Transmission of Soluble and Insoluble α-Synuclein to Mice.

abstract：:The formation of Lewy bodies (LBs) and their relationship to other types of nigral inclusions associated with Parkinson disease (PD), such as pale bodies (PBs), remain poorly understood. Known constituents of LBs include alpha-synuclein (alphaS) and ubiquitin (Ub), providing windows to their morphogenesis. Additionall...

journal_title：Journal of neuropathology and experimental neurology

authors： Kuusisto E,Parkkinen L,Alafuzoff I

更新日期：2003-12-01 00:00:00

abstract：:This report describes a phenotypic differentiation pattern conceived to distinguish invading monocytes from resident microglia in frozen and formalin-fixed human CNS. Phagocytic cells in normal and diseased CNS (multiple sclerosis and encephalitis) were studied immunohistochemically with a panel of antibodies, and phe...

journal_title：Journal of neuropathology and experimental neurology

authors： Ulvestad E,Williams K,Mørk S,Antel J,Nyland H

更新日期：1994-09-01 00:00:00

abstract：:Neutral glycolipids and gangliosides were analyzed in 149 astrocytomas (A), 46 oligodendrogliomas (O), and 21 oligoastrocytomas (OA) to determine if specific glycolipids correlate with histologic diagnosis and grade. Positivity for asialoGM1 (GA1) and negativity for paragloboside by immuno-TLC correlated with histolog...

journal_title：Journal of neuropathology and experimental neurology

authors： Yates AJ,Comas T,Scheithauer BW,Burger PC,Pearl DK

更新日期：1999-12-01 00:00:00

abstract：:The sciatic/tibial/plantar nerve complex of normal aged rats displays striking morphological changes that are most pronounced distally. Nerve fiber abnormalities include: (a) large numbers of axonal glycogenosomes, mitochondria, dense membranous bodies, and decorated particles; (b) adaxonal Schwann cell processes sequ...

journal_title：Journal of neuropathology and experimental neurology

authors： Grover-Johnson N,Spencer PS

更新日期：1981-03-01 00:00:00

abstract：:Experimental cerebral ischemia was produced in gerbils by occlusion of the right common carotid artery in the neck. The evolution of the ischemic lesions was followed from five minutes to six hours by using the immunohistochemical techniques for tubulin and creatine kinase BB-isoenzyme. The earliest lesion was found i...

journal_title：Journal of neuropathology and experimental neurology

authors： Yanagihara T,Yoshimine T,Morimoto K,Yamamoto K,Homburger HA

更新日期：1985-03-01 00:00:00

abstract：:Mutations in the parkin gene are the most common cause of early-onset autosomal recessive Parkinson disease (PD). The pathogenic mechanisms of how parkin mutations lead to the development of PD are not fully understood. Studies of cell cultures and of Drosophila have suggested a dominant negative effect for the clinic...

journal_title：Journal of neuropathology and experimental neurology

authors： Van Rompuy AS,Lobbestael E,Van der Perren A,Van den Haute C,Baekelandt V

更新日期：2014-02-01 00:00:00

abstract：:Two basic proteins, P1 of molecular weight 14,200 and P2 of molecular weight 12,300, purified from bovine peripheral nerve, were assayed for biological activity. The P1 protein is an exclusively neuritogenic agent, capable of producing clinical signs of experimental allergic neuritis (EAN) and histological abnormaliti...

journal_title：Journal of neuropathology and experimental neurology

authors： Abramsky O,Teitelbaum D,Webb C,Arnon R

更新日期：1975-01-01 00:00:00

abstract：:Ca2+ currents are thought to enhance glutamate excitotoxicity. To investigate whether reduced expression of the Ca2+ limiting GluR2(B) subunit enhances seizure-induced vulnerability to either CA1 or CA3 neurons, we delivered GluR2(B) oligodeoxynucleotides (AS-ODNs) to the dorsal hippocampus of adult rats before induci...

journal_title：Journal of neuropathology and experimental neurology

authors： Friedman LK,Velísková J,Kaur J,Magrys BW,Liu H

更新日期：2003-07-01 00:00:00

abstract：:Early inflammatory events may inhibit functional recovery after injury in both the peripheral and central nervous systems. We investigated the role of the inflammatory tumor necrosis factor/nuclear factor-kappaB (NF-kappaB) axis on events subsequent to sciatic nerve crush injury in adult rats. Electrophoretic mobility...

journal_title：Journal of neuropathology and experimental neurology

authors： Smith D,Tweed C,Fernyhough P,Glazner GW

更新日期：2009-06-01 00:00:00

abstract：:A single oral dose of clofibrate (30 mg/100 gm body weight) given to 250-300 gm male rats produced myotonic discharges from both the gastrocnemius and soleus muscles 2 hours after feeding. Rats fed the same dosage for 14 consecutive days exhibited electromyographic discharges consistent with profound myotonia. Fibers ...

