Abeta species removal after abeta42 immunization.

abstract：:Abnormalities were detected by two-dimensional gel electrophoresis in the protein composition of both the dorsal and ventral roots of three of six patients who succumbed to amyotrophic lateral sclerosis (ALS). The abnormalities consisted of a cascade of acidic protein spots on silver-stained gels which were shown by i...

journal_title：Journal of neuropathology and experimental neurology

authors： Brock TO,McIlwain DL

更新日期：1984-11-01 00:00:00

abstract：:The role of anti-myelin antibodies in the pathogenesis of experimental autoimmune neuritis (EAN) induced in the Lewis rat by immunization with peripheral nerve myelin has been assessed. Passive transfer with lymph node cells (LNC) or purified serum immunoglobulin from rats with EAN was employed to directly measure the...

journal_title：Journal of neuropathology and experimental neurology

authors： Taylor JM,Pollard JD

更新日期：2001-06-01 00:00:00

abstract：:Werdnig-Hoffmann disease (WHD) is the most severe clinical type of spinal muscular atrophy characterized by loss of lower motor neurons and paralysis. We examined the hypothesis that disease pathogenesis is based on an inappropriate persistence of normally occurring motor neuron programmed cell death. The diagnosis of...

journal_title：Journal of neuropathology and experimental neurology

authors： Simic G,Seso-Simic D,Lucassen PJ,Islam A,Krsnik Z,Cviko A,Jelasic D,Barisic N,Winblad B,Kostovic I,Kruslin B

更新日期：2000-05-01 00:00:00

abstract：:Histopathologic evaluation of brain tissue derived from surgically treated patients with medically refractory temporal lobe epilepsy (TLE) frequently reveals structural brain lesions in the surgical specimen. While several of the most commonly encountered lesions such as low-grade neoplasms or vascular malformations a...

journal_title：Journal of neuropathology and experimental neurology

authors： Kasper BS,Stefan H,Buchfelder M,Paulus W

更新日期：1999-01-01 00:00:00

abstract：:Mucopolysaccharidosis IIID (MPS IIID) is one of the rarest of the MPS-III syndromes. To date, the clinical manifestations of 10 patients have been reported, the deficient N-acetylglucosamine 6-sulfatase (G6S) enzyme has been purified, and the G6S gene has been cloned, sequenced and localized. However, morphological ma...

journal_title：Journal of neuropathology and experimental neurology

authors： Jones MZ,Alroy J,Rutledge JC,Taylor JW,Alvord EC Jr,Toone J,Applegarth D,Hopwood JJ,Skutelsky E,Ianelli C,Thorley-Lawson D,Mitchell-Herpolsheimer C,Arias A,Sharp P,Evans W,Sillence D,Cavanagh KT

更新日期：1997-10-01 00:00:00

abstract：:PROX1 is a prospero-related transcription factor that plays a critical role in the development of various organs including the mammalian lymphatic and central nervous systems; it controls cell proliferation and differentiation through different transcription pathwaysand has both oncogenic and tumor-suppressive functio...

journal_title：Journal of neuropathology and experimental neurology

authors： Elsir T,Eriksson A,Orrego A,Lindström MS,Nistér M

更新日期：2010-02-01 00:00:00

abstract：:In order to induce a non-lethal infection restricted to central aminergic neurons projecting to the olfactory bulbs a series of temperature sensitive (ts) and G-protein monoclonal antibody escape mutants of vesicular stomatitis virus (VSV) were instilled into the nasal cavity of mice. In three-week (wk)-old NMRI mice ...

journal_title：Journal of neuropathology and experimental neurology

authors： Lundh B,Löve A,Kristensson K,Norrby E

更新日期：1988-09-01 00:00:00

abstract：:In many degenerative and metabolic muscle diseases cells die without a marked inflammatory response. A potential mechanism how this could be accomplished is apoptotic cell death. Since there are no data available about apoptosis in cells of myogenic origin, we examined rat skeletal myoblasts for their potential to und...

