Abstract：
:Cortical lesions (CLs) are an important component of multiple sclerosis (MS) pathology; they correlate better with physical disability and cognitive impairment than white matter lesions (WMLs). Because remyelination can be extensive in CLs, we quantified remyelination in gray matter (GM) and white matter (WM), addressing oligodendrocyte (OGD) maturation state and clinical relevance of remyelination. Brain tissue samples from 21 chronic MS patients were immunohistochemically stained for myelin proteolipid protein, Olig2, which is strongly expressed in OGD precursor cells (OPCs), but weakly expressed in mature OGDs and other OGD markers. Sections were scored for the presence of normal-appearing WM and GM, de- and remyelination, and OPC and OGD cell counts. Remyelination was significantly more extensive in CLs than in WMLs with a trend toward more GM remyelination in primary progressive MS (PPMS) vs relapse-onset MS patients. More OPCs were found in remyelinated and nonremyelinated CLs vs remyelinated WMLs and nonremyelinated WMLs. Thus, there is more remyelination in the GM than in the WM in MS patient brains, with a trend toward more remyelination in those with PPMS. There does not seem to be a significant OPC recruitment failure in the GM, which casts new light on the process of remyelination failure.
journal_name
J Neuropathol Exp Neuroljournal_title
Journal of neuropathology and experimental neurologyauthors
Strijbis EMM,Kooi EJ,van der Valk P,Geurts JJGdoi
10.1093/jnen/nlx023subject
Has Abstractpub_date
2017-05-01 00:00:00pages
390-401issue
5eissn
0022-3069issn
1554-6578pii
3828779journal_volume
76pub_type
杂志文章abstract：:The effects of regional heterogeneity on the accuracy of histological grading of gliomas are well known, but little has been reported about its implications for other diagnostic modalities. This study investigated the relationships of regional heterogeneity in tumor proliferative activity, measured by Ki-67 labeling i...
journal_title：Journal of neuropathology and experimental neurology
pub_type： 杂志文章
doi：10.1097/00005072-199311000-00008
更新日期：1993-11-01 00:00:00
abstract：:During brain development and blood-brain barrier (BBB) differentiation the expression of P-glycoprotein (P-gp) may complement the protective function of the placental barrier against xenobiotic substances. To establish an immunohistochemical procedure for P-gp detection, different anti-P-gp monoclonal antibodies were ...
journal_title：Journal of neuropathology and experimental neurology
pub_type： 杂志文章
doi：10.1097/nen.0b013e31815f65d9
更新日期：2008-01-01 00:00:00
abstract：:Peripheral polyneuropathies are common and their diagnosis may be challenging. We compared the results from sural-nerve and skin biopsies in 33 patients with a polyneuropathy and neuropathic pain examined in our hospital over a 6-year period. The biopsies were all from the same lower limb of each patient. Intraepiderm...
journal_title：Journal of neuropathology and experimental neurology
pub_type： 杂志文章
doi：10.1093/jnen/nlv005
更新日期：2016-01-01 00:00:00
abstract：:Systemically-administered inorganic mercury localizes to motor neurons, but it is not known if mercury injures these neurons. We therefore looked for signs of damage to the motor and sensory neurons of mice that had been exposed to inorganic mercury. Young adult mice were injected intraperitoneally with either 1 or 2 ...
journal_title：Journal of neuropathology and experimental neurology
pub_type： 杂志文章
doi：10.1097/00005072-199804000-00009
更新日期：1998-04-01 00:00:00
abstract：:A recent analysis of a group of patients with central pontine myelinolysis (CPM) disclosed that a rapid rise in serum sodium from a hyponatremic baseline preceded the clinical onset of the disorder. To test the view that electrolyte derangements may be crucial in the pathogenesis of CPM, rats were given hypertonic sal...