journal_title：Journal of neuropathology and experimental neurology

authors： Ontell M,Paul HS,Adibi SA,Martin JL

更新日期：1979-11-01 00:00:00

abstract：:In an earlier study we found that a substantial percentage of mice surviving infection with canine distemper virus (CDV) slowly developed a morbid obesity syndrome. In the present study we wished to explore the role of the virus in the development of this syndrome. The distribution of viral antigen(s) in brains of pre...

journal_title：Journal of neuropathology and experimental neurology

authors： Nagashima K,Zabriskie JB,Lyons MJ

更新日期：1992-01-01 00:00:00

abstract：:We investigated the immunohistochemical localization of several proteins related to excitation-contraction coupling and ultrastructural alterations of the sarcotubular system in biopsied muscles from a father and a daughter in a family with permanent myopathy with hypokalemic periodic paralysis (PMPP) due to a mutatio...

journal_title：Journal of neuropathology and experimental neurology

authors： Nagasaka T,Hata T,Shindo K,Adachi Y,Takeuchi M,Saito K,Takiyama Y

更新日期：2020-12-04 00:00:00

abstract：:Smooth muscle cells cultured from leptomeningeal vessels from old dogs with amyloid-angiopathy accumulate intracellular deposits that are immunoreactive for amyloid-beta peptide (A beta). We used this cellular model in the present study to examine the influence of sera and cerebrospinal fluid on intracellular accumula...

journal_title：Journal of neuropathology and experimental neurology

authors： Mazur-Kolecka B,Frackowiak J,Carroll RT,Wisniewski HM

更新日期：1997-03-01 00:00:00

abstract：:The long-term disabilities associated with spinal cord injury (SCI) are primarily due to the absence of robust neuronal regeneration and functional plasticity. The inability of the axon to regenerate after SCI is contributed by several intrinsic factors that trigger a cascade of molecular growth program and modulates ...

journal_title：Journal of neuropathology and experimental neurology

authors： Bhowmick S,Abdul-Muneer PM

更新日期：2021-01-20 00:00:00

abstract：:A number of studies have implicated a proline-directed protein kinase, glycogen synthase kinase-3 (GSK-3) in the hyperphosphorylation of tau in Alzheimer's disease (AD). Toward understanding the role of GSK-3 in the abnormal hyperphosphorylation of tau in AD we have found that GSK-3 is prominently present in neuronal ...

journal_title：Journal of neuropathology and experimental neurology

authors： Pei JJ,Tanaka T,Tung YC,Braak E,Iqbal K,Grundke-Iqbal I

更新日期：1997-01-01 00:00:00

abstract：:We report a novel case of a World Health Organization grade 3 anaplastic meningioma arising from the olfactory groove in an 83-year-old woman. Molecular and methylation profiling confirm this lesion to be an NF2 subtype, methylation class intermediate type B meningioma. As most meningiomas in this location are indolen...

journal_title：Journal of neuropathology and experimental neurology

authors： Foo ASC,Tan DTM,Tan CL,Sahm F,von Deimling A,Yeo TT

更新日期：2017-12-01 00:00:00

abstract：:The relevance of cerebral amyloid angiopathy (CAA) to the pathogenesis of Alzheimer disease (AD) and dementia in general emphasizes the importance of developing novel targeting approaches for detecting and treating cerebrovascular amyloid (CVA) deposits. We developed a nanoparticle-based technology that uses a monoclo...

journal_title：Journal of neuropathology and experimental neurology

authors： Poduslo JF,Hultman KL,Curran GL,Preboske GM,Chamberlain R,Marjańska M,Garwood M,Jack CR Jr,Wengenack TM

更新日期：2011-08-01 00:00:00

abstract：:Neurofilamentous axonal swellings occur in a number of degenerative and toxic disorders of the nervous system. In one of these, experimental intoxication with beta, beta'-iminodiproprionitrile (IDPN), accumulation of neurofilaments has been shown to result from a defect in slow axonal transport. The consequence of thi...

journal_title：Journal of neuropathology and experimental neurology

authors： Clark AW,Griffin JW,Price DL

更新日期：1980-01-01 00:00:00

abstract：:The aim of this study was to clarify pathological and anatomical relationships between adamantinomatous craniopharyngiomas (ACP) and their surrounding structures. We previously established a QST classification scheme based on the apparent anatomic origin of the tumors. According to this classification, 13 type Q tumor...

journal_title：Journal of neuropathology and experimental neurology

authors： Liu Y,Qi ST,Wang CH,Pan J,Fan J,Peng JX,Zhang X,Bao Y,Liu YW

更新日期：2018-11-01 00:00:00

abstract：:Multiple sclerosis (MS) is an inflammatory demyelinating disorder of the CNS. A recent study identified 4 patterns of demyelination in active MS lesions. The characteristics of pattern II lesions suggested a primary inflammatory mechanism of myelin injury, while pattern III lesions showed features consistent with dyin...

journal_title：Journal of neuropathology and experimental neurology

authors： Mahad DJ,Trebst C,Kivisäkk P,Staugaitis SM,Tucky B,Wei T,Lucchinetti CF,Lassmann H,Ransohoff RM

