Experimental allergic neuritis in the Lewis rat.

abstract：:Retraction of distal sensory axons is a prominent feature in diabetic peripheral neuropathy (DPN), a process amenable to insulin therapy. Nevertheless, diabetic patients and long-term diabetic mice develop motor deficits after longer durations of DPN, a process that may be related to insulin deficiency. To compare the...

journal_title：Journal of neuropathology and experimental neurology

authors： Francis GJ,Martinez JA,Liu WQ,Zochodne DW,Hanson LR,Frey WH 2nd,Toth C

更新日期：2011-05-01 00:00:00

abstract：:Kii amyotrophic lateral sclerosis/parkinsonism-dementia complex (ALS/PDC) is a progressive neurodegenerative disorder that is endemic to the Kii peninsula of Japan. The disorder is clinically characterized by a variable combination of parkinsonism, dementia, and motor neuron symptoms. Despite extensive investigations,...

journal_title：Journal of neuropathology and experimental neurology

authors： Verheijen BM,Morimoto S,Sasaki R,Oyanagi K,Kokubo Y,Kuzuhara S,van Leeuwen FW

更新日期：2020-08-01 00:00:00

abstract：:We have reported that the ambient gyrus is the site with the greatest accumulation of argyrophilic grains (AGs) and that the degeneration of the ambient gyrus is responsible for dementia with grains. Here we analyzed 1,405 serial autopsy cases from 2 hospitals and detected AGs only in cases older than 56 years of age....

journal_title：Journal of neuropathology and experimental neurology

authors： Saito Y,Ruberu NN,Sawabe M,Arai T,Tanaka N,Kakuta Y,Yamanouchi H,Murayama S

更新日期：2004-09-01 00:00:00

abstract：:Glomeruloid bodies (GBs), tumor-associated vascular structures with a superficial resemblance to renal glomeruli, are important histopathological features of glioblastoma multiforme, but have also been described in other types of tumors and in cerebral metastases. The purpose of this study was to elucidate the pathoge...

journal_title：Journal of neuropathology and experimental neurology

authors： Döme B,Tímár J,Paku S

更新日期：2003-06-01 00:00:00

abstract：:Essential tremor (ET) patients develop more cognitive impairment and dementia than controls, although there are surprisingly few data on the neuropathological basis for cognitive changes in ET. In this postmortem study, we assessed tau and other pathologies in 26 ET cases and 73 controls (non-ET) (1:3 matching). The m...

journal_title：Journal of neuropathology and experimental neurology

authors： Farrell K,Cosentino S,Iida MA,Chapman S,Bennett DA,Faust PL,Louis ED,Crary JF

更新日期：2019-01-01 00:00:00

abstract：:The changes of nitric oxide synthase (NOS) activity and expression in experimental diabetic neuropathy have not been examined. Increases in ganglia NOS might be similar to those that follow axotomy, whereas declines in endothelial NOS (eNOS) and immunological NOS (iNOS) might explain dysfunction of microvessels or mac...

journal_title：Journal of neuropathology and experimental neurology

authors： Zochodne DW,Verge VM,Cheng C,Höke A,Jolley C,Thomsen K,Rubin I,Lauritzen M

更新日期：2000-09-01 00:00:00

abstract：:The 2016 WHO classification of brain tumors represents a major step towards the integration of molecular data into pathologic diagnoses. Our institution has included massively parallel sequencing technology in the diagnostic work-up of all gliomas since January 2016. The utilized platform successfully identifies copy ...

journal_title：Journal of neuropathology and experimental neurology

authors： Parilla M,Kadri S,Patil SA,Fitzpatrick C,Ritterhouse L,Segal J,Collins J,Pytel P

更新日期：2019-03-01 00:00:00

abstract：:Peptidylarginine deiminase (PAD) and citrullinated proteins have emerged as key molecules in various human diseases, but detailed subcellular localizations of PAD2 and citrullinated proteins are poorly mapped in brain under normal and pathologic conditions. We performed subcellular fractionation and electron microscop...

