Neuropathological and neuropsychological changes in "normal" aging: evidence for preclinical Alzheimer disease in cognitively normal individuals.

abstract：:Placement of a freezing probe on the skull of neonatal rats produces four-layered microgyria, complete with a lamina dissecans and microsulcus. We studied the developmental course of this induced microgyria under light microscopy by examining changes in neurons, glia, and macrophages following a focal freezing insult ...

journal_title：Journal of neuropathology and experimental neurology

authors： Rosen GD,Press DM,Sherman GF,Galaburda AM

更新日期：1992-11-01 00:00:00

abstract：:Herpes simplex virus type 1 (HSV-1) is the cause of a serious and often fatal encephalitis. Patients who survive herpes simplex encephalitis (HSE) experience behavioral abnormalities including profound cognitive dysfunctions. We have developed a rat model of acute HSE to investigate the cognitive impairments caused by...

journal_title：Journal of neuropathology and experimental neurology

authors： Beers DR,Henkel JS,Schaefer DC,Rose JW,Stroop WG

更新日期：1993-05-01 00:00:00

abstract：:Cerebral accumulation of amyloid-beta (Abeta) is characteristic of Alzheimer disease and of amyloid precursor protein (APP) transgenic mice. Here, we assessed the efficacy of CI-1011, an inhibitor of acyl-coenzyme A:cholesterol acyltransferase, which is suitable for clinical use, in reducing amyloid pathology in both ...

journal_title：Journal of neuropathology and experimental neurology

authors： Huttunen HJ,Havas D,Peach C,Barren C,Duller S,Xia W,Frosch MP,Hutter-Paier B,Windisch M,Kovacs DM

更新日期：2010-08-01 00:00:00

abstract：:X-linked Charcot-Marie-Tooth disease (CMTX) is an inherited demyelinating neuropathy caused by mutations in the gene encoding the gap junction protein connexin32 (Cx32). Despite the identification of over 160 different mutations in the Cx32 coding sequence, it is not known whether the mutations cause the disease manif...

journal_title：Journal of neuropathology and experimental neurology

authors： Abel A,Bone LJ,Messing A,Scherer SS,Fischbeck KH

更新日期：1999-07-01 00:00:00

abstract：:The blood-brain barrier (BBB) is recognized as a barrier to the trafficking of molecules and cellular elements into the central nervous system (CNS). Horseradish peroxidase (HRP) exclusion is used as a measure of BBB integrity. The BBB is altered and becomes permeable during the course of experimental allergic encepha...

journal_title：Journal of neuropathology and experimental neurology

authors： Knobler RL,Marini JC,Goldowitz D,Lublin FD

更新日期：1992-01-01 00:00:00

abstract：:Inclusion body myositis (IBM) is a late-onset inflammatory myopathy with distinctive clinical and histopathological features. The molecular basis for the disease remains unknown, but abnormal nuclear morphology and the accumulation of a protein that binds single-stranded DNA in a sequence-independent fashion suggest a...

journal_title：Journal of neuropathology and experimental neurology

authors： Horvath R,Fu K,Johns T,Genge A,Karpati G,Shoubridge EA

更新日期：1998-05-01 00:00:00

abstract：:TAR DNA-binding protein 43 (TDP-43) is a major component of the inclusions in frontotemporal lobar degeneration with ubiquitinated inclusions (FTLD-U). We studied TDP-43 pathology in the hippocampus and frontal cortex of autopsy brains from patients with FTLD-U (n = 68), dementia lacking distinctive histopathology (n ...

journal_title：Journal of neuropathology and experimental neurology

authors： Hatanpaa KJ,Bigio EH,Cairns NJ,Womack KB,Weintraub S,Morris JC,Foong C,Xiao G,Hladik C,Mantanona TY,White CL 3rd

更新日期：2008-04-01 00:00:00

abstract：:Although stroke is among the most common causes of death and chronic disability worldwide, the proteome of the ischemic human brain remains unknown. Only a few studies have investigated the ischemic brain proteome in rodent stroke models. We performed a proteomic study of the human brain after ischemic stroke using a ...

