RNA content and volume of motor neurons in amyotrophic lateral sclerosis. I. The cervical swelling.

abstract：:The prognosis of gliomas is generally poor since these tumors elude established therapeutic approaches. Immunotherapy might present an effective therapy in particular because the glioma cells are diffusely dispersed in the infiltration zone of the tumor and show a strong propensity to invade the surrounding brain alon...

journal_title：Journal of neuropathology and experimental neurology

authors： Vetter M,Hofer MJ,Roth E,Pircher HP,Pagenstecher A

更新日期：2009-05-01 00:00:00

abstract：:Progressive multifocal leukoencephalopathy (PML) occurs most often in immunosuppressed individuals. The lesions of PML result from astrocyte and oligodendrocyte infection by the polyomavirus JC (JCV); JCV has also been shown to infect and destroy cerebellar granule cell neurons (GCNs) in 2 human immunodeficiency virus...

journal_title：Journal of neuropathology and experimental neurology

authors： Wüthrich C,Cheng YM,Joseph JT,Kesari S,Beckwith C,Stopa E,Bell JE,Koralnik IJ

更新日期：2009-01-01 00:00:00

abstract：:Interferon-stimulated gene 15 (ISG15), an antagonist of the ubiquitin pathway, is elevated in cells and brain tissues obtained from ataxia telangiectasia (A-T) patients. Previous studies reveal that an elevated ISG15 pathway inhibits ubiquitin-dependent protein degradation, leading to activation of basal autophagy as ...

journal_title：Journal of neuropathology and experimental neurology

authors： Kim CD,Reed RE,Juncker MA,Fang Z,Desai SD

更新日期：2017-07-01 00:00:00

abstract：:The microtubule-associated phosphoprotein, tau, is an integral component of paired helical filaments in Alzheimer neurofibrillary tangles (NFT). The mechanism of NFT formation is unknown but aberrant phosphorylation of tau may be contributory. Calcium/calmodulin-dependent protein kinase type II (CaM kinase II), the mo...

journal_title：Journal of neuropathology and experimental neurology

authors： McKee AC,Kosik KS,Kennedy MB,Kowall NW

更新日期：1990-01-01 00:00:00

abstract：:In many degenerative and metabolic muscle diseases cells die without a marked inflammatory response. A potential mechanism how this could be accomplished is apoptotic cell death. Since there are no data available about apoptosis in cells of myogenic origin, we examined rat skeletal myoblasts for their potential to und...

journal_title：Journal of neuropathology and experimental neurology

authors： Stangel M,Zettl UK,Mix E,Zielasek J,Toyka KV,Hartung HP,Gold R

更新日期：1996-01-01 00:00:00

abstract：:Fragmentation of genomic DNA, a major biochemical feature of programmed cell death (apoptosis), is easily detected when apoptosis is prevalent. In brain tissue apoptotic cells are usually scarce and detection requires more sensitive techniques. We describe a highly sensitive method to quantify apoptosis in frozen huma...

journal_title：Journal of neuropathology and experimental neurology

authors： Olano JP,Wolf D,Keherly M,Gelman BB

更新日期：1996-11-01 00:00:00

abstract：:Neuron loss, synaptic decline, and spongiform change are the hallmarks of sporadic Creutzfeldt-Jakob disease (sCJD), and may be related to deficiencies in mitochondria, energy metabolism, and protein synthesis. To investigate these relationships, we determined the expression levels of genes encoding subunits of the 5 ...

journal_title：Journal of neuropathology and experimental neurology

authors： Ansoleaga B,Garcia-Esparcia P,Llorens F,Hernández-Ortega K,Carmona Tech M,Antonio Del Rio J,Zerr I,Ferrer I

更新日期：2016-08-01 00:00:00

abstract：:Cerebral autosomal recessive arteriopathy with subcortical infarcts and leukoencephalopathy (CARASIL) is a nonhypertensive hereditary cerebral small vessel disease that is caused by mutations in a single gene, HTRA1. The HTRA1 protein normally represses transforming growth factor-β (TGF-β) signaling and its mutations ...

journal_title：Journal of neuropathology and experimental neurology

authors： Ito S,Takao M,Fukutake T,Hatsuta H,Funabe S,Ito N,Shimoe Y,Niki T,Nakano I,Fukayama M,Murayama S

更新日期：2016-11-01 00:00:00

abstract：:A previous autopsy study of patients with amnestic-type mild cognitive impairment (MCI) suggested an overrepresentation of argyrophilic grain disease (AGD). We studied 34 patients who had diagnoses of amnestic MCI during progression to dementia and who came to autopsy. Neuropathologic evaluation included routine histo...

journal_title：Journal of neuropathology and experimental neurology

authors： Jicha GA,Petersen RC,Knopman DS,Boeve BF,Smith GE,Geda YE,Johnson KA,Cha R,Delucia MW,Braak H,Dickson DW,Parisi JE

更新日期：2006-06-01 00:00:00

abstract：:Ethanol is a potent neurotoxin particularly for the developing nervous system. Intrauterine exposure to ethanol during the last trimester of human gestation can produce a broad spectrum of neuropathologic consequences. This period of human brain development is roughly equivalent to the first week of rodent postnatal l...

