Natalizumab-associated progressive multifocal leukoencephalopathy in a patient with multiple sclerosis: a postmortem study.

abstract：:The role of regenerating axons in the restructuring of the endoneurium into minifascicles after peripheral nerve injury was investigated. Endoneurial changes were studied in the control distal stumps of crushed rat sciatic nerves and in the distal nerve stumps in which, in addition to other cellular elements, the orig...

journal_title：Journal of neuropathology and experimental neurology

authors： Popović M,Bresjanac M,Sketelj J

更新日期：1994-11-01 00:00:00

abstract：:In Niemann-Pick Type C (NPC) disease, the concentration of cholesterol increases with age in every tissue except the brain. This study investigates whether accumulation of cholesterol might also occur within the cells of the central nervous system (CNS), but be obscured by the simultaneous loss of sterol from myelin a...

journal_title：Journal of neuropathology and experimental neurology

authors： Xie C,Burns DK,Turley SD,Dietschy JM

更新日期：2000-12-01 00:00:00

abstract：:Protein aggregate myopathies, including myofibrillar myopathies and sporadic inclusion body myositis (sIBM), are characterized by abnormal protein aggregates composed of various muscular and ectopic proteins. Previous studies have shown the crucial role ofdysregulated transcription factors such as neuron-restrictive s...

journal_title：Journal of neuropathology and experimental neurology

authors： Olivé M,Janué A,Moreno D,Gámez J,Torrejón-Escribano B,Ferrer I

更新日期：2009-03-01 00:00:00

abstract：:The role of axonal transport in the pathogenesis of the axonal swellings which develop at the severed ends of transected axons was studied by electron microscopic (EM) autoradiography. Proteins carried by fast anterograde transport in rat sciatic nerves were labeled with [3H]-leucine or [3H]-fucose; [3H]-leucine, [3H]...

journal_title：Journal of neuropathology and experimental neurology

authors： Griffin JW,Price DL,Engel WK,Drachman DB

更新日期：1977-03-01 00:00:00

abstract：:Most malignant human tumors display a high degree of intratumoral heterogeneity at the time of diagnosis that contributes to treatment failure. This also applies to malignant peripheral nerve sheath tumors (MPNSTs) and aggressive soft tissue sarcomas that arise sporadically or in the context of neurofibromatosis type ...

journal_title：Journal of neuropathology and experimental neurology

authors： Koelsch B,van den Berg L,Grabellus F,Fischer C,Kutritz A,Kindler-Röhrborn A

更新日期：2013-05-01 00:00:00

abstract：:Tissue hypoxia and necrosis represent pathophysiologic and histologic hallmarks of glioblastoma (GBM). Although hypoxia inducible factor 1α (HIF-1α) plays crucial roles in the malignant phenotypes of GBM, developing HIF-1α-targeted agents has been hampered by the lack of a suitable preclinical model that recapitulates...

journal_title：Journal of neuropathology and experimental neurology

authors： Nigim F,Cavanaugh J,Patel AP,Curry WT Jr,Esaki S,Kasper EM,Chi AS,Louis DN,Martuza RL,Rabkin SD,Wakimoto H

更新日期：2015-07-01 00:00:00

abstract：:The aim of this study was to clarify the relationship between craniopharyngiomas (CP) and the third ventricle floor by analyzing the membranes between them. Eight fetal specimens were first examined by hematoxylin and eosin and immunofluorescence staining to determine optimal markers for identifying membrane structure...

journal_title：Journal of neuropathology and experimental neurology

authors： Qi S,Liu Y,Wang C,Fan J,Pan J,Zhang X,Lu Y

更新日期：2020-09-01 00:00:00

abstract：:Increasing evidence has demonstrated a vital role of microRNAs (miRNAs) in diverse biological processes. However, their functions in developing brain with hypoxia-ischemia (HI) remain largely unknown. Through a miRNA microarray analysis in a P10 rat model of cerebral HI, we found that miR-30d-5p was one of the most de...

journal_title：Journal of neuropathology and experimental neurology

authors： Zhao F,Qu Y,Zhu J,Zhang L,Huang L,Liu H,Li S,Mu D

更新日期：2017-08-01 00:00:00

abstract：:The DNA repair protein O6-methylguanine-DNA methyltransferase (MGMT) removes temozolomide-induced alkylation, thereby preventing DNA damage and cytotoxicity. We investigated the prognostic effect of different MGMT methylation levels on overall and progression-free survival in 327 patients with primary glioblastoma und...

journal_title：Journal of neuropathology and experimental neurology

authors： Dahlrot RH,Larsen P,Boldt HB,Kreutzfeldt MS,Hansen S,Hjelmborg JB,Kristensen BW

更新日期：2019-07-01 00:00:00

abstract：:Frontotemporal dementia with parkinsonism (FTDP-17) is an autosomal dominant disorder that presents clinically with dementia, extrapyramidal signs, and behavioral disturbances in mid-life and progresses to death within 5 to 10 years. Pathologically, the disorder is characterized by variable neuronal loss and gliosis i...