journal_title：Journal of neuropathology and experimental neurology

authors： Jang B,Shin HY,Choi JK,Nguyen du PT,Jeong BH,Ishigami A,Maruyama N,Carp RI,Kim YS,Choi EK

更新日期：2011-02-01 00:00:00

abstract：:The occurrence of neuroinflammation after spinal cord injury (SCI) is well established, but its function is debated, with both beneficial and detrimental consequences ascribed. A discriminate of the role of neuroinflammation may be the time period after SCI, and there is evidence to favor early neuroinflammation being...

journal_title：Journal of neuropathology and experimental neurology

authors： Rice T,Larsen J,Rivest S,Yong VW

更新日期：2007-03-01 00:00:00

abstract：:Experimental cerebral ischemia was produced in gerbils by occlusion of the right common carotid artery in the neck. The evolution of the ischemic lesions was followed from five minutes to six hours by using the immunohistochemical techniques for tubulin and creatine kinase BB-isoenzyme. The earliest lesion was found i...

journal_title：Journal of neuropathology and experimental neurology

authors： Yanagihara T,Yoshimine T,Morimoto K,Yamamoto K,Homburger HA

更新日期：1985-03-01 00:00:00

abstract：:Genome-wide association studies have established BIN1 (Bridging Integrator 1) as the most significant late-onset Alzheimer disease (AD) susceptibility locus after APOE We analyzed BIN1 protein expression using automated immunohistochemistry on the hippocampal CA1 region in 19 patients with either no, mild, or moderate...

journal_title：Journal of neuropathology and experimental neurology

authors： Adams SL,Tilton K,Kozubek JA,Seshadri S,Delalle I

更新日期：2016-08-01 00:00:00

abstract：:White matter hyperintensities (WMH) are prevalent. Although arteriolar disease has been implicated in their pathogenesis, venous pathology warrants consideration. We investigated relationships of WMH with histologic venous, arteriolar and white matter abnormalities and correlated findings with premortem neuroimaging. ...

journal_title：Journal of neuropathology and experimental neurology

authors： Keith J,Gao FQ,Noor R,Kiss A,Balasubramaniam G,Au K,Rogaeva E,Masellis M,Black SE

更新日期：2017-04-01 00:00:00

abstract：:Neuron loss, synaptic decline, and spongiform change are the hallmarks of sporadic Creutzfeldt-Jakob disease (sCJD), and may be related to deficiencies in mitochondria, energy metabolism, and protein synthesis. To investigate these relationships, we determined the expression levels of genes encoding subunits of the 5 ...

journal_title：Journal of neuropathology and experimental neurology

authors： Ansoleaga B,Garcia-Esparcia P,Llorens F,Hernández-Ortega K,Carmona Tech M,Antonio Del Rio J,Zerr I,Ferrer I

更新日期：2016-08-01 00:00:00

abstract：:The oligoastrocytoma, as a mixed glioma, represents a nosologic dilemma with respect to precisely defining the oligodendroglial and astroglial phenotypes that constitute the neoplastic cell lineages of these tumors. In this study, cell image analysis with Feulgen-stained nuclei was used to distinguish between oligoden...

journal_title：Journal of neuropathology and experimental neurology

authors： Decaestecker C,Lopes BS,Gordower L,Camby I,Cras P,Martin JJ,Kiss R,VandenBerg SR,Salmon I

更新日期：1997-04-01 00:00:00

abstract：:Retinoblastoma protein (pRb) is a ubiquitous 928-amino acid cell cycle regulatory molecule with diverse biologic activities. One critical function of pRb is the control of the G1-to-S phase checkpoint of the cell cycle. In the hypophosphorylated state, pRb suppresses the activity of E2F transcription factors thereby i...

journal_title：Journal of neuropathology and experimental neurology

authors： Stone JG,Siedlak SL,Tabaton M,Hirano A,Castellani RJ,Santocanale C,Perry G,Smith MA,Zhu X,Lee HG

