Dysembryoplastic neuroeptihelial tumor (DNT): an immunohistochemical and ultrastructural study.

abstract：:Histopathologic evaluation of brain tissue derived from surgically treated patients with medically refractory temporal lobe epilepsy (TLE) frequently reveals structural brain lesions in the surgical specimen. While several of the most commonly encountered lesions such as low-grade neoplasms or vascular malformations a...

journal_title：Journal of neuropathology and experimental neurology

authors： Kasper BS,Stefan H,Buchfelder M,Paulus W

更新日期：1999-01-01 00:00:00

abstract：:The tau deposits found in neurodegenerative diseases are classified based on their isoforms, that is, 3-repeat (3R) tau and 4-repeat (4R) tau. These isoforms are distinguishable using the antibodies RD3 and RD4, respectively, and Gallyas (Gal) and Campbell-Switzer (CS) silver staining methods, respectively. Tau is als...

journal_title：Journal of neuropathology and experimental neurology

authors： Ichihara K,Uchihara T,Nakamura A,Suzuki Y,Mizutani T

更新日期：2009-09-01 00:00:00

abstract：:In a series of 126 meningiomas, tumor and patient characteristics were investigated and statistically analyzed. A combined cytogenetic and molecular genetic approach was used to study chromosomal abnormalities and loss of markers on chromosome 22q. This approach was successfully applied to 93 meningiomas. In 66 cases,...

journal_title：Journal of neuropathology and experimental neurology

authors： Lekanne Deprez RH,Riegman PH,van Drunen E,Warringa UL,Groen NA,Stefanko SZ,Koper JW,Avezaat CJ,Mulder PG,Zwarthoff EC

更新日期：1995-03-01 00:00:00

abstract：:Chronic experimental allergic encephalomyelitis (EAE), produced in inbred guinea pigs given a single inoculation during the juvenile period with isologous spinal cord in complete Freund's adjuvant, has been studied by light and electron microscopy. Most animals showed a delayed onset of nurologic signs from 12 to 68 w...

journal_title：Journal of neuropathology and experimental neurology

authors： Snyder DH,Valsamis MP,Stone SH,Raine CS

更新日期：1975-05-01 00:00:00

abstract：:Lewy bodies and Lewy neurites are the hallmark neuropathologic findings in Parkinson disease, Parkinson disease with dementia, dementia with Lewy bodies, and other alpha-synucleinopathies. They have also been described in the brains of normal older individuals and referred to as incidental Lewy body disease. The purpo...

journal_title：Journal of neuropathology and experimental neurology

authors： Markesbery WR,Jicha GA,Liu H,Schmitt FA

更新日期：2009-07-01 00:00:00

abstract：:Mitochondrial Zn2+ accumulation, particularly in CA1 neurons, occurs after ischemia and likely contributes to mitochondrial dysfunction and subsequent neurodegeneration. However, the relationship between mitochondrial Zn2+ accumulation and their disruption has not been examined at the ultrastructural level in vivo. We...

journal_title：Journal of neuropathology and experimental neurology

authors： Yin HZ,Wang HL,Ji SG,Medvedeva YV,Tian G,Bazrafkan AK,Maki NZ,Akbari Y,Weiss JH

更新日期：2019-07-01 00:00:00

abstract：:Intracranial hemangiopericytic meningiomas (HM) from seven patients were examined by immunostaining, transmission electron microscopy (TEM), scanning electron microscopy (SEM) and cell culture. Positive staining for Factor VIII-related antigen was restricted to capillary endothelial cells. There was no reaction with a...

journal_title：Journal of neuropathology and experimental neurology

authors： Nakamura M,Inoue HK,Ono N,Kunimine H,Tamada J

更新日期：1987-01-01 00:00:00

abstract：:Microglial activation and behavioral abnormalities occur before neuronal loss in experimental murine prion disease; the behavioral changes coincide with a reduction in synaptic plasticity. Because synaptic plasticity depends on an intact perineuronal net (PN), a specialized extracellular matrix that surrounds parvalbu...

journal_title：Journal of neuropathology and experimental neurology

authors： Franklin SL,Love S,Greene JR,Betmouni S

更新日期：2008-03-01 00:00:00

abstract：:The sciatic/tibial/plantar nerve complex of normal aged rats displays striking morphological changes that are most pronounced distally. Nerve fiber abnormalities include: (a) large numbers of axonal glycogenosomes, mitochondria, dense membranous bodies, and decorated particles; (b) adaxonal Schwann cell processes sequ...

journal_title：Journal of neuropathology and experimental neurology

authors： Grover-Johnson N,Spencer PS

更新日期：1981-03-01 00:00:00

abstract：:In many degenerative and metabolic muscle diseases cells die without a marked inflammatory response. A potential mechanism how this could be accomplished is apoptotic cell death. Since there are no data available about apoptosis in cells of myogenic origin, we examined rat skeletal myoblasts for their potential to und...