journal_title：Journal of neuropathology and experimental neurology

authors： Stangel M,Zettl UK,Mix E,Zielasek J,Toyka KV,Hartung HP,Gold R

更新日期：1996-01-01 00:00:00

abstract：:The concept of the presence of mucopolysaccharides forming an interstitial ground substance in central nervous tissues is revived. The biochemical reports of both neutral and acid mucopolysaccharides in both gray and white matter of the normal brain are reviewed. The earlier histochemical reports and the histochemical...

journal_title：Journal of neuropathology and experimental neurology

authors： Feigin I

更新日期：1980-01-01 00:00:00

abstract：:Neurofilamentous axonal swellings occur in a number of degenerative and toxic disorders of the nervous system. In one of these, experimental intoxication with beta, beta'-iminodiproprionitrile (IDPN), accumulation of neurofilaments has been shown to result from a defect in slow axonal transport. The consequence of thi...

journal_title：Journal of neuropathology and experimental neurology

authors： Clark AW,Griffin JW,Price DL

更新日期：1980-01-01 00:00:00

abstract：:Pediatric and NF2-associated meningiomas are uncommon and poorly characterized in comparison to sporadic adult cases. In order to elucidate their molecular features, we analyzed MIB-1, progesterone receptor (PR), NF2, merlin, DAL-1, DAL-1 protein, and chromosomal arms 1p and 14q in 53 meningiomas from 40 pediatric/NF2...

journal_title：Journal of neuropathology and experimental neurology

authors： Perry A,Giannini C,Raghavan R,Scheithauer BW,Banerjee R,Margraf L,Bowers DC,Lytle RA,Newsham IF,Gutmann DH

更新日期：2001-10-01 00:00:00

abstract：:Most malignant human tumors display a high degree of intratumoral heterogeneity at the time of diagnosis that contributes to treatment failure. This also applies to malignant peripheral nerve sheath tumors (MPNSTs) and aggressive soft tissue sarcomas that arise sporadically or in the context of neurofibromatosis type ...

journal_title：Journal of neuropathology and experimental neurology

authors： Koelsch B,van den Berg L,Grabellus F,Fischer C,Kutritz A,Kindler-Röhrborn A

更新日期：2013-05-01 00:00:00

abstract：:There is increasing evidence that oxidative damage plays a major role in amyotrophic lateral sclerosis (ALS), but how it contributes to motor neuron degeneration and astrocytic gliosis, two pathologic hallmarks of the disease, is unknown. A few studies have suggested that ALS motor neurons die via apoptosis and show u...

journal_title：Journal of neuropathology and experimental neurology

authors： Migheli A,Piva R,Atzori C,Troost D,Schiffer D

更新日期：1997-12-01 00:00:00

abstract：:Increasing evidence has demonstrated a vital role of microRNAs (miRNAs) in diverse biological processes. However, their functions in developing brain with hypoxia-ischemia (HI) remain largely unknown. Through a miRNA microarray analysis in a P10 rat model of cerebral HI, we found that miR-30d-5p was one of the most de...

journal_title：Journal of neuropathology and experimental neurology

authors： Zhao F,Qu Y,Zhu J,Zhang L,Huang L,Liu H,Li S,Mu D

更新日期：2017-08-01 00:00:00

abstract：:Reactive astrogliosis is associated with many pathologic processes in the central nervous system, including gliomas. The glycoprotein podoplanin (PDPN) is upregulated in malignant gliomas. Using a syngeneic intracranial glioma mouse model, we show that PDPN is highly expressed in a subset of glial fibrillary acidic pr...

journal_title：Journal of neuropathology and experimental neurology

authors： Kolar K,Freitas-Andrade M,Bechberger JF,Krishnan H,Goldberg GS,Naus CC,Sin WC

