Abstract：
:Systemically-administered inorganic mercury localizes to motor neurons, but it is not known if mercury injures these neurons. We therefore looked for signs of damage to the motor and sensory neurons of mice that had been exposed to inorganic mercury. Young adult mice were injected intraperitoneally with either 1 or 2 microg/g of mercuric chloride and perfused 1 or 30 weeks later. The cellular distribution of mercury in the spinal cord was examined with silver nitrate autometallography. The numbers and sizes of myelinated axons in the L5 anterior and posterior roots were quantitated using an image analysis program. Mercury was found throughout the cytoplasm of motor neuron cell bodies after 1 week and in paranuclear aggregations after 30 weeks. Thirty weeks after exposure to either 1 or 2 microg/g of mercury, fewer large myelinated axons were seen in mercury-injected groups than in controls, though total numbers of myelinated axons did not differ between groups. A slight increase in numbers of small axons was seen in the posterior roots of mice exposed to 1 microg/g of mercury. In conclusion, inorganic mercury remains within mouse neurons for prolonged periods and causes a reduction in the size of myelinated axons in the anterior root and to a lesser extent the posterior spinal root. Inorganic mercury within motor neurons therefore appears to behave as a slowly-acting neurotoxin that shrinks motor axons.
journal_name
J Neuropathol Exp Neuroljournal_title
Journal of neuropathology and experimental neurologyauthors
Pamphlett R,Png FYdoi
10.1097/00005072-199804000-00009subject
Has Abstractpub_date
1998-04-01 00:00:00pages
360-6issue
4eissn
0022-3069issn
1554-6578journal_volume
57pub_type
杂志文章abstract：:Spinal muscular atrophy (SMA) is characterized by loss of motor neurons in the spinal cord that results in muscle denervation and profound weakness in affected patients. We sought evidence for primary muscle involvement in the disease during human development by analyzing the expression of several muscle cytoskeletal ...
journal_title：Journal of neuropathology and experimental neurology
pub_type： 杂志文章
doi：10.1097/NEN.0000000000000078
更新日期：2014-06-01 00:00:00
abstract：:Vascular dementia (VaD) is cognitive decline linked to reduced cerebral blood perfusion, yet there are few therapeutic options to protect cognitive function following cerebrovascular accidents. The purpose of this study was to profile gene expression changes unique to VaD to identify and characterize disease relevant ...
journal_title：Journal of neuropathology and experimental neurology
pub_type： 杂志文章
doi：10.1093/jnen/nlz023
更新日期：2019-05-01 00:00:00
abstract：:Temporal lobe epilepsy (TLE) is characterized by hippocampal sclerosis together with profound losses and phenotypic changes of different classes of interneurons, including those expressing somatostatin (SRIF). To understand the functional significance of the plasticity of SRIF transmission in TLE, unraveling the statu...
journal_title：Journal of neuropathology and experimental neurology
pub_type： 杂志文章
doi：10.1097/01.jnen.0000186923.50215.50
更新日期：2005-11-01 00:00:00
abstract：:A working group supported by the Office of Rare Diseases of the National Institutes of Health formulated neuropathologic criteria for corticobasal degeneration (CBD) that were subsequently validated by an independent group of neuropathologists. The criteria do not require a specific clinical phenotype, since CBD can h...
journal_title：Journal of neuropathology and experimental neurology
pub_type： 指南,杂志文章,实务指引
doi：10.1093/jnen/61.11.935
更新日期：2002-11-01 00:00:00
abstract：:In order to induce a non-lethal infection restricted to central aminergic neurons projecting to the olfactory bulbs a series of temperature sensitive (ts) and G-protein monoclonal antibody escape mutants of vesicular stomatitis virus (VSV) were instilled into the nasal cavity of mice. In three-week (wk)-old NMRI mice ...