journal_title：Journal of neuropathology and experimental neurology

authors： Stangel M,Zettl UK,Mix E,Zielasek J,Toyka KV,Hartung HP,Gold R

更新日期：1996-01-01 00:00:00

abstract：:The development of deformities during the course of leprosy disease is a major public health concern worldwide. It is possible that cytokine production and apoptosis of Schwann cells (SCs) directly affect nerve degeneration and regeneration leading to injury of the myelin sheath and axon. In the present study, the exp...

journal_title：Journal of neuropathology and experimental neurology

authors： Oliveira RB,Sampaio EP,Aarestrup F,Teles RM,Silva TP,Oliveira AL,Antas PR,Sarno EN

更新日期：2005-10-01 00:00:00

abstract：:Immunohistochemical identification of myelin basic protein (MBP) is a sensitive method for assessing myelination in the human fetal central nervous system (CNS). However, the temporospatial relationship of expression of two other major myelin proteins, proteolipid protein (PLP) and myelin-associated glycoprotein (MAG)...

journal_title：Journal of neuropathology and experimental neurology

authors： Weidenheim KM,Bodhireddy SR,Rashbaum WK,Lyman WD

更新日期：1996-06-01 00:00:00

abstract：:The favorable response of oligodendrogliomas correlates well with characteristic chromosomal losses, of which loss of the short arm of chromosome 1 is most predictive. Oligodendrogliomas are histopathologically heterogeneous tumors and, in addition to the classic honeycomb histology, fields of nonclassic histology are...

journal_title：Journal of neuropathology and experimental neurology

authors： Kros JM,van der Weiden M,Zheng PP,Hop WC,van den Bent MJ,Kouwenhoven MC

更新日期：2007-12-01 00:00:00

abstract：:Peripheral neuropathy is a significant complication of diabetes resulting in increased patient morbidity and mortality. Deficiencies of neurotrophic substances (e.g. NGE NT-3, and IGF-I) have been proposed as pathogenetic mechanisms in the development of distal symmetrical sensory diabetic polyneuropathy, and salutary...

journal_title：Journal of neuropathology and experimental neurology

authors： Schmidt RE,Dorsey DA,Beaudet LN,Parvin CA,Escandon E

更新日期：2001-03-01 00:00:00

abstract：:Placement of a freezing probe on the skull of neonatal rats produces four-layered microgyria, complete with a lamina dissecans and microsulcus. We studied the developmental course of this induced microgyria under light microscopy by examining changes in neurons, glia, and macrophages following a focal freezing insult ...

journal_title：Journal of neuropathology and experimental neurology

authors： Rosen GD,Press DM,Sherman GF,Galaburda AM

更新日期：1992-11-01 00:00:00

abstract：:The aim of this study was to clarify pathological and anatomical relationships between adamantinomatous craniopharyngiomas (ACP) and their surrounding structures. We previously established a QST classification scheme based on the apparent anatomic origin of the tumors. According to this classification, 13 type Q tumor...

journal_title：Journal of neuropathology and experimental neurology

authors： Liu Y,Qi ST,Wang CH,Pan J,Fan J,Peng JX,Zhang X,Bao Y,Liu YW

更新日期：2018-11-01 00:00:00

abstract：:The oligoastrocytoma, as a mixed glioma, represents a nosologic dilemma with respect to precisely defining the oligodendroglial and astroglial phenotypes that constitute the neoplastic cell lineages of these tumors. In this study, cell image analysis with Feulgen-stained nuclei was used to distinguish between oligoden...

journal_title：Journal of neuropathology and experimental neurology

authors： Decaestecker C,Lopes BS,Gordower L,Camby I,Cras P,Martin JJ,Kiss R,VandenBerg SR,Salmon I

更新日期：1997-04-01 00:00:00

abstract：:Retinoblastoma protein (pRb) is a ubiquitous 928-amino acid cell cycle regulatory molecule with diverse biologic activities. One critical function of pRb is the control of the G1-to-S phase checkpoint of the cell cycle. In the hypophosphorylated state, pRb suppresses the activity of E2F transcription factors thereby i...

journal_title：Journal of neuropathology and experimental neurology

authors： Stone JG,Siedlak SL,Tabaton M,Hirano A,Castellani RJ,Santocanale C,Perry G,Smith MA,Zhu X,Lee HG

更新日期：2011-07-01 00:00:00

abstract：:The frontotemporal dementias (FTDs) are a heterogeneous group of neurodegenerative disorders that are characterized clinically by dementia, personality changes, language impairment, and occasionally extrapyramidal movement disorders. Historically, the diagnosis and classification of FTDs has been fraught with difficul...

journal_title：Journal of neuropathology and experimental neurology

authors： Mott RT,Dickson DW,Trojanowski JQ,Zhukareva V,Lee VM,Forman M,Van Deerlin V,Ervin JF,Wang DS,Schmechel DE,Hulette CM

更新日期：2005-05-01 00:00:00

abstract：:Bone marrow stromal cells (BMSCs) have the potential to improve functional recovery in patients with spinal cord injury (SCI); however, they are limited by low survival rates after transplantation in the injured tissue. Our objective was to clarify the effects of a temporal blockade of interleukin 6 (IL-6)/IL-6 recept...

