Abstract：
:Immune mechanisms have been increasingly recognized in the pathogenesis of hippocampal sclerosis (HS), but infiltration of cytotoxic T-cells and its pathological significance in patients with HS has not been explored. We examined 30 cases of surgically resected hippocampi, including 16 International League Against Epilepsy (ILAE) type 1, 9 ILAE type 2, 1 ILAE type 3 HS, and 4 ILAE No-HS, as well as 6 autopsy No-HS hippocampi. The HS hippocampi showed sparse to scattered CD8-positive T-cells, rare CD4-positive T-cells, and a modest increase in CD68-positive microglia/macrophages, which were significantly more numerous than those in the No-HS controls. The infiltration of CD8-positive T-cells was significantly greater in the CA1 subfield than other subfields of type 1 and type 2 HS. The numbers of CD8-positive T-cells positively correlated with those of CD4-positive T-cells; there was a lower ratio of CD4/CD8-positive T-cells. There were positive correlations between these cells and scores of neuronal loss but no significant correlation between the infiltration of these cells and epilepsy disease duration or age of epilepsy onset. These findings suggest that an autoimmune process may be involved in the pathogenesis of HS and infiltration of immune cells, particularly CD8-positive cytotoxic T-cells, may contribute to neuronal loss in HS.
journal_name
J Neuropathol Exp Neuroljournal_title
Journal of neuropathology and experimental neurologyauthors
Lu JQ,Steve TA,Wheatley M,Gross DWdoi
10.1093/jnen/nlx001subject
Has Abstractpub_date
2017-03-01 00:00:00pages
206-215issue
3eissn
0022-3069issn
1554-6578pii
3072055journal_volume
76pub_type
杂志文章abstract：:Borna disease virus (BDV) replicates only in cells in the central (CNS) and peripheral (PNS) nervous system in adult rats. Infection of the nervous system is associated with a transient, intense mononuclear meningoencephalitis and immunemediated loss of BDV-infected neurons. The identification of BDV antigen in neuron...
journal_title：Journal of neuropathology and experimental neurology
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doi：10.1097/00005072-198911000-00005
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journal_title：Journal of neuropathology and experimental neurology
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journal_title：Journal of neuropathology and experimental neurology
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更新日期：2010-10-01 00:00:00
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journal_title：Journal of neuropathology and experimental neurology
pub_type： 杂志文章
doi：10.1097/NEN.0b013e3182a79de9
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abstract：:The brainstem and cervical spinal cord were sampled from 45 cases of sudden infant death syndrome (SIDS), from 17 control cases without neurological disease, and from three negative control cases with abnormal growth of the central nervous system (36-98 postconceptional weeks). Morphometric analyses were performed on ...
journal_title：Journal of neuropathology and experimental neurology
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doi：
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journal_title：Journal of neuropathology and experimental neurology
pub_type： 杂志文章
doi：10.1097/NEN.0b013e3181da84db
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journal_title：Journal of neuropathology and experimental neurology
pub_type： 杂志文章
doi：10.1097/00005072-199906000-00004
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journal_title：Journal of neuropathology and experimental neurology
pub_type： 杂志文章
doi：10.1093/jnen/nly100
更新日期：2018-12-01 00:00:00
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pub_type： 杂志文章,评审
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journal_title：Journal of neuropathology and experimental neurology
pub_type： 杂志文章
doi：10.1097/00005072-198609000-00003
更新日期：1986-09-01 00:00:00
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journal_title：Journal of neuropathology and experimental neurology
pub_type： 杂志文章
doi：10.1097/00005072-199401000-00007
更新日期：1994-01-01 00:00:00
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journal_title：Journal of neuropathology and experimental neurology
pub_type： 杂志文章
doi：10.1097/nen.0b013e31802d9011
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journal_title：Journal of neuropathology and experimental neurology
pub_type： 杂志文章
doi：10.1097/00005072-197503000-00005
更新日期：1975-03-01 00:00:00
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journal_title：Journal of neuropathology and experimental neurology
pub_type： 杂志文章
doi：10.1097/00005072-198503000-00009
更新日期：1985-03-01 00:00:00
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journal_title：Journal of neuropathology and experimental neurology
pub_type： 杂志文章,评审
doi：10.1097/00005072-199205000-00001
更新日期：1992-05-01 00:00:00
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journal_title：Journal of neuropathology and experimental neurology
pub_type： 杂志文章
doi：10.1097/NEN.0b013e3182020b7b
更新日期：2011-01-01 00:00:00
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journal_title：Journal of neuropathology and experimental neurology
pub_type： 杂志文章
doi：10.1093/jnen/nly081
更新日期：2018-11-01 00:00:00
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journal_title：Journal of neuropathology and experimental neurology
pub_type： 杂志文章
doi：10.1097/NEN.0000000000000047
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journal_title：Journal of neuropathology and experimental neurology
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journal_title：Journal of neuropathology and experimental neurology
pub_type： 杂志文章,评审
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journal_title：Journal of neuropathology and experimental neurology
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journal_title：Journal of neuropathology and experimental neurology
pub_type： 杂志文章
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更新日期：2010-01-01 00:00:00
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journal_title：Journal of neuropathology and experimental neurology
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journal_title：Journal of neuropathology and experimental neurology
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doi：10.1097/00005072-199305000-00006
更新日期：1993-05-01 00:00:00
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journal_title：Journal of neuropathology and experimental neurology
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doi：10.1097/NEN.0b013e318177e5fd
更新日期：2008-06-01 00:00:00
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journal_title：Journal of neuropathology and experimental neurology
pub_type： 杂志文章
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更新日期：2006-08-01 00:00:00
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journal_title：Journal of neuropathology and experimental neurology
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更新日期：2013-03-01 00:00:00
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journal_title：Journal of neuropathology and experimental neurology
pub_type： 杂志文章
doi：10.1097/00005072-197907000-00006
更新日期：1979-07-01 00:00:00
abstract：:Sequential immunocytochemical double labeling of glial fibrillary acidic protein (GFAP) and transferrin (Tf) was used for the simultaneous identification of astrocytes and oligodendrocytes in paraffin-embedded sections of the rat brain. Paraformaldehyde or formalin-alcohol-acetic acid fixation followed by protease tre...
journal_title：Journal of neuropathology and experimental neurology
pub_type： 杂志文章
doi：10.1097/00005072-199103000-00007
更新日期：1991-03-01 00:00:00
abstract：:Neuropathologic examination of 3 patients with Alzheimer disease in the Elan Pharmaceuticals trial using antibodies specific for different Abeta species showed in one case, 4 months after the immunization, evidence of a stage of active plaque clearance with "moth-eaten" plaques and abundant Abeta phagocytosis by micro...
journal_title：Journal of neuropathology and experimental neurology
pub_type： 杂志文章,多中心研究
doi：10.1097/01.jnen.0000240466.10758.ce
更新日期：2006-11-01 00:00:00
