Is there a role for the autochthonous bubble in the pathogenesis of spinal cord decompression sickness?

abstract：:Diabetic polyneuropathy (DPN) shows more severe functional and structural changes in type 1 than in type 2 human and experimental diabetes. We have previously suggested that these differences may be due to insulin and/or C-peptide deficiencies in type 1 diabetes. To further explore these differences between type I and...

journal_title：Journal of neuropathology and experimental neurology

authors： Pierson CR,Zhang W,Murakawa Y,Sima AA

更新日期：2003-03-01 00:00:00

abstract：:To understand neuroinflammation-related gene regulation during normal aging and in sporadic Alzheimer disease (sAD), we performed functional genomics analysis and analyzed messenger RNA (mRNA) expression by quantitative reverse transcription-polymerase chain reaction of 22 genes involved in neuroinflammation-like resp...

journal_title：Journal of neuropathology and experimental neurology

authors： López-González I,Schlüter A,Aso E,Garcia-Esparcia P,Ansoleaga B,LLorens F,Carmona M,Moreno J,Fuso A,Portero-Otin M,Pamplona R,Pujol A,Ferrer I

更新日期：2015-04-01 00:00:00

abstract：:Borna disease virus (BDV) replicates only in cells in the central (CNS) and peripheral (PNS) nervous system in adult rats. Infection of the nervous system is associated with a transient, intense mononuclear meningoencephalitis and immunemediated loss of BDV-infected neurons. The identification of BDV antigen in neuron...

journal_title：Journal of neuropathology and experimental neurology

authors： Carbone KM,Trapp BD,Griffin JW,Duchala CS,Narayan O

更新日期：1989-11-01 00:00:00

abstract：:Progressive multifocal leukoencephalopathy (PML) occurs most often in immunosuppressed individuals. The lesions of PML result from astrocyte and oligodendrocyte infection by the polyomavirus JC (JCV); JCV has also been shown to infect and destroy cerebellar granule cell neurons (GCNs) in 2 human immunodeficiency virus...

journal_title：Journal of neuropathology and experimental neurology

authors： Wüthrich C,Cheng YM,Joseph JT,Kesari S,Beckwith C,Stopa E,Bell JE,Koralnik IJ

更新日期：2009-01-01 00:00:00

abstract：:The accumulation of misfolded or unfolded proteins in the endoplasmic reticulum (ER) lumen causes a cellular stress response termed the unfolded protein response. Although ER stress has been implicated in various neurodegenerative diseases, the morphological features of aggregated proteins in ER lumina that may cause ...

journal_title：Journal of neuropathology and experimental neurology

authors： Sasaki S

更新日期：2010-04-01 00:00:00

abstract：:The effects of hypoglycemia on cerebrovascular permeability to a protein, horseradish peroxidase (HRP), were studied in mice given 3 or 8 units of crytalline zinc insulin intraperitoneally. HRP (10 mg in 0.1 ml saline) was injected intravenously 15 to 20 minutes prior to sacrifice. Both mildly and severely hypoglycemi...

journal_title：Journal of neuropathology and experimental neurology

authors： Hsu DW,Hedley-Whyte ET

更新日期：1980-05-01 00:00:00

abstract：:The immunopathological findings and their effects upon the vascular permeability of the ciliary process, choroid plexus and renal glomeruli to intravenously injected 125I-bovine serum albumin (BSA) have been studied in 26 rats who survived a prolonged period of bovine serum albuminemia following the experimental chron...

journal_title：Journal of neuropathology and experimental neurology

authors： Peress NS,Miller F,Palu W

更新日期：1977-07-01 00:00:00

abstract：:Alpha-synuclein (alpha-synuclein) lesions are characteristic of idiopathic Parkinson disease (PD) and other alpha-synucleinopathies. To study the frequency of alpha-synuclein lesions in normal aging and how frequently they coexist with lesions of Alzheimer disease (AD), we examined the autopsy brains from normal and d...

journal_title：Journal of neuropathology and experimental neurology

authors： Mikolaenko I,Pletnikova O,Kawas CH,O'Brien R,Resnick SM,Crain B,Troncoso JC

更新日期：2005-02-01 00:00:00

abstract：:We investigated the temporal course of blood-nerve barrier (BNB) breakdown during the evolution of tellurium neuropathy, ricin neuropathy, and Wallerian degeneration following nerve transection or nerve crush. Blood-nerve barrier permeability was assessed with a 4,000-molecular weight fluoresceinated dextran from thre...

journal_title：Journal of neuropathology and experimental neurology

authors： Bouldin TW,Earnhardt TS,Goines ND

更新日期：1991-11-01 00:00:00

abstract：:Studies dealing with transport of proteins from the oligodendrocyte cell body to the myelin sheath reveal the presence of different transport pathways. Proteolipid protein (PLP) is synthesized at the rough endoplasmic reticulum (ER) and then processed through the Golgi apparatus and transported to the myelin membranes...

