Early pathologic changes in hereditary diffuse leukoencephalopathy with spheroids.

abstract：:Alpha-synuclein (alpha-synuclein) lesions are characteristic of idiopathic Parkinson disease (PD) and other alpha-synucleinopathies. To study the frequency of alpha-synuclein lesions in normal aging and how frequently they coexist with lesions of Alzheimer disease (AD), we examined the autopsy brains from normal and d...

journal_title：Journal of neuropathology and experimental neurology

authors： Mikolaenko I,Pletnikova O,Kawas CH,O'Brien R,Resnick SM,Crain B,Troncoso JC

更新日期：2005-02-01 00:00:00

abstract：:The long-term disabilities associated with spinal cord injury (SCI) are primarily due to the absence of robust neuronal regeneration and functional plasticity. The inability of the axon to regenerate after SCI is contributed by several intrinsic factors that trigger a cascade of molecular growth program and modulates ...

journal_title：Journal of neuropathology and experimental neurology

authors： Bhowmick S,Abdul-Muneer PM

更新日期：2021-01-20 00:00:00

abstract：:Oligodendrogliomas are characterized by frequent loss of heterozygosity (LOH) on chromosomes 1p and 19q, but additional genetic alterations are likely to be involved. In this study, we screened 28 oligodendrogliomas (WHO grade II) and 20 anaplastic oligodendrogliomas (WHO grade III) for alterations in the RB1/CDK4/p16...

journal_title：Journal of neuropathology and experimental neurology

authors： Watanabe T,Yokoo H,Yokoo M,Yonekawa Y,Kleihues P,Ohgaki H

更新日期：2001-12-01 00:00:00

abstract：:The microtubule-associated phosphoprotein, tau, is an integral component of paired helical filaments in Alzheimer neurofibrillary tangles (NFT). The mechanism of NFT formation is unknown but aberrant phosphorylation of tau may be contributory. Calcium/calmodulin-dependent protein kinase type II (CaM kinase II), the mo...

journal_title：Journal of neuropathology and experimental neurology

authors： McKee AC,Kosik KS,Kennedy MB,Kowall NW

更新日期：1990-01-01 00:00:00

abstract：:Infection with human immunodeficiency virus (HIV) clade C is the most common HIV infection worldwide, yet its impact on the nervous system remains largely unknown. Autopsy studies from regions affected by this virus are scarce, and HIV dementia has only rarely been reported from these countries. Most patients who deve...

journal_title：Journal of neuropathology and experimental neurology

authors： Mahadevan A,Shankar SK,Satishchandra P,Ranga U,Chickabasaviah YT,Santosh V,Vasanthapuram R,Pardo CA,Nath A,Zink MC

更新日期：2007-09-01 00:00:00

abstract：:A number of studies have implicated a proline-directed protein kinase, glycogen synthase kinase-3 (GSK-3) in the hyperphosphorylation of tau in Alzheimer's disease (AD). Toward understanding the role of GSK-3 in the abnormal hyperphosphorylation of tau in AD we have found that GSK-3 is prominently present in neuronal ...

journal_title：Journal of neuropathology and experimental neurology

authors： Pei JJ,Tanaka T,Tung YC,Braak E,Iqbal K,Grundke-Iqbal I

更新日期：1997-01-01 00:00:00

abstract：:We report a novel case of a World Health Organization grade 3 anaplastic meningioma arising from the olfactory groove in an 83-year-old woman. Molecular and methylation profiling confirm this lesion to be an NF2 subtype, methylation class intermediate type B meningioma. As most meningiomas in this location are indolen...

journal_title：Journal of neuropathology and experimental neurology

authors： Foo ASC,Tan DTM,Tan CL,Sahm F,von Deimling A,Yeo TT

更新日期：2017-12-01 00:00:00

abstract：:Selenoprotein P (Sepp1) is involved in selenium homeostasis. Mice with a deletion of Sepp1, replacement of it by the shortened form Sepp1(Delta240-361), or deletion of its receptor apolipoprotein E receptor 2 develop severe neurologic dysfunction when fed low-selenium diet. Because the brainstems of Sepp1(-/-) mice ha...