journal_title：Journal of neuropathology and experimental neurology
pub_type： 杂志文章
doi：10.1097/00005072-198201000-00007
更新日期：1982-01-01 00:00:00
abstract：:Frontotemporal dementia with parkinsonism (FTDP-17) is an autosomal dominant disorder that presents clinically with dementia, extrapyramidal signs, and behavioral disturbances in mid-life and progresses to death within 5 to 10 years. Pathologically, the disorder is characterized by variable neuronal loss and gliosis i...
journal_title：Journal of neuropathology and experimental neurology
pub_type： 杂志文章
doi：10.1097/00005072-199908000-00008
更新日期：1999-08-01 00:00:00
abstract：:LR11 is an ApoE receptor that is enriched in the brain. We have shown that LR11 is markedly downregulated in patients with sporadic Alzheimer disease (AD). This finding led us to explore whether reduced LR11 expression reflects a primary mechanism of disease or merely a secondary consequence of other AD-associated cha...
journal_title：Journal of neuropathology and experimental neurology
pub_type： 杂志文章
doi：10.1097/01.jnen.0000228205.19915.20
更新日期：2006-09-01 00:00:00
abstract：:White matter hyperintensities (WMH) are prevalent. Although arteriolar disease has been implicated in their pathogenesis, venous pathology warrants consideration. We investigated relationships of WMH with histologic venous, arteriolar and white matter abnormalities and correlated findings with premortem neuroimaging. ...
journal_title：Journal of neuropathology and experimental neurology
pub_type： 杂志文章
doi：10.1093/jnen/nlx009
更新日期：2017-04-01 00:00:00
abstract：:Histological examination by light and electron microscopy of the spinal cords of four dogs rapidly perfusion-fixed after the onset of decompression sickness revealed the presence of numerous non-staining, space-occupying lesions that were absent in similarly prepared sections of control or ischemic spinal cords. We pr...
journal_title：Journal of neuropathology and experimental neurology
pub_type： 杂志文章
doi：10.1097/00005072-198807000-00008
更新日期：1988-07-01 00:00:00
abstract：:This is the fourth recorded patient with extension of syringomyelia into the brain rostral to the mesencephalon verified at autopsy. A syrinx was demonstrated from the low thoracic segments of the spinal cord to the cervico-medullary junction, where a fibrovascular malformation and dural-arachnoid adhesions deformed t...
journal_title：Journal of neuropathology and experimental neurology
pub_type： 杂志文章
doi：10.1097/00005072-198111000-00005
更新日期：1981-11-01 00:00:00
abstract：:This study explores the biochemical basis that may distinguish neurologic and nonneurologic forms of Gaucher's disease. Crude membrane preparations from spleens of controls and patients representing the three clinical categories of Gaucher's disease were delipidated by extraction with sodium cholate and n-butanol. Tot...
journal_title：Journal of neuropathology and experimental neurology
pub_type： 杂志文章
doi：10.1097/00005072-198211000-00006
更新日期：1982-11-01 00:00:00
abstract：:Much of the morbidity after traumatic brain injury (TBI) is associated with traumatic axonal injury (TAI). Although most TAI studies focus on corpus callosum white matter, the visual system has received increased interest. To assess visual system TAI, we developed a mouse model of optic nerve TAI. It is unknown, howev...
journal_title：Journal of neuropathology and experimental neurology
pub_type： 杂志文章
doi：10.1097/NEN.0b013e31829d8d9d
更新日期：2013-08-01 00:00:00
abstract：:Nicotinic acetylcholine receptors (nAChRs) mediate fast synaptic transmission in autonomic ganglia, which innervate and control the activity of most visceral organs. By combining ultrastructural, immunocytochemical, and pharmacological analyses, we characterized the nAChR subtypes in the rat superior cervical ganglion...
journal_title：Journal of neuropathology and experimental neurology
pub_type： 杂志文章
doi：10.1093/jnen/63.2.138
更新日期：2004-02-01 00:00:00
abstract：:The relevance of cerebral amyloid angiopathy (CAA) to the pathogenesis of Alzheimer disease (AD) and dementia in general emphasizes the importance of developing novel targeting approaches for detecting and treating cerebrovascular amyloid (CVA) deposits. We developed a nanoparticle-based technology that uses a monoclo...
