Neutral amino acid transport properties of cerebral endothelial cells in vitro.

abstract：:Human neurodegenerative diseases can be characterized as disorders of protein aggregation. As a key player in cellular autophagy and the ubiquitin proteasome system, p62 may represent an effective immunohistochemical target, as well as mechanistic operator, across neurodegenerative proteinopathies. In this study, 2 no...

journal_title：Journal of neuropathology and experimental neurology

authors： Trejo-Lopez JA,Sorrentino ZA,Riffe CJ,Prokop S,Dickson DW,Yachnis AT,Giasson BI

更新日期：2020-04-01 00:00:00

abstract：:Lhermitte-Duclos disease (LDD) is a rare cerebellar tumor associated with Cowden disease (CD) and germline mutations in the PTEN gene. To further define these relationships, we reviewed clinical and pathologic findings in 31 LDD cases and analyzed the status of the PTEN pathway in 11 of them. We hypothesized that the ...

journal_title：Journal of neuropathology and experimental neurology

authors： Abel TW,Baker SJ,Fraser MM,Tihan T,Nelson JS,Yachnis AT,Bouffard JP,Mena H,Burger PC,Eberhart CG

更新日期：2005-04-01 00:00:00

abstract：:The content of RNA and the volume of motor neurons isolated from the lateral portion of the cervical swelling were examined in six control and six amyotrophic lateral sclerosis (ALS) cases obtained at autopsy. The mean volume of motor neurons in the ALS group did not differ significantly from the values obtained in th...

journal_title：Journal of neuropathology and experimental neurology

authors： Davidson TJ,Hartmann HA,Johnson PC

更新日期：1981-01-01 00:00:00

abstract：:Morphologic investigations of the human visual pathways have been limited by the infeasibility of modern neuroanatomical approaches. Although contemporary methods for tracing axon pathways (such as tracer injections and electrophysiology) have elucidated the visual system in experimental animals, these techniques cann...

journal_title：Journal of neuropathology and experimental neurology

authors： Sadun AA,Smith LE,Kenyon KR

更新日期：1983-03-01 00:00:00

abstract：:Smooth muscle cells cultured from leptomeningeal vessels from old dogs with amyloid-angiopathy accumulate intracellular deposits that are immunoreactive for amyloid-beta peptide (A beta). We used this cellular model in the present study to examine the influence of sera and cerebrospinal fluid on intracellular accumula...

journal_title：Journal of neuropathology and experimental neurology

authors： Mazur-Kolecka B,Frackowiak J,Carroll RT,Wisniewski HM

更新日期：1997-03-01 00:00:00

abstract：:Experimental autoimmune neuritis (EAN) is a demyelinating disease of the peripheral nervous system (PNS). This acute inflammatory disease is mediated by CD4+ T cells and bears significant similarities to the Guillain-Barré syndrome of humans. In the present study, we investigated the function of IL-18 in T cell-mediat...

journal_title：Journal of neuropathology and experimental neurology

authors： Yu S,Chen Z,Mix E,Zhu SW,Winblad B,Ljunggren HG,Zhu J

更新日期：2002-07-01 00:00:00

abstract：:To understand the basis of oligodendrocyte (OL) susceptibility to oxidative injury, purified rat OL cultures at different stages of maturation were exposed to nitric oxide (NO) donors with fast or slow kinetics of release and to tert-butyl-hydroperoxide, a membrane-permeant organic hydroperoxide. OL precursors (pre-OL...

journal_title：Journal of neuropathology and experimental neurology

authors： Bernardo A,Greco A,Levi G,Minghetti L

更新日期：2003-05-01 00:00:00

abstract：:McArdle disease (muscle glycogenosis type V) is caused by myophosphorylase deficiency, which leads to impaired glycogen breakdown. We investigated how myophosphorylase deficiency affects muscle physiology, morphology, and glucose metabolism in 20-week-old McArdle mice and compared the findings to those in McArdle dise...

