Downregulation of the potassium chloride cotransporter KCC2 in vulnerable motoneurons in the SOD1-G93A mouse model of amyotrophic lateral sclerosis.

abstract：:Recent studies have shown that the Alzheimer disease (AD) neocortex is characterized by a loss of large neurons, the presence of dilated terminal axons, widespread loss of synapses, and a disruption of the dendritic cytoskeleton which is manifested as Tau immunoreactive threads. In the present study we have investigat...

journal_title：Journal of neuropathology and experimental neurology

authors： Masliah E,Ellisman M,Carragher B,Mallory M,Young S,Hansen L,DeTeresa R,Terry RD

更新日期：1992-07-01 00:00:00

abstract：:This study describes, for the first time, the neuropathy of zinc pyridinethione (ZPT) toxicity in rats. Although hind-limb weakness has been previously reported as a consequence of dietary ZPT ingestion in rats and rabbits, the cause of the paralysis has been unexplained. Sequential morphologic studies in rats fed a d...

journal_title：Journal of neuropathology and experimental neurology

authors： Sahenk Z,Mendell JR

更新日期：1979-09-01 00:00:00

abstract：:The substantia nigra is not the induction site in the brain of the neurodegenerative process underlying Parkinson disease (PD). Instead, the results of this semi-quantitative study of 30 autopsy cases with incidental Lewy body pathology indicate that PD in the brain commences with the formation of the very first immun...

journal_title：Journal of neuropathology and experimental neurology

authors： Del Tredici K,Rüb U,De Vos RA,Bohl JR,Braak H

更新日期：2002-05-01 00:00:00

abstract：:A working group supported by the Office of Rare Diseases of the National Institutes of Health formulated neuropathologic criteria for corticobasal degeneration (CBD) that were subsequently validated by an independent group of neuropathologists. The criteria do not require a specific clinical phenotype, since CBD can h...

journal_title：Journal of neuropathology and experimental neurology

authors： Dickson DW,Bergeron C,Chin SS,Duyckaerts C,Horoupian D,Ikeda K,Jellinger K,Lantos PL,Lippa CF,Mirra SS,Tabaton M,Vonsattel JP,Wakabayashi K,Litvan I,Office of Rare Diseases of the National Institutes of Health.

更新日期：2002-11-01 00:00:00

abstract：:Central nervous system (CNS) tissue was studied by immunocytochemistry and electron microscopy from three cases of multiple sclerosis (MS) in which evidence of ongoing myelin breakdown could be documented. The study focussed upon the role of glial cells in the pathogenesis of demyelination. In acute MS, demyelination ...

journal_title：Journal of neuropathology and experimental neurology

authors： Lee SC,Moore GR,Golenwsky G,Raine CS

更新日期：1990-03-01 00:00:00

abstract：:Chronic traumatic encephalopathy (CTE) is a progressive neurodegenerative disorder associated with repetitive traumatic brain injury. Multiple system atrophy (MSA) is a Parkinsonian disorder that can result in repetitive falls with associated head trauma. We hypothesized that patients with neurodegenerative disorders ...

journal_title：Journal of neuropathology and experimental neurology

authors： Koga S,Dickson DW,Bieniek KF

更新日期：2016-10-01 00:00:00

abstract：:Nijmegen breakage syndrome caused by NBS1 germline mutations is a rare autosomal recessive disease with clinical features that include microcephaly, increased radiosensitivity, and predisposition to cancer. NBS1 plays a key role in DNA double-strand break repair and the maintenance of genomic stability. We screened 87...

journal_title：Journal of neuropathology and experimental neurology

authors： Watanabe T,Nobusawa S,Lu S,Huang J,Mittelbronn M,Ohgaki H

更新日期：2009-02-01 00:00:00

abstract：:Familial Danish dementia (FDD) is pathologically characterized by widespread cerebral amyloid angiopathy (CAA), parenchymal protein deposits, and neurofibrillary degeneration. FDD is associated with a mutation of the BRI2 gene located on chromosome 13. In FDD there is a decamer duplication, which abolishes the normal ...

journal_title：Journal of neuropathology and experimental neurology

authors： Holton JL,Lashley T,Ghiso J,Braendgaard H,Vidal R,Guerin CJ,Gibb G,Hanger DP,Rostagno A,Anderton BH,Strand C,Ayling H,Plant G,Frangione B,Bojsen-Møller M,Revesz T

更新日期：2002-03-01 00:00:00

abstract：:The age-related change in the neuronal RNA content, volume, and the RNA concentration of 2,160 single cell bodies was examined from the prefrontal cortex. Human brains from 15 normal and 3 demented patients of ages ranging from 8 months to 94 years were obtained at post-mortem examination. The neuronal RNA showed an a...

journal_title：Journal of neuropathology and experimental neurology

authors： Uemura E,Hartmann HA

更新日期：1978-09-01 00:00:00

abstract：:This study examines a radiation-induced invasion and spread of Schwann cells into ventral gray regions of the lumbar spinal cord. The prevalence of these cells within the gray matter and the time course of their appearance in the ventral spinal cord is quite different from the pattern of Schwann cell development in do...