journal_title：Journal of neuropathology and experimental neurology
pub_type： 杂志文章
doi：10.1097/NEN.0b013e318225038c
更新日期：2011-08-01 00:00:00
abstract：:Spirochetal infections are an important cause of neurological disease. In previous studies of the pathogenesis of spirochetal brain infection, mice inoculated with Borrelia turicatae, an agent of tick-borne relapsing fever in North America, developed mild meningitis and parenchymal activation/infiltration by interleuk...
journal_title：Journal of neuropathology and experimental neurology
pub_type： 杂志文章
doi：10.1097/NEN.0b013e318187a279
更新日期：2008-10-01 00:00:00
abstract：:The role of regenerating axons in the restructuring of the endoneurium into minifascicles after peripheral nerve injury was investigated. Endoneurial changes were studied in the control distal stumps of crushed rat sciatic nerves and in the distal nerve stumps in which, in addition to other cellular elements, the orig...
journal_title：Journal of neuropathology and experimental neurology
pub_type： 杂志文章
doi：10.1097/00005072-199411000-00006
更新日期：1994-11-01 00:00:00
abstract：:Histopathologic evaluation of brain tissue derived from surgically treated patients with medically refractory temporal lobe epilepsy (TLE) frequently reveals structural brain lesions in the surgical specimen. While several of the most commonly encountered lesions such as low-grade neoplasms or vascular malformations a...
journal_title：Journal of neuropathology and experimental neurology
pub_type： 杂志文章
doi：10.1097/00005072-199901000-00003
更新日期：1999-01-01 00:00:00
abstract：:We describe the clinical, pathological, ultrastructural and biochemical features in the case of a 15-year-old boy with multiple sulfatase deficiency. Clinical abnormalities included hypotonia, retarded psychomotor development, hepatosplenomegaly, pigmentary degeneration of the retina, myoclonic seizures, aortic insuff...
journal_title：Journal of neuropathology and experimental neurology
pub_type： 杂志文章,评审
doi：10.1097/00005072-199007000-00005
更新日期：1990-07-01 00:00:00
abstract：:During the Zika epidemic in Brazil, a baby was born at term with microcephaly and arthrogryposis. The mother had Zika symptoms at 10 weeks of gestation. At 17 weeks, ultrasound showed cerebral malformation and ventriculomegaly. At 24 weeks, the amniotic fluid contained ZIKV RNA and at birth, placenta and maternal bloo...
journal_title：Journal of neuropathology and experimental neurology
pub_type： 杂志文章
doi：10.1093/jnen/nlx116
更新日期：2018-03-01 00:00:00
abstract：:The DNA repair protein O6-methylguanine-DNA methyltransferase (MGMT) removes temozolomide-induced alkylation, thereby preventing DNA damage and cytotoxicity. We investigated the prognostic effect of different MGMT methylation levels on overall and progression-free survival in 327 patients with primary glioblastoma und...
journal_title：Journal of neuropathology and experimental neurology
pub_type： 杂志文章
doi：10.1093/jnen/nlz032
更新日期：2019-07-01 00:00:00
abstract：:The role of anti-myelin antibodies in the pathogenesis of experimental autoimmune neuritis (EAN) induced in the Lewis rat by immunization with peripheral nerve myelin has been assessed. Passive transfer with lymph node cells (LNC) or purified serum immunoglobulin from rats with EAN was employed to directly measure the...
journal_title：Journal of neuropathology and experimental neurology
pub_type： 杂志文章
doi：10.1093/jnen/60.6.637
更新日期：2001-06-01 00:00:00
abstract：:The phenotypic identities and characterization of neural networks disrupted after neonatal hypoxia-ischemia (HI) in the preterm brain remain to be elucidated. Interruption of the central serotonergic (5-hydroxytryptamine [5-HT]) system can lead to numerous functional deficits, many of which match those in human preter...