journal_title：Journal of neuropathology and experimental neurology
pub_type： 杂志文章
doi：10.1097/00005072-198809000-00001
更新日期：1988-09-01 00:00:00
abstract：:Peripheral polyneuropathies are common and their diagnosis may be challenging. We compared the results from sural-nerve and skin biopsies in 33 patients with a polyneuropathy and neuropathic pain examined in our hospital over a 6-year period. The biopsies were all from the same lower limb of each patient. Intraepiderm...
journal_title：Journal of neuropathology and experimental neurology
pub_type： 杂志文章
doi：10.1093/jnen/nlv005
更新日期：2016-01-01 00:00:00
abstract：:A superoxide dismutase 1 (SOD-1)genetic defect has been identified in familial amyotrophic lateral sclerosis (ALS) and motor neuron degeneration has been described in SOD-1 transgenic mice. Because an excitotoxic mechanism has been implicated in ALS, we undertook studies to provide a description of excitotoxic degener...
journal_title：Journal of neuropathology and experimental neurology
pub_type： 杂志文章
doi：10.1097/00005072-199602000-00010
更新日期：1996-02-01 00:00:00
abstract：:Nicotinic acetylcholine receptors (nAChRs) mediate fast synaptic transmission in autonomic ganglia, which innervate and control the activity of most visceral organs. By combining ultrastructural, immunocytochemical, and pharmacological analyses, we characterized the nAChR subtypes in the rat superior cervical ganglion...
journal_title：Journal of neuropathology and experimental neurology
pub_type： 杂志文章
doi：10.1093/jnen/63.2.138
更新日期：2004-02-01 00:00:00
abstract：:Rupture of a saccular intracranial aneurysm (sIA) is often fatal. Thus, early detection of rupture-prone sIAs is vital. Myeloperoxidase (MPO), derived mainly from neutrophils, associates with sIA rupture, and therefore its role in sIA pathogenesis warrants further studies. We analyzed MPO and its association with othe...
journal_title：Journal of neuropathology and experimental neurology
pub_type： 杂志文章
doi：10.1093/jnen/nly028
更新日期：2018-06-01 00:00:00
abstract：:Glioblastoma (GBM), representing WHO grade IV astrocytoma, is a relatively common primary brain tumor in adults with an exceptionally dismal prognosis. With an incidence rate of over 10 000 cases in the United States annually, the median survival rate ranges from 10-15 months in IDH1/2-wildtype tumors and 24-31 months...
journal_title：Journal of neuropathology and experimental neurology
pub_type： 杂志文章
doi：10.1093/jnen/nlz025
更新日期：2019-06-01 00:00:00
abstract：:An overlapping population of adult primary sensory neurons that innervate the skin express the glial cell-derived neurotrophic factor coreceptor α1 (GFRα1), the lectin IB4, and the "regenerative brake" phosphatase and tensin homolog deleted on chromosome 10. Using an adapted turning and growth assay, we analyzed the g...
journal_title：Journal of neuropathology and experimental neurology
pub_type： 杂志文章
doi：10.1097/NEN.0000000000000101
更新日期：2014-09-01 00:00:00
abstract：:The role of anti-myelin antibodies in the pathogenesis of experimental autoimmune neuritis (EAN) induced in the Lewis rat by immunization with peripheral nerve myelin has been assessed. Passive transfer with lymph node cells (LNC) or purified serum immunoglobulin from rats with EAN was employed to directly measure the...
journal_title：Journal of neuropathology and experimental neurology
pub_type： 杂志文章
doi：10.1093/jnen/60.6.637
更新日期：2001-06-01 00:00:00
abstract：:Purified myelin from the peripheral nervous system of guinea pig, frog (Rana catesbeiana), rat, rabbit, beef, and human in Freund's adjuvant were injected into the Lewis rat. Groups of rats receiving injections of myelin from different species were examined for signs of dysfunction and lesions in the PNS and CNS. Inje...
journal_title：Journal of neuropathology and experimental neurology
pub_type： 杂志文章
doi：10.1097/00005072-197907000-00003
更新日期：1979-07-01 00:00:00
abstract：:The DNA repair protein O6-methylguanine-DNA methyltransferase (MGMT) removes temozolomide-induced alkylation, thereby preventing DNA damage and cytotoxicity. We investigated the prognostic effect of different MGMT methylation levels on overall and progression-free survival in 327 patients with primary glioblastoma und...
