当前位置： SCI文献检索 > JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY期刊下所有文献 > Electron microscopic study of capillary wall in human cerebral edema.

Electron microscopic study of capillary wall in human cerebral edema.

Abstract：

:Cortical biopsies of 17 patients with diagnoses of congenital malformation, cerebral tumor or brain trauma complicated by subdural hematoma or hygroma were studied with the electron microscope; the alterations of the blood-brain barrier in moderate and severe perifocal cerebral edema were observed. Moderate edema was found associated with central nervous system malformations, while severe edema was seen accompanying brain tumors and serious head injuries. The peripheral cytoplasm of endothelial cells displayed increased formation of microvilli and clear or amorphous electron-dense vacuoles, as well as pinocytotic and coated vesicles. In severe edema, the formation of elongated or chained vacuoles forming transendothelial channels was observed. In moderate edema, endothelial junctions exhibited a tortuous pathway, with a luminal portion sealed by tight junctions and dilated, open, basal portions ending at the basement membrane. In severe edema, the zonulae accludentes partially disappeared and the endothelial junction basal segments became irregularly dilated. The basement membrane showed enlargement, rarefaction, vacuolization, and the presence of collagen fibers. Fine expansion of the basement membrane was distinguished, showing matrix loss and clear, irregularly-dilated channels. Capillaries with reduplicated basement membrane were also observed. The pericytes exhibited edema, vacuolization, and phagocytic activity. In moderate cerebral edema, the clear or dense edematous and vacuolated perivascular end-feet of astrocytes appeared closely applied to the basement membrane, while in severe cerebral edema, they were separated from the basement membrane and showed gradual disappearance of the gap junctions. In all cases, moderately or markedly dilated extracellular spaces were observed in the pericapillary neuropil.

journal_name

J Neuropathol Exp Neurol

journal_title

Journal of neuropathology and experimental neurology

authors

Castejón OJ

doi

10.1097/00005072-198005000-00006

subject

Has Abstract

pub_date

1980-05-01 00:00:00

pages

296-328

issue

3

eissn

0022-3069

issn

1554-6578

journal_volume

39

pub_type

杂志文章

相关文献

JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY文献大全
  • Dysferlin, annexin A1, and mitsugumin 53 are upregulated in muscular dystrophy and localize to longitudinal tubules of the T-system with stretch.

    abstract：:Mutations in dysferlin cause an inherited muscular dystrophy because of defective membrane repair. Three interacting partners of dysferlin are also implicated in membrane resealing: caveolin-3 (in limb girdle muscular dystrophy type 1C), annexin A1, and the newly identified protein mitsugumin 53 (MG53). Mitsugumin 53 ...

    journal_title：Journal of neuropathology and experimental neurology

    pub_type： 杂志文章

    doi：10.1097/NEN.0b013e31821350b0

    authors： Waddell LB,Lemckert FA,Zheng XF,Tran J,Evesson FJ,Hawkes JM,Lek A,Street NE,Lin P,Clarke NF,Landstrom AP,Ackerman MJ,Weisleder N,Ma J,North KN,Cooper ST

    更新日期：2011-04-01 00:00:00

  • Neutral amino acid transport properties of cerebral endothelial cells in vitro.

    abstract：:An A and L system of neutral amino acid transport has been demonstrated previously in cerebral microvessels in vivo and in isolated microvessels in vitro. This report describes the neutral amino acid transport properties of cultured cerebral endothelial cells and investigates the influence of astroglia on the transpor...

    journal_title：Journal of neuropathology and experimental neurology

    pub_type： 杂志文章

    doi：10.1097/00005072-198303000-00008

    authors： Cancilla PA,DeBault LE

    更新日期：1983-03-01 00:00:00

  • PTEN Blocking Stimulates Corticospinal and Raphespinal Axonal Regeneration and Promotes Functional Recovery After Spinal Cord Injury.

    abstract：:The long-term disabilities associated with spinal cord injury (SCI) are primarily due to the absence of robust neuronal regeneration and functional plasticity. The inability of the axon to regenerate after SCI is contributed by several intrinsic factors that trigger a cascade of molecular growth program and modulates ...