journal_title：Journal of neuropathology and experimental neurology

authors： Cuadrado E,Rosell A,Colomé N,Hernández-Guillamon M,García-Berrocoso T,Ribo M,Alcazar A,Ortega-Aznar A,Salinas M,Canals F,Montaner J

更新日期：2010-11-01 00:00:00

abstract：:Hereditary gelsolin amyloidosis (AGel amyloidosis) is a systemic disorder reported worldwide in kindreds with a G654A or G654T gelsolin gene mutation. The clinically characteristic peripheral nerve involvement has been poorly characterized morphologically, and its pathogenesis remains unknown. We studied peripheral ne...

journal_title：Journal of neuropathology and experimental neurology

authors： Kiuru-Enari S,Somer H,Seppäläinen AM,Notkola IL,Haltia M

更新日期：2002-06-01 00:00:00

abstract：:This study establishes the sequence of myelination in a population of autopsied infants from birth through the second postnatal year. Myelination was assessed in 62 precisely defined central nervous system (CNS) sites of 162 infants with diverse diseases who were autopsied from 1972 to 1984 at Children's Hospital, Bos...

journal_title：Journal of neuropathology and experimental neurology

authors： Brody BA,Kinney HC,Kloman AS,Gilles FH

更新日期：1987-05-01 00:00:00

abstract：:Nicotinic acetylcholine receptors (nAChRs) mediate fast synaptic transmission in autonomic ganglia, which innervate and control the activity of most visceral organs. By combining ultrastructural, immunocytochemical, and pharmacological analyses, we characterized the nAChR subtypes in the rat superior cervical ganglion...

journal_title：Journal of neuropathology and experimental neurology

authors： Del Signore A,Gotti C,Rizzo A,Moretti M,Paggi P

更新日期：2004-02-01 00:00:00

abstract：:Neurofibromatosis 2 (NF2), a dominantly inherited disorder, is typically manifested as bilateral vestibular Schwannomas and predisposes to other nervous system tumors. Vestibular Schwannomas also occur sporadically but the onset is usually at an older age. Surgical and histological studies have shown that vestibular S...

journal_title：Journal of neuropathology and experimental neurology

authors： Antinheimo J,Haapasalo H,Seppälä M,Sainio M,Carpen O,Jääskeläinen J

更新日期：1995-11-01 00:00:00

abstract：:Peripheral polyneuropathies are common and their diagnosis may be challenging. We compared the results from sural-nerve and skin biopsies in 33 patients with a polyneuropathy and neuropathic pain examined in our hospital over a 6-year period. The biopsies were all from the same lower limb of each patient. Intraepiderm...

journal_title：Journal of neuropathology and experimental neurology

authors： Duchesne M,Magy L,Richard L,Ingrand P,Neau JP,Mathis S,Vallat JM

更新日期：2016-01-01 00:00:00

abstract：:Neuron loss, synaptic decline, and spongiform change are the hallmarks of sporadic Creutzfeldt-Jakob disease (sCJD), and may be related to deficiencies in mitochondria, energy metabolism, and protein synthesis. To investigate these relationships, we determined the expression levels of genes encoding subunits of the 5 ...

journal_title：Journal of neuropathology and experimental neurology

authors： Ansoleaga B,Garcia-Esparcia P,Llorens F,Hernández-Ortega K,Carmona Tech M,Antonio Del Rio J,Zerr I,Ferrer I

更新日期：2016-08-01 00:00:00

abstract：:Cell adhesion molecules participate in target-effector cell interactions in cell-mediated cytotoxicity and in leukodiapedesis in inflammatory diseases. Two ligand-receptor pairs may play a role in the adhesion of cytotoxic T cells to their targets: 1) intercellular adhesion molecule-1 (ICAM-1) and lymphocyte function-...

