Morphogenesis of Lewy bodies: dissimilar incorporation of alpha-synuclein, ubiquitin, and p62.

abstract：:After the finding that anti-prion antibodies stain sensory and sympathetic ganglia in variant Creutzfeldt-Jakob disease (vCJD), it was suggested that this localization supported the oral route of entry. However, prion accumulation subsequently also appeared in the peripheral nervous system (PNS) in sporadic cases. Thi...

journal_title：Journal of neuropathology and experimental neurology

authors： Lee CC,Kuo LT,Wang CH,Scaravilli F,An SF

更新日期：2005-08-01 00:00:00

abstract：:A direct causal relationship between a human DNA virus, adeno serotype 12, and malignant transformation in target cells (sensory retinal neuronal precursors) was suggested by the development of a remarkably uniform retinoblastoma-like neoplasm in rats. In order to focus upon incipient photoreceptor differentiation, 27...

journal_title：Journal of neuropathology and experimental neurology

authors： Mukai N,Murao T

更新日期：1975-01-01 00:00:00

abstract：:A single oral dose of clofibrate (30 mg/100 gm body weight) given to 250-300 gm male rats produced myotonic discharges from both the gastrocnemius and soleus muscles 2 hours after feeding. Rats fed the same dosage for 14 consecutive days exhibited electromyographic discharges consistent with profound myotonia. Fibers ...

journal_title：Journal of neuropathology and experimental neurology

authors： Ontell M,Paul HS,Adibi SA,Martin JL

更新日期：1979-11-01 00:00:00

abstract：:Deletions on the short arm of chromosome 1 (1p) and the long arm of chromosome 19 (19q) are molecular hallmark lesions of oligodendroglial tumors. Ever since oligodendroglial tumors with 1p and 19q deletions were shown to respond to chemotherapy, neuropathologists have been facing increasing requests for such molecula...

journal_title：Journal of neuropathology and experimental neurology

authors： Hartmann C,Mueller W,Lass U,Kamel-Reid S,von Deimling A

更新日期：2005-01-01 00:00:00

abstract：:Alpha-synuclein (alpha-synuclein) lesions are characteristic of idiopathic Parkinson disease (PD) and other alpha-synucleinopathies. To study the frequency of alpha-synuclein lesions in normal aging and how frequently they coexist with lesions of Alzheimer disease (AD), we examined the autopsy brains from normal and d...

journal_title：Journal of neuropathology and experimental neurology

authors： Mikolaenko I,Pletnikova O,Kawas CH,O'Brien R,Resnick SM,Crain B,Troncoso JC

更新日期：2005-02-01 00:00:00

abstract：:We review the newest advances related to seeking the pathogenic mechanism(s) of sporadic inclusion-body myositis (s-IBM) and present the pathologic diagnostic criteria of s-IBM. We discuss the possible pathogenic role of several themes, such as 1) increased amyloid-beta precursor protein (AbetaPP) and of its fragment ...

journal_title：Journal of neuropathology and experimental neurology

authors： Askanas V,Engel WK

更新日期：2001-01-01 00:00:00

abstract：:The hyperacute form of experimental allergic encephalomyelitis (EAE), characterized by a short incubation period, severe paralysis, high mortality, and abundant polymorphonuclear leukocytes and fibrin in the lesions, was produced in rats without the use of pertussis vaccine (previously considered an essential requirem...

journal_title：Journal of neuropathology and experimental neurology

authors： Levine S,Saltzman A

更新日期：1989-05-01 00:00:00

abstract：:Pilocytic astrocytoma (PA) is the most common glioma of childhood. Despite their relatively high incidence, the molecular mechanisms responsible for tumorigenesis and growth of PA are poorly understood. Previous in vitro studies in our laboratory showed that despite the absence of ErbB1, PA was sensitive to ErbB1 tyro...

journal_title：Journal of neuropathology and experimental neurology

authors： Addo-Yobo SO,Straessle J,Anwar A,Donson AM,Kleinschmidt-Demasters BK,Foreman NK