journal_title：Journal of neuropathology and experimental neurology

authors： Krag TO,Pinós T,Nielsen TL,Brull A,Andreu AL,Vissing J

更新日期：2016-05-01 00:00:00

abstract：:The interaction of phosphatidylserine (PS), exposed on the surface of apoptotic cells and with its specific receptor (PtdSerR) expressed by microglia, is a crucial event in the recognition and clearance of apoptotic neurons. Here, we extend our previous studies in which PS-liposomes mimicking apoptotic cells were used...

journal_title：Journal of neuropathology and experimental neurology

authors： De Simone R,Ajmone-Cat MA,Tirassa P,Minghetti L

更新日期：2003-02-01 00:00:00

abstract：:Abnormalities were detected by two-dimensional gel electrophoresis in the protein composition of both the dorsal and ventral roots of three of six patients who succumbed to amyotrophic lateral sclerosis (ALS). The abnormalities consisted of a cascade of acidic protein spots on silver-stained gels which were shown by i...

journal_title：Journal of neuropathology and experimental neurology

authors： Brock TO,McIlwain DL

更新日期：1984-11-01 00:00:00

abstract：:Rupture of a saccular intracranial aneurysm (sIA) is often fatal. Thus, early detection of rupture-prone sIAs is vital. Myeloperoxidase (MPO), derived mainly from neutrophils, associates with sIA rupture, and therefore its role in sIA pathogenesis warrants further studies. We analyzed MPO and its association with othe...

journal_title：Journal of neuropathology and experimental neurology

authors： Ollikainen E,Tulamo R,Lehti S,Hernesniemi J,Niemelä M,Kovanen PT,Frösen J

更新日期：2018-06-01 00:00:00

abstract：:Increased numbers of corpora amylacea have been observed in the resected mesial temporal lobe of many patients with complex partial seizures (CPS) and Ammon's horn sclerosis (AHS). Several heat shock proteins (HSPs) are induced by seizures and have been suggested as an etiologic factor in the formation corpora amylace...

journal_title：Journal of neuropathology and experimental neurology

authors： Erdamar S,Zhu ZQ,Hamilton WJ,Armstrong DL,Grossman RG

更新日期：2000-08-01 00:00:00

abstract：:In multiple sclerosis, remyelination becomes limited after repeated or prolonged episodes of demyelination. To test the effect of platelet-derived growth factor-A (PDGF-A) in recovery from chronic demyelination we induced corpus callosum demyelination using cuprizone treatment in hPDGF-A transgenic (tg) mice with the ...

journal_title：Journal of neuropathology and experimental neurology

authors： Vana AC,Flint NC,Harwood NE,Le TQ,Fruttiger M,Armstrong RC

更新日期：2007-11-01 00:00:00

abstract：:Glial cytoplasmic inclusions (GCIs) are a pathologic hallmark of multiple system atrophy (MSA), but their pathogenetic roles need to be clarified. To determine possible roles of GCIs in individual cells, serial optical sections obtained by confocal microscopy were reconstructed to yield 3-dimensional (3D) images of th...

journal_title：Journal of neuropathology and experimental neurology

authors： Uyama N,Uchihara T,Mochizuki Y,Nakamura A,Takahashi R,Mizutani T

更新日期：2009-10-01 00:00:00

abstract：:Kii amyotrophic lateral sclerosis/parkinsonism-dementia complex (ALS/PDC) is a progressive neurodegenerative disorder that is endemic to the Kii peninsula of Japan. The disorder is clinically characterized by a variable combination of parkinsonism, dementia, and motor neuron symptoms. Despite extensive investigations,...

journal_title：Journal of neuropathology and experimental neurology

authors： Verheijen BM,Morimoto S,Sasaki R,Oyanagi K,Kokubo Y,Kuzuhara S,van Leeuwen FW