journal_title：Journal of neuropathology and experimental neurology

authors： Sims TJ,Durgun MB,Gilmore SA

更新日期：1998-09-01 00:00:00

abstract：:Neuroaxonal dystrophy, a distinctive axonopathy characterized by marked enlargement of distal axons, is the hallmark pathologic alteration in aged and diabetic human prevertebral sympathetic ganglia and in corresponding rodent models. Neuroaxonal dystrophy is thought to represent the abnormal outcome of cycles of syna...

journal_title：Journal of neuropathology and experimental neurology

authors： Schmidt RE,Parvin CA,Green KG

更新日期：2008-12-01 00:00:00

abstract：:It is recognized that IDH mutation negative, low-grade epilepsy associated tumors (LEAT) can show diffuse growth patterns and lack the diagnostic hallmarks of either classical dysembryoplastic neuroepithelial tumors (DNT) or typical ganglioglioma. "Nonspecific or diffuse DNT" and more recently "polymorphous low-grade ...

journal_title：Journal of neuropathology and experimental neurology

authors： Al-Hajri A,Al-Mughairi S,Somani A,An S,Liu J,Miserocchi A,McEvoy AW,Yousry T,Hoskote C,Thom M

更新日期：2017-12-01 00:00:00

abstract：:The long-term disabilities associated with spinal cord injury (SCI) are primarily due to the absence of robust neuronal regeneration and functional plasticity. The inability of the axon to regenerate after SCI is contributed by several intrinsic factors that trigger a cascade of molecular growth program and modulates ...

journal_title：Journal of neuropathology and experimental neurology

authors： Bhowmick S,Abdul-Muneer PM

更新日期：2021-01-20 00:00:00

abstract：:This report describes a phenotypic differentiation pattern conceived to distinguish invading monocytes from resident microglia in frozen and formalin-fixed human CNS. Phagocytic cells in normal and diseased CNS (multiple sclerosis and encephalitis) were studied immunohistochemically with a panel of antibodies, and phe...

journal_title：Journal of neuropathology and experimental neurology

authors： Ulvestad E,Williams K,Mørk S,Antel J,Nyland H

更新日期：1994-09-01 00:00:00

abstract：:The relevance of cerebral amyloid angiopathy (CAA) to the pathogenesis of Alzheimer disease (AD) and dementia in general emphasizes the importance of developing novel targeting approaches for detecting and treating cerebrovascular amyloid (CVA) deposits. We developed a nanoparticle-based technology that uses a monoclo...

journal_title：Journal of neuropathology and experimental neurology

authors： Poduslo JF,Hultman KL,Curran GL,Preboske GM,Chamberlain R,Marjańska M,Garwood M,Jack CR Jr,Wengenack TM

更新日期：2011-08-01 00:00:00

abstract：:Adult male rats were housed in a colony environment for six months, with ad lib access to anise-flavored 10% ethanol in water. Animals were then removed from the colony, and their consumption of alcohol during a period in isolated housing was measured. Individual rats were scored as high, moderate, and low consumers. ...

journal_title：Journal of neuropathology and experimental neurology

authors： Goldstein B,Maxwell DS,Ellison G,Hammer RP

更新日期：1983-09-01 00:00:00

abstract：:The content of RNA and volume of individual neurons isolated from the nucleus dorsalis and from the ventrolateral portion of the lumbar swelling were determined in eight cases of amyotrophic lateral sclerosis (ALS) and eight controls whose spinal cords were obtained at autopsy. The mean content of RNA in the lumbar mo...

journal_title：Journal of neuropathology and experimental neurology

authors： Davidson TJ,Hartmann HA

更新日期：1981-03-01 00:00:00

abstract：:Diabetic polyneuropathy (DPN) shows more severe functional and structural changes in type 1 than in type 2 human and experimental diabetes. We have previously suggested that these differences may be due to insulin and/or C-peptide deficiencies in type 1 diabetes. To further explore these differences between type I and...

journal_title：Journal of neuropathology and experimental neurology

authors： Pierson CR,Zhang W,Murakawa Y,Sima AA

更新日期：2003-03-01 00:00:00

abstract：:Side population (SP) cells identified using the Hoechst 33342 fluorescent dye efflux technique overlap with the tumor stem cell fraction that is responsible for tumorigenesis and recurrence in malignant gliomas. Because diffuse invasion of glioma cells represents the main obstacle to successful therapy and underlies r...

journal_title：Journal of neuropathology and experimental neurology

authors： Weber K,Paulus W,Senner V

更新日期：2010-06-01 00:00:00

abstract：:A previous autopsy study of patients with amnestic-type mild cognitive impairment (MCI) suggested an overrepresentation of argyrophilic grain disease (AGD). We studied 34 patients who had diagnoses of amnestic MCI during progression to dementia and who came to autopsy. Neuropathologic evaluation included routine histo...

journal_title：Journal of neuropathology and experimental neurology

authors： Jicha GA,Petersen RC,Knopman DS,Boeve BF,Smith GE,Geda YE,Johnson KA,Cha R,Delucia MW,Braak H,Dickson DW,Parisi JE