    journal_title：Journal of neuropathology and experimental neurology

    pub_type： 杂志文章

    doi：10.1093/jnen/nlaa147

    authors： Bhowmick S,Abdul-Muneer PM

    更新日期：2021-01-20 00:00:00

  • Immunocytochemical double labeling of glial fibrillary acidic protein and transferrin permits the identification of astrocytes and oligodendrocytes in the rat brain.

    abstract：:Sequential immunocytochemical double labeling of glial fibrillary acidic protein (GFAP) and transferrin (Tf) was used for the simultaneous identification of astrocytes and oligodendrocytes in paraffin-embedded sections of the rat brain. Paraformaldehyde or formalin-alcohol-acetic acid fixation followed by protease tre...

    journal_title：Journal of neuropathology and experimental neurology

    pub_type： 杂志文章

    doi：10.1097/00005072-199103000-00007

    authors： Martin SM,Landel HB,Lansing AJ,Vijayan VK

    更新日期：1991-03-01 00:00:00

  • Genome-Wide Analysis of Glioblastoma Patients with Unexpectedly Long Survival.

    abstract：:Glioblastoma (GBM), representing WHO grade IV astrocytoma, is a relatively common primary brain tumor in adults with an exceptionally dismal prognosis. With an incidence rate of over 10 000 cases in the United States annually, the median survival rate ranges from 10-15 months in IDH1/2-wildtype tumors and 24-31 months...

    journal_title：Journal of neuropathology and experimental neurology

    pub_type： 杂志文章

    doi：10.1093/jnen/nlz025

    authors： Richardson TE,Patel S,Serrano J,Sathe AA,Daoud EV,Oliver D,Maher EA,Madrigales A,Mickey BE,Taxter T,Jour G,White CL,Raisanen JM,Xing C,Snuderl M,Hatanpaa KJ

    更新日期：2019-06-01 00:00:00

  • c-Jun, JNK/SAPK kinases and transcription factor NF-kappa B are selectively activated in astrocytes, but not motor neurons, in amyotrophic lateral sclerosis.

    abstract：:There is increasing evidence that oxidative damage plays a major role in amyotrophic lateral sclerosis (ALS), but how it contributes to motor neuron degeneration and astrocytic gliosis, two pathologic hallmarks of the disease, is unknown. A few studies have suggested that ALS motor neurons die via apoptosis and show u...

    journal_title：Journal of neuropathology and experimental neurology

    pub_type： 杂志文章

    doi：10.1097/00005072-199712000-00006

    authors： Migheli A,Piva R,Atzori C,Troost D,Schiffer D

    更新日期：1997-12-01 00:00:00

  • Microglial activation parallels system degeneration in multiple system atrophy.

    abstract：:Multiple system atrophy (MSA) is a neurodegenerative disorder that predominantly affects motor-related neuroanatomic structures. The role of microglia in MSA is unknown. To address this issue, we conducted quantitative image studies on the brains from 13 cases of MSA, comprising 8 cerebellar and 5 parkinsonian variant...

    journal_title：Journal of neuropathology and experimental neurology

    pub_type： 杂志文章

    doi：10.1093/jnen/63.1.43

    authors： Ishizawa K,Komori T,Sasaki S,Arai N,Mizutani T,Hirose T

    更新日期：2004-01-01 00:00:00

  • Accumulation of amyloid beta and tau and the formation of neurofilament inclusions following diffuse brain injury in the pig.

    abstract：:Brain trauma in humans increases the risk for developing Alzheimer disease (AD) and may induce the acute formation of AD-like plaques containing amyloid beta (A beta). To further explore the potential link between brain trauma and neurodegeneration, we conducted neuropathological studies using a pig model of diffuse b...

    journal_title：Journal of neuropathology and experimental neurology

    pub_type： 杂志文章

    doi：10.1097/00005072-199909000-00008

    authors： Smith DH,Chen XH,Nonaka M,Trojanowski JQ,Lee VM,Saatman KE,Leoni MJ,Xu BN,Wolf JA,Meaney DF

    更新日期：1999-09-01 00:00:00

  • Somatostatin receptor type 2 undergoes plastic changes in the human epileptic dentate gyrus.