journal_title：Journal of neuropathology and experimental neurology

authors： Valentine WM,Abel TW,Hill KE,Austin LM,Burk RF

更新日期：2008-01-01 00:00:00

abstract：:Brain aging is accompanied by increased oxidative stress and what has been termed "neuroinflammation," which might contribute to age-related neurodegenerative diseases. We analyzed expression in the transcription of innate inflammatory response genes in eleven representative regions including frontal, parietal, inferi...

journal_title：Journal of neuropathology and experimental neurology

authors： López-González I,Tebé Cordomí C,Ferrer I

更新日期：2017-02-01 00:00:00

abstract：:Mitochondrial Zn2+ accumulation, particularly in CA1 neurons, occurs after ischemia and likely contributes to mitochondrial dysfunction and subsequent neurodegeneration. However, the relationship between mitochondrial Zn2+ accumulation and their disruption has not been examined at the ultrastructural level in vivo. We...

journal_title：Journal of neuropathology and experimental neurology

authors： Yin HZ,Wang HL,Ji SG,Medvedeva YV,Tian G,Bazrafkan AK,Maki NZ,Akbari Y,Weiss JH

更新日期：2019-07-01 00:00:00

abstract：:The idiopathic inflammatory myopathies (IIMs) dermatomyositis, polymyositis, and inclusion body myositis are characterized by myofiber degeneration and inflammation. The triggering factors of muscle autoaggression in these disorders are unknown, but infiltrating T cells may be activated locally and proliferate in situ...

journal_title：Journal of neuropathology and experimental neurology

authors： Bernasconi P,Cappelletti C,Navone F,Nessi V,Baggi F,Vernos I,Romaggi S,Confalonieri P,Mora M,Morandi L,Mantegazza R

更新日期：2008-06-01 00:00:00

abstract：:Defects in synaptic development and plasticity may lead to autism. Brain-derived neurotrophic factor (BDNF) plays a critical role in synaptogenesis and synaptic plasticity. BDNF is synthesized as a precursor, pro-BDNF, which can be processed into either a truncated form or into mature BDNF. Previous studies reported i...

journal_title：Journal of neuropathology and experimental neurology

authors： Garcia KL,Yu G,Nicolini C,Michalski B,Garzon DJ,Chiu VS,Tongiorgi E,Szatmari P,Fahnestock M

更新日期：2012-04-01 00:00:00

abstract：:We have encountered a series of 8 third ventricular neoplasms with a distinctive chordoid appearance that appear to represent a clinicopathologic entity. The tumors occurred in 7 females and 1 male, ranging in age from 31 to 70 years. In all cases, imaging studies showed a large well-circumscribed third ventricular ma...

journal_title：Journal of neuropathology and experimental neurology

authors： Brat DJ,Scheithauer BW,Staugaitis SM,Cortez SC,Brecher K,Burger PC

更新日期：1998-03-01 00:00:00

abstract：:Neuroaxonal dystrophy, a distinctive axonopathy characterized by marked enlargement of distal axons, is the hallmark pathologic alteration in aged and diabetic human prevertebral sympathetic ganglia and in corresponding rodent models. Neuroaxonal dystrophy is thought to represent the abnormal outcome of cycles of syna...

journal_title：Journal of neuropathology and experimental neurology

authors： Schmidt RE,Parvin CA,Green KG

更新日期：2008-12-01 00:00:00

abstract：:The ascending reticular activating system (ARAS) mediates arousal, an essential component of human consciousness. Lesions of the ARAS cause coma, the most severe disorder of consciousness. Because of current methodological limitations, including of postmortem tissue analysis, the neuroanatomic connectivity of the huma...