journal_title：Journal of neuropathology and experimental neurology

authors： Bauer J,Bradl M,Klein M,Leisser M,Deckwerth TL,Wekerle H,Lassmann H

更新日期：2002-01-01 00:00:00

abstract：:Deletions on the short arm of chromosome 1 (1p) and the long arm of chromosome 19 (19q) are molecular hallmark lesions of oligodendroglial tumors. Ever since oligodendroglial tumors with 1p and 19q deletions were shown to respond to chemotherapy, neuropathologists have been facing increasing requests for such molecula...

journal_title：Journal of neuropathology and experimental neurology

authors： Hartmann C,Mueller W,Lass U,Kamel-Reid S,von Deimling A

更新日期：2005-01-01 00:00:00

abstract：:The role of axonal transport in the pathogenesis of the axonal swellings which develop at the severed ends of transected axons was studied by electron microscopic (EM) autoradiography. Proteins carried by fast anterograde transport in rat sciatic nerves were labeled with [3H]-leucine or [3H]-fucose; [3H]-leucine, [3H]...

journal_title：Journal of neuropathology and experimental neurology

authors： Griffin JW,Price DL,Engel WK,Drachman DB

更新日期：1977-03-01 00:00:00

abstract：:Granule cell dispersion (GCD) is observed in approximately 40% of cases of hippocampal sclerosis (HS) in patients with epilepsy. Studies in animal models suggest that GCD may be a consequence of enhanced proliferation of granule cell precursors as a result of seizures. We quantified the number of cells in cycle in sub...

journal_title：Journal of neuropathology and experimental neurology

authors： Thom M,Martinian L,Williams G,Stoeber K,Sisodiya SM

更新日期：2005-03-01 00:00:00

abstract：:To evaluate cognitive performance among persons who did and did not develop clinical Alzheimer disease (AD) but had AD neuropathology at autopsy, we examined neuropsychological performance in cognitively healthy (Clinical Dementia Rating [CDR] = 0) participants who returned for at least 1 follow-up and died within 2 y...

journal_title：Journal of neuropathology and experimental neurology

authors： Hassenstab J,Monsell SE,Mock C,Roe CM,Cairns NJ,Morris JC,Kukull W

更新日期：2015-11-01 00:00:00

abstract：:PROX1 is a prospero-related transcription factor that plays a critical role in the development of various organs including the mammalian lymphatic and central nervous systems; it controls cell proliferation and differentiation through different transcription pathwaysand has both oncogenic and tumor-suppressive functio...

journal_title：Journal of neuropathology and experimental neurology

authors： Elsir T,Eriksson A,Orrego A,Lindström MS,Nistér M

更新日期：2010-02-01 00:00:00

abstract：:Since first described, amyotrophic lateral sclerosis/parkinsonism-dementia complex (ALS/PDC) of Guam has represented an important model of age-related neurodegenerative disease. ALS/PDC is characterized neuropathologically by severe widespread involvement by neurofibrillary tangles (NFTs). Over the past 30 years there...

journal_title：Journal of neuropathology and experimental neurology

authors： Perl DP,Hof PR,Purohit DP,Loerzel AJ,Kakulas BA

更新日期：2003-04-01 00:00:00

abstract：:Remyelination capacity decreases with age in adult mice, but data comparing remyelination capacity after toxic demyelination in developing mice versus adult mice are not available. We treated 3-week-old and adult C57BL/6 mice with cuprizone for 1 to 5 weeks and studied demyelination/remyelination and cellular reaction...

journal_title：Journal of neuropathology and experimental neurology

authors： Pfeifenbring S,Nessler S,Wegner C,Stadelmann C,Brück W

更新日期：2015-08-01 00:00:00

abstract：:Little is known about the molecular features of desmoplastic infantile ganglioglioma (DIG) and desmoplastic infantile astrocytoma (DIA). We performed a genome-wide DNA copy number analysis in combination with a multiplex ligation-dependent probe amplification-based analysis of copy number changes of candidate genes in...

journal_title：Journal of neuropathology and experimental neurology

authors： Gessi M,Zur Mühlen A,Hammes J,Waha A,Denkhaus D,Pietsch T

更新日期：2013-09-01 00:00:00

abstract：:Neutral glycolipids and gangliosides were analyzed in 149 astrocytomas (A), 46 oligodendrogliomas (O), and 21 oligoastrocytomas (OA) to determine if specific glycolipids correlate with histologic diagnosis and grade. Positivity for asialoGM1 (GA1) and negativity for paragloboside by immuno-TLC correlated with histolog...

journal_title：Journal of neuropathology and experimental neurology

authors： Yates AJ,Comas T,Scheithauer BW,Burger PC,Pearl DK

更新日期：1999-12-01 00:00:00

abstract：:We studied differences in the number and morphology of parvalbumin-immunoreactive (PV-IR) interneurons in 43 hippocampal specimens from patients with classical Ammon's horn sclerosis (AHS) who underwent anterior temporal lobectomy, as compared with 14 autopsy and non-AHS surgical control specimens. PV-IR neuronal loss...