    abstract：:Temporal lobe epilepsy (TLE) is characterized by hippocampal sclerosis together with profound losses and phenotypic changes of different classes of interneurons, including those expressing somatostatin (SRIF). To understand the functional significance of the plasticity of SRIF transmission in TLE, unraveling the statu...

    journal_title：Journal of neuropathology and experimental neurology

    pub_type： 杂志文章

    doi：10.1097/01.jnen.0000186923.50215.50

    authors： Csaba Z,Pirker S,Lelouvier B,Simon A,Videau C,Epelbaum J,Czech T,Baumgartner C,Sperk G,Dournaud P

    更新日期：2005-11-01 00:00:00

  • Ultrastructural Lesions of Nodo-Paranodopathies in Peripheral Neuropathies.

    abstract：:Whatever the cause of myelin damage of the peripheral nervous system, the initial attack on myelin by a dysimmune process may begin either at the internodal area or in the paranodal and nodal regions. The term "nodo-paranodopathy" was first applied to some "axonal Guillain-Barré syndrome" subtypes, then extended to ca...

    journal_title：Journal of neuropathology and experimental neurology

    pub_type： 杂志文章,评审

    doi：10.1093/jnen/nlz134

    authors： Vallat JM,Magy L,Corcia P,Boulesteix JM,Uncini A,Mathis S

    更新日期：2020-03-01 00:00:00

  • Endoplasmic reticulum stress in motor neurons of the spinal cord in sporadic amyotrophic lateral sclerosis.

    abstract：:The accumulation of misfolded or unfolded proteins in the endoplasmic reticulum (ER) lumen causes a cellular stress response termed the unfolded protein response. Although ER stress has been implicated in various neurodegenerative diseases, the morphological features of aggregated proteins in ER lumina that may cause ...

    journal_title：Journal of neuropathology and experimental neurology

    pub_type： 杂志文章

    doi：10.1097/NEN.0b013e3181d44992

    authors： Sasaki S

    更新日期：2010-04-01 00:00:00

  • Effect of NGF and neurotrophin-3 treatment on experimental diabetic autonomic neuropathy.

    abstract：:Peripheral neuropathy is a significant complication of diabetes resulting in increased patient morbidity and mortality. Deficiencies of neurotrophic substances (e.g. NGE NT-3, and IGF-I) have been proposed as pathogenetic mechanisms in the development of distal symmetrical sensory diabetic polyneuropathy, and salutary...

    journal_title：Journal of neuropathology and experimental neurology

    pub_type： 杂志文章

    doi：10.1093/jnen/60.3.263

    authors： Schmidt RE,Dorsey DA,Beaudet LN,Parvin CA,Escandon E

    更新日期：2001-03-01 00:00:00

  • Fibroblasts can express glial fibrillary acidic protein (GFAP) in vivo.

    abstract：:Neuropathologists use anti-glial fibrillary acidic protein (GFAP) antibodies as specific markers for glial cells, and neurobiologists use GFAP for targeting transgenes to glial cells. Since GFAP has also been detected in non-glial cells, we systematically analyzed GFAP expression in human and murine non-CNS tissues us...

    journal_title：Journal of neuropathology and experimental neurology

    pub_type： 杂志文章

    doi：10.1093/jnen/60.5.449

    authors： Hainfellner JA,Voigtländer T,Ströbel T,Mazal PR,Maddalena AS,Aguzzi A,Budka H

    更新日期：2001-05-01 00:00:00

  • Brain structures selectively targeted by canine distemper virus in a mouse model infection.

    abstract：:Paramyxoviruses such as measles virus or canine distemper virus are etiological agents for acute and chronic encephalitis (measles inclusion body encephalitis, subacute sclerosing panencephalitis and chronic distemper encephalitis or old dog encephalitis). The mechanisms by which viral injury leads to neurological dis...

    journal_title：Journal of neuropathology and experimental neurology

    pub_type： 杂志文章

    doi：10.1097/00005072-199309000-00005

    authors： Bernard A,Fevre-Montange M,Bencsik A,Giraudon P,Wild TF,Confavreux C,Belin MF

