Mutational profile of the PTEN gene in primary human astrocytic tumors and cultivated xenografts.

abstract：:Immune mechanisms have been increasingly recognized in the pathogenesis of hippocampal sclerosis (HS), but infiltration of cytotoxic T-cells and its pathological significance in patients with HS has not been explored. We examined 30 cases of surgically resected hippocampi, including 16 International League Against Epi...

journal_title：Journal of neuropathology and experimental neurology

authors： Lu JQ,Steve TA,Wheatley M,Gross DW

更新日期：2017-03-01 00:00:00

abstract：:Brain atrophy is a common finding in patients with AIDS, but the relationship of atrophy to HIV-associated dementia is unclear. We used unbiased, stereological methods on postmortem brain specimens to estimate volumes of different brain regions in patients prospectively diagnosed with and without HIV-associated dement...

journal_title：Journal of neuropathology and experimental neurology

authors： Subbiah P,Mouton P,Fedor H,McArthur JC,Glass JD

更新日期：1996-10-01 00:00:00

abstract：:Herpes simplex virus type 1 (HSV-1) is the cause of a serious and often fatal encephalitis. Patients who survive herpes simplex encephalitis (HSE) experience behavioral abnormalities including profound cognitive dysfunctions. We have developed a rat model of acute HSE to investigate the cognitive impairments caused by...

journal_title：Journal of neuropathology and experimental neurology

authors： Beers DR,Henkel JS,Schaefer DC,Rose JW,Stroop WG

更新日期：1993-05-01 00:00:00

abstract：:Experimental cerebral ischemia was produced in gerbils by occlusion of the right common carotid artery in the neck. The evolution of the ischemic lesions was followed from five minutes to six hours by using the immunohistochemical techniques for tubulin and creatine kinase BB-isoenzyme. The earliest lesion was found i...

journal_title：Journal of neuropathology and experimental neurology

authors： Yanagihara T,Yoshimine T,Morimoto K,Yamamoto K,Homburger HA

更新日期：1985-03-01 00:00:00

abstract：:Localized hypertrophic neuropathy is a rare Schwann cell proliferation that usually affects single nerves from the extremities, and it is of unclear etiology in its pure form. RASopathies are a defined group of genetic diseases with overlapping clinical features, usually secondary to germline mutations in genes encodi...

journal_title：Journal of neuropathology and experimental neurology

authors： Vizcaino MA,Belzberg A,Ahlawat S,Belakhoua S,Chen L,Staedtke V,Rodriguez FJ

更新日期：2020-06-01 00:00:00

abstract：:The effects of hypoglycemia on cerebrovascular permeability to a protein, horseradish peroxidase (HRP), were studied in mice given 3 or 8 units of crytalline zinc insulin intraperitoneally. HRP (10 mg in 0.1 ml saline) was injected intravenously 15 to 20 minutes prior to sacrifice. Both mildly and severely hypoglycemi...

journal_title：Journal of neuropathology and experimental neurology

authors： Hsu DW,Hedley-Whyte ET

更新日期：1980-05-01 00:00:00

abstract：:Human neurodegenerative diseases can be characterized as disorders of protein aggregation. As a key player in cellular autophagy and the ubiquitin proteasome system, p62 may represent an effective immunohistochemical target, as well as mechanistic operator, across neurodegenerative proteinopathies. In this study, 2 no...

journal_title：Journal of neuropathology and experimental neurology

authors： Trejo-Lopez JA,Sorrentino ZA,Riffe CJ,Prokop S,Dickson DW,Yachnis AT,Giasson BI

更新日期：2020-04-01 00:00:00

abstract：:Spinal muscular atrophy (SMA) is characterized by loss of motor neurons in the spinal cord that results in muscle denervation and profound weakness in affected patients. We sought evidence for primary muscle involvement in the disease during human development by analyzing the expression of several muscle cytoskeletal ...

journal_title：Journal of neuropathology and experimental neurology

authors： Martínez-Hernández R,Bernal S,Alias L,Tizzano EF

更新日期：2014-06-01 00:00:00

abstract：:Whatever the cause of myelin damage of the peripheral nervous system, the initial attack on myelin by a dysimmune process may begin either at the internodal area or in the paranodal and nodal regions. The term "nodo-paranodopathy" was first applied to some "axonal Guillain-Barré syndrome" subtypes, then extended to ca...

journal_title：Journal of neuropathology and experimental neurology

authors： Vallat JM,Magy L,Corcia P,Boulesteix JM,Uncini A,Mathis S

更新日期：2020-03-01 00:00:00

abstract：:Mutations in the parkin gene are the most common cause of early-onset autosomal recessive Parkinson disease (PD). The pathogenic mechanisms of how parkin mutations lead to the development of PD are not fully understood. Studies of cell cultures and of Drosophila have suggested a dominant negative effect for the clinic...

journal_title：Journal of neuropathology and experimental neurology

authors： Van Rompuy AS,Lobbestael E,Van der Perren A,Van den Haute C,Baekelandt V

