Platelet-derived growth factor promotes repair of chronically demyelinated white matter.

abstract：:Loss of chromosome 1p/19q in oligodendrogliomas represents a powerful predictor of good prognosis. Expression of internexin (INA), a neuronal specific intermediate filament protein, has recently been proposed as a surrogate marker for 1p/19q deletion based on the high degree of correlation between both parameters in o...

journal_title：Journal of neuropathology and experimental neurology

authors： Buckley PG,Alcock L,Heffernan J,Woods J,Brett F,Stallings RL,Farrell MA

更新日期：2011-03-01 00:00:00

abstract：:A primary cerebellar rhabdomyosarcoma (RMS) in a six and a half year old boy is reported. Microscopy of the surgical material revealed lobules of closely packed cells with a high mitotic rate, pleomorphic hyperchromatic nuclei and scant cytoplasm. At their periphery, the lobules merged with rounded cells with similar ...

journal_title：Journal of neuropathology and experimental neurology

authors： Hinton DR,Halliday WC

更新日期：1984-07-01 00:00:00

abstract：:Cortical lesions (CLs) are an important component of multiple sclerosis (MS) pathology; they correlate better with physical disability and cognitive impairment than white matter lesions (WMLs). Because remyelination can be extensive in CLs, we quantified remyelination in gray matter (GM) and white matter (WM), address...

journal_title：Journal of neuropathology and experimental neurology

authors： Strijbis EMM,Kooi EJ,van der Valk P,Geurts JJG

更新日期：2017-05-01 00:00:00

abstract：:Inclusion body myositis (IBM) is a late-onset inflammatory myopathy with distinctive clinical and histopathological features. The molecular basis for the disease remains unknown, but abnormal nuclear morphology and the accumulation of a protein that binds single-stranded DNA in a sequence-independent fashion suggest a...

journal_title：Journal of neuropathology and experimental neurology

authors： Horvath R,Fu K,Johns T,Genge A,Karpati G,Shoubridge EA

更新日期：1998-05-01 00:00:00

abstract：:Reactive axonal change has long been recognized as a feature of traumatic brain injury. To date, the histological methods used to identify reactive axons have been of limited utility, and they have not provided insight into the initial intraaxonal event that triggers reactive change. In this investigation, monoclonal ...

journal_title：Journal of neuropathology and experimental neurology

authors： Yaghmai A,Povlishock J

更新日期：1992-03-01 00:00:00

abstract：:Nijmegen breakage syndrome caused by NBS1 germline mutations is a rare autosomal recessive disease with clinical features that include microcephaly, increased radiosensitivity, and predisposition to cancer. NBS1 plays a key role in DNA double-strand break repair and the maintenance of genomic stability. We screened 87...

journal_title：Journal of neuropathology and experimental neurology

authors： Watanabe T,Nobusawa S,Lu S,Huang J,Mittelbronn M,Ohgaki H

更新日期：2009-02-01 00:00:00

abstract：:The evolving neuropathology of primarily undamaged cortical regions adjacent to the injured site has been studied in 36 infants who survived a variety of perinatally acquired encephalopathies (microgyrias, ulegyrias, multicystic encephalopathies, porencephalies, and hydranencephalies) and later died of unrelated cause...

journal_title：Journal of neuropathology and experimental neurology

authors： Marín-Padilla M

更新日期：1999-05-01 00:00:00

abstract：:The human polyomavirus JC (JCV) is the etiologic agent of progressive multifocal leukoencephalopathy (PML), a demyelinating disease of the CNS that occurs in immunosuppressed individuals. Because polyomavirus-induced CNS pathology usually occurs as a result of the reactivation of latent virus, little is known about th...

journal_title：Journal of neuropathology and experimental neurology

authors： Axthelm MK,Koralnik IJ,Dang X,Wüthrich C,Rohne D,Stillman IE,Letvin NL

更新日期：2004-07-01 00:00:00

abstract：:Histological examination by light and electron microscopy of the spinal cords of four dogs rapidly perfusion-fixed after the onset of decompression sickness revealed the presence of numerous non-staining, space-occupying lesions that were absent in similarly prepared sections of control or ischemic spinal cords. We pr...

journal_title：Journal of neuropathology and experimental neurology

authors： Francis TJ,Pezeshkpour GH,Dutka AJ,Hallenbeck JM,Flynn ET

更新日期：1988-07-01 00:00:00

abstract：:X-linked Charcot-Marie-Tooth disease (CMTX) is an inherited demyelinating neuropathy caused by mutations in the gene encoding the gap junction protein connexin32 (Cx32). Despite the identification of over 160 different mutations in the Cx32 coding sequence, it is not known whether the mutations cause the disease manif...

journal_title：Journal of neuropathology and experimental neurology

authors： Abel A,Bone LJ,Messing A,Scherer SS,Fischbeck KH

更新日期：1999-07-01 00:00:00

abstract：:The aim of this study was to identify aberrantly expressed proteins in pediatric primitive neuroectodermal tumors (PNETs) and ependymomas. Tumor tissue of 29 PNET and 12 ependymoma patients was subjected to 2-dimensional difference gel electrophoresis. Gel analysis resulted in 79 protein spots being differentially exp...

