A familial form of pallidoluysionigral degeneration and amyotrophic lateral sclerosis with divergent clinical presentations.

abstract：:Progressive multifocal leukoencephalopathy (PML) occurs most often in immunosuppressed individuals. The lesions of PML result from astrocyte and oligodendrocyte infection by the polyomavirus JC (JCV); JCV has also been shown to infect and destroy cerebellar granule cell neurons (GCNs) in 2 human immunodeficiency virus...

journal_title：Journal of neuropathology and experimental neurology

authors： Wüthrich C,Cheng YM,Joseph JT,Kesari S,Beckwith C,Stopa E,Bell JE,Koralnik IJ

更新日期：2009-01-01 00:00:00

abstract：:Mild traumatic brain injury resulting from exposure to an explosive blast is associated with significant neurobehavioral outcomes in soldiers. Little is known about the neuropathologic consequences of such an insult to the human brain. This study is an attempt to understand the effects of an explosive blast in a large...

journal_title：Journal of neuropathology and experimental neurology

authors： de Lanerolle NC,Bandak F,Kang D,Li AY,Du F,Swauger P,Parks S,Ling G,Kim JH

更新日期：2011-11-01 00:00:00

abstract：:Glioblastoma (GBM), representing WHO grade IV astrocytoma, is a relatively common primary brain tumor in adults with an exceptionally dismal prognosis. With an incidence rate of over 10 000 cases in the United States annually, the median survival rate ranges from 10-15 months in IDH1/2-wildtype tumors and 24-31 months...

journal_title：Journal of neuropathology and experimental neurology

authors： Richardson TE,Patel S,Serrano J,Sathe AA,Daoud EV,Oliver D,Maher EA,Madrigales A,Mickey BE,Taxter T,Jour G,White CL,Raisanen JM,Xing C,Snuderl M,Hatanpaa KJ

更新日期：2019-06-01 00:00:00

abstract：:Universally accepted neuropathologic criteria for differentiating Alzheimer disease (AD) from healthy brain aging do not exist. We tested the hypothesis that Bielschowsky silver stained total, cored, and neuritic senile plaques (TSPs, CSPs, and NSPs, respectively), rather than neurofibrillary tangles (NFTs), best disc...

journal_title：Journal of neuropathology and experimental neurology

authors： McKeel DW Jr,Price JL,Miller JP,Grant EA,Xiong C,Berg L,Morris JC

更新日期：2004-10-01 00:00:00

abstract：:Older adults with intact cognition before death and substantial Alzheimer disease (AD) lesions at autopsy have been termed "asymptomatic AD subjects" (ASYMAD). We previously reported hypertrophy of neuronal cell bodies, nuclei, and nucleoli in the CA1 of the hippocampus (CA1), anterior cingulate gyrus, posterior cingu...

journal_title：Journal of neuropathology and experimental neurology

authors： Iacono D,Resnick SM,O'Brien R,Zonderman AB,An Y,Pletnikova O,Rudow G,Crain B,Troncoso JC

更新日期：2014-04-01 00:00:00

abstract：:Neuropathologic examination of 3 patients with Alzheimer disease in the Elan Pharmaceuticals trial using antibodies specific for different Abeta species showed in one case, 4 months after the immunization, evidence of a stage of active plaque clearance with "moth-eaten" plaques and abundant Abeta phagocytosis by micro...

journal_title：Journal of neuropathology and experimental neurology

authors： Nicoll JA,Barton E,Boche D,Neal JW,Ferrer I,Thompson P,Vlachouli C,Wilkinson D,Bayer A,Games D,Seubert P,Schenk D,Holmes C

更新日期：2006-11-01 00:00:00

abstract：:Chronic traumatic encephalopathy (CTE) is a progressive neurodegenerative disorder associated with repetitive traumatic brain injury. Multiple system atrophy (MSA) is a Parkinsonian disorder that can result in repetitive falls with associated head trauma. We hypothesized that patients with neurodegenerative disorders ...