更新日期：2011-07-01 00:00:00

abstract：:Hydrocephalic hyh mice are born with moderate hydrocephalus and a normal cerebral aqueduct. At about the fifth postnatal day the aqueduct becomes obliterated and severe hydrocephalus develops. The aim of the present investigation was to investigate the mechanism of this hydrocephalus, probably starting during fetal li...

journal_title：Journal of neuropathology and experimental neurology

authors： Jiménez AJ,Tomé M,Páez P,Wagner C,Rodríguez S,Fernández-Llebrez P,Rodríguez EM,Pérez-Fígares JM

更新日期：2001-11-01 00:00:00

abstract：:The long-term disabilities associated with spinal cord injury (SCI) are primarily due to the absence of robust neuronal regeneration and functional plasticity. The inability of the axon to regenerate after SCI is contributed by several intrinsic factors that trigger a cascade of molecular growth program and modulates ...

journal_title：Journal of neuropathology and experimental neurology

authors： Bhowmick S,Abdul-Muneer PM

更新日期：2021-01-20 00:00:00

abstract：:Hereditary diffuse leukoencephalopathy with spheroids (HDLS) is a familial neurodegenerative disease clinically characterized by progressive cognitive and motor dysfunction. Mutations in the colony-stimulating factor 1 receptor (CSF1R) gene have recently been identified in HDLS patients. The presence of diffuse axonal...

journal_title：Journal of neuropathology and experimental neurology

authors： Riku Y,Ando T,Goto Y,Mano K,Iwasaki Y,Sobue G,Yoshida M

更新日期：2014-12-01 00:00:00

abstract：:The concept of the presence of mucopolysaccharides forming an interstitial ground substance in central nervous tissues is revived. The biochemical reports of both neutral and acid mucopolysaccharides in both gray and white matter of the normal brain are reviewed. The earlier histochemical reports and the histochemical...

journal_title：Journal of neuropathology and experimental neurology

authors： Feigin I

更新日期：1980-01-01 00:00:00

abstract：:Granule cell dispersion (GCD) is observed in approximately 40% of cases of hippocampal sclerosis (HS) in patients with epilepsy. Studies in animal models suggest that GCD may be a consequence of enhanced proliferation of granule cell precursors as a result of seizures. We quantified the number of cells in cycle in sub...

journal_title：Journal of neuropathology and experimental neurology

authors： Thom M,Martinian L,Williams G,Stoeber K,Sisodiya SM

更新日期：2005-03-01 00:00:00

abstract：:Hypoxia administered after transient global cerebral ischemia (tGCI) has been shown to induce neuroprotection in adult rats, but the underlying mechanisms for this protection are unclear. Here, we tested the hypothesis that hypoxic postconditioning (HPC) induces neuroprotection through upregulation of hypoxia-inducibl...

journal_title：Journal of neuropathology and experimental neurology

authors： Zhu T,Zhan L,Liang D,Hu J,Lu Z,Zhu X,Sun W,Liu L,Xu E

更新日期：2014-10-01 00:00:00

abstract：:Localized hypertrophic neuropathy is a rare Schwann cell proliferation that usually affects single nerves from the extremities, and it is of unclear etiology in its pure form. RASopathies are a defined group of genetic diseases with overlapping clinical features, usually secondary to germline mutations in genes encodi...

journal_title：Journal of neuropathology and experimental neurology

authors： Vizcaino MA,Belzberg A,Ahlawat S,Belakhoua S,Chen L,Staedtke V,Rodriguez FJ

更新日期：2020-06-01 00:00:00

abstract：:Inclusion body myositis (IBM) is a late-onset inflammatory myopathy with distinctive clinical and histopathological features. The molecular basis for the disease remains unknown, but abnormal nuclear morphology and the accumulation of a protein that binds single-stranded DNA in a sequence-independent fashion suggest a...