journal_title：Journal of neuropathology and experimental neurology
pub_type： 杂志文章
doi：10.1093/jnen/nlz032
更新日期：2019-07-01 00:00:00
abstract：:The concern of the potential transmission of animal spongiform encephalopathies to humans, which arose as soon as the interspecies transmission of these diseases was recognized, has been reinforced with the emergence of bovine spongiform encephalopathy (BSE) in cattle. Recent experimental findings suggest that the inf...
journal_title：Journal of neuropathology and experimental neurology
pub_type： 杂志文章,评审
doi：10.1093/jnen/61.5.377
更新日期：2002-05-01 00:00:00
abstract：:Cortical biopsies of 17 patients with diagnoses of congenital malformation, cerebral tumor or brain trauma complicated by subdural hematoma or hygroma were studied with the electron microscope; the alterations of the blood-brain barrier in moderate and severe perifocal cerebral edema were observed. Moderate edema was ...
journal_title：Journal of neuropathology and experimental neurology
pub_type： 杂志文章
doi：10.1097/00005072-198005000-00006
更新日期：1980-05-01 00:00:00
abstract：:Sequential immunocytochemical double labeling of glial fibrillary acidic protein (GFAP) and transferrin (Tf) was used for the simultaneous identification of astrocytes and oligodendrocytes in paraffin-embedded sections of the rat brain. Paraformaldehyde or formalin-alcohol-acetic acid fixation followed by protease tre...
journal_title：Journal of neuropathology and experimental neurology
pub_type： 杂志文章
doi：10.1097/00005072-199103000-00007
更新日期：1991-03-01 00:00:00
abstract：:Growing evidence indicates that alterations within the peripheral nervous system (PNS) are involved at an early stage in the amyotrophic lateral sclerosis (ALS) pathogenetic cascade. In this study, magnetic resonance imaging (MRI), neurophysiologic analyses, and histologic analyses were used to monitor the extent of P...
journal_title：Journal of neuropathology and experimental neurology
pub_type： 杂志文章
doi：10.1097/NEN.0000000000000081
更新日期：2014-07-01 00:00:00
abstract：:Numerous studies have established the key role of the Golgi apparatus (GA) in post-translational processing, transport and targeting of proteins destined for secretion, lysosomes and plasma membranes. Moreover, several studies performed in our laboratories have shown that the size of the immunocytochemically detected ...
journal_title：Journal of neuropathology and experimental neurology
pub_type： 杂志文章
doi：10.1097/00005072-199509000-00013
更新日期：1995-09-01 00:00:00
abstract：:Precise temporal and spatial coordination of expression of the myogenic regulatory factors (MRF) plays a critical role in the development of skeletal muscle. Whether this pattern is recapitulated postnatally during regeneration of mature muscle after injury is not known. The aim of this study was to determine the cell...
journal_title：Journal of neuropathology and experimental neurology
pub_type： 杂志文章
doi：10.1097/00005072-199605000-00002
更新日期：1996-05-01 00:00:00
abstract：:A primary cerebellar rhabdomyosarcoma (RMS) in a six and a half year old boy is reported. Microscopy of the surgical material revealed lobules of closely packed cells with a high mitotic rate, pleomorphic hyperchromatic nuclei and scant cytoplasm. At their periphery, the lobules merged with rounded cells with similar ...
journal_title：Journal of neuropathology and experimental neurology
pub_type： 杂志文章
doi：10.1097/00005072-198407000-00008
更新日期：1984-07-01 00:00:00
abstract：:In an earlier study we found that a substantial percentage of mice surviving infection with canine distemper virus (CDV) slowly developed a morbid obesity syndrome. In the present study we wished to explore the role of the virus in the development of this syndrome. The distribution of viral antigen(s) in brains of pre...