journal_title：Journal of neuropathology and experimental neurology

authors： Koga S,Dickson DW,Bieniek KF

更新日期：2016-10-01 00:00:00

abstract：:The idiopathic inflammatory myopathies (IIMs) dermatomyositis, polymyositis, and inclusion body myositis are characterized by myofiber degeneration and inflammation. The triggering factors of muscle autoaggression in these disorders are unknown, but infiltrating T cells may be activated locally and proliferate in situ...

journal_title：Journal of neuropathology and experimental neurology

authors： Bernasconi P,Cappelletti C,Navone F,Nessi V,Baggi F,Vernos I,Romaggi S,Confalonieri P,Mora M,Morandi L,Mantegazza R

更新日期：2008-06-01 00:00:00

abstract：:Centrosome amplification is a pivotal mechanism underlying tumorigenesis but its role in gliomas is underinvestigated. The present study specifically examines the expression and distribution of the centrosome-associated cytoskeletal protein gamma-tubulin in 56 primary diffuse astrocytic gliomas (grades II-IV) and in 4...

journal_title：Journal of neuropathology and experimental neurology

authors： Katsetos CD,Reddy G,Dráberová E,Smejkalová B,Del Valle L,Ashraf Q,Tadevosyan A,Yelin K,Maraziotis T,Mishra OP,Mörk S,Legido A,Nissanov J,Baas PW,de Chadarévian JP,Dráber P

更新日期：2006-05-01 00:00:00

abstract：:In a recent study we estimated the number and frequency distribution of the diameters of the cytons of all of the combined motoneuron columns of L3, L4 and L5 ventral horn of the spinal cord of man. In the present study we have estimated the number and frequency distribution of the diameter of motoneuron cytons in the...

journal_title：Journal of neuropathology and experimental neurology

authors： Kawamura Y,Dyck PJ

更新日期：1977-11-01 00:00:00

abstract：:We previously found that vascular smooth muscle actin (SMA) is reduced in the brains of patients with late stage Alzheimer disease (AD) compared with brains of nondemented, neuropathologically normal subjects. To assess the pathogenetic significance and disease specificity of this finding, we studied 3 additional pati...

journal_title：Journal of neuropathology and experimental neurology

authors： Hulette CM,Ervin JF,Edmonds Y,Antoine S,Stewart N,Szymanski MH,Hayden KM,Pieper CF,Burke JR,Welsh-Bohmer KA

更新日期：2009-04-01 00:00:00

abstract：:The sciatic/tibial/plantar nerve complex of normal aged rats displays striking morphological changes that are most pronounced distally. Nerve fiber abnormalities include: (a) large numbers of axonal glycogenosomes, mitochondria, dense membranous bodies, and decorated particles; (b) adaxonal Schwann cell processes sequ...

journal_title：Journal of neuropathology and experimental neurology

authors： Grover-Johnson N,Spencer PS

更新日期：1981-03-01 00:00:00

abstract：:The choroid plexus (CP) is considered to be a point of leukocyte entry into the CNS during normal immune surveillance and in neuroinflammatory diseases. The structural and functional alterations within the CP that support this migration are not understood. We used quantitative, high-resolution, 3-dimensional (3-D) flu...

journal_title：Journal of neuropathology and experimental neurology

authors： Shrestha B,Paul D,Pachter JS

更新日期：2014-11-01 00:00:00

abstract：:Immunohistochemical identification of myelin basic protein (MBP) is a sensitive method for assessing myelination in the human fetal central nervous system (CNS). However, the temporospatial relationship of expression of two other major myelin proteins, proteolipid protein (PLP) and myelin-associated glycoprotein (MAG)...