更新日期：2020-08-01 00:00:00

abstract：:Cerebral cavernous malformations (CCMs) often cause hemorrhages that can result in severe clinical manifestations, including hemiparesis and seizures. The underlying mechanisms of the aggressive behavior of CCMs are undetermined to date, but alterations of vascular matrix components may be involved. We compared the lo...

journal_title：Journal of neuropathology and experimental neurology

authors： Schneider H,Errede M,Ulrich NH,Virgintino D,Frei K,Bertalanffy H

更新日期：2011-06-01 00:00:00

abstract：:Primary central nervous system lymphomas (PCNSLs) are more resistant to radiotherapy and chemotherapy in AIDS (A-PCNSLs) than in non-AIDS patients (NA-PCNSLs). We investigated 23 A-PCNSLs and 24 NA-PCNSLs. Lymphoma cell kinetics (i.e. proliferation [mitotic index, MIB-1 and PCNA labeling indices], apoptosis and turnov...

journal_title：Journal of neuropathology and experimental neurology

authors： Christov C,Adle-Biassette H,Lechapt E,Poron F,Gray F,Gaulard P,Gherardi RK

更新日期：1999-10-01 00:00:00

abstract：:During brain development and blood-brain barrier (BBB) differentiation the expression of P-glycoprotein (P-gp) may complement the protective function of the placental barrier against xenobiotic substances. To establish an immunohistochemical procedure for P-gp detection, different anti-P-gp monoclonal antibodies were ...

journal_title：Journal of neuropathology and experimental neurology

authors： Virgintino D,Errede M,Girolamo F,Capobianco C,Robertson D,Vimercati A,Serio G,Di Benedetto A,Yonekawa Y,Frei K,Roncali L

更新日期：2008-01-01 00:00:00

abstract：:After the finding that anti-prion antibodies stain sensory and sympathetic ganglia in variant Creutzfeldt-Jakob disease (vCJD), it was suggested that this localization supported the oral route of entry. However, prion accumulation subsequently also appeared in the peripheral nervous system (PNS) in sporadic cases. Thi...

journal_title：Journal of neuropathology and experimental neurology

authors： Lee CC,Kuo LT,Wang CH,Scaravilli F,An SF

更新日期：2005-08-01 00:00:00

abstract：:In order to induce a non-lethal infection restricted to central aminergic neurons projecting to the olfactory bulbs a series of temperature sensitive (ts) and G-protein monoclonal antibody escape mutants of vesicular stomatitis virus (VSV) were instilled into the nasal cavity of mice. In three-week (wk)-old NMRI mice ...

journal_title：Journal of neuropathology and experimental neurology

authors： Lundh B,Löve A,Kristensson K,Norrby E

更新日期：1988-09-01 00:00:00

abstract：:We investigated the temporal course of blood-nerve barrier (BNB) breakdown during the evolution of tellurium neuropathy, ricin neuropathy, and Wallerian degeneration following nerve transection or nerve crush. Blood-nerve barrier permeability was assessed with a 4,000-molecular weight fluoresceinated dextran from thre...

journal_title：Journal of neuropathology and experimental neurology

authors： Bouldin TW,Earnhardt TS,Goines ND

更新日期：1991-11-01 00:00:00

abstract：:Programmed cell death (PCD) via apoptosis is characterized by nuclear pyknosis and fragmentation, and biochemically by oligonucleosomal cleavage of DNA. Apoptosis occurs in the developing nervous system, whereas its role in neurodegenerative diseases is still debated. Recognition of apoptotic cells has recently been f...

journal_title：Journal of neuropathology and experimental neurology

authors： Migheli A,Cavalla P,Marino S,Schiffer D

更新日期：1994-11-01 00:00:00

abstract：:Normal human frontal lobe white matter obtained at autopsy was used to determine the extent of in situ post-mortem degradation of myelin basic protein (BP). Effects of the following two factors were studied: 1) time interval between death and autopsy, and 2) freezing and thawing the tissue. Quantitative extraction of...