journal_title：Journal of neuropathology and experimental neurology

authors： Edlow BL,Takahashi E,Wu O,Benner T,Dai G,Bu L,Grant PE,Greer DM,Greenberg SM,Kinney HC,Folkerth RD

更新日期：2012-06-01 00:00:00

abstract：:The role of anti-myelin antibodies in the pathogenesis of experimental autoimmune neuritis (EAN) induced in the Lewis rat by immunization with peripheral nerve myelin has been assessed. Passive transfer with lymph node cells (LNC) or purified serum immunoglobulin from rats with EAN was employed to directly measure the...

journal_title：Journal of neuropathology and experimental neurology

authors： Taylor JM,Pollard JD

更新日期：2001-06-01 00:00:00

abstract：:The development of deformities during the course of leprosy disease is a major public health concern worldwide. It is possible that cytokine production and apoptosis of Schwann cells (SCs) directly affect nerve degeneration and regeneration leading to injury of the myelin sheath and axon. In the present study, the exp...

journal_title：Journal of neuropathology and experimental neurology

authors： Oliveira RB,Sampaio EP,Aarestrup F,Teles RM,Silva TP,Oliveira AL,Antas PR,Sarno EN

更新日期：2005-10-01 00:00:00

abstract：:Temporal lobe epilepsy (TLE) is characterized by hippocampal sclerosis together with profound losses and phenotypic changes of different classes of interneurons, including those expressing somatostatin (SRIF). To understand the functional significance of the plasticity of SRIF transmission in TLE, unraveling the statu...

journal_title：Journal of neuropathology and experimental neurology

authors： Csaba Z,Pirker S,Lelouvier B,Simon A,Videau C,Epelbaum J,Czech T,Baumgartner C,Sperk G,Dournaud P

更新日期：2005-11-01 00:00:00

abstract：:Versican is a large extracellular proteoglycan and is expressed in a variety of tissues including the central nervous system. A malignant astrocytoma cell line U87 with high motility expressed a higher level of versican than another malignant astrocytoma cell line U343 with lower motility. We observed that the U87 cel...

journal_title：Journal of neuropathology and experimental neurology

authors： Ang LC,Zhang Y,Cao L,Yang BL,Young B,Kiani C,Lee V,Allan K,Yang BB

更新日期：1999-06-01 00:00:00

abstract：:McArdle disease (muscle glycogenosis type V) is caused by myophosphorylase deficiency, which leads to impaired glycogen breakdown. We investigated how myophosphorylase deficiency affects muscle physiology, morphology, and glucose metabolism in 20-week-old McArdle mice and compared the findings to those in McArdle dise...

journal_title：Journal of neuropathology and experimental neurology

authors： Krag TO,Pinós T,Nielsen TL,Brull A,Andreu AL,Vissing J

更新日期：2016-05-01 00:00:00

abstract：:Acetylcholinesterase (AChE) activity has been studied in normal, control and denervated muscle of rabbits by electron microscopic-cytochemistry and radiometric assay. A small amount of butyrylcholinesterase (BuChE) activity is also found in biochemical assay of unfixed muscle, but it is not demonstrable cytochemically...

journal_title：Journal of neuropathology and experimental neurology

authors： Tennyson VM,Kremzner LT,Brzin M

更新日期：1977-03-01 00:00:00

abstract：:This study examines a radiation-induced invasion and spread of Schwann cells into ventral gray regions of the lumbar spinal cord. The prevalence of these cells within the gray matter and the time course of their appearance in the ventral spinal cord is quite different from the pattern of Schwann cell development in do...

journal_title：Journal of neuropathology and experimental neurology

authors： Sims TJ,Durgun MB,Gilmore SA

更新日期：1998-09-01 00:00:00

abstract：:During the Zika epidemic in Brazil, a baby was born at term with microcephaly and arthrogryposis. The mother had Zika symptoms at 10 weeks of gestation. At 17 weeks, ultrasound showed cerebral malformation and ventriculomegaly. At 24 weeks, the amniotic fluid contained ZIKV RNA and at birth, placenta and maternal bloo...