journal_title：Journal of neuropathology and experimental neurology

authors： de Bont JM,den Boer ML,Kros JM,Passier MM,Reddingius RE,Smitt PA,Luider TM,Pieters R

更新日期：2007-06-01 00:00:00

abstract：:Alpha-synuclein (alpha-syn) is an important component of neuronal and glial inclusions in brains of patients with several neurodegenerative disorders. Sporadic inclusion-body myositis (s-IBM) is the most common progressive muscle disease of older patients. Its muscle phenotype shows several similarities with Alzheimer...

journal_title：Journal of neuropathology and experimental neurology

authors： Askanas V,Engel WK,Alvarez RB,McFerrin J,Broccolini A

更新日期：2000-07-01 00:00:00

abstract：:Whatever the cause of myelin damage of the peripheral nervous system, the initial attack on myelin by a dysimmune process may begin either at the internodal area or in the paranodal and nodal regions. The term "nodo-paranodopathy" was first applied to some "axonal Guillain-Barré syndrome" subtypes, then extended to ca...

journal_title：Journal of neuropathology and experimental neurology

authors： Vallat JM,Magy L,Corcia P,Boulesteix JM,Uncini A,Mathis S

更新日期：2020-03-01 00:00:00

abstract：:Vascular dementia (VaD) is cognitive decline linked to reduced cerebral blood perfusion, yet there are few therapeutic options to protect cognitive function following cerebrovascular accidents. The purpose of this study was to profile gene expression changes unique to VaD to identify and characterize disease relevant ...

journal_title：Journal of neuropathology and experimental neurology

authors： McKay EC,Beck JS,Khoo SK,Dykema KJ,Cottingham SL,Winn ME,Paulson HL,Lieberman AP,Counts SE

更新日期：2019-05-01 00:00:00

abstract：:Intrauterine infection and inflammation have been linked to preterm birth and brain damage. We hypothesized that recombinant human erythropoietin (rhEPO) would ameliorate brain damage in anovine model of fetal inflammation. At 107 +/- 1 day of gestational age (DGA), chronically catheterized fetal sheep received on 3 c...

journal_title：Journal of neuropathology and experimental neurology

authors： Rees S,Hale N,De Matteo R,Cardamone L,Tolcos M,Loeliger M,Mackintosh A,Shields A,Probyn M,Greenwood D,Harding R

更新日期：2010-03-01 00:00:00

abstract：:The age-related change in the neuronal RNA content, volume, and the RNA concentration of 2,160 single cell bodies was examined from the prefrontal cortex. Human brains from 15 normal and 3 demented patients of ages ranging from 8 months to 94 years were obtained at post-mortem examination. The neuronal RNA showed an a...

journal_title：Journal of neuropathology and experimental neurology

authors： Uemura E,Hartmann HA

更新日期：1978-09-01 00:00:00

abstract：:Rates of remyelination decline with age and this has been attributed to slower recruitment of oligodendrocyte progenitor cells (OPCs) into areas of demyelination and slower differentiation of OPCs into remyelinating oligodendrocytes. When considering causes for reduced recruitment rates, intrinsic causes (alterations ...

journal_title：Journal of neuropathology and experimental neurology

authors： Chari DM,Crang AJ,Blakemore WF

更新日期：2003-09-01 00:00:00

abstract：:G-protein coupled receptor kinases (GRKs) constitute a serine/threonine kinase family playing a major role in agonist-induced phosphorylation and desensitization of G-protein coupled receptors. Recently, GRK2 and GRK5 have been demonstrated to phosphorylate alpha-synuclein (Ser129) and other synuclein isoforms. We stu...

journal_title：Journal of neuropathology and experimental neurology

authors： Takahashi M,Uchikado H,Caprotti D,Weidenheim KM,Dickson DW,Ksiezak-Reding H,Pasinetti GM

更新日期：2006-12-01 00:00:00

abstract：:The content of RNA and the volume of motor neurons isolated from the lateral portion of the cervical swelling were examined in six control and six amyotrophic lateral sclerosis (ALS) cases obtained at autopsy. The mean volume of motor neurons in the ALS group did not differ significantly from the values obtained in th...

journal_title：Journal of neuropathology and experimental neurology

authors： Davidson TJ,Hartmann HA,Johnson PC

更新日期：1981-01-01 00:00:00

abstract：:Ethanol is a potent neurotoxin particularly for the developing nervous system. Intrauterine exposure to ethanol during the last trimester of human gestation can produce a broad spectrum of neuropathologic consequences. This period of human brain development is roughly equivalent to the first week of rodent postnatal l...