journal_title：Journal of neuropathology and experimental neurology

authors： Zhu ZQ,Armstrong DL,Hamilton WJ,Grossman RG

更新日期：1997-09-01 00:00:00

abstract：:The idiopathic inflammatory myopathies are diseases of unknown etiology characterized by T cell-mediated myocytotoxicity in polymyositis and complement-mediated angiopathy of muscle fibers in dermatomyositis. A variable degree of fibrosis is present in muscles in these conditions both perimysially and endomysially. We...

journal_title：Journal of neuropathology and experimental neurology

authors： Confalonieri P,Bernasconi P,Cornelio F,Mantegazza R

更新日期：1997-05-01 00:00:00

abstract：:Inclusion body myositis (IBM) is a late-onset inflammatory myopathy with distinctive clinical and histopathological features. The molecular basis for the disease remains unknown, but abnormal nuclear morphology and the accumulation of a protein that binds single-stranded DNA in a sequence-independent fashion suggest a...

journal_title：Journal of neuropathology and experimental neurology

authors： Horvath R,Fu K,Johns T,Genge A,Karpati G,Shoubridge EA

更新日期：1998-05-01 00:00:00

abstract：:Retraction of distal sensory axons is a prominent feature in diabetic peripheral neuropathy (DPN), a process amenable to insulin therapy. Nevertheless, diabetic patients and long-term diabetic mice develop motor deficits after longer durations of DPN, a process that may be related to insulin deficiency. To compare the...

journal_title：Journal of neuropathology and experimental neurology

authors： Francis GJ,Martinez JA,Liu WQ,Zochodne DW,Hanson LR,Frey WH 2nd,Toth C

更新日期：2011-05-01 00:00:00

abstract：:The concept of the presence of mucopolysaccharides forming an interstitial ground substance in central nervous tissues is revived. The biochemical reports of both neutral and acid mucopolysaccharides in both gray and white matter of the normal brain are reviewed. The earlier histochemical reports and the histochemical...

journal_title：Journal of neuropathology and experimental neurology

authors： Feigin I

更新日期：1980-01-01 00:00:00

abstract：:The periaqueductal gray (PAG) plays a central role in the integration of defense responses to threatening or stressful stimuli. Little is known about the neurochemical development of the human PAG around the time of birth, when the fetus makes the transition to extrauterine life and independent defense responses are n...

journal_title：Journal of neuropathology and experimental neurology

authors： Reddy SC,Panigrahy A,White WF,Kinney HC

更新日期：1996-04-01 00:00:00

abstract：:Essential tremor (ET) patients develop more cognitive impairment and dementia than controls, although there are surprisingly few data on the neuropathological basis for cognitive changes in ET. In this postmortem study, we assessed tau and other pathologies in 26 ET cases and 73 controls (non-ET) (1:3 matching). The m...

journal_title：Journal of neuropathology and experimental neurology

authors： Farrell K,Cosentino S,Iida MA,Chapman S,Bennett DA,Faust PL,Louis ED,Crary JF

更新日期：2019-01-01 00:00:00

abstract：:Experimental autoimmune neuritis (EAN) is a demyelinating disease of the peripheral nervous system (PNS). This acute inflammatory disease is mediated by CD4+ T cells and bears significant similarities to the Guillain-Barré syndrome of humans. In the present study, we investigated the function of IL-18 in T cell-mediat...

journal_title：Journal of neuropathology and experimental neurology

authors： Yu S,Chen Z,Mix E,Zhu SW,Winblad B,Ljunggren HG,Zhu J

更新日期：2002-07-01 00:00:00

abstract：:Atypical teratoid/rhabdoid tumors are malignant embryonal tumors characterized by the presence of rhabdoid cells, genetic alterations affecting the SMARCB1 gene (hSNF5/INI1), and a poor prognosis. Whether INI1 plays a role in the pathogenesis of other central nervous system tumors is uncertain. We report on cases of 2...

journal_title：Journal of neuropathology and experimental neurology

authors： Hasselblatt M,Oyen F,Gesk S,Kordes U,Wrede B,Bergmann M,Schmid H,Frühwald MC,Schneppenheim R,Siebert R,Paulus W

更新日期：2009-12-01 00:00:00

abstract：:To understand the basis of oligodendrocyte (OL) susceptibility to oxidative injury, purified rat OL cultures at different stages of maturation were exposed to nitric oxide (NO) donors with fast or slow kinetics of release and to tert-butyl-hydroperoxide, a membrane-permeant organic hydroperoxide. OL precursors (pre-OL...

journal_title：Journal of neuropathology and experimental neurology

authors： Bernardo A,Greco A,Levi G,Minghetti L

更新日期：2003-05-01 00:00:00

abstract：:In a recent study we estimated the number and frequency distribution of the diameters of the cytons of all of the combined motoneuron columns of L3, L4 and L5 ventral horn of the spinal cord of man. In the present study we have estimated the number and frequency distribution of the diameter of motoneuron cytons in the...

journal_title：Journal of neuropathology and experimental neurology

authors： Kawamura Y,Dyck PJ

更新日期：1977-11-01 00:00:00