journal_title：Journal of neuropathology and experimental neurology
pub_type： 杂志文章
doi：10.1097/NEN.0b013e3182020b7b
更新日期：2011-01-01 00:00:00
abstract：:Aberrant epidermal growth factor receptor (EGFR) expression promotes the pathogenesis of malignant peripheral nerve sheath tumors (MPNSTs), the most common malignancy associated with neurofibromatosis type 1, but the mechanisms by which EGFR expression promotes MPNST pathogenesis are poorly understood. We hypothesized...
journal_title：Journal of neuropathology and experimental neurology
pub_type： 杂志文章
doi：10.1097/NEN.0b013e3182859939
更新日期：2013-03-01 00:00:00
abstract：:Shigella dysenteriae strains produce an exotoxin (SdT) which inhibits protein synthesis in susceptible cells and is neurotoxic in some species. Intraneural microinjection of highly purified SdT into the cervical vagus nerves of rats, mice, guinea pigs and rabbits produced cytopathic changes within 24 hours in vagal se...
journal_title：Journal of neuropathology and experimental neurology
pub_type： 杂志文章
doi：10.1097/00005072-198509000-00005
更新日期：1985-09-01 00:00:00
abstract：:A working group supported by the Office of Rare Diseases of the National Institutes of Health formulated neuropathologic criteria for corticobasal degeneration (CBD) that were subsequently validated by an independent group of neuropathologists. The criteria do not require a specific clinical phenotype, since CBD can h...
journal_title：Journal of neuropathology and experimental neurology
pub_type： 指南,杂志文章,实务指引
doi：10.1093/jnen/61.11.935
更新日期：2002-11-01 00:00:00
abstract：:Diabetic polyneuropathy (DPN) shows more severe functional and structural changes in type 1 than in type 2 human and experimental diabetes. We have previously suggested that these differences may be due to insulin and/or C-peptide deficiencies in type 1 diabetes. To further explore these differences between type I and...
journal_title：Journal of neuropathology and experimental neurology
pub_type： 杂志文章
doi：10.1093/jnen/62.3.260
更新日期：2003-03-01 00:00:00
abstract：:Mucopolysaccharidosis IIID (MPS IIID) is one of the rarest of the MPS-III syndromes. To date, the clinical manifestations of 10 patients have been reported, the deficient N-acetylglucosamine 6-sulfatase (G6S) enzyme has been purified, and the G6S gene has been cloned, sequenced and localized. However, morphological ma...
journal_title：Journal of neuropathology and experimental neurology
pub_type： 杂志文章,评审
doi：
更新日期：1997-10-01 00:00:00
abstract：:A series of 43 human gliomas, consisting of 30 glioblastomas, 7 anaplastic astrocytomas, 3 low grade astrocytomas, 2 ependymomas, and 1 oligodendroglioma, was studied for amplification of the epidermal growth factor receptor (EGFR) and mouse double minute 2 (MDM2) genes. DNA extracted from formalin-fixed, paraffin-emb...
journal_title：Journal of neuropathology and experimental neurology
pub_type： 杂志文章
doi：10.1097/00005072-199501000-00007
更新日期：1995-01-01 00:00:00
abstract：:Brain parenchymal involvement of mycosis fungoides (MF) is very rare. This study reports a patient with known cutaneous MF (under treatment) who presented with a CNS syndrome and multiple brain lesions. Brain biopsy demonstrated massive eosinophilic infiltrates but no MF cells. Despite treatment, new lesions developed...
journal_title：Journal of neuropathology and experimental neurology
pub_type： 杂志文章
doi：10.1097/NEN.0000000000000245
更新日期：2015-10-01 00:00:00
abstract：:The occurrence of neuroinflammation after spinal cord injury (SCI) is well established, but its function is debated, with both beneficial and detrimental consequences ascribed. A discriminate of the role of neuroinflammation may be the time period after SCI, and there is evidence to favor early neuroinflammation being...
journal_title：Journal of neuropathology and experimental neurology
pub_type： 杂志文章
doi：10.1097/01.jnen.0000248552.07338.7f
更新日期：2007-03-01 00:00:00