journal_title：Journal of neuropathology and experimental neurology

authors： Nowoslawski L,Klocke BJ,Roth KA

更新日期：2005-06-01 00:00:00

abstract：:Mouse central nervous system tissue cultured for different lengths of time was analyzed for the proliferation of macrophages. These cells were identified and characterized by ultrastructural features, cell surface determinants and their ability to ingest latex particles and bacteria. Under the experimental conditions ...

journal_title：Journal of neuropathology and experimental neurology

authors： Raedler E,Raedler A

更新日期：1984-09-01 00:00:00

abstract：:Long-term administration of chloroquine to rats induces a vacuolar myopathy, which is specifically termed chloroquine myopathy (CM). In CM, tau mRNA levels were transiently upregulated in the early phase, while tau itself slowly accumulated in the late phase. The temporal profiles of tau mRNA levels and its accumulati...

journal_title：Journal of neuropathology and experimental neurology

authors： Murakami N,Oyama F,Gu Y,McLennan IS,Nonaka I,Ihara Y

更新日期：1998-07-01 00:00:00

abstract：:We describe a family with a rapidly progressive neurodegenerative disorder characterized by amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) but with unusual neuropathologic features that include pallidoluysionigral degeneration. The proband presented with primary progressive aphasia that evolved ...

journal_title：Journal of neuropathology and experimental neurology

authors： Portera-Cailliau C,Russ C,Brown RH Jr,Budson AE,Vonsattel JP,Folkerth RD,Corbo JC

更新日期：2007-07-01 00:00:00

abstract：:The DNA repair protein O6-methylguanine-DNA methyltransferase (MGMT) removes temozolomide-induced alkylation, thereby preventing DNA damage and cytotoxicity. We investigated the prognostic effect of different MGMT methylation levels on overall and progression-free survival in 327 patients with primary glioblastoma und...

journal_title：Journal of neuropathology and experimental neurology

authors： Dahlrot RH,Larsen P,Boldt HB,Kreutzfeldt MS,Hansen S,Hjelmborg JB,Kristensen BW

更新日期：2019-07-01 00:00:00

abstract：:The interaction of phosphatidylserine (PS), exposed on the surface of apoptotic cells and with its specific receptor (PtdSerR) expressed by microglia, is a crucial event in the recognition and clearance of apoptotic neurons. Here, we extend our previous studies in which PS-liposomes mimicking apoptotic cells were used...

journal_title：Journal of neuropathology and experimental neurology

authors： De Simone R,Ajmone-Cat MA,Tirassa P,Minghetti L

更新日期：2003-02-01 00:00:00

abstract：:Axonal damage is the major cause of irreversible neurologic disability in patients with multiple sclerosis. Although axonal damage correlates with antibodies against neurofilament light (NF-L) protein, a major component of the axonal cytoskeleton, the possible pathogenic role of autoimmunity to axonal antigens such as...

journal_title：Journal of neuropathology and experimental neurology

authors： Huizinga R,Heijmans N,Schubert P,Gschmeissner S,'t Hart BA,Herrmann H,Amor S

更新日期：2007-04-01 00:00:00

abstract：:Cortical biopsies of 17 patients with diagnoses of congenital malformation, cerebral tumor or brain trauma complicated by subdural hematoma or hygroma were studied with the electron microscope; the alterations of the blood-brain barrier in moderate and severe perifocal cerebral edema were observed. Moderate edema was ...

journal_title：Journal of neuropathology and experimental neurology

authors： Castejón OJ

更新日期：1980-05-01 00:00:00

abstract：:Brainstem Lewy bodies (LB) are neuronal inclusions that are closely related to Parkinson's disease (PD). The filamentous component of LB from patients with PD contains biochemically altered neurofilaments (NF). Herein we have tested the hypothesis that the oxidized products of catechols may covalently crosslink NF. Ne...

journal_title：Journal of neuropathology and experimental neurology

authors： Montine TJ,Farris DB,Graham DG

更新日期：1995-05-01 00:00:00

abstract：:Cerebellar ataxia is a prominent clinical symptom in patients with mitochondrial DNA (mtDNA) disease. This is often progressive with onset in young adulthood. We performed a detailed neuropathologic investigation of the olivary-cerebellum in 14 genetically and clinically well-defined patients with mtDNA disease. Quant...

journal_title：Journal of neuropathology and experimental neurology

authors： Lax NZ,Hepplewhite PD,Reeve AK,Nesbitt V,McFarland R,Jaros E,Taylor RW,Turnbull DM

更新日期：2012-02-01 00:00:00

abstract：:The idiopathic inflammatory myopathies (IIMs) dermatomyositis, polymyositis, and inclusion body myositis are characterized by myofiber degeneration and inflammation. The triggering factors of muscle autoaggression in these disorders are unknown, but infiltrating T cells may be activated locally and proliferate in situ...

journal_title：Journal of neuropathology and experimental neurology

authors： Bernasconi P,Cappelletti C,Navone F,Nessi V,Baggi F,Vernos I,Romaggi S,Confalonieri P,Mora M,Morandi L,Mantegazza R

更新日期：2008-06-01 00:00:00