzer (CS) silver staining methods, respectively. Tau is als...

    journal_title:Journal of neuropathology and experimental neurology

    pub_type: 杂志文章


    authors: Ichihara K,Uchihara T,Nakamura A,Suzuki Y,Mizutani T

    更新日期:2009-09-01 00:00:00

  • Immunohistochemical investigation of cerebral ischemia in gerbils.

    abstract::Experimental cerebral ischemia was produced in gerbils by occlusion of the right common carotid artery in the neck. The evolution of the ischemic lesions was followed from five minutes to six hours by using the immunohistochemical techniques for tubulin and creatine kinase BB-isoenzyme. The earliest lesion was found i...

    journal_title:Journal of neuropathology and experimental neurology

    pub_type: 杂志文章


    authors: Yanagihara T,Yoshimine T,Morimoto K,Yamamoto K,Homburger HA

    更新日期:1985-03-01 00:00:00

  • Retroperitoneal ganglioneuroblastoma: a kaleidoscope of neuronal degeneration. A light and electron microscopic study.

    abstract::The light and electron microscopic features of an unique retroperitoneal ganglioneuroblastoma in a four-year-old female are described. The unprecedented concurrence of Hirano, zebra, membranous cytoplasmic (MCB), and Pick bodies in the same population of neoplastic, sympathetic ganglion cells provides further evidence...

    journal_title:Journal of neuropathology and experimental neurology

    pub_type: 杂志文章


    authors: Powers JM,Balentine JD,Wiśniewski HM,Terry RD

    更新日期:1976-01-01 00:00:00

  • Upregulation of hypoxia-inducible factor (HIF)-1alpha and HIF-2alpha in leptomeningeal vascular malformations of Sturge-Weber syndrome.

    abstract::Cutaneous and leptomeningeal vascular malformations are hallmarks of the Sturge-Weber Syndrome (SWS), resulting in chronic ischemic tissue damage. The mechanisms underlying the pathobiology of these progressive lesions are unknown. Aberrant expression of angiogenic factors has been implicated in the genesis and mainte...

    journal_title:Journal of neuropathology and experimental neurology

    pub_type: 杂志文章


    authors: Comati A,Beck H,Halliday W,Snipes GJ,Plate KH,Acker T

    更新日期:2007-01-01 00:00:00

  • Peri-Infarct Upregulation of the Oxytocin Receptor in Vascular Dementia.

    abstract::Vascular dementia (VaD) is cognitive decline linked to reduced cerebral blood perfusion, yet there are few therapeutic options to protect cognitive function following cerebrovascular accidents. The purpose of this study was to profile gene expression changes unique to VaD to identify and characterize disease relevant ...

    journal_title:Journal of neuropathology and experimental neurology

    pub_type: 杂志文章


    authors: McKay EC,Beck JS,Khoo SK,Dykema KJ,Cottingham SL,Winn ME,Paulson HL,Lieberman AP,Counts SE

    更新日期:2019-05-01 00:00:00

  • Comparative Ultrastructural and Stereological Analyses of Unruptured and Ruptured Saccular Intracranial Aneurysms.

    abstract::Insight into processes leading to rupture of intracranial aneurysms (IAs) may identify biomarkers for rupture or lead to management strategies reducing the risk of rupture. We characterized and quantified (ultra)structural differences between unruptured and ruptured aneurysmal walls. Six unruptured and 6 ruptured IA f...

    journal_title:Journal of neuropathology and experimental neurology

    pub_type: 杂志文章


    authors: Korkmaz E,Kleinloog R,Verweij BH,Allijn IE,Hekking LHP,Regli L,Rinkel GJE,Ruigrok YM,Andries Post J

    更新日期:2017-10-01 00:00:00

  • Neutral amino acid transport properties of cerebral endothelial cells in vitro.

    abstract::An A and L system of neutral amino acid transport has been demonstrated previously in cerebral microvessels in vivo and in isolated microvessels in vitro. This report describes the neutral amino acid transport properties of cultured cerebral endothelial cells and investigates the influence of astroglia on the transpor...

    journal_title:Journal of neuropathology and experimental neurology

    pub_type: 杂志文章


    authors: Cancilla PA,DeBault LE

    更新日期:1983-03-01 00:00:00

  • Sudden infant death syndrome: postnatal changes in the volumes of the pons, medulla and cervical spinal cord.

    abstract::The brainstem and cervical spinal cord were sampled from 45 cases of sudden infant death syndrome (SIDS), from 17 control cases without neurological disease, and from three negative control cases with abnormal growth of the central nervous system (36-98 postconceptional weeks). Morphometric analyses were performed on ...

    journal_title:Journal of neuropathology and experimental neurology

    pub_type: 杂志文章


    authors: O'Kusky JR,Kozuki DE,Norman MG

    更新日期:1995-07-01 00:00:00

  • Subcellular localization of peptidylarginine deiminase 2 and citrullinated proteins in brains of scrapie-infected mice: nuclear localization of PAD2 and membrane fraction-enriched citrullinated proteins.

    abstract::Peptidylarginine deiminase (PAD) and citrullinated proteins have emerged as key molecules in various human diseases, but detailed subcellular localizations of PAD2 and citrullinated proteins are poorly mapped in brain under normal and pathologic conditions. We performed subcellular fractionation and electron microscop...

    journal_title:Journal of neuropathology and experimental neurology

    pub_type: 杂志文章


    authors: Jang B,Shin HY,Choi JK,Nguyen du PT,Jeong BH,Ishigami A,Maruyama N,Carp RI,Kim YS,Choi EK

    更新日期:2011-02-01 00:00:00

  • Inclusion-body myositis: newest concepts of pathogenesis and relation to aging and Alzheimer disease.

    abstract::We review the newest advances related to seeking the pathogenic mechanism(s) of sporadic inclusion-body myositis (s-IBM) and present the pathologic diagnostic criteria of s-IBM. We discuss the possible pathogenic role of several themes, such as 1) increased amyloid-beta precursor protein (AbetaPP) and of its fragment ...

    journal_title:Journal of neuropathology and experimental neurology

    pub_type: 杂志文章,评审


    authors: Askanas V,Engel WK

    更新日期:2001-01-01 00:00:00