journal_title：Journal of neuropathology and experimental neurology
pub_type： 杂志文章
doi：10.1097/00005072-199201000-00012
更新日期：1992-01-01 00:00:00
abstract：:The long-term disabilities associated with spinal cord injury (SCI) are primarily due to the absence of robust neuronal regeneration and functional plasticity. The inability of the axon to regenerate after SCI is contributed by several intrinsic factors that trigger a cascade of molecular growth program and modulates ...
journal_title：Journal of neuropathology and experimental neurology
pub_type： 杂志文章
doi：10.1093/jnen/nlaa147
更新日期：2021-01-20 00:00:00
abstract：:Friedreich's Ataxia (FRDA) is caused by a homozygous intronic GAA expansion in the FXN gene. FRDA affects primarily the peripheral nervous system (PNS) with cumulative evidence from postmortem studies and in vitro models suggesting a developmental component of its pathology. In the present study, we aimed at gaining f...
journal_title：Journal of neuropathology and experimental neurology
pub_type： 杂志文章
doi：10.1093/jnen/nly100
更新日期：2018-12-01 00:00:00
abstract：:A single oral dose of clofibrate (30 mg/100 gm body weight) given to 250-300 gm male rats produced myotonic discharges from both the gastrocnemius and soleus muscles 2 hours after feeding. Rats fed the same dosage for 14 consecutive days exhibited electromyographic discharges consistent with profound myotonia. Fibers ...
journal_title：Journal of neuropathology and experimental neurology
pub_type： 杂志文章
doi：10.1097/00005072-197911000-00004
更新日期：1979-11-01 00:00:00
abstract：:This investigation tested the hypothesis that the growth inhibiting effects of human beta-interferon on cultured human glioma cells involves changes in the ganglioside composition of these cells. Four cell lines derived from human malignant gliomas (12-18, U-251 MG, I29-A, 7-24) and two lines from human fetal brain (C...
journal_title：Journal of neuropathology and experimental neurology
pub_type： 杂志文章
doi：10.1097/00005072-198803000-00004
更新日期：1988-03-01 00:00:00
abstract：:The kinin B1 receptor is an inducible receptor expressed in response to inflammatory mediators. We sought to determine whether kinin B1 receptor can be expressed on human brain endothelial cells (HBECs) in vitro and whether signaling via this receptor can regulate permeability and chemokine production properties of th...
journal_title：Journal of neuropathology and experimental neurology
pub_type： 杂志文章
doi：10.1093/jnen/59.10.896
更新日期：2000-10-01 00:00:00
abstract：:The diagnosis of Alzheimer disease (AD) according to current criteria is a combined clinical and pathological exercise. The clinical discrimination of AD from other types of dementia may be complicated when the patient suffers from more than one disease. In particular the concomitant presence of other neurological con...
journal_title：Journal of neuropathology and experimental neurology
pub_type： 杂志文章
doi：10.1097/00005072-199702000-00007
更新日期：1997-02-01 00:00:00
abstract：:The presence of intermediate filaments (IF) (diameter 10 nm) is a characteristic electron microscopic finding in the cytoplasm of meningioma cells. To identify these IF, immunohistochemical staining for cytokeratins and vimentin and two-dimensional (2-D) gel electrophoresis followed by immunoblot analysis were applied...
journal_title：Journal of neuropathology and experimental neurology
pub_type： 杂志文章
doi：10.1097/00005072-198511000-00007
更新日期：1985-11-01 00:00:00
abstract：:In 63 patients with malabsorption syndromes, 16 with congenital biliary atresia (BA) and 47 with cystic fibrosis (CF), axonal dystrophy in the gracile nucleus (ADG) was studied. Of the 16 patients with BA, ADG of considerable severity was observed in all 10 over one year of age. Of the 47 patients with CF, it was obse...
journal_title：Journal of neuropathology and experimental neurology
pub_type： 杂志文章
doi：10.1097/00005072-198009000-00007
更新日期：1980-09-01 00:00:00