journal_title：Journal of neuropathology and experimental neurology

authors： Tan Y,Uchida K,Nakajima H,Guerrero AR,Watanabe S,Hirai T,Takeura N,Liu SY,Johnson WE,Baba H

更新日期：2013-10-01 00:00:00

abstract：:Glomeruloid bodies (GBs), tumor-associated vascular structures with a superficial resemblance to renal glomeruli, are important histopathological features of glioblastoma multiforme, but have also been described in other types of tumors and in cerebral metastases. The purpose of this study was to elucidate the pathoge...

journal_title：Journal of neuropathology and experimental neurology

authors： Döme B,Tímár J,Paku S

更新日期：2003-06-01 00:00:00

abstract：:The role of regenerating axons in the restructuring of the endoneurium into minifascicles after peripheral nerve injury was investigated. Endoneurial changes were studied in the control distal stumps of crushed rat sciatic nerves and in the distal nerve stumps in which, in addition to other cellular elements, the orig...

journal_title：Journal of neuropathology and experimental neurology

authors： Popović M,Bresjanac M,Sketelj J

更新日期：1994-11-01 00:00:00

abstract：:The development and differentiation of oligodendrocytes (OC) in developing mouse spinal cord (MSC) were investigated by correlative analysis of light and electron microscopy (EM), and immunoperoxidase studies for glial fibrillary acidic protein (GFAP) and myelin basic protein (MBP). The sequential development of glial...

journal_title：Journal of neuropathology and experimental neurology

authors： Choi BH

更新日期：1986-09-01 00:00:00

abstract：:We report a novel case of a World Health Organization grade 3 anaplastic meningioma arising from the olfactory groove in an 83-year-old woman. Molecular and methylation profiling confirm this lesion to be an NF2 subtype, methylation class intermediate type B meningioma. As most meningiomas in this location are indolen...

journal_title：Journal of neuropathology and experimental neurology

authors： Foo ASC,Tan DTM,Tan CL,Sahm F,von Deimling A,Yeo TT

更新日期：2017-12-01 00:00:00

abstract：:The genetic abnormality most frequently identified in glioblastomas is loss of alleles on chromosome 10. We have performed a comprehensive study of the PTEN tumor suppressor gene on 10q23, including loss of heterozygosity (LOH) analysis, multiplex PCR, mutation analysis, and reverse transcription PCR (RT-PCR). In tota...

journal_title：Journal of neuropathology and experimental neurology

authors： Schmidt EE,Ichimura K,Goike HM,Moshref A,Liu L,Collins VP

更新日期：1999-11-01 00:00:00

abstract：:Insight into processes leading to rupture of intracranial aneurysms (IAs) may identify biomarkers for rupture or lead to management strategies reducing the risk of rupture. We characterized and quantified (ultra)structural differences between unruptured and ruptured aneurysmal walls. Six unruptured and 6 ruptured IA f...

journal_title：Journal of neuropathology and experimental neurology

authors： Korkmaz E,Kleinloog R,Verweij BH,Allijn IE,Hekking LHP,Regli L,Rinkel GJE,Ruigrok YM,Andries Post J

更新日期：2017-10-01 00:00:00

abstract：:This morphometric study explores temporal and topographic changes in the estimated neuronal number in human neocortex during the latter half of gestation and early infancy. Neuronal estimates are calculated from standardized measurements of cortical layer thickness and neuronal density in 6 neocortical regions in 9 hu...

journal_title：Journal of neuropathology and experimental neurology

authors： Rabinowicz T,de Courten-Myers GM,Petetot JM,Xi G,de los Reyes E

更新日期：1996-03-01 00:00:00

abstract：:Protein aggregate myopathies, including myofibrillar myopathies and sporadic inclusion body myositis (sIBM), are characterized by abnormal protein aggregates composed of various muscular and ectopic proteins. Previous studies have shown the crucial role ofdysregulated transcription factors such as neuron-restrictive s...

journal_title：Journal of neuropathology and experimental neurology

authors： Olivé M,Janué A,Moreno D,Gámez J,Torrejón-Escribano B,Ferrer I

更新日期：2009-03-01 00:00:00

abstract：:CD44 is a glycoprotein present on the surface of some lymphocyte cell populations and other non-lymphoid cells, and is involved in many functions related to cell-cell and cell-matrix interactions. In this study, expression of CD44 antigen in primary neural cell cultures derived from fetal and adult human brains was in...

journal_title：Journal of neuropathology and experimental neurology

authors： Moretto G,Xu RY,Kim SU

更新日期：1993-07-01 00:00:00

abstract：:Despite the key role of γ-aminobutyric acid (GABA) neurons in the modulation of cerebral cortical output, little is known about their development in the human cortex. We analyzed several GABAergic parameters in standardized regions of the cerebral cortex and white matter in a total of 38 human fetuses and infants from...

journal_title：Journal of neuropathology and experimental neurology

authors： Xu G,Broadbelt KG,Haynes RL,Folkerth RD,Borenstein NS,Belliveau RA,Trachtenberg FL,Volpe JJ,Kinney HC

更新日期：2011-10-01 00:00:00