更新日期：2006-08-01 00:00:00

abstract：:In the central nervous system, tuberous sclerosis complex (TSC) is characterized by a range of lesions including cortical tubers, white matter heterotopias, subependymal nodules, and subependymal giant cell astrocytomas (SEGAs). Recent studies have implicated an important role for the TSC genes TSC1 and TSC2, in a sig...

journal_title：Journal of neuropathology and experimental neurology

authors： Chan JA,Zhang H,Roberts PS,Jozwiak S,Wieslawa G,Lewin-Kowalik J,Kotulska K,Kwiatkowski DJ

更新日期：2004-12-01 00:00:00

abstract：:Cysteine-S-sulfate is an abnormal metabolite discovered in the urine and blood of a patient with cysteine oxidase deficiency, a rare disorder of sulfur amino acid metabolism associated with brain damage and mental retardation. The molecular structure of cysteine-S-sulfate closely resembles that of glutamate and relate...

journal_title：Journal of neuropathology and experimental neurology

authors： Olney JW,Misra CH,de Gubareff T

更新日期：1975-03-01 00:00:00

abstract：:Neuropathologists use anti-glial fibrillary acidic protein (GFAP) antibodies as specific markers for glial cells, and neurobiologists use GFAP for targeting transgenes to glial cells. Since GFAP has also been detected in non-glial cells, we systematically analyzed GFAP expression in human and murine non-CNS tissues us...

journal_title：Journal of neuropathology and experimental neurology

authors： Hainfellner JA,Voigtländer T,Ströbel T,Mazal PR,Maddalena AS,Aguzzi A,Budka H

更新日期：2001-05-01 00:00:00

abstract：:Placement of a freezing probe on the skull of neonatal rats produces four-layered microgyria, complete with a lamina dissecans and microsulcus. We studied the developmental course of this induced microgyria under light microscopy by examining changes in neurons, glia, and macrophages following a focal freezing insult ...

journal_title：Journal of neuropathology and experimental neurology

authors： Rosen GD,Press DM,Sherman GF,Galaburda AM

更新日期：1992-11-01 00:00:00

abstract：:A retrospective analysis of 14 patients who presented with a progressively expanding mass lesion(s) shown at biopsy/autopsy to represent acute demyelination was carried out. The aims of this study were to determine the optimal neuropathological approach to diagnosis and to determine the clinical evolution of this cond...

journal_title：Journal of neuropathology and experimental neurology

authors： Annesley-Williams D,Farrell MA,Staunton H,Brett FM

更新日期：2000-06-01 00:00:00

abstract：:This study establishes the sequence of myelination in a population of autopsied infants from birth through the second postnatal year. Myelination was assessed in 62 precisely defined central nervous system (CNS) sites of 162 infants with diverse diseases who were autopsied from 1972 to 1984 at Children's Hospital, Bos...

journal_title：Journal of neuropathology and experimental neurology

authors： Brody BA,Kinney HC,Kloman AS,Gilles FH

更新日期：1987-05-01 00:00:00

abstract：:Progressive supranuclear palsy (PSP), corticobasal degeneration (CBD), sporadic multisystem tauopathy, and some forms of frontotemporal dementia with Parkinsonism linked to chromosome 17 are characterized by neuronal and glial lesions accumulating tau protein containing 4 conserved repeats in microtubule-binding domai...

journal_title：Journal of neuropathology and experimental neurology

authors： Josephs KA,Katsuse O,Beccano-Kelly DA,Lin WL,Uitti RJ,Fujino Y,Boeve BF,Hutton ML,Baker MC,Dickson DW

更新日期：2006-04-01 00:00:00

abstract：:The most common histologic feature in patients with frontotemporal lobar degeneration (FTLD) is intracellular brain inclusions of yet uncharacterized proteins that react with antiubiquitin (Ub) antibodies, but not with tau or synuclein (FTLD-U). We identified a four-generation Belgian FTLD family in which 8 patients h...