    更新日期：1993-09-01 00:00:00

  • Myeloperoxidase Associates With Degenerative Remodeling and Rupture of the Saccular Intracranial Aneurysm Wall.

    abstract：:Rupture of a saccular intracranial aneurysm (sIA) is often fatal. Thus, early detection of rupture-prone sIAs is vital. Myeloperoxidase (MPO), derived mainly from neutrophils, associates with sIA rupture, and therefore its role in sIA pathogenesis warrants further studies. We analyzed MPO and its association with othe...

    journal_title：Journal of neuropathology and experimental neurology

    pub_type： 杂志文章

    doi：10.1093/jnen/nly028

    authors： Ollikainen E,Tulamo R,Lehti S,Hernesniemi J,Niemelä M,Kovanen PT,Frösen J

    更新日期：2018-06-01 00:00:00

  • IgG and complement deposition and neuronal loss in cats and humans with epilepsy and voltage-gated potassium channel complex antibodies.

    abstract：:Voltage-gated potassium channel complex (VGKC-complex) antibody (Ab) encephalitis is a well-recognized form of limbic encephalitis in humans, usually occurring in the absence of an underlying tumor. The patients have a subacute onset of seizures, magnetic resonance imaging findings suggestive of hippocampal inflammati...

    journal_title：Journal of neuropathology and experimental neurology

    pub_type： 杂志文章

    doi：10.1097/NEN.0000000000000063

    authors： Klang A,Schmidt P,Kneissl S,Bagó Z,Vincent A,Lang B,Moloney T,Bien CG,Halász P,Bauer J,Pákozdy A

    更新日期：2014-05-01 00:00:00

  • Hamartin and tuberin interaction with the G2/M cyclin-dependent kinase CDK1 and its regulatory cyclins A and B.

    abstract：:Tuberous sclerosis (TSC) is a multi-system disorder characterized by hamartomatous tumors and abnormal brain development, with multiple foci of disrupted neuronal migration and giant dysmorphic neurons within cortical tubers. TSC is associated with mutations in 2 genes, TSC1 and TSC2, which encode hamartin and tuberin...

    journal_title：Journal of neuropathology and experimental neurology

    pub_type： 杂志文章

    doi：10.1093/jnen/60.7.711

    authors： Catania MG,Mischel PS,Vinters HV

    更新日期：2001-07-01 00:00:00

  • Familial Danish dementia: a novel form of cerebral amyloidosis associated with deposition of both amyloid-Dan and amyloid-beta.

    abstract：:Familial Danish dementia (FDD) is pathologically characterized by widespread cerebral amyloid angiopathy (CAA), parenchymal protein deposits, and neurofibrillary degeneration. FDD is associated with a mutation of the BRI2 gene located on chromosome 13. In FDD there is a decamer duplication, which abolishes the normal ...

    journal_title：Journal of neuropathology and experimental neurology

    pub_type： 杂志文章

    doi：10.1093/jnen/61.3.254

    authors： Holton JL,Lashley T,Ghiso J,Braendgaard H,Vidal R,Guerin CJ,Gibb G,Hanger DP,Rostagno A,Anderton BH,Strand C,Ayling H,Plant G,Frangione B,Bojsen-Møller M,Revesz T

    更新日期：2002-03-01 00:00:00

  • Ultrastructural analysis and TUNEL demonstrate motor neuron apoptosis in Werdnig-Hoffmann disease.

    abstract：:Werdnig-Hoffmann disease (WHD) is the most severe clinical type of spinal muscular atrophy characterized by loss of lower motor neurons and paralysis. We examined the hypothesis that disease pathogenesis is based on an inappropriate persistence of normally occurring motor neuron programmed cell death. The diagnosis of...

    journal_title：Journal of neuropathology and experimental neurology

    pub_type： 杂志文章

    doi：10.1093/jnen/59.5.398

    authors： Simic G,Seso-Simic D,Lucassen PJ,Islam A,Krsnik Z,Cviko A,Jelasic D,Barisic N,Winblad B,Kostovic I,Kruslin B

    更新日期：2000-05-01 00:00:00

  • Impairment of tight junctions and glucose transport in endothelial cells of human cerebral cavernous malformations.

