Abstract:
:Long-term administration of chloroquine to rats induces a vacuolar myopathy, which is specifically termed chloroquine myopathy (CM). In CM, tau mRNA levels were transiently upregulated in the early phase, while tau itself slowly accumulated in the late phase. The temporal profiles of tau mRNA levels and its accumulation were very similar to those of beta-amyloid protein precursor (APP) and its carboxyl-terminal fragments, both of which have been known to be degraded in lysosomes. Immunocytochemistry showed that tau progressively accumulated in the rimmed vacuoles exhibiting increased acid phosphatase activities, and immunoelectron microscopy demonstrated that tau was located within autophagic vacuoles. These results suggest that the accumulation of tau in CM is due to defective tau degradation in the lysosomal compartment in the muscle.
journal_name
J Neuropathol Exp Neuroljournal_title
Journal of neuropathology and experimental neurologyauthors
Murakami N,Oyama F,Gu Y,McLennan IS,Nonaka I,Ihara Ydoi
10.1097/00005072-199807000-00003subject
Has Abstractpub_date
1998-07-01 00:00:00pages
664-73issue
7eissn
0022-3069issn
1554-6578journal_volume
57pub_type
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journal_title:Journal of neuropathology and experimental neurology
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