journal_title：Journal of neuropathology and experimental neurology

authors： Pirici D,Vandenberghe R,Rademakers R,Dermaut B,Cruts M,Vennekens K,Cuijt I,Lübke U,Ceuterick C,Martin JJ,Van Broeckhoven C,Kumar-Singh S

更新日期：2006-03-01 00:00:00

abstract：:The aim of our study is to evaluate the extent and distribution of grey matter demyelinating lesions in multiple sclerosis (MS), addressing also neuronal loss and synaptic loss. Whole coronal sections of 6 MS brains and 6 control brains were selected. Immunohistochemistry was performed for myelin basic protein, neurof...

journal_title：Journal of neuropathology and experimental neurology

authors： Vercellino M,Plano F,Votta B,Mutani R,Giordana MT,Cavalla P

更新日期：2005-12-01 00:00:00

abstract：:Centrosome amplification is a pivotal mechanism underlying tumorigenesis but its role in gliomas is underinvestigated. The present study specifically examines the expression and distribution of the centrosome-associated cytoskeletal protein gamma-tubulin in 56 primary diffuse astrocytic gliomas (grades II-IV) and in 4...

journal_title：Journal of neuropathology and experimental neurology

authors： Katsetos CD,Reddy G,Dráberová E,Smejkalová B,Del Valle L,Ashraf Q,Tadevosyan A,Yelin K,Maraziotis T,Mishra OP,Mörk S,Legido A,Nissanov J,Baas PW,de Chadarévian JP,Dráber P

更新日期：2006-05-01 00:00:00

abstract：:In multiple sclerosis, remyelination becomes limited after repeated or prolonged episodes of demyelination. To test the effect of platelet-derived growth factor-A (PDGF-A) in recovery from chronic demyelination we induced corpus callosum demyelination using cuprizone treatment in hPDGF-A transgenic (tg) mice with the ...

journal_title：Journal of neuropathology and experimental neurology

authors： Vana AC,Flint NC,Harwood NE,Le TQ,Fruttiger M,Armstrong RC

更新日期：2007-11-01 00:00:00

abstract：:Bone marrow stromal cells (BMSCs) have the potential to improve functional recovery in patients with spinal cord injury (SCI); however, they are limited by low survival rates after transplantation in the injured tissue. Our objective was to clarify the effects of a temporal blockade of interleukin 6 (IL-6)/IL-6 recept...

journal_title：Journal of neuropathology and experimental neurology

authors： Tan Y,Uchida K,Nakajima H,Guerrero AR,Watanabe S,Hirai T,Takeura N,Liu SY,Johnson WE,Baba H

更新日期：2013-10-01 00:00:00

abstract：:The 2016 WHO classification of brain tumors represents a major step towards the integration of molecular data into pathologic diagnoses. Our institution has included massively parallel sequencing technology in the diagnostic work-up of all gliomas since January 2016. The utilized platform successfully identifies copy ...

journal_title：Journal of neuropathology and experimental neurology

authors： Parilla M,Kadri S,Patil SA,Fitzpatrick C,Ritterhouse L,Segal J,Collins J,Pytel P

更新日期：2019-03-01 00:00:00

abstract：:Large complex membranous bodies are described in the cerebral cortex of adult rats. Although these bodies are not very prevalent, they appear with increasing frequency as the age of the animal increases from 12 to 28 months. The membranous bodies are composed of varying amounts of membranes, cytoplasm and empty vacuol...

journal_title：Journal of neuropathology and experimental neurology

authors： Vaughan DW

更新日期：1976-03-01 00:00:00

abstract：:Despite the key role of γ-aminobutyric acid (GABA) neurons in the modulation of cerebral cortical output, little is known about their development in the human cortex. We analyzed several GABAergic parameters in standardized regions of the cerebral cortex and white matter in a total of 38 human fetuses and infants from...