更新日期：2014-02-01 00:00:00

abstract：:The role of regenerating axons in the restructuring of the endoneurium into minifascicles after peripheral nerve injury was investigated. Endoneurial changes were studied in the control distal stumps of crushed rat sciatic nerves and in the distal nerve stumps in which, in addition to other cellular elements, the orig...

journal_title：Journal of neuropathology and experimental neurology

authors： Popović M,Bresjanac M,Sketelj J

更新日期：1994-11-01 00:00:00

abstract：:Fragmentation of genomic DNA, a major biochemical feature of programmed cell death (apoptosis), is easily detected when apoptosis is prevalent. In brain tissue apoptotic cells are usually scarce and detection requires more sensitive techniques. We describe a highly sensitive method to quantify apoptosis in frozen huma...

journal_title：Journal of neuropathology and experimental neurology

authors： Olano JP,Wolf D,Keherly M,Gelman BB

更新日期：1996-11-01 00:00:00

abstract：:Since first described, amyotrophic lateral sclerosis/parkinsonism-dementia complex (ALS/PDC) of Guam has represented an important model of age-related neurodegenerative disease. ALS/PDC is characterized neuropathologically by severe widespread involvement by neurofibrillary tangles (NFTs). Over the past 30 years there...

journal_title：Journal of neuropathology and experimental neurology

authors： Perl DP,Hof PR,Purohit DP,Loerzel AJ,Kakulas BA

更新日期：2003-04-01 00:00:00

abstract：:Mutations in the cathepsin D (CTSD) gene cause an aggressive neurodegenerative disease (congenital neuronal ceroid lipofuscinosis) that leads to early death. Recent evidence suggests that presynaptic abnormalities play a major role in the pathogenesis of CTSD deficiencies. To identify the early events that lead to syn...

journal_title：Journal of neuropathology and experimental neurology

authors： Koch S,Molchanova SM,Wright AK,Edwards A,Cooper JD,Taira T,Gillingwater TH,Tyynelä J

更新日期：2011-12-01 00:00:00

abstract：:The tau deposits found in neurodegenerative diseases are classified based on their isoforms, that is, 3-repeat (3R) tau and 4-repeat (4R) tau. These isoforms are distinguishable using the antibodies RD3 and RD4, respectively, and Gallyas (Gal) and Campbell-Switzer (CS) silver staining methods, respectively. Tau is als...

journal_title：Journal of neuropathology and experimental neurology

authors： Ichihara K,Uchihara T,Nakamura A,Suzuki Y,Mizutani T

更新日期：2009-09-01 00:00:00

abstract：:In an effort to develop a method of tissue injury which would provide a model for the study of axonal regrowth in adult mammalian central nervous system (CNS), we have analyzed the effects of freezing in the dorsal columns of more than 200 rat spinal cords. The effects of temperature and time of exposure upon the size...

journal_title：Journal of neuropathology and experimental neurology

authors： Collins GH,West NR,Parmely JD,Samson FM,Ward DA

更新日期：1986-11-01 00:00:00

abstract：:The balance between excitatory and inhibitory synaptic inputs is critical for the physiological control of motoneurons. The maintenance of a low-intracellular chloride concentration by the potassium chloride cotransporter 2 (KCC2) is essential for the efficacy of fast synaptic inhibition of mature motoneurons in respo...

journal_title：Journal of neuropathology and experimental neurology

authors： Fuchs A,Ringer C,Bilkei-Gorzo A,Weihe E,Roeper J,Schütz B

更新日期：2010-10-01 00:00:00

abstract：:In order to induce a non-lethal infection restricted to central aminergic neurons projecting to the olfactory bulbs a series of temperature sensitive (ts) and G-protein monoclonal antibody escape mutants of vesicular stomatitis virus (VSV) were instilled into the nasal cavity of mice. In three-week (wk)-old NMRI mice ...

journal_title：Journal of neuropathology and experimental neurology

authors： Lundh B,Löve A,Kristensson K,Norrby E

更新日期：1988-09-01 00:00:00

abstract：:Neuroaxonal dystrophy, a distinctive axonopathy characterized by marked enlargement of distal axons, is the hallmark pathologic alteration in aged and diabetic human prevertebral sympathetic ganglia and in corresponding rodent models. Neuroaxonal dystrophy is thought to represent the abnormal outcome of cycles of syna...

journal_title：Journal of neuropathology and experimental neurology

authors： Schmidt RE,Parvin CA,Green KG

更新日期：2008-12-01 00:00:00

abstract：:Central nervous system (CNS) tissue was studied by immunocytochemistry and electron microscopy from three cases of multiple sclerosis (MS) in which evidence of ongoing myelin breakdown could be documented. The study focussed upon the role of glial cells in the pathogenesis of demyelination. In acute MS, demyelination ...

journal_title：Journal of neuropathology and experimental neurology

authors： Lee SC,Moore GR,Golenwsky G,Raine CS

更新日期：1990-03-01 00:00:00

abstract：:A recent analysis of a group of patients with central pontine myelinolysis (CPM) disclosed that a rapid rise in serum sodium from a hyponatremic baseline preceded the clinical onset of the disorder. To test the view that electrolyte derangements may be crucial in the pathogenesis of CPM, rats were given hypertonic sal...