journal_title：Journal of neuropathology and experimental neurology

authors： Ansari KA,Rand A,Hendrickson H,Bentley MD

更新日期：1976-03-01 00:00:00

abstract：:The development and differentiation of oligodendrocytes (OC) in developing mouse spinal cord (MSC) were investigated by correlative analysis of light and electron microscopy (EM), and immunoperoxidase studies for glial fibrillary acidic protein (GFAP) and myelin basic protein (MBP). The sequential development of glial...

journal_title：Journal of neuropathology and experimental neurology

authors： Choi BH

更新日期：1986-09-01 00:00:00

abstract：:Adult male rats were housed in a colony environment for six months, with ad lib access to anise-flavored 10% ethanol in water. Animals were then removed from the colony, and their consumption of alcohol during a period in isolated housing was measured. Individual rats were scored as high, moderate, and low consumers. ...

journal_title：Journal of neuropathology and experimental neurology

authors： Goldstein B,Maxwell DS,Ellison G,Hammer RP

更新日期：1983-09-01 00:00:00

abstract：:Atypical teratoid/rhabdoid tumors are malignant embryonal tumors characterized by the presence of rhabdoid cells, genetic alterations affecting the SMARCB1 gene (hSNF5/INI1), and a poor prognosis. Whether INI1 plays a role in the pathogenesis of other central nervous system tumors is uncertain. We report on cases of 2...

journal_title：Journal of neuropathology and experimental neurology

authors： Hasselblatt M,Oyen F,Gesk S,Kordes U,Wrede B,Bergmann M,Schmid H,Frühwald MC,Schneppenheim R,Siebert R,Paulus W

更新日期：2009-12-01 00:00:00

abstract：:In situ hybridization (ISH) for JC virus (JCV) is generally applied for the diagnosis of progressive multifocal leukoencephalopathy (PML). To explore the usefulness of immunohistochemistry (IHC) for JCV early proteins, 14 paraffin-embedded postmortem brain specimens with histologic features compatible with PML were te...

journal_title：Journal of neuropathology and experimental neurology

authors： Muñoz-Mármol AM,Mola G,Fernández-Vasalo A,Vela E,Mate JL,Ariza A

更新日期：2004-11-01 00:00:00

abstract：:In 63 patients with malabsorption syndromes, 16 with congenital biliary atresia (BA) and 47 with cystic fibrosis (CF), axonal dystrophy in the gracile nucleus (ADG) was studied. Of the 16 patients with BA, ADG of considerable severity was observed in all 10 over one year of age. Of the 47 patients with CF, it was obse...

journal_title：Journal of neuropathology and experimental neurology

authors： Sung JH,Park SH,Mastri AR,Warwick WJ

更新日期：1980-09-01 00:00:00

abstract：:The abundant axonal microtubule-associated protein tau regulates microtubule and actin dynamics, thereby contributing to normal neuronal function. We examined whether mice deficient in tau (Tau(-/-)) or with high levels of human tau differ from wild-type (WT) mice in their susceptibility to neuroaxonal injury in exper...

journal_title：Journal of neuropathology and experimental neurology

authors： Weinger JG,Davies P,Acker CM,Brosnan CF,Tsiperson V,Bayewitz A,Shafit-Zagardo B

更新日期：2012-05-01 00:00:00

abstract：:A superoxide dismutase 1 (SOD-1)genetic defect has been identified in familial amyotrophic lateral sclerosis (ALS) and motor neuron degeneration has been described in SOD-1 transgenic mice. Because an excitotoxic mechanism has been implicated in ALS, we undertook studies to provide a description of excitotoxic degener...

journal_title：Journal of neuropathology and experimental neurology

authors： Ikonomidou C,Qin Qin Y,Labruyere J,Olney JW

更新日期：1996-02-01 00:00:00