journal_title：Journal of neuropathology and experimental neurology

authors： Weidenheim KM,Bodhireddy SR,Rashbaum WK,Lyman WD

更新日期：1996-06-01 00:00:00

abstract：:After the finding that anti-prion antibodies stain sensory and sympathetic ganglia in variant Creutzfeldt-Jakob disease (vCJD), it was suggested that this localization supported the oral route of entry. However, prion accumulation subsequently also appeared in the peripheral nervous system (PNS) in sporadic cases. Thi...

journal_title：Journal of neuropathology and experimental neurology

authors： Lee CC,Kuo LT,Wang CH,Scaravilli F,An SF

更新日期：2005-08-01 00:00:00

abstract：:Granule cell dispersion (GCD) is observed in approximately 40% of cases of hippocampal sclerosis (HS) in patients with epilepsy. Studies in animal models suggest that GCD may be a consequence of enhanced proliferation of granule cell precursors as a result of seizures. We quantified the number of cells in cycle in sub...

journal_title：Journal of neuropathology and experimental neurology

authors： Thom M,Martinian L,Williams G,Stoeber K,Sisodiya SM

更新日期：2005-03-01 00:00:00

abstract：:Atypical teratoid/rhabdoid tumors are malignant embryonal tumors characterized by the presence of rhabdoid cells, genetic alterations affecting the SMARCB1 gene (hSNF5/INI1), and a poor prognosis. Whether INI1 plays a role in the pathogenesis of other central nervous system tumors is uncertain. We report on cases of 2...

journal_title：Journal of neuropathology and experimental neurology

authors： Hasselblatt M,Oyen F,Gesk S,Kordes U,Wrede B,Bergmann M,Schmid H,Frühwald MC,Schneppenheim R,Siebert R,Paulus W

更新日期：2009-12-01 00:00:00

abstract：:This investigation tested the hypothesis that the growth inhibiting effects of human beta-interferon on cultured human glioma cells involves changes in the ganglioside composition of these cells. Four cell lines derived from human malignant gliomas (12-18, U-251 MG, I29-A, 7-24) and two lines from human fetal brain (C...

journal_title：Journal of neuropathology and experimental neurology

authors： Yates AJ,Markowitz DL,Stephens RE,Pearl DK,Whisler RL

更新日期：1988-03-01 00:00:00

abstract：:In the present study, we investigated the expression of protease-activated receptors (PARs), receptors for thrombin, in substantia nigra pars compacta (SNpc) of Parkinson disease (PD) brains and cultures of human neurons, astrocytes, oligodendrocytes, and microglia as determined by immunocytochemistry and reverse tran...

journal_title：Journal of neuropathology and experimental neurology

authors： Ishida Y,Nagai A,Kobayashi S,Kim SU

更新日期：2006-01-01 00:00:00

abstract：:Long-term administration of chloroquine to rats induces a vacuolar myopathy, which is specifically termed chloroquine myopathy (CM). In CM, tau mRNA levels were transiently upregulated in the early phase, while tau itself slowly accumulated in the late phase. The temporal profiles of tau mRNA levels and its accumulati...

journal_title：Journal of neuropathology and experimental neurology

authors： Murakami N,Oyama F,Gu Y,McLennan IS,Nonaka I,Ihara Y

更新日期：1998-07-01 00:00:00

abstract：:Alzheimer-type I astrogliopathy (AIA) is an uncommon neuropathological phenomenon encountered in Wilson's disease and less often in acquired hepatic encephalopathy. Since its first description in 1912 it has received little attention. However, after 1971, when the nature of its morphogenesis began to be recognized and...

journal_title：Journal of neuropathology and experimental neurology

authors： Ma KC

更新日期：2001-02-01 00:00:00

abstract：:The effects of regional heterogeneity on the accuracy of histological grading of gliomas are well known, but little has been reported about its implications for other diagnostic modalities. This study investigated the relationships of regional heterogeneity in tumor proliferative activity, measured by Ki-67 labeling i...