journal_title：Journal of neuropathology and experimental neurology

authors： Hulette CM,Pericak-Vance MA,Roses AD,Schmechel DE,Yamaoka LH,Gaskell PC,Welsh-Bohmer KA,Crowther RA,Spillantini MG

更新日期：1999-08-01 00:00:00

abstract：:The balance between excitatory and inhibitory synaptic inputs is critical for the physiological control of motoneurons. The maintenance of a low-intracellular chloride concentration by the potassium chloride cotransporter 2 (KCC2) is essential for the efficacy of fast synaptic inhibition of mature motoneurons in respo...

journal_title：Journal of neuropathology and experimental neurology

authors： Fuchs A,Ringer C,Bilkei-Gorzo A,Weihe E,Roeper J,Schütz B

更新日期：2010-10-01 00:00:00

abstract：:Increased numbers of corpora amylacea have been observed in the resected mesial temporal lobe of many patients with complex partial seizures (CPS) and Ammon's horn sclerosis (AHS). Several heat shock proteins (HSPs) are induced by seizures and have been suggested as an etiologic factor in the formation corpora amylace...

journal_title：Journal of neuropathology and experimental neurology

authors： Erdamar S,Zhu ZQ,Hamilton WJ,Armstrong DL,Grossman RG

更新日期：2000-08-01 00:00:00

abstract：:Progressive supranuclear palsy (PSP), corticobasal degeneration (CBD), sporadic multisystem tauopathy, and some forms of frontotemporal dementia with Parkinsonism linked to chromosome 17 are characterized by neuronal and glial lesions accumulating tau protein containing 4 conserved repeats in microtubule-binding domai...

journal_title：Journal of neuropathology and experimental neurology

authors： Josephs KA,Katsuse O,Beccano-Kelly DA,Lin WL,Uitti RJ,Fujino Y,Boeve BF,Hutton ML,Baker MC,Dickson DW

更新日期：2006-04-01 00:00:00

abstract：:The effect of experimental obstructive jaundice on the oxidative status of brain tissues in rats was examined. Twenty-four male Wistar rats were divided into 4 groups: Group I was the control, group II was the sham operated, and groups III and IV were bile duct ligated and killed on the 5th and the 10th day, respectiv...

journal_title：Journal of neuropathology and experimental neurology

authors： Chroni E,Patsoukis N,Karageorgos N,Konstantinou D,Georgiou C

更新日期：2006-02-01 00:00:00

abstract：:Selenoprotein P (Sepp1) is involved in selenium homeostasis. Mice with a deletion of Sepp1, replacement of it by the shortened form Sepp1(Delta240-361), or deletion of its receptor apolipoprotein E receptor 2 develop severe neurologic dysfunction when fed low-selenium diet. Because the brainstems of Sepp1(-/-) mice ha...

journal_title：Journal of neuropathology and experimental neurology

authors： Valentine WM,Abel TW,Hill KE,Austin LM,Burk RF

更新日期：2008-01-01 00:00:00

abstract：:Vanishing white matter disease (VWM) is a progressive cavitating disease of central white matter due to a deficiency of the translation initiation factor eIF2B. Oligodendrocytes appear to be numerically increased in some white matter areas, while decreased in others. We compared oligodendrocytes of cerebral, cerebella...

journal_title：Journal of neuropathology and experimental neurology

authors： Van Haren K,van der Voorn JP,Peterson DR,van der Knaap MS,Powers JM

更新日期：2004-06-01 00:00:00

abstract：:The muscle biopsy from a 12-year-old boy with chronic creatine kinase elevation was studied by electron microscopy. At the age of 7 years the patient had a possible abortive attack of malignant hyperthermia. The biopsy specimen contained many fibres with segmental contracture and necrosis; thin sections showed defects...

journal_title：Journal of neuropathology and experimental neurology

authors： Schmalbruch H

更新日期：1979-07-01 00:00:00

abstract：:Cerebellar ataxia is a prominent clinical symptom in patients with mitochondrial DNA (mtDNA) disease. This is often progressive with onset in young adulthood. We performed a detailed neuropathologic investigation of the olivary-cerebellum in 14 genetically and clinically well-defined patients with mtDNA disease. Quant...

journal_title：Journal of neuropathology and experimental neurology

authors： Lax NZ,Hepplewhite PD,Reeve AK,Nesbitt V,McFarland R,Jaros E,Taylor RW,Turnbull DM

更新日期：2012-02-01 00:00:00

abstract：:White matter hyperintensities (WMH) are prevalent. Although arteriolar disease has been implicated in their pathogenesis, venous pathology warrants consideration. We investigated relationships of WMH with histologic venous, arteriolar and white matter abnormalities and correlated findings with premortem neuroimaging. ...

journal_title：Journal of neuropathology and experimental neurology

authors： Keith J,Gao FQ,Noor R,Kiss A,Balasubramaniam G,Au K,Rogaeva E,Masellis M,Black SE

更新日期：2017-04-01 00:00:00

abstract：:The roles of bone morphogenetic proteins (BMPs) and their receptors (BMPRs) in meningioma biology are not known. In this study, frozen tissues from 26 World Health Organization Grades I to III meningiomas were analyzed by Western blot for BMP-2/4, BMPR IA, and BMPR II, and activation of downstream p-Smad1, p38 mitogen...