journal_title：Journal of neuropathology and experimental neurology

authors： Horvath R,Fu K,Johns T,Genge A,Karpati G,Shoubridge EA

更新日期：1998-05-01 00:00:00

abstract：:The sudden infant death syndrome (SIDS) is the leading cause of postneonatal infant mortality in the United States today, with an overall rate of 0.39/1000 live births. It is defined as the sudden and unexpected death of an infant <12 months of age that remains unexplained after a complete autopsy, death scene investi...

journal_title：Journal of neuropathology and experimental neurology

authors： Kinney HC,Haynes RL

更新日期：2019-09-01 00:00:00

abstract：:We have encountered a series of 8 third ventricular neoplasms with a distinctive chordoid appearance that appear to represent a clinicopathologic entity. The tumors occurred in 7 females and 1 male, ranging in age from 31 to 70 years. In all cases, imaging studies showed a large well-circumscribed third ventricular ma...

journal_title：Journal of neuropathology and experimental neurology

authors： Brat DJ,Scheithauer BW,Staugaitis SM,Cortez SC,Brecher K,Burger PC

更新日期：1998-03-01 00:00:00

abstract：:Neurofibrillary tangles (NFTs) represent products of insoluble tau protein in the brains of patients with Alzheimer disease (AD). The cerebrospinal fluid (CSF) tau level is a biomarker in AD diagnosis. The soluble portion of tau protein in brain parenchyma is presumably the source for CSF tau but this has not previous...

journal_title：Journal of neuropathology and experimental neurology

authors： Han P,Serrano G,Beach TG,Caselli RJ,Yin J,Zhuang N,Shi J

更新日期：2017-01-01 00:00:00

abstract：:Atypical teratoid/rhabdoid tumors are malignant embryonal tumors characterized by the presence of rhabdoid cells, genetic alterations affecting the SMARCB1 gene (hSNF5/INI1), and a poor prognosis. Whether INI1 plays a role in the pathogenesis of other central nervous system tumors is uncertain. We report on cases of 2...

journal_title：Journal of neuropathology and experimental neurology

authors： Hasselblatt M,Oyen F,Gesk S,Kordes U,Wrede B,Bergmann M,Schmid H,Frühwald MC,Schneppenheim R,Siebert R,Paulus W

更新日期：2009-12-01 00:00:00

abstract：:Wallerian degeneration of the CNS is accompanied by axonal dystrophy or swelling. To understand the mechanisms by which swellings arise, we studied their spatiotemporal dynamics, ultrastructure, composition, and the conditions that affect their formation in vivo and ex vivo. In contrast to peripheral nerve axons, lesi...

journal_title：Journal of neuropathology and experimental neurology

authors： Beirowski B,Nógrádi A,Babetto E,Garcia-Alias G,Coleman MP

更新日期：2010-05-01 00:00:00

abstract：:It is recognized that IDH mutation negative, low-grade epilepsy associated tumors (LEAT) can show diffuse growth patterns and lack the diagnostic hallmarks of either classical dysembryoplastic neuroepithelial tumors (DNT) or typical ganglioglioma. "Nonspecific or diffuse DNT" and more recently "polymorphous low-grade ...

journal_title：Journal of neuropathology and experimental neurology

authors： Al-Hajri A,Al-Mughairi S,Somani A,An S,Liu J,Miserocchi A,McEvoy AW,Yousry T,Hoskote C,Thom M

更新日期：2017-12-01 00:00:00

abstract：:Although stroke is among the most common causes of death and chronic disability worldwide, the proteome of the ischemic human brain remains unknown. Only a few studies have investigated the ischemic brain proteome in rodent stroke models. We performed a proteomic study of the human brain after ischemic stroke using a ...

journal_title：Journal of neuropathology and experimental neurology

authors： Cuadrado E,Rosell A,Colomé N,Hernández-Guillamon M,García-Berrocoso T,Ribo M,Alcazar A,Ortega-Aznar A,Salinas M,Canals F,Montaner J

更新日期：2010-11-01 00:00:00