    abstract：:Cerebral cavernous malformations (CCMs) often cause hemorrhages that can result in severe clinical manifestations, including hemiparesis and seizures. The underlying mechanisms of the aggressive behavior of CCMs are undetermined to date, but alterations of vascular matrix components may be involved. We compared the lo...

    journal_title：Journal of neuropathology and experimental neurology

    pub_type： 杂志文章

    doi：10.1097/NEN.0b013e31821bc40e

    authors： Schneider H,Errede M,Ulrich NH,Virgintino D,Frei K,Bertalanffy H

    更新日期：2011-06-01 00:00:00

  • TDP-43 in the ubiquitin pathology of frontotemporal dementia with VCP gene mutations.

    abstract：:Frontotemporal dementia with inclusion body myopathy and Paget disease of bone is a rare, autosomal-dominant disorder caused by mutations in the gene valosin-containing protein (VCP). The CNS pathology is characterized by a novel pattern of ubiquitin pathology distinct from sporadic and familial frontotemporal lobar d...

    journal_title：Journal of neuropathology and experimental neurology

    pub_type： 杂志文章

    doi：10.1097/nen.0b013e31803020b9

    authors： Neumann M,Mackenzie IR,Cairns NJ,Boyer PJ,Markesbery WR,Smith CD,Taylor JP,Kretzschmar HA,Kimonis VE,Forman MS

    更新日期：2007-02-01 00:00:00

  • Abnormal alpha-synuclein interactions with Rab proteins in alpha-synuclein A30P transgenic mice.

    abstract：:Mutation A30P in the alpha-synuclein gene is a cause of familial Parkinson disease. Transgenic mice expressing wild mouse and mutant human A30P alpha-synuclein, Tg5093 mice (Tg), show a progressive motor disorder characterized by tremor, rigidity, and dystonia, accompanied by accumulation of alpha-synuclein in the som...

    journal_title：Journal of neuropathology and experimental neurology

    pub_type： 杂志文章

    doi：10.1093/jnen/63.4.302

    authors： Dalfó E,Gómez-Isla T,Rosa JL,Nieto Bodelón M,Cuadrado Tejedor M,Barrachina M,Ambrosio S,Ferrer I

    更新日期：2004-04-01 00:00:00

  • Identification of novel biomarkers in pediatric primitive neuroectodermal tumors and ependymomas by proteome-wide analysis.

    abstract：:The aim of this study was to identify aberrantly expressed proteins in pediatric primitive neuroectodermal tumors (PNETs) and ependymomas. Tumor tissue of 29 PNET and 12 ependymoma patients was subjected to 2-dimensional difference gel electrophoresis. Gel analysis resulted in 79 protein spots being differentially exp...

    journal_title：Journal of neuropathology and experimental neurology

    pub_type： 杂志文章

    doi：10.1097/01.jnen.0000240475.35414.c3

    authors： de Bont JM,den Boer ML,Kros JM,Passier MM,Reddingius RE,Smitt PA,Luider TM,Pieters R

    更新日期：2007-06-01 00:00:00

  • Pathogenesis of tuberous sclerosis subependymal giant cell astrocytomas: biallelic inactivation of TSC1 or TSC2 leads to mTOR activation.

    abstract：:In the central nervous system, tuberous sclerosis complex (TSC) is characterized by a range of lesions including cortical tubers, white matter heterotopias, subependymal nodules, and subependymal giant cell astrocytomas (SEGAs). Recent studies have implicated an important role for the TSC genes TSC1 and TSC2, in a sig...

    journal_title：Journal of neuropathology and experimental neurology

    pub_type： 杂志文章

    doi：10.1093/jnen/63.12.1236

    authors： Chan JA,Zhang H,Roberts PS,Jozwiak S,Wieslawa G,Lewin-Kowalik J,Kotulska K,Kwiatkowski DJ

    更新日期：2004-12-01 00:00:00

  • High-throughput molecular profiling of high-grade astrocytomas: the utility of fluorescence in situ hybridization on tissue microarrays (TMA-FISH).

    abstract：:Due to recent biological and technical advances, the list of potentially useful candidate genes is rapidly expanding in the study of brain tumors. However, traditional methods of screening individual genes in individual samples are slow and tedious, often with consumption of precious resources after only a few experim...