journal_title：Journal of neuropathology and experimental neurology

authors： De Bleecker JL,Engel AG

更新日期：1994-07-01 00:00:00

abstract：:An experimental neuropathy in rats produced by tying loosely constrictive ligatures around one sciatic nerve has recently been shown to produce pain-related behavior that follows a reproducible time course. In the present study, we assessed the degree of thermal hyperesthesia and examined the sciatic nerves by light a...

journal_title：Journal of neuropathology and experimental neurology

authors： Sommer C,Galbraith JA,Heckman HM,Myers RR

更新日期：1993-05-01 00:00:00

abstract：:Aberrant axonal reorganization and altered distribution of neurotransmitter receptor subtypes have been proposed as major pathogenic mechanisms for hippocampal hyperexcitability in chronic temporal lobe epilepsies (TLE). Recent data point to excitatory class I metabotropic glutamate receptors (mGluR1 and mGluR5) as in...

journal_title：Journal of neuropathology and experimental neurology

authors： Blümcke I,Becker AJ,Klein C,Scheiwe C,Lie AA,Beck H,Waha A,Friedl MG,Kuhn R,Emson P,Elger C,Wiestler OD

更新日期：2000-01-01 00:00:00

abstract：:Increasing evidence has demonstrated a vital role of microRNAs (miRNAs) in diverse biological processes. However, their functions in developing brain with hypoxia-ischemia (HI) remain largely unknown. Through a miRNA microarray analysis in a P10 rat model of cerebral HI, we found that miR-30d-5p was one of the most de...

journal_title：Journal of neuropathology and experimental neurology

authors： Zhao F,Qu Y,Zhu J,Zhang L,Huang L,Liu H,Li S,Mu D

更新日期：2017-08-01 00:00:00

abstract：:There are phenotypic and functional differences between vascular endothelium from different tissues and between microvascular and macrovascular endothelial cells (ECs) from the same tissue. Relatively little is known about the human blood-nerve barrier (BNB). We report the development of an in vitro BNB model using pr...

journal_title：Journal of neuropathology and experimental neurology

authors： Yosef N,Xia RH,Ubogu EE

更新日期：2010-01-01 00:00:00

abstract：:To determine whether arterial wall degeneration, in combination with hemodynamic insult, causes cerebral artery aneurysms in a dog model, we simulated the geometry and hemodynamics of a human artery by surgical reconstruction of both common carotid arteries in 12 dogs. The dogs were then randomly assigned to one of th...

journal_title：Journal of neuropathology and experimental neurology

authors： Zhu YQ,Li MH,Yan L,Tan HQ,Cheng YS

更新日期：2014-09-01 00:00:00

abstract：:Xeroderma pigmentosum group A (XPA) and Cockayne syndrome (CS) are hereditary DNA repair disorders complicated by progressive neurodegeneration. Here we immunohistochemically examine the in situ expression of materials that are produced by oxidative stress and glutamate transporters (which can contribute to prevention...

journal_title：Journal of neuropathology and experimental neurology

authors： Hayashi M,Itoh M,Araki S,Kumada S,Shioda K,Tamagawa K,Mizutani T,Morimatsu Y,Minagawa M,Oda M

更新日期：2001-04-01 00:00:00

abstract：:The most common histologic feature in patients with frontotemporal lobar degeneration (FTLD) is intracellular brain inclusions of yet uncharacterized proteins that react with antiubiquitin (Ub) antibodies, but not with tau or synuclein (FTLD-U). We identified a four-generation Belgian FTLD family in which 8 patients h...

journal_title：Journal of neuropathology and experimental neurology

authors： Pirici D,Vandenberghe R,Rademakers R,Dermaut B,Cruts M,Vennekens K,Cuijt I,Lübke U,Ceuterick C,Martin JJ,Van Broeckhoven C,Kumar-Singh S

