Loss of chromosome 1p/19q in oligodendroglial tumors: refinement of chromosomal critical regions and evaluation of internexin immunostaining as a surrogate marker.

abstract：:Genetic and lifestyle-related risk factors for Alzheimer disease (AD) are associated with an increase in oxidative stress, suggesting that oxidative stress is involved at an early stage of the pathologic cascade. Moreover, oxidative stress is mechanistically and chronologically associated with other key features of AD...

journal_title：Journal of neuropathology and experimental neurology

authors： Nunomura A,Castellani RJ,Zhu X,Moreira PI,Perry G,Smith MA

更新日期：2006-07-01 00:00:00

abstract：:Hereditary gelsolin amyloidosis (AGel amyloidosis) is a systemic disorder reported worldwide in kindreds with a G654A or G654T gelsolin gene mutation. The clinically characteristic peripheral nerve involvement has been poorly characterized morphologically, and its pathogenesis remains unknown. We studied peripheral ne...

journal_title：Journal of neuropathology and experimental neurology

authors： Kiuru-Enari S,Somer H,Seppäläinen AM,Notkola IL,Haltia M

更新日期：2002-06-01 00:00:00

abstract：:Sibling concurrence of pathologically confirmed prion disease has only been reported in association with pathogenic mutation of the prion protein gene (PRNP). Here, we report 2 siblings with classic neuropathologic features of sporadic Creutzfeldt-Jakob disease unexplained by PRNP mutation or known risk factors for ia...

journal_title：Journal of neuropathology and experimental neurology

authors： Webb TE,Pal S,Siddique D,Heaney DC,Linehan JM,Wadsworth JD,Joiner S,Beck J,Wroe SJ,Stevenson V,Brandner S,Mead S,Collinge J

更新日期：2008-09-01 00:00:00

abstract：:Oxidative stress has been proposed as a potential mechanism for neurodegenerative diseases, such as Alzheimer disease (AD), Parkinson disease (PD), and amyotrophic lateral sclerosis (ALS). In response to oxidative stress, the levels of numerous cytoprotective products are increased via alteration of the Kelch-like ECH...

journal_title：Journal of neuropathology and experimental neurology

authors： Tanji K,Maruyama A,Odagiri S,Mori F,Itoh K,Kakita A,Takahashi H,Wakabayashi K

更新日期：2013-01-01 00:00:00

abstract：:Kii amyotrophic lateral sclerosis/parkinsonism-dementia complex (ALS/PDC) is a progressive neurodegenerative disorder that is endemic to the Kii peninsula of Japan. The disorder is clinically characterized by a variable combination of parkinsonism, dementia, and motor neuron symptoms. Despite extensive investigations,...

journal_title：Journal of neuropathology and experimental neurology

authors： Verheijen BM,Morimoto S,Sasaki R,Oyanagi K,Kokubo Y,Kuzuhara S,van Leeuwen FW

更新日期：2020-08-01 00:00:00

abstract：:A number of studies have implicated a proline-directed protein kinase, glycogen synthase kinase-3 (GSK-3) in the hyperphosphorylation of tau in Alzheimer's disease (AD). Toward understanding the role of GSK-3 in the abnormal hyperphosphorylation of tau in AD we have found that GSK-3 is prominently present in neuronal ...

journal_title：Journal of neuropathology and experimental neurology

authors： Pei JJ,Tanaka T,Tung YC,Braak E,Iqbal K,Grundke-Iqbal I

更新日期：1997-01-01 00:00:00

abstract：:There is increasing evidence that oxidative damage plays a major role in amyotrophic lateral sclerosis (ALS), but how it contributes to motor neuron degeneration and astrocytic gliosis, two pathologic hallmarks of the disease, is unknown. A few studies have suggested that ALS motor neurons die via apoptosis and show u...

journal_title：Journal of neuropathology and experimental neurology

authors： Migheli A,Piva R,Atzori C,Troost D,Schiffer D

更新日期：1997-12-01 00:00:00

abstract：:Because the presence of carbonic anhydrase C (CA C) has been demonstrated in the oligodendrocytes of the mouse, rat and man, anti-CA C serum has been considered to be a possible specific marker for these cells. In order to determine its value in human neurooncology, specimens from 110 human tumors from the central and...

