Stereological analysis of cerebral atrophy in human immunodeficiency virus-associated dementia.

abstract：:The light and electron microscopic features of an unique retroperitoneal ganglioneuroblastoma in a four-year-old female are described. The unprecedented concurrence of Hirano, zebra, membranous cytoplasmic (MCB), and Pick bodies in the same population of neoplastic, sympathetic ganglion cells provides further evidence...

journal_title：Journal of neuropathology and experimental neurology

authors： Powers JM,Balentine JD,Wiśniewski HM,Terry RD

更新日期：1976-01-01 00:00:00

abstract：:Systemically-administered inorganic mercury localizes to motor neurons, but it is not known if mercury injures these neurons. We therefore looked for signs of damage to the motor and sensory neurons of mice that had been exposed to inorganic mercury. Young adult mice were injected intraperitoneally with either 1 or 2 ...

journal_title：Journal of neuropathology and experimental neurology

authors： Pamphlett R,Png FY

更新日期：1998-04-01 00:00:00

abstract：:In situ hybridization (ISH) for JC virus (JCV) is generally applied for the diagnosis of progressive multifocal leukoencephalopathy (PML). To explore the usefulness of immunohistochemistry (IHC) for JCV early proteins, 14 paraffin-embedded postmortem brain specimens with histologic features compatible with PML were te...

journal_title：Journal of neuropathology and experimental neurology

authors： Muñoz-Mármol AM,Mola G,Fernández-Vasalo A,Vela E,Mate JL,Ariza A

更新日期：2004-11-01 00:00:00

abstract：:Mutations in the leucine-rich repeat kinase 2 gene (LRRK2) have been recently identified in families with autosomal-dominant late-onset Parkinson disease. We report that by reverse transcriptase-polymerase chain reaction, the mRNA of LRRK2 is expressed in soluble extracts of human brain, liver, and heart and in cultur...

journal_title：Journal of neuropathology and experimental neurology

authors： Miklossy J,Arai T,Guo JP,Klegeris A,Yu S,McGeer EG,McGeer PL

更新日期：2006-10-01 00:00:00

abstract：:Much of the morbidity after traumatic brain injury (TBI) is associated with traumatic axonal injury (TAI). Although most TAI studies focus on corpus callosum white matter, the visual system has received increased interest. To assess visual system TAI, we developed a mouse model of optic nerve TAI. It is unknown, howev...

journal_title：Journal of neuropathology and experimental neurology

authors： Wang J,Fox MA,Povlishock JT

更新日期：2013-08-01 00:00:00

abstract：:Injury to neonatal nerves, unlike adult nerves, results in poor regeneration and extensive motoneuron death. We examined whether exposure to a more mature nerve environment could rescue axotomized motoneurons following neonatal injury. The sciatic nerve in 1 hindlimb of 3-day-old (P3) rats was transected and the cut e...

journal_title：Journal of neuropathology and experimental neurology

authors： Low HL,Nogradi A,Vrbová G,Greensmith L

更新日期：2003-01-01 00:00:00

abstract：:We investigated whether antibody production to antigens arising in the subarachnoid space is depressed acutely after spinal cord injury (SCI), and whether such depression is due to abnormal catecholamine levels. To assess antibody responses, ovalbumin (OVA) was injected into the spinal subarachnoid space (i.t.) of rat...

journal_title：Journal of neuropathology and experimental neurology

authors： Vega JL,Ganea D,Jonakait GM

更新日期：2003-08-01 00:00:00

abstract：:The age-related change in the neuronal RNA content, volume, and the RNA concentration of 2,160 single cell bodies was examined from the prefrontal cortex. Human brains from 15 normal and 3 demented patients of ages ranging from 8 months to 94 years were obtained at post-mortem examination. The neuronal RNA showed an a...

journal_title：Journal of neuropathology and experimental neurology

authors： Uemura E,Hartmann HA

更新日期：1978-09-01 00:00:00

abstract：:A stereological estimation of nuclear volume in recurrent and non-recurrent meningiomas was made. The aim was to investigate whether this method could discriminate between these two groups. We found that the mean nuclear volumes in recurrent meningiomas were all larger at debut than in any of the control tumors. The m...

journal_title：Journal of neuropathology and experimental neurology

authors： Madsen C,Schrøder HD

更新日期：1994-05-01 00:00:00

abstract：:It is recognized that IDH mutation negative, low-grade epilepsy associated tumors (LEAT) can show diffuse growth patterns and lack the diagnostic hallmarks of either classical dysembryoplastic neuroepithelial tumors (DNT) or typical ganglioglioma. "Nonspecific or diffuse DNT" and more recently "polymorphous low-grade ...

journal_title：Journal of neuropathology and experimental neurology

authors： Al-Hajri A,Al-Mughairi S,Somani A,An S,Liu J,Miserocchi A,McEvoy AW,Yousry T,Hoskote C,Thom M