journal_title：Journal of neuropathology and experimental neurology

authors： Johnson MD,O'Connell MJ,Vito F,Pilcher W

更新日期：2009-11-01 00:00:00

abstract：:There are phenotypic and functional differences between vascular endothelium from different tissues and between microvascular and macrovascular endothelial cells (ECs) from the same tissue. Relatively little is known about the human blood-nerve barrier (BNB). We report the development of an in vitro BNB model using pr...

journal_title：Journal of neuropathology and experimental neurology

authors： Yosef N,Xia RH,Ubogu EE

更新日期：2010-01-01 00:00:00

abstract：:Histological examination by light and electron microscopy of the spinal cords of four dogs rapidly perfusion-fixed after the onset of decompression sickness revealed the presence of numerous non-staining, space-occupying lesions that were absent in similarly prepared sections of control or ischemic spinal cords. We pr...

journal_title：Journal of neuropathology and experimental neurology

authors： Francis TJ,Pezeshkpour GH,Dutka AJ,Hallenbeck JM,Flynn ET

更新日期：1988-07-01 00:00:00

abstract：:Morphologic investigations of the human visual pathways have been limited by the infeasibility of modern neuroanatomical approaches. Although contemporary methods for tracing axon pathways (such as tracer injections and electrophysiology) have elucidated the visual system in experimental animals, these techniques cann...

journal_title：Journal of neuropathology and experimental neurology

authors： Sadun AA,Smith LE,Kenyon KR

更新日期：1983-03-01 00:00:00

abstract：:LR11 is an ApoE receptor that is enriched in the brain. We have shown that LR11 is markedly downregulated in patients with sporadic Alzheimer disease (AD). This finding led us to explore whether reduced LR11 expression reflects a primary mechanism of disease or merely a secondary consequence of other AD-associated cha...

journal_title：Journal of neuropathology and experimental neurology

authors： Dodson SE,Gearing M,Lippa CF,Montine TJ,Levey AI,Lah JJ

更新日期：2006-09-01 00:00:00

abstract：:This study describes, for the first time, the neuropathy of zinc pyridinethione (ZPT) toxicity in rats. Although hind-limb weakness has been previously reported as a consequence of dietary ZPT ingestion in rats and rabbits, the cause of the paralysis has been unexplained. Sequential morphologic studies in rats fed a d...

journal_title：Journal of neuropathology and experimental neurology

authors： Sahenk Z,Mendell JR

更新日期：1979-09-01 00:00:00

abstract：:Cerebral cavernous malformations (CCMs) often cause hemorrhages that can result in severe clinical manifestations, including hemiparesis and seizures. The underlying mechanisms of the aggressive behavior of CCMs are undetermined to date, but alterations of vascular matrix components may be involved. We compared the lo...

journal_title：Journal of neuropathology and experimental neurology

authors： Schneider H,Errede M,Ulrich NH,Virgintino D,Frei K,Bertalanffy H

更新日期：2011-06-01 00:00:00

abstract：:Central nervous system (CNS) tissue was studied by immunocytochemistry and electron microscopy from three cases of multiple sclerosis (MS) in which evidence of ongoing myelin breakdown could be documented. The study focussed upon the role of glial cells in the pathogenesis of demyelination. In acute MS, demyelination ...

journal_title：Journal of neuropathology and experimental neurology

authors： Lee SC,Moore GR,Golenwsky G,Raine CS

更新日期：1990-03-01 00:00:00

abstract：:Recent studies highlight the importance of BRAF alterations resulting in mitogen activated protein kinase (MAK/ERK) pathway activation in low-grade CNS tumors. We studied 106 low-grade CNS neoplasms in a cohort of primarily pediatric patients to identify the prevalence and clinicopathologic significance of these alter...

journal_title：Journal of neuropathology and experimental neurology

authors： Lin A,Rodriguez FJ,Karajannis MA,Williams SC,Legault G,Zagzag D,Burger PC,Allen JC,Eberhart CG,Bar EE

更新日期：2012-01-01 00:00:00

abstract：:Rates of remyelination decline with age and this has been attributed to slower recruitment of oligodendrocyte progenitor cells (OPCs) into areas of demyelination and slower differentiation of OPCs into remyelinating oligodendrocytes. When considering causes for reduced recruitment rates, intrinsic causes (alterations ...

journal_title：Journal of neuropathology and experimental neurology

authors： Chari DM,Crang AJ,Blakemore WF

更新日期：2003-09-01 00:00:00

abstract：:The presence of diffuse or primitive senile plaques in the neocortex of cognitively normal elderly at autopsy has been presumed to represent normal aging. Alternatively, these patients may have developed dementia and clinical Alzheimer disease (AD) if they had survived. In this setting, these patients could be subject...

journal_title：Journal of neuropathology and experimental neurology

authors： Hulette CM,Welsh-Bohmer KA,Murray MG,Saunders AM,Mash DC,McIntyre LM

更新日期：1998-12-01 00:00:00