journal_title：Journal of neuropathology and experimental neurology

authors： Nakagawa Y,Perentes E,Rubinstein LJ

更新日期：1987-07-01 00:00:00

abstract：:During the Zika epidemic in Brazil, a baby was born at term with microcephaly and arthrogryposis. The mother had Zika symptoms at 10 weeks of gestation. At 17 weeks, ultrasound showed cerebral malformation and ventriculomegaly. At 24 weeks, the amniotic fluid contained ZIKV RNA and at birth, placenta and maternal bloo...

journal_title：Journal of neuropathology and experimental neurology

authors： Chimelli L,Moura Pone S,Avvad-Portari E,Farias Meira Vasconcelos Z,Araújo Zin A,Prado Cunha D,Raposo Thompson N,Lopes Moreira ME,Wiley CA,da Silva Pone MV

更新日期：2018-03-01 00:00:00

abstract：:Fas-apoptotic inhibitory molecule 2 (Faim2) is a neuron-specific membrane protein and a member of the evolutionary conserved lifeguard apoptosis regulatory gene family. Its neuroprotective effect in acute neurological diseases has been demonstrated in an in vivo model of focal cerebral ischemia. Here we show that Faim...

journal_title：Journal of neuropathology and experimental neurology

authors： Tauber SC,Harms K,Falkenburger B,Weis J,Sellhaus B,Nau R,Schulz JB,Reich A

更新日期：2014-01-01 00:00:00

abstract：:Cerebral microbleeds (CMB) are a common MRI finding, representing underlying cerebral microhemorrhages (CMH). The etiology of CMB and microhemorrhages is obscure. We conducted a pathological investigation of CMH, combining standard and immunohistological analyses of postmortem human brains. We analyzed 5 brain regions...

journal_title：Journal of neuropathology and experimental neurology

authors： Wadi LC,Grigoryan MM,Kim RC,Fang C,Kim J,Corrada MM,Paganini-Hill A,Fisher MJ

更新日期：2020-10-01 00:00:00

abstract：:To understand the basis of oligodendrocyte (OL) susceptibility to oxidative injury, purified rat OL cultures at different stages of maturation were exposed to nitric oxide (NO) donors with fast or slow kinetics of release and to tert-butyl-hydroperoxide, a membrane-permeant organic hydroperoxide. OL precursors (pre-OL...

journal_title：Journal of neuropathology and experimental neurology

authors： Bernardo A,Greco A,Levi G,Minghetti L

更新日期：2003-05-01 00:00:00

abstract：:Aberrant epidermal growth factor receptor (EGFR) expression promotes the pathogenesis of malignant peripheral nerve sheath tumors (MPNSTs), the most common malignancy associated with neurofibromatosis type 1, but the mechanisms by which EGFR expression promotes MPNST pathogenesis are poorly understood. We hypothesized...

journal_title：Journal of neuropathology and experimental neurology

authors： Byer SJ,Brossier NM,Peavler LT,Eckert JM,Watkins S,Roth KA,Carroll SL

更新日期：2013-03-01 00:00:00

abstract：:Fibrosis is the main cause of irreversible nerve damage in leprosy. Phenotypic changes in Mycobacterium leprae (ML)-infected Schwann cells (SCs) have been suggested to mediate this process. We found that SC line cultures stimulated with ML upregulated transforming growth factor-β1 (TGF-β1), and that TGF-β1 or ML induc...

journal_title：Journal of neuropathology and experimental neurology

authors： Petito RB,Amadeu TP,Pascarelli BM,Jardim MR,Vital RT,Antunes SL,Sarno EN

更新日期：2013-04-01 00:00:00

abstract：:Multiple system atrophy (MSA) is a neurodegenerative disorder that predominantly affects motor-related neuroanatomic structures. The role of microglia in MSA is unknown. To address this issue, we conducted quantitative image studies on the brains from 13 cases of MSA, comprising 8 cerebellar and 5 parkinsonian variant...