更新日期：2015-01-01 00:00:00

abstract：:Natalizumab, a monoclonal antibody directed against α4 integrins, has, to date, been associated with 399 cases of progressive multifocal leukoencephalopathy (PML) worldwide in patients receiving treatment for multiple sclerosis (MS). Because of the limited number of histologic studies, the possible interplay between M...

journal_title：Journal of neuropathology and experimental neurology

authors： Wüthrich C,Popescu BF,Gheuens S,Marvi M,Ziman R,Denq SP,Tham M,Norton E,Parisi JE,Dang X,Lucchinetti CF,Koralnik IJ

更新日期：2013-11-01 00:00:00

abstract：:Molecular pathology has identified 2 distinct forms of neuronal inclusion body in Amyotrophic Lateral Sclerosis (ALS). ALS-type inclusions are skeins or small dense filamentous aggregates which can only be demonstrated by ubiquitin immunocytochemistry (ICC). In contrast hyaline conglomerates (HC) are large multifocal ...

journal_title：Journal of neuropathology and experimental neurology

authors： Ince PG,Tomkins J,Slade JY,Thatcher NM,Shaw PJ

更新日期：1998-10-01 00:00:00

abstract：:A spontaneous spongy degeneration of the brain stem and spinal cord was discovered in a murine model of accelerated senescence (SAM), cared for under both conventional (SAM-P/8) and specific pathogen-free (SAM-P/8/Ta) conditions. SAM-P/8 and SAM-P/8/Ta showed no clinical neurological abnormalities, yet there was a det...

journal_title：Journal of neuropathology and experimental neurology

authors： Yagi H,Irino M,Matsushita T,Katoh S,Umezawa M,Tsuboyama T,Hosokawa M,Akiguchi I,Tokunaga R,Takeda T

更新日期：1989-09-01 00:00:00

abstract：:Cerebral autosomal recessive arteriopathy with subcortical infarcts and leukoencephalopathy (CARASIL) is a nonhypertensive hereditary cerebral small vessel disease that is caused by mutations in a single gene, HTRA1. The HTRA1 protein normally represses transforming growth factor-β (TGF-β) signaling and its mutations ...

journal_title：Journal of neuropathology and experimental neurology

authors： Ito S,Takao M,Fukutake T,Hatsuta H,Funabe S,Ito N,Shimoe Y,Niki T,Nakano I,Fukayama M,Murayama S

更新日期：2016-11-01 00:00:00

abstract：:Mitochondrial Zn2+ accumulation, particularly in CA1 neurons, occurs after ischemia and likely contributes to mitochondrial dysfunction and subsequent neurodegeneration. However, the relationship between mitochondrial Zn2+ accumulation and their disruption has not been examined at the ultrastructural level in vivo. We...

journal_title：Journal of neuropathology and experimental neurology

authors： Yin HZ,Wang HL,Ji SG,Medvedeva YV,Tian G,Bazrafkan AK,Maki NZ,Akbari Y,Weiss JH

更新日期：2019-07-01 00:00:00

abstract：:Cerebral accumulation of amyloid-beta (Abeta) is characteristic of Alzheimer disease and of amyloid precursor protein (APP) transgenic mice. Here, we assessed the efficacy of CI-1011, an inhibitor of acyl-coenzyme A:cholesterol acyltransferase, which is suitable for clinical use, in reducing amyloid pathology in both ...

journal_title：Journal of neuropathology and experimental neurology

authors： Huttunen HJ,Havas D,Peach C,Barren C,Duller S,Xia W,Frosch MP,Hutter-Paier B,Windisch M,Kovacs DM

更新日期：2010-08-01 00:00:00

abstract：:Vanishing white matter disease (VWM) is a progressive cavitating disease of central white matter due to a deficiency of the translation initiation factor eIF2B. Oligodendrocytes appear to be numerically increased in some white matter areas, while decreased in others. We compared oligodendrocytes of cerebral, cerebella...