journal_title：Journal of neuropathology and experimental neurology

authors： Chimelli L,Moura Pone S,Avvad-Portari E,Farias Meira Vasconcelos Z,Araújo Zin A,Prado Cunha D,Raposo Thompson N,Lopes Moreira ME,Wiley CA,da Silva Pone MV

更新日期：2018-03-01 00:00:00

abstract：:The concept of the presence of mucopolysaccharides forming an interstitial ground substance in central nervous tissues is revived. The biochemical reports of both neutral and acid mucopolysaccharides in both gray and white matter of the normal brain are reviewed. The earlier histochemical reports and the histochemical...

journal_title：Journal of neuropathology and experimental neurology

authors： Feigin I

更新日期：1980-01-01 00:00:00

abstract：:The neurodegenerative synucleinopathies, which include Parkinson disease, multiple-system atrophy, and Lewy body disease, are characterized by the presence of abundant neuronal inclusions called Lewy bodies and Lewy neurites. These disorders remain incurable, and a greater understanding of the pathologic processes is ...

journal_title：Journal of neuropathology and experimental neurology

authors： Jones DR,Delenclos M,Baine AT,DeTure M,Murray ME,Dickson DW,McLean PJ

更新日期：2015-12-01 00:00:00

abstract：:The concern of the potential transmission of animal spongiform encephalopathies to humans, which arose as soon as the interspecies transmission of these diseases was recognized, has been reinforced with the emergence of bovine spongiform encephalopathy (BSE) in cattle. Recent experimental findings suggest that the inf...

journal_title：Journal of neuropathology and experimental neurology

authors： Baron T

更新日期：2002-05-01 00:00:00

abstract：:Granule cell dispersion (GCD) is observed in approximately 40% of cases of hippocampal sclerosis (HS) in patients with epilepsy. Studies in animal models suggest that GCD may be a consequence of enhanced proliferation of granule cell precursors as a result of seizures. We quantified the number of cells in cycle in sub...

journal_title：Journal of neuropathology and experimental neurology

authors： Thom M,Martinian L,Williams G,Stoeber K,Sisodiya SM

更新日期：2005-03-01 00:00:00

abstract：:The substantia nigra is not the induction site in the brain of the neurodegenerative process underlying Parkinson disease (PD). Instead, the results of this semi-quantitative study of 30 autopsy cases with incidental Lewy body pathology indicate that PD in the brain commences with the formation of the very first immun...

journal_title：Journal of neuropathology and experimental neurology

authors： Del Tredici K,Rüb U,De Vos RA,Bohl JR,Braak H

更新日期：2002-05-01 00:00:00

abstract：:In a series of 126 meningiomas, tumor and patient characteristics were investigated and statistically analyzed. A combined cytogenetic and molecular genetic approach was used to study chromosomal abnormalities and loss of markers on chromosome 22q. This approach was successfully applied to 93 meningiomas. In 66 cases,...

journal_title：Journal of neuropathology and experimental neurology

authors： Lekanne Deprez RH,Riegman PH,van Drunen E,Warringa UL,Groen NA,Stefanko SZ,Koper JW,Avezaat CJ,Mulder PG,Zwarthoff EC

更新日期：1995-03-01 00:00:00

abstract：:Since first described, amyotrophic lateral sclerosis/parkinsonism-dementia complex (ALS/PDC) of Guam has represented an important model of age-related neurodegenerative disease. ALS/PDC is characterized neuropathologically by severe widespread involvement by neurofibrillary tangles (NFTs). Over the past 30 years there...

journal_title：Journal of neuropathology and experimental neurology

authors： Perl DP,Hof PR,Purohit DP,Loerzel AJ,Kakulas BA

更新日期：2003-04-01 00:00:00