更新日期：2017-12-01 00:00:00

abstract：:The tau deposits found in neurodegenerative diseases are classified based on their isoforms, that is, 3-repeat (3R) tau and 4-repeat (4R) tau. These isoforms are distinguishable using the antibodies RD3 and RD4, respectively, and Gallyas (Gal) and Campbell-Switzer (CS) silver staining methods, respectively. Tau is als...

journal_title：Journal of neuropathology and experimental neurology

authors： Ichihara K,Uchihara T,Nakamura A,Suzuki Y,Mizutani T

更新日期：2009-09-01 00:00:00

abstract：:The presence of diffuse or primitive senile plaques in the neocortex of cognitively normal elderly at autopsy has been presumed to represent normal aging. Alternatively, these patients may have developed dementia and clinical Alzheimer disease (AD) if they had survived. In this setting, these patients could be subject...

journal_title：Journal of neuropathology and experimental neurology

authors： Hulette CM,Welsh-Bohmer KA,Murray MG,Saunders AM,Mash DC,McIntyre LM

更新日期：1998-12-01 00:00:00

abstract：:Prolonged deprivation of vitamin B12 in rhesus monkeys produced changes in the central nervous system that were indistinguishable topographically and histologically from those of human subacute combined degeneration. Ultrastructural studies of early lesions of the spinal cord disclosed a degeneration of myelin charact...

journal_title：Journal of neuropathology and experimental neurology

authors： Agamanolis DP,Victor M,Harris JW,Hines JD,Chester EM,Kark JA

更新日期：1978-05-01 00:00:00

abstract：:Spinal muscular atrophy (SMA) is characterized by loss of motor neurons in the spinal cord that results in muscle denervation and profound weakness in affected patients. We sought evidence for primary muscle involvement in the disease during human development by analyzing the expression of several muscle cytoskeletal ...

journal_title：Journal of neuropathology and experimental neurology

authors： Martínez-Hernández R,Bernal S,Alias L,Tizzano EF

更新日期：2014-06-01 00:00:00

abstract：:Lysosomal storage disorders constitute a large group of genetic diseases, many of which are characterized by mental retardation and other neurologic symptoms. The mechanisms of neural dysfunction remain poorly understood. Because neural progenitor cells (NPCs) are fundamentally important to normal brain development an...

journal_title：Journal of neuropathology and experimental neurology

authors： Walton RM,Wolfe JH

更新日期：2007-08-01 00:00:00

abstract：:The presence of intermediate filaments (IF) (diameter 10 nm) is a characteristic electron microscopic finding in the cytoplasm of meningioma cells. To identify these IF, immunohistochemical staining for cytokeratins and vimentin and two-dimensional (2-D) gel electrophoresis followed by immunoblot analysis were applied...

journal_title：Journal of neuropathology and experimental neurology

authors： Halliday WC,Yeger H,Duwe GF,Phillips MJ

更新日期：1985-11-01 00:00:00

abstract：:Neuroaxonal dystrophy, a distinctive axonopathy characterized by marked enlargement of distal axons, is the hallmark pathologic alteration in aged and diabetic human prevertebral sympathetic ganglia and in corresponding rodent models. Neuroaxonal dystrophy is thought to represent the abnormal outcome of cycles of syna...

journal_title：Journal of neuropathology and experimental neurology

authors： Schmidt RE,Parvin CA,Green KG

更新日期：2008-12-01 00:00:00

abstract：:Lhermitte-Duclos disease (LDD) is a rare cerebellar tumor associated with Cowden disease (CD) and germline mutations in the PTEN gene. To further define these relationships, we reviewed clinical and pathologic findings in 31 LDD cases and analyzed the status of the PTEN pathway in 11 of them. We hypothesized that the ...

journal_title：Journal of neuropathology and experimental neurology

authors： Abel TW,Baker SJ,Fraser MM,Tihan T,Nelson JS,Yachnis AT,Bouffard JP,Mena H,Burger PC,Eberhart CG

更新日期：2005-04-01 00:00:00

abstract：:We performed a prospective, longitudinal immunohistochemical study of the spinal cords of transgenic mice with a G93A mutant SOD1 gene at 4 fixed points in time, using antibodies to inducible nitric oxide synthase (iNOS) and nitrotyrosine. The purpose of this study was to characterize the temporal and topographic dist...

journal_title：Journal of neuropathology and experimental neurology

authors： Sasaki S,Warita H,Abe K,Iwata M

更新日期：2001-09-01 00:00:00

abstract：:The occurrence of neuroinflammation after spinal cord injury (SCI) is well established, but its function is debated, with both beneficial and detrimental consequences ascribed. A discriminate of the role of neuroinflammation may be the time period after SCI, and there is evidence to favor early neuroinflammation being...