journal_title：Journal of neuropathology and experimental neurology

authors： Van Haren K,van der Voorn JP,Peterson DR,van der Knaap MS,Powers JM

更新日期：2004-06-01 00:00:00

abstract：:The development and differentiation of oligodendrocytes (OC) in developing mouse spinal cord (MSC) were investigated by correlative analysis of light and electron microscopy (EM), and immunoperoxidase studies for glial fibrillary acidic protein (GFAP) and myelin basic protein (MBP). The sequential development of glial...

journal_title：Journal of neuropathology and experimental neurology

authors： Choi BH

更新日期：1986-09-01 00:00:00

abstract：:To determine if central nervous system (CNS) microvessel endothelial cells express class II major histocompatibility complex (MHC) molecules in early demyelinating lesions in humans, cerebral white matter (WM) biopsies from patients with acute inflammatory/demyelinating conditions, including 4 with multiple sclerosis ...

journal_title：Journal of neuropathology and experimental neurology

authors： van der Maesen K,Hinojoza JR,Sobel RA

更新日期：1999-04-01 00:00:00

abstract：:In the present study, we investigated the expression of protease-activated receptors (PARs), receptors for thrombin, in substantia nigra pars compacta (SNpc) of Parkinson disease (PD) brains and cultures of human neurons, astrocytes, oligodendrocytes, and microglia as determined by immunocytochemistry and reverse tran...

journal_title：Journal of neuropathology and experimental neurology

authors： Ishida Y,Nagai A,Kobayashi S,Kim SU

更新日期：2006-01-01 00:00:00

abstract：:Cerebral amyloid angiopathy (CAA), the deposition of beta-amyloid (Abeta3) in cerebral vessels, has been implicated as a common cause of hemorrhagic stroke and other forms of vascular disease. CAA is also a frequent concomitant of Alzheimer disease (AD). While the longterm consequences of CAA are well recognized from ...

journal_title：Journal of neuropathology and experimental neurology

authors： Domnitz SB,Robbins EM,Hoang AW,Garcia-Alloza M,Hyman BT,Rebeck GW,Greenberg SM,Bacskai BJ,Frosch MP

更新日期：2005-07-01 00:00:00

abstract：:Glomeruloid bodies (GBs), tumor-associated vascular structures with a superficial resemblance to renal glomeruli, are important histopathological features of glioblastoma multiforme, but have also been described in other types of tumors and in cerebral metastases. The purpose of this study was to elucidate the pathoge...

journal_title：Journal of neuropathology and experimental neurology

authors： Döme B,Tímár J,Paku S

更新日期：2003-06-01 00:00:00

abstract：:Intracranial hemangiopericytic meningiomas (HM) from seven patients were examined by immunostaining, transmission electron microscopy (TEM), scanning electron microscopy (SEM) and cell culture. Positive staining for Factor VIII-related antigen was restricted to capillary endothelial cells. There was no reaction with a...

journal_title：Journal of neuropathology and experimental neurology

authors： Nakamura M,Inoue HK,Ono N,Kunimine H,Tamada J

更新日期：1987-01-01 00:00:00

abstract：:Lysosomal storage disorders constitute a large group of genetic diseases, many of which are characterized by mental retardation and other neurologic symptoms. The mechanisms of neural dysfunction remain poorly understood. Because neural progenitor cells (NPCs) are fundamentally important to normal brain development an...

journal_title：Journal of neuropathology and experimental neurology

authors： Walton RM,Wolfe JH

更新日期：2007-08-01 00:00:00

abstract：:The immunopathological findings and their effects upon the vascular permeability of the ciliary process, choroid plexus and renal glomeruli to intravenously injected 125I-bovine serum albumin (BSA) have been studied in 26 rats who survived a prolonged period of bovine serum albuminemia following the experimental chron...

journal_title：Journal of neuropathology and experimental neurology

authors： Peress NS,Miller F,Palu W

更新日期：1977-07-01 00:00:00