journal_title：Journal of neuropathology and experimental neurology

authors： Nowoslawski L,Klocke BJ,Roth KA

更新日期：2005-06-01 00:00:00

abstract：:Purified myelin from the peripheral nervous system of guinea pig, frog (Rana catesbeiana), rat, rabbit, beef, and human in Freund's adjuvant were injected into the Lewis rat. Groups of rats receiving injections of myelin from different species were examined for signs of dysfunction and lesions in the PNS and CNS. Inje...

journal_title：Journal of neuropathology and experimental neurology

authors： Smith ME,Forno LS,Hofmann WW

更新日期：1979-07-01 00:00:00

abstract：:Lymphocytic choriomeningitis virus-induced central nervous system disease is characterized by death during a seizure approximately seven days after intracerebral inoculation. This process is mediated by thymus dependent lymphocytes, sensitized against viral antigens. Various forms of immunosuppressive treatment preven...

journal_title：Journal of neuropathology and experimental neurology

authors： Camenga DL,Walker DH,Murphy FA

更新日期：1977-01-01 00:00:00

abstract：:The external segment of the globus pallidus (GPe) in humans and the equivalent structure in rodents, the globus pallidus (GP), influence signal processing in the basal ganglia under normal and pathological conditions. Parvalbumin (PV) immunoreactivity defines 2 main neuronal subpopulations in the GP/GPe: PV-immunoposi...

journal_title：Journal of neuropathology and experimental neurology

authors： Fernández-Suárez D,Celorrio M,Lanciego JL,Franco R,Aymerich MS

更新日期：2012-11-01 00:00:00

abstract：:Multiple system atrophy (MSA) is a neurodegenerative disorder that predominantly affects motor-related neuroanatomic structures. The role of microglia in MSA is unknown. To address this issue, we conducted quantitative image studies on the brains from 13 cases of MSA, comprising 8 cerebellar and 5 parkinsonian variant...

journal_title：Journal of neuropathology and experimental neurology

authors： Ishizawa K,Komori T,Sasaki S,Arai N,Mizutani T,Hirose T

更新日期：2004-01-01 00:00:00

abstract：:The diagnosis of Alzheimer disease (AD) according to current criteria is a combined clinical and pathological exercise. The clinical discrimination of AD from other types of dementia may be complicated when the patient suffers from more than one disease. In particular the concomitant presence of other neurological con...

journal_title：Journal of neuropathology and experimental neurology

authors： Nagy Z,Esiri MM,Jobst KA,Morris JH,King EM,McDonald B,Joachim C,Litchfield S,Barnetson L,Smith AD

更新日期：1997-02-01 00:00:00

abstract：:Numerous studies have established the key role of the Golgi apparatus (GA) in post-translational processing, transport and targeting of proteins destined for secretion, lysosomes and plasma membranes. Moreover, several studies performed in our laboratories have shown that the size of the immunocytochemically detected ...

journal_title：Journal of neuropathology and experimental neurology

authors： Salehi A,Ravid R,Gonatas NK,Swaab DF

更新日期：1995-09-01 00:00:00

abstract：:Progressive supranuclear palsy (PSP), corticobasal degeneration (CBD), sporadic multisystem tauopathy, and some forms of frontotemporal dementia with Parkinsonism linked to chromosome 17 are characterized by neuronal and glial lesions accumulating tau protein containing 4 conserved repeats in microtubule-binding domai...

journal_title：Journal of neuropathology and experimental neurology

authors： Josephs KA,Katsuse O,Beccano-Kelly DA,Lin WL,Uitti RJ,Fujino Y,Boeve BF,Hutton ML,Baker MC,Dickson DW

更新日期：2006-04-01 00:00:00

abstract：:Truncations of tau protein at aspartic acid421 (D421) and glutamic acid391 (E391) residues are associated with neurofibrillary tangles (NFTs) in the brains of Alzheimer disease (AD) patients. Using immunohistochemistry with antibodies to D421- and E391-truncated tau (Tau-C3 and MN423, respectively), we correlated the ...

journal_title：Journal of neuropathology and experimental neurology

authors： Basurto-Islas G,Luna-Muñoz J,Guillozet-Bongaarts AL,Binder LI,Mena R,García-Sierra F

更新日期：2008-05-01 00:00:00

abstract：:Cysteine-S-sulfate is an abnormal metabolite discovered in the urine and blood of a patient with cysteine oxidase deficiency, a rare disorder of sulfur amino acid metabolism associated with brain damage and mental retardation. The molecular structure of cysteine-S-sulfate closely resembles that of glutamate and relate...

journal_title：Journal of neuropathology and experimental neurology

authors： Olney JW,Misra CH,de Gubareff T

更新日期：1975-03-01 00:00:00

abstract：:We performed a prospective, longitudinal immunohistochemical study of the spinal cords of transgenic mice with a G93A mutant SOD1 gene at 4 fixed points in time, using antibodies to inducible nitric oxide synthase (iNOS) and nitrotyrosine. The purpose of this study was to characterize the temporal and topographic dist...