更新日期：2004-03-01 00:00:00

abstract：:Lysosomal beta-hexosaminidase consists of 2 subunits, alpha and beta. Mutations in the alpha-subunit gene cause Tay-Sachs disease, while mutations in the beta-subunit gene cause Sandhoff disease. Mice generated by targeted disruption of either the alpha- or beta-subunit genes displayed the pathological features of Tay...

journal_title：Journal of neuropathology and experimental neurology

authors： Suzuki K,Sango K,Proia RL,Langaman C

更新日期：1997-06-01 00:00:00

abstract：:Whatever the cause of myelin damage of the peripheral nervous system, the initial attack on myelin by a dysimmune process may begin either at the internodal area or in the paranodal and nodal regions. The term "nodo-paranodopathy" was first applied to some "axonal Guillain-Barré syndrome" subtypes, then extended to ca...

journal_title：Journal of neuropathology and experimental neurology

authors： Vallat JM,Magy L,Corcia P,Boulesteix JM,Uncini A,Mathis S

更新日期：2020-03-01 00:00:00

abstract：:An experimental neuropathy in rats produced by tying loosely constrictive ligatures around one sciatic nerve has recently been shown to produce pain-related behavior that follows a reproducible time course. In the present study, we assessed the degree of thermal hyperesthesia and examined the sciatic nerves by light a...

journal_title：Journal of neuropathology and experimental neurology

authors： Sommer C,Galbraith JA,Heckman HM,Myers RR

更新日期：1993-05-01 00:00:00

abstract：:A superoxide dismutase 1 (SOD-1)genetic defect has been identified in familial amyotrophic lateral sclerosis (ALS) and motor neuron degeneration has been described in SOD-1 transgenic mice. Because an excitotoxic mechanism has been implicated in ALS, we undertook studies to provide a description of excitotoxic degener...

journal_title：Journal of neuropathology and experimental neurology

authors： Ikonomidou C,Qin Qin Y,Labruyere J,Olney JW

更新日期：1996-02-01 00:00:00

abstract：:We have encountered a series of 8 third ventricular neoplasms with a distinctive chordoid appearance that appear to represent a clinicopathologic entity. The tumors occurred in 7 females and 1 male, ranging in age from 31 to 70 years. In all cases, imaging studies showed a large well-circumscribed third ventricular ma...

journal_title：Journal of neuropathology and experimental neurology

authors： Brat DJ,Scheithauer BW,Staugaitis SM,Cortez SC,Brecher K,Burger PC

更新日期：1998-03-01 00:00:00

abstract：:We describe the clinical, pathological, ultrastructural and biochemical features in the case of a 15-year-old boy with multiple sulfatase deficiency. Clinical abnormalities included hypotonia, retarded psychomotor development, hepatosplenomegaly, pigmentary degeneration of the retina, myoclonic seizures, aortic insuff...

journal_title：Journal of neuropathology and experimental neurology

authors： Guerra WF,Verity MA,Fluharty AL,Nguyen HT,Philippart M

更新日期：1990-07-01 00:00:00

abstract：:Canine smooth muscle cells (SMCs), cultured from amyloid-affected brain blood vessels accumulate Alzheimer amyloid-beta peptide (Abeta) intracellularly, either spontaneously or after treatment with apolipoprotein E (apoE). ApoE is codeposited with Abeta, which suggests that apoE participates in Abeta accumulation. We ...

journal_title：Journal of neuropathology and experimental neurology

authors： Mazur-Kolecka B,Frackowiak J,Krzeslowska J,Ramakrishna N,Haske T,Emmerling MR,Zhang W,Kim KS,Wisniewski HM

更新日期：1999-03-01 00:00:00

abstract：:To assess the range of differentiation of the cells comprising dysembryoplastic neuroepithelial tumor (DNT), particularly the oligodendrocyte-like cells (OLC), 14 DNT were immunochemically studied with a spectrum of neuronal and glial markers. Eight tumors were also studied ultrastructurally. Neurofilament protein, cl...

journal_title：Journal of neuropathology and experimental neurology

authors： Hirose T,Scheithauer BW,Lopes MB,VandenBerg SR

更新日期：1994-03-01 00:00:00

abstract：:An effective method was sought to immunize rats against the growth of intracerebrally (IC) injected T9 tumor, a gliosarcoma cell line. Rats which were immunized with either 10(6) T9 cells mixed with 0.14 mg C. parvum, or 10(7) irradiated T9 cells showed tumor immunity to intradermal (ID) transplantation. However, to o...

journal_title：Journal of neuropathology and experimental neurology

authors： Kida Y,Cravioto H,Hochwald GM,Hochgeschwender U,Ransohoff J

更新日期：1983-03-01 00:00:00

abstract：:Bcl-2, a cell death suppressor protein, is expressed during brain development but is largely down-regulated in the adult central nervous system. We previously reported strong expression of bcl-2 in small, "oligodendrocyte-like" cells (OLC) found in glioneuronal hamartias. These hamartias are microscopic cell rests fou...

journal_title：Journal of neuropathology and experimental neurology

authors： Yachnis AT,Roper SN,Love A,Fancey JT,Muir D

更新日期：2000-02-01 00:00:00