journal_title：Journal of neuropathology and experimental neurology

authors： Xu G,Broadbelt KG,Haynes RL,Folkerth RD,Borenstein NS,Belliveau RA,Trachtenberg FL,Volpe JJ,Kinney HC

更新日期：2011-10-01 00:00:00

abstract：:Shigella dysenteriae strains produce an exotoxin (SdT) which inhibits protein synthesis in susceptible cells and is neurotoxic in some species. Intraneural microinjection of highly purified SdT into the cervical vagus nerves of rats, mice, guinea pigs and rabbits produced cytopathic changes within 24 hours in vagal se...

journal_title：Journal of neuropathology and experimental neurology

authors： Wiley RG,Donohue-Rolfe A,Keusch GT

更新日期：1985-09-01 00:00:00

abstract：:Precise temporal and spatial coordination of expression of the myogenic regulatory factors (MRF) plays a critical role in the development of skeletal muscle. Whether this pattern is recapitulated postnatally during regeneration of mature muscle after injury is not known. The aim of this study was to determine the cell...

journal_title：Journal of neuropathology and experimental neurology

authors： Bhagavati S,Ghatpande A,Shafiq SA,Leung B

更新日期：1996-05-01 00:00:00

abstract：:This is a report of an unusual, densely cellular, midcerebellar neoplasm in a seven-year-old boy. Although clinically consistent with a medulloblastoma, immunohistochemistry and electron microscopy demonstrated glial and rhabdomyoblastic differentiation in the tumor. We discuss the differential diagnosis of this tumor...

journal_title：Journal of neuropathology and experimental neurology

authors： Dickson DW,Hart MN,Menezes A,Cancilla PA

更新日期：1983-11-01 00:00:00

abstract：:Pediatric and NF2-associated meningiomas are uncommon and poorly characterized in comparison to sporadic adult cases. In order to elucidate their molecular features, we analyzed MIB-1, progesterone receptor (PR), NF2, merlin, DAL-1, DAL-1 protein, and chromosomal arms 1p and 14q in 53 meningiomas from 40 pediatric/NF2...

journal_title：Journal of neuropathology and experimental neurology

authors： Perry A,Giannini C,Raghavan R,Scheithauer BW,Banerjee R,Margraf L,Bowers DC,Lytle RA,Newsham IF,Gutmann DH

更新日期：2001-10-01 00:00:00

abstract：:Normal human frontal lobe white matter obtained at autopsy was used to determine the extent of in situ post-mortem degradation of myelin basic protein (BP). Effects of the following two factors were studied: 1) time interval between death and autopsy, and 2) freezing and thawing the tissue. Quantitative extraction of...

journal_title：Journal of neuropathology and experimental neurology

authors： Ansari KA,Rand A,Hendrickson H,Bentley MD

更新日期：1976-03-01 00:00:00

abstract：:Hydrocephalic hyh mice are born with moderate hydrocephalus and a normal cerebral aqueduct. At about the fifth postnatal day the aqueduct becomes obliterated and severe hydrocephalus develops. The aim of the present investigation was to investigate the mechanism of this hydrocephalus, probably starting during fetal li...

journal_title：Journal of neuropathology and experimental neurology

authors： Jiménez AJ,Tomé M,Páez P,Wagner C,Rodríguez S,Fernández-Llebrez P,Rodríguez EM,Pérez-Fígares JM

更新日期：2001-11-01 00:00:00

abstract：:A previous autopsy study of patients with amnestic-type mild cognitive impairment (MCI) suggested an overrepresentation of argyrophilic grain disease (AGD). We studied 34 patients who had diagnoses of amnestic MCI during progression to dementia and who came to autopsy. Neuropathologic evaluation included routine histo...

journal_title：Journal of neuropathology and experimental neurology

authors： Jicha GA,Petersen RC,Knopman DS,Boeve BF,Smith GE,Geda YE,Johnson KA,Cha R,Delucia MW,Braak H,Dickson DW,Parisi JE

更新日期：2006-06-01 00:00:00