更新日期：2006-06-01 00:00:00

abstract：:Natalizumab, a monoclonal antibody directed against α4 integrins, has, to date, been associated with 399 cases of progressive multifocal leukoencephalopathy (PML) worldwide in patients receiving treatment for multiple sclerosis (MS). Because of the limited number of histologic studies, the possible interplay between M...

journal_title：Journal of neuropathology and experimental neurology

authors： Wüthrich C,Popescu BF,Gheuens S,Marvi M,Ziman R,Denq SP,Tham M,Norton E,Parisi JE,Dang X,Lucchinetti CF,Koralnik IJ

更新日期：2013-11-01 00:00:00

abstract：:Smooth muscle cells cultured from leptomeningeal vessels from old dogs with amyloid-angiopathy accumulate intracellular deposits that are immunoreactive for amyloid-beta peptide (A beta). We used this cellular model in the present study to examine the influence of sera and cerebrospinal fluid on intracellular accumula...

journal_title：Journal of neuropathology and experimental neurology

authors： Mazur-Kolecka B,Frackowiak J,Carroll RT,Wisniewski HM

更新日期：1997-03-01 00:00:00

abstract：:Programmed cell death (PCD) via apoptosis is characterized by nuclear pyknosis and fragmentation, and biochemically by oligonucleosomal cleavage of DNA. Apoptosis occurs in the developing nervous system, whereas its role in neurodegenerative diseases is still debated. Recognition of apoptotic cells has recently been f...

journal_title：Journal of neuropathology and experimental neurology

authors： Migheli A,Cavalla P,Marino S,Schiffer D

更新日期：1994-11-01 00:00:00

abstract：:Rates of remyelination decline with age and this has been attributed to slower recruitment of oligodendrocyte progenitor cells (OPCs) into areas of demyelination and slower differentiation of OPCs into remyelinating oligodendrocytes. When considering causes for reduced recruitment rates, intrinsic causes (alterations ...

journal_title：Journal of neuropathology and experimental neurology

authors： Chari DM,Crang AJ,Blakemore WF

更新日期：2003-09-01 00:00:00

abstract：:In attempting to control the pain of disseminated carcinoma, a variety of agents has been injected intrathecally. This report deals with the neuropathologic changes in spinal roots and spinal cord of four patients into whose lumbar sacs 100 to 285 ml of distilled water was infused. Survival following the procedure ra...

journal_title：Journal of neuropathology and experimental neurology

authors： Kelly JM,Asbury AK,King JS

更新日期：1975-09-01 00:00:00

abstract：:We have previously studied in nonhuman primates several aspects of the acute rejection of myofibers, including the histological characteristics, the mechanisms of myofiber elimination by the T cells, and the development of anti-donor antibodies. Here, we report the participation of the complement membrane attack compl...

journal_title：Journal of neuropathology and experimental neurology

authors： Skuk D,Tremblay JP

更新日期：2019-01-01 00:00:00

abstract：:Human neurodegenerative diseases can be characterized as disorders of protein aggregation. As a key player in cellular autophagy and the ubiquitin proteasome system, p62 may represent an effective immunohistochemical target, as well as mechanistic operator, across neurodegenerative proteinopathies. In this study, 2 no...

journal_title：Journal of neuropathology and experimental neurology

authors： Trejo-Lopez JA,Sorrentino ZA,Riffe CJ,Prokop S,Dickson DW,Yachnis AT,Giasson BI

更新日期：2020-04-01 00:00:00

abstract：:To assess the range of differentiation of the cells comprising dysembryoplastic neuroepithelial tumor (DNT), particularly the oligodendrocyte-like cells (OLC), 14 DNT were immunochemically studied with a spectrum of neuronal and glial markers. Eight tumors were also studied ultrastructurally. Neurofilament protein, cl...

journal_title：Journal of neuropathology and experimental neurology

authors： Hirose T,Scheithauer BW,Lopes MB,VandenBerg SR

更新日期：1994-03-01 00:00:00

abstract：:Early inflammatory events may inhibit functional recovery after injury in both the peripheral and central nervous systems. We investigated the role of the inflammatory tumor necrosis factor/nuclear factor-kappaB (NF-kappaB) axis on events subsequent to sciatic nerve crush injury in adult rats. Electrophoretic mobility...

journal_title：Journal of neuropathology and experimental neurology

authors： Smith D,Tweed C,Fernyhough P,Glazner GW

更新日期：2009-06-01 00:00:00

abstract：:Neurofibrillary tangles (NFTs) represent products of insoluble tau protein in the brains of patients with Alzheimer disease (AD). The cerebrospinal fluid (CSF) tau level is a biomarker in AD diagnosis. The soluble portion of tau protein in brain parenchyma is presumably the source for CSF tau but this has not previous...

journal_title：Journal of neuropathology and experimental neurology

authors： Han P,Serrano G,Beach TG,Caselli RJ,Yin J,Zhuang N,Shi J

更新日期：2017-01-01 00:00:00