    journal_title：Journal of neuropathology and experimental neurology

    pub_type： 杂志文章

    doi：10.1093/jnen/61.12.1078

    authors： Fuller CE,Wang H,Zhang W,Fuller GN,Perry A

    更新日期：2002-12-01 00:00:00

  • The Serotonin Brainstem Hypothesis for the Sudden Infant Death Syndrome.

    abstract：:The sudden infant death syndrome (SIDS) is the leading cause of postneonatal infant mortality in the United States today, with an overall rate of 0.39/1000 live births. It is defined as the sudden and unexpected death of an infant <12 months of age that remains unexplained after a complete autopsy, death scene investi...

    journal_title：Journal of neuropathology and experimental neurology

    pub_type： 杂志文章,评审

    doi：10.1093/jnen/nlz062

    authors： Kinney HC,Haynes RL

    更新日期：2019-09-01 00:00:00

  • Acute down-regulation of antibody production following spinal cord injury: role of systemic catecholamines.

    abstract：:We investigated whether antibody production to antigens arising in the subarachnoid space is depressed acutely after spinal cord injury (SCI), and whether such depression is due to abnormal catecholamine levels. To assess antibody responses, ovalbumin (OVA) was injected into the spinal subarachnoid space (i.t.) of rat...

    journal_title：Journal of neuropathology and experimental neurology

    pub_type： 杂志文章

    doi：10.1093/jnen/62.8.848

    authors： Vega JL,Ganea D,Jonakait GM

    更新日期：2003-08-01 00:00:00

  • Expression of Mutant Ubiquitin and Proteostasis Impairment in Kii Amyotrophic Lateral Sclerosis/Parkinsonism-Dementia Complex Brains.

    abstract：:Kii amyotrophic lateral sclerosis/parkinsonism-dementia complex (ALS/PDC) is a progressive neurodegenerative disorder that is endemic to the Kii peninsula of Japan. The disorder is clinically characterized by a variable combination of parkinsonism, dementia, and motor neuron symptoms. Despite extensive investigations,...

    journal_title：Journal of neuropathology and experimental neurology

    pub_type： 杂志文章

    doi：10.1093/jnen/nlaa056

    authors： Verheijen BM,Morimoto S,Sasaki R,Oyanagi K,Kokubo Y,Kuzuhara S,van Leeuwen FW

    更新日期：2020-08-01 00:00:00

  • Cytogenetic, molecular genetic and pathological analyses in 126 meningiomas.

    abstract：:In a series of 126 meningiomas, tumor and patient characteristics were investigated and statistically analyzed. A combined cytogenetic and molecular genetic approach was used to study chromosomal abnormalities and loss of markers on chromosome 22q. This approach was successfully applied to 93 meningiomas. In 66 cases,...

    journal_title：Journal of neuropathology and experimental neurology

    pub_type： 杂志文章

    doi：10.1097/00005072-199503000-00009

    authors： Lekanne Deprez RH,Riegman PH,van Drunen E,Warringa UL,Groen NA,Stefanko SZ,Koper JW,Avezaat CJ,Mulder PG,Zwarthoff EC

    更新日期：1995-03-01 00:00:00

  • TAR DNA-binding protein 43 immunohistochemistry reveals extensive neuritic pathology in FTLD-U: a midwest-southwest consortium for FTLD study.

    abstract：:TAR DNA-binding protein 43 (TDP-43) is a major component of the inclusions in frontotemporal lobar degeneration with ubiquitinated inclusions (FTLD-U). We studied TDP-43 pathology in the hippocampus and frontal cortex of autopsy brains from patients with FTLD-U (n = 68), dementia lacking distinctive histopathology (n ...

    journal_title：Journal of neuropathology and experimental neurology

    pub_type： 杂志文章,多中心研究

    doi：10.1097/NEN.0b013e31816a12a6

    authors： Hatanpaa KJ,Bigio EH,Cairns NJ,Womack KB,Weintraub S,Morris JC,Foong C,Xiao G,Hladik C,Mantanona TY,White CL 3rd

    更新日期：2008-04-01 00:00:00