journal_title：Journal of neuropathology and experimental neurology

authors： Sasaki S,Warita H,Abe K,Iwata M

更新日期：2001-09-01 00:00:00

abstract：:The aim of our study is to evaluate the extent and distribution of grey matter demyelinating lesions in multiple sclerosis (MS), addressing also neuronal loss and synaptic loss. Whole coronal sections of 6 MS brains and 6 control brains were selected. Immunohistochemistry was performed for myelin basic protein, neurof...

journal_title：Journal of neuropathology and experimental neurology

authors： Vercellino M,Plano F,Votta B,Mutani R,Giordana MT,Cavalla P

更新日期：2005-12-01 00:00:00

abstract：:Neutral glycolipids and gangliosides were analyzed in 149 astrocytomas (A), 46 oligodendrogliomas (O), and 21 oligoastrocytomas (OA) to determine if specific glycolipids correlate with histologic diagnosis and grade. Positivity for asialoGM1 (GA1) and negativity for paragloboside by immuno-TLC correlated with histolog...

journal_title：Journal of neuropathology and experimental neurology

authors： Yates AJ,Comas T,Scheithauer BW,Burger PC,Pearl DK

更新日期：1999-12-01 00:00:00

abstract：:Remyelination capacity decreases with age in adult mice, but data comparing remyelination capacity after toxic demyelination in developing mice versus adult mice are not available. We treated 3-week-old and adult C57BL/6 mice with cuprizone for 1 to 5 weeks and studied demyelination/remyelination and cellular reaction...

journal_title：Journal of neuropathology and experimental neurology

authors： Pfeifenbring S,Nessler S,Wegner C,Stadelmann C,Brück W

更新日期：2015-08-01 00:00:00

abstract：:Immunofluorescence with laminin antisera revealed a striking change in the localization of this basal membrane glycoprotein in rat sciatic nerve as a result of Wallerian degeneration. The staining was confined to the endoneurium in normal sciatic nerve and during the first days of degeneration. On day 11 endoneurial t...

journal_title：Journal of neuropathology and experimental neurology

authors： Bignami A,Chi NH,Dahl D

更新日期：1984-01-01 00:00:00

abstract：:LR11 is an ApoE receptor that is enriched in the brain. We have shown that LR11 is markedly downregulated in patients with sporadic Alzheimer disease (AD). This finding led us to explore whether reduced LR11 expression reflects a primary mechanism of disease or merely a secondary consequence of other AD-associated cha...

journal_title：Journal of neuropathology and experimental neurology

authors： Dodson SE,Gearing M,Lippa CF,Montine TJ,Levey AI,Lah JJ

更新日期：2006-09-01 00:00:00

abstract：:Experimental cerebral ischemia was produced in gerbils by occlusion of the right common carotid artery in the neck. The evolution of the ischemic lesions was followed from five minutes to six hours by using the immunohistochemical techniques for tubulin and creatine kinase BB-isoenzyme. The earliest lesion was found i...

journal_title：Journal of neuropathology and experimental neurology

authors： Yanagihara T,Yoshimine T,Morimoto K,Yamamoto K,Homburger HA

更新日期：1985-03-01 00:00:00

abstract：:An experimental neuropathy in rats produced by tying loosely constrictive ligatures around one sciatic nerve has recently been shown to produce pain-related behavior that follows a reproducible time course. In the present study, we assessed the degree of thermal hyperesthesia and examined the sciatic nerves by light a...

journal_title：Journal of neuropathology and experimental neurology

authors： Sommer C,Galbraith JA,Heckman HM,Myers RR

更新日期：1993-05-01 00:00:00

abstract：:This morphometric study explores temporal and topographic changes in the estimated neuronal number in human neocortex during the latter half of gestation and early infancy. Neuronal estimates are calculated from standardized measurements of cortical layer thickness and neuronal density in 6 neocortical regions in 9 hu...

journal_title：Journal of neuropathology and experimental neurology

authors： Rabinowicz T,de Courten-Myers GM,Petetot JM,Xi G,de los Reyes E

更新日期：1996-03-01 00:00:00

abstract：:Hydrocephalic hyh mice are born with moderate hydrocephalus and a normal cerebral aqueduct. At about the fifth postnatal day the aqueduct becomes obliterated and severe hydrocephalus develops. The aim of the present investigation was to investigate the mechanism of this hydrocephalus, probably starting during fetal li...

journal_title：Journal of neuropathology and experimental neurology

authors： Jiménez AJ,Tomé M,Páez P,Wagner C,Rodríguez S,Fernández-Llebrez P,Rodríguez EM,Pérez-Fígares JM

更新日期：2001-11-01 00:00:00

abstract：:Histopathologic evaluation of brain tissue derived from surgically treated patients with medically refractory temporal lobe epilepsy (TLE) frequently reveals structural brain lesions in the surgical specimen. While several of the most commonly encountered lesions such as low-grade neoplasms or vascular malformations a...

journal_title：Journal of neuropathology and experimental neurology

authors： Kasper BS,Stefan H,Buchfelder M,Paulus W

更新日期：1999-01-01 00:00:00