journal_title：Journal of neuropathology and experimental neurology

authors： Coons SW,Johnson PC

更新日期：1993-11-01 00:00:00

abstract：:In situ hybridization (ISH) for JC virus (JCV) is generally applied for the diagnosis of progressive multifocal leukoencephalopathy (PML). To explore the usefulness of immunohistochemistry (IHC) for JCV early proteins, 14 paraffin-embedded postmortem brain specimens with histologic features compatible with PML were te...

journal_title：Journal of neuropathology and experimental neurology

authors： Muñoz-Mármol AM,Mola G,Fernández-Vasalo A,Vela E,Mate JL,Ariza A

更新日期：2004-11-01 00:00:00

abstract：:Gliomas with hybrid oligodendroglial/astrocytic features are diagnostically problematic, and our ability to predict tumor behavior is limited. Some likely represent intermingled mixed oligoastrocytomas (MOAs), though precise diagnostic criteria and specific markers for this lesion are lacking. From the files at Washin...

journal_title：Journal of neuropathology and experimental neurology

authors： Fuller CE,Schmidt RE,Roth KA,Burger PC,Scheithauer BW,Banerjee R,Trinkaus K,Lytle R,Perry A

更新日期：2003-11-01 00:00:00

abstract：:The hyperacute form of experimental allergic encephalomyelitis (EAE), characterized by a short incubation period, severe paralysis, high mortality, and abundant polymorphonuclear leukocytes and fibrin in the lesions, was produced in rats without the use of pertussis vaccine (previously considered an essential requirem...

journal_title：Journal of neuropathology and experimental neurology

authors： Levine S,Saltzman A

更新日期：1989-05-01 00:00:00

abstract：:We review the newest advances related to seeking the pathogenic mechanism(s) of sporadic inclusion-body myositis (s-IBM) and present the pathologic diagnostic criteria of s-IBM. We discuss the possible pathogenic role of several themes, such as 1) increased amyloid-beta precursor protein (AbetaPP) and of its fragment ...

journal_title：Journal of neuropathology and experimental neurology

authors： Askanas V,Engel WK

更新日期：2001-01-01 00:00:00

abstract：:To determine whether arterial wall degeneration, in combination with hemodynamic insult, causes cerebral artery aneurysms in a dog model, we simulated the geometry and hemodynamics of a human artery by surgical reconstruction of both common carotid arteries in 12 dogs. The dogs were then randomly assigned to one of th...

journal_title：Journal of neuropathology and experimental neurology

authors： Zhu YQ,Li MH,Yan L,Tan HQ,Cheng YS

更新日期：2014-09-01 00:00:00

abstract：:Large complex membranous bodies are described in the cerebral cortex of adult rats. Although these bodies are not very prevalent, they appear with increasing frequency as the age of the animal increases from 12 to 28 months. The membranous bodies are composed of varying amounts of membranes, cytoplasm and empty vacuol...

journal_title：Journal of neuropathology and experimental neurology

authors： Vaughan DW

更新日期：1976-03-01 00:00:00

abstract：:Genetic and lifestyle-related risk factors for Alzheimer disease (AD) are associated with an increase in oxidative stress, suggesting that oxidative stress is involved at an early stage of the pathologic cascade. Moreover, oxidative stress is mechanistically and chronologically associated with other key features of AD...

journal_title：Journal of neuropathology and experimental neurology

authors： Nunomura A,Castellani RJ,Zhu X,Moreira PI,Perry G,Smith MA

更新日期：2006-07-01 00:00:00

abstract：:The changes of nitric oxide synthase (NOS) activity and expression in experimental diabetic neuropathy have not been examined. Increases in ganglia NOS might be similar to those that follow axotomy, whereas declines in endothelial NOS (eNOS) and immunological NOS (iNOS) might explain dysfunction of microvessels or mac...

journal_title：Journal of neuropathology and experimental neurology

authors： Zochodne DW,Verge VM,Cheng C,Höke A,Jolley C,Thomsen K,Rubin I,Lauritzen M

更新日期：2000-09-01 00:00:00