journal_title：Journal of neuropathology and experimental neurology

authors： Rice T,Larsen J,Rivest S,Yong VW

更新日期：2007-03-01 00:00:00

abstract：:Ischemic brain damage can be prevented or at least significantly reduced when there is a preceding brief ischemic period that does not exceed the threshold for tissue damage--a phenomenon termed "ischemic preconditioning" (ischemic PC). Experimental PC in rodents is now considered to be a model for transient ischemic ...

journal_title：Journal of neuropathology and experimental neurology

authors： Sommer C

更新日期：2008-02-01 00:00:00

abstract：:The evolving neuropathology of primarily undamaged cortical regions adjacent to the injured site has been studied in 36 infants who survived a variety of perinatally acquired encephalopathies (microgyrias, ulegyrias, multicystic encephalopathies, porencephalies, and hydranencephalies) and later died of unrelated cause...

journal_title：Journal of neuropathology and experimental neurology

authors： Marín-Padilla M

更新日期：1999-05-01 00:00:00

abstract：:To evaluate cognitive performance among persons who did and did not develop clinical Alzheimer disease (AD) but had AD neuropathology at autopsy, we examined neuropsychological performance in cognitively healthy (Clinical Dementia Rating [CDR] = 0) participants who returned for at least 1 follow-up and died within 2 y...

journal_title：Journal of neuropathology and experimental neurology

authors： Hassenstab J,Monsell SE,Mock C,Roe CM,Cairns NJ,Morris JC,Kukull W

更新日期：2015-11-01 00:00:00

abstract：:Maternal cigarette smoking during pregnancy is associated with a significantly increased risk of Sudden Infant Death Syndrome (SIDS). This study investigated the effects of prenatal exposure to carbon monoxide (CO), a major component of cigarette smoke, on the neuroglial and neurochemical development of the medulla in...

journal_title：Journal of neuropathology and experimental neurology

authors： Tolcos M,McGregor H,Walker D,Rees S

更新日期：2000-03-01 00:00:00

abstract：:Calpain, a calcium-activated neutral protease family, has been implicated in the neuropathologic sequelae accompanying various neurological disorders. We have characterized the distribution and time course of calpain activation following brain injury in the rat, using a monoclonal antibody that recognizes calpain-gene...

journal_title：Journal of neuropathology and experimental neurology

authors： Saatman KE,Bozyczko-Coyne D,Marcy V,Siman R,McIntosh TK

更新日期：1996-07-01 00:00:00

abstract：:Pilocytic astrocytoma (PA) is the most common glioma of childhood. Despite their relatively high incidence, the molecular mechanisms responsible for tumorigenesis and growth of PA are poorly understood. Previous in vitro studies in our laboratory showed that despite the absence of ErbB1, PA was sensitive to ErbB1 tyro...

journal_title：Journal of neuropathology and experimental neurology

authors： Addo-Yobo SO,Straessle J,Anwar A,Donson AM,Kleinschmidt-Demasters BK,Foreman NK

更新日期：2006-08-01 00:00:00

abstract：:Bcl-2, a cell death suppressor protein, is expressed during brain development but is largely down-regulated in the adult central nervous system. We previously reported strong expression of bcl-2 in small, "oligodendrocyte-like" cells (OLC) found in glioneuronal hamartias. These hamartias are microscopic cell rests fou...

journal_title：Journal of neuropathology and experimental neurology

authors： Yachnis AT,Roper SN,Love A,Fancey JT,Muir D

更新日期：2000-02-01 00:00:00

abstract：:Spirochetal infections are an important cause of neurological disease. In previous studies of the pathogenesis of spirochetal brain infection, mice inoculated with Borrelia turicatae, an agent of tick-borne relapsing fever in North America, developed mild meningitis and parenchymal activation/infiltration by interleuk...

journal_title：Journal of neuropathology and experimental neurology

authors： Londoño D,Carvajal J,Arguelles-Grande C,Marques A,Cadavid D

更新日期：2008-10-01 00:00:00

abstract：:Multiple system atrophy (MSA) is a neurodegenerative disorder that predominantly affects motor-related neuroanatomic structures. The role of microglia in MSA is unknown. To address this issue, we conducted quantitative image studies on the brains from 13 cases of MSA, comprising 8 cerebellar and 5 parkinsonian variant...

journal_title：Journal of neuropathology and experimental neurology

authors： Ishizawa K,Komori T,Sasaki S,Arai N,Mizutani T,Hirose T

更新日期：2004-01-01 00:00:00

abstract：:Cutaneous and leptomeningeal vascular malformations are hallmarks of the Sturge-Weber Syndrome (SWS), resulting in chronic ischemic tissue damage. The mechanisms underlying the pathobiology of these progressive lesions are unknown. Aberrant expression of angiogenic factors has been implicated in the genesis and mainte...

journal_title：Journal of neuropathology and experimental neurology

authors： Comati A,Beck H,Halliday W,Snipes GJ,Plate KH,Acker T

更新日期：2007-01-01 00:00:00