更新日期：2006-03-01 00:00:00

abstract：:Canine smooth muscle cells (SMCs), cultured from amyloid-affected brain blood vessels accumulate Alzheimer amyloid-beta peptide (Abeta) intracellularly, either spontaneously or after treatment with apolipoprotein E (apoE). ApoE is codeposited with Abeta, which suggests that apoE participates in Abeta accumulation. We ...

journal_title：Journal of neuropathology and experimental neurology

authors： Mazur-Kolecka B,Frackowiak J,Krzeslowska J,Ramakrishna N,Haske T,Emmerling MR,Zhang W,Kim KS,Wisniewski HM

更新日期：1999-03-01 00:00:00

abstract：:This study examines a radiation-induced invasion and spread of Schwann cells into ventral gray regions of the lumbar spinal cord. The prevalence of these cells within the gray matter and the time course of their appearance in the ventral spinal cord is quite different from the pattern of Schwann cell development in do...

journal_title：Journal of neuropathology and experimental neurology

authors： Sims TJ,Durgun MB,Gilmore SA

更新日期：1998-09-01 00:00:00

abstract：:Chronic traumatic encephalopathy (CTE) is a progressive neurodegenerative disorder associated with repetitive traumatic brain injury. Multiple system atrophy (MSA) is a Parkinsonian disorder that can result in repetitive falls with associated head trauma. We hypothesized that patients with neurodegenerative disorders ...

journal_title：Journal of neuropathology and experimental neurology

authors： Koga S,Dickson DW,Bieniek KF

更新日期：2016-10-01 00:00:00

abstract：:Neuropathologic examination of 3 patients with Alzheimer disease in the Elan Pharmaceuticals trial using antibodies specific for different Abeta species showed in one case, 4 months after the immunization, evidence of a stage of active plaque clearance with "moth-eaten" plaques and abundant Abeta phagocytosis by micro...

journal_title：Journal of neuropathology and experimental neurology

authors： Nicoll JA,Barton E,Boche D,Neal JW,Ferrer I,Thompson P,Vlachouli C,Wilkinson D,Bayer A,Games D,Seubert P,Schenk D,Holmes C

更新日期：2006-11-01 00:00:00

abstract：:Tissue microarrays (TMAs), also known as "tissue chips," are a recently developed method that allows small cores or discs of tissue from dozens or hundreds of (usually paraffin-embedded) specimens to be re-embedded in a tissue block, which can then be further sectioned. The tissue cores can subsequently be studied usi...

journal_title：Journal of neuropathology and experimental neurology

authors： Goldstine J,Seligson DB,Beizai P,Miyata H,Vinters HV

更新日期：2002-08-01 00:00:00

abstract：:The microtubule-associated phosphoprotein, tau, is an integral component of paired helical filaments in Alzheimer neurofibrillary tangles (NFT). The mechanism of NFT formation is unknown but aberrant phosphorylation of tau may be contributory. Calcium/calmodulin-dependent protein kinase type II (CaM kinase II), the mo...

journal_title：Journal of neuropathology and experimental neurology

authors： McKee AC,Kosik KS,Kennedy MB,Kowall NW

更新日期：1990-01-01 00:00:00

abstract：:We investigated whether antibody production to antigens arising in the subarachnoid space is depressed acutely after spinal cord injury (SCI), and whether such depression is due to abnormal catecholamine levels. To assess antibody responses, ovalbumin (OVA) was injected into the spinal subarachnoid space (i.t.) of rat...

journal_title：Journal of neuropathology and experimental neurology

authors： Vega JL,Ganea D,Jonakait GM

更新日期：2003-08-01 00:00:00

abstract：:We review the newest advances related to seeking the pathogenic mechanism(s) of sporadic inclusion-body myositis (s-IBM) and present the pathologic diagnostic criteria of s-IBM. We discuss the possible pathogenic role of several themes, such as 1) increased amyloid-beta precursor protein (AbetaPP) and of its fragment ...

journal_title：Journal of neuropathology and experimental neurology

authors： Askanas V,Engel WK

更新日期：2001-01-01 00:00:00