journal_title：Journal of neuropathology and experimental neurology

authors： Kleinschmidt-DeMasters BK,Norenberg MD

更新日期：1982-01-01 00:00:00

abstract：:The light and electron microscopic features of an unique retroperitoneal ganglioneuroblastoma in a four-year-old female are described. The unprecedented concurrence of Hirano, zebra, membranous cytoplasmic (MCB), and Pick bodies in the same population of neoplastic, sympathetic ganglion cells provides further evidence...

journal_title：Journal of neuropathology and experimental neurology

authors： Powers JM,Balentine JD,Wiśniewski HM,Terry RD

更新日期：1976-01-01 00:00:00

abstract：:Neuron-derived molecules are potent regulators of oligodendrocyte differentiation and myelination during brain development and upon demyelination. Their analysis will thus contribute to understanding remyelination failure in demyelinating diseases, such as multiple sclerosis (MS). Previously, we have identified neuron...

journal_title：Journal of neuropathology and experimental neurology

authors： de Jong CGHM,Stancic M,Pinxterhuis TH,van Horssen J,van Dam AM,Gabius HJ,Baron W

更新日期：2018-11-01 00:00:00

abstract：:Recent studies highlight the importance of BRAF alterations resulting in mitogen activated protein kinase (MAK/ERK) pathway activation in low-grade CNS tumors. We studied 106 low-grade CNS neoplasms in a cohort of primarily pediatric patients to identify the prevalence and clinicopathologic significance of these alter...

journal_title：Journal of neuropathology and experimental neurology

authors： Lin A,Rodriguez FJ,Karajannis MA,Williams SC,Legault G,Zagzag D,Burger PC,Allen JC,Eberhart CG,Bar EE

更新日期：2012-01-01 00:00:00

abstract：:We report a novel case of a World Health Organization grade 3 anaplastic meningioma arising from the olfactory groove in an 83-year-old woman. Molecular and methylation profiling confirm this lesion to be an NF2 subtype, methylation class intermediate type B meningioma. As most meningiomas in this location are indolen...

journal_title：Journal of neuropathology and experimental neurology

authors： Foo ASC,Tan DTM,Tan CL,Sahm F,von Deimling A,Yeo TT

更新日期：2017-12-01 00:00:00

abstract：:Reactive axonal change has long been recognized as a feature of traumatic brain injury. To date, the histological methods used to identify reactive axons have been of limited utility, and they have not provided insight into the initial intraaxonal event that triggers reactive change. In this investigation, monoclonal ...

journal_title：Journal of neuropathology and experimental neurology

authors： Yaghmai A,Povlishock J

更新日期：1992-03-01 00:00:00

abstract：:The diagnosis of Alzheimer disease (AD) according to current criteria is a combined clinical and pathological exercise. The clinical discrimination of AD from other types of dementia may be complicated when the patient suffers from more than one disease. In particular the concomitant presence of other neurological con...

journal_title：Journal of neuropathology and experimental neurology

authors： Nagy Z,Esiri MM,Jobst KA,Morris JH,King EM,McDonald B,Joachim C,Litchfield S,Barnetson L,Smith AD

更新日期：1997-02-01 00:00:00

abstract：:A working group supported by the Office of Rare Diseases of the National Institutes of Health formulated neuropathologic criteria for corticobasal degeneration (CBD) that were subsequently validated by an independent group of neuropathologists. The criteria do not require a specific clinical phenotype, since CBD can h...

journal_title：Journal of neuropathology and experimental neurology

authors： Dickson DW,Bergeron C,Chin SS,Duyckaerts C,Horoupian D,Ikeda K,Jellinger K,Lantos PL,Lippa CF,Mirra SS,Tabaton M,Vonsattel JP,Wakabayashi K,Litvan I,Office of Rare Diseases of the National Institutes of Health.

更新日期：2002-11-01 00:00:00

abstract：:1,25-dihydroxyvitamin D3 (1,25-D3) is already known to prevent clinical signs of experimental allergic encephalomyelitis when animals are treated during the immunization phase. In the present work we have evaluated the ability of 1,25-D3 to inhibit chronic relapsing experimental allergic encephalomylitis (EAE) of the ...

journal_title：Journal of neuropathology and experimental neurology

authors： Nataf S,Garcion E,Darcy F,Chabannes D,Muller JY,Brachet P

更新日期：1996-08-01 00:00:00

abstract：:Brain aging is accompanied by increased oxidative stress and what has been termed "neuroinflammation," which might contribute to age-related neurodegenerative diseases. We analyzed expression in the transcription of innate inflammatory response genes in eleven representative regions including frontal, parietal, inferi...

journal_title：Journal of neuropathology and experimental neurology

authors： López-González I,Tebé Cordomí C,Ferrer I

更新日期：2017-02-01 00:00:00