journal_title：Journal of neuropathology and experimental neurology

authors： Ishizawa K,Komori T,Sasaki S,Arai N,Mizutani T,Hirose T

更新日期：2004-01-01 00:00:00

abstract：:Mitochondrial Zn2+ accumulation, particularly in CA1 neurons, occurs after ischemia and likely contributes to mitochondrial dysfunction and subsequent neurodegeneration. However, the relationship between mitochondrial Zn2+ accumulation and their disruption has not been examined at the ultrastructural level in vivo. We...

journal_title：Journal of neuropathology and experimental neurology

authors： Yin HZ,Wang HL,Ji SG,Medvedeva YV,Tian G,Bazrafkan AK,Maki NZ,Akbari Y,Weiss JH

更新日期：2019-07-01 00:00:00

abstract：:CD44 is a glycoprotein present on the surface of some lymphocyte cell populations and other non-lymphoid cells, and is involved in many functions related to cell-cell and cell-matrix interactions. In this study, expression of CD44 antigen in primary neural cell cultures derived from fetal and adult human brains was in...

journal_title：Journal of neuropathology and experimental neurology

authors： Moretto G,Xu RY,Kim SU

更新日期：1993-07-01 00:00:00

abstract：:The concern of the potential transmission of animal spongiform encephalopathies to humans, which arose as soon as the interspecies transmission of these diseases was recognized, has been reinforced with the emergence of bovine spongiform encephalopathy (BSE) in cattle. Recent experimental findings suggest that the inf...

journal_title：Journal of neuropathology and experimental neurology

authors： Baron T

更新日期：2002-05-01 00:00:00

abstract：:Vascular dementia (VaD) is cognitive decline linked to reduced cerebral blood perfusion, yet there are few therapeutic options to protect cognitive function following cerebrovascular accidents. The purpose of this study was to profile gene expression changes unique to VaD to identify and characterize disease relevant ...

journal_title：Journal of neuropathology and experimental neurology

authors： McKay EC,Beck JS,Khoo SK,Dykema KJ,Cottingham SL,Winn ME,Paulson HL,Lieberman AP,Counts SE

更新日期：2019-05-01 00:00:00

abstract：:Well myelinated cultures of newborn mouse cerebellum, exposed to varying concentrations of sodium diethyldithiocarbamate (DDC), a heavy metal chelating agent, were examined by light and electron microscopy. DDC treatment of cultures for 24-48 hours produced swellings of axons and presynaptic endings, the morphological...

journal_title：Journal of neuropathology and experimental neurology

authors： Kim SU,Rizzuto N

更新日期：1975-11-01 00:00:00

abstract：:Most malignant human tumors display a high degree of intratumoral heterogeneity at the time of diagnosis that contributes to treatment failure. This also applies to malignant peripheral nerve sheath tumors (MPNSTs) and aggressive soft tissue sarcomas that arise sporadically or in the context of neurofibromatosis type ...

journal_title：Journal of neuropathology and experimental neurology

authors： Koelsch B,van den Berg L,Grabellus F,Fischer C,Kutritz A,Kindler-Röhrborn A

更新日期：2013-05-01 00:00:00

abstract：:The synthesis and endoneurial distribution of apolipoproteins in response to myelin degradation was elucidated morphologically and biochemically in rodent models of segmental demyelination. At the onset of acute demyelination induced by tellurium (Te) poisoning, macrophages infiltrated the endoneurium and then began t...

journal_title：Journal of neuropathology and experimental neurology

authors： Gelman BB,Goodrum J,Bouldin TW

更新日期：1991-07-01 00:00:00

abstract：:An experimental neuropathy in rats produced by tying loosely constrictive ligatures around one sciatic nerve has recently been shown to produce pain-related behavior that follows a reproducible time course. In the present study, we assessed the degree of thermal hyperesthesia and examined the sciatic nerves by light a...

journal_title：Journal of neuropathology and experimental neurology

authors： Sommer C,Galbraith JA,Heckman HM,Myers RR

更新日期：1993-05-01 00:00:00

abstract：:Lysosomal beta-hexosaminidase consists of 2 subunits, alpha and beta. Mutations in the alpha-subunit gene cause Tay-Sachs disease, while mutations in the beta-subunit gene cause Sandhoff disease. Mice generated by targeted disruption of either the alpha- or beta-subunit genes displayed the pathological features of Tay...

journal_title：Journal of neuropathology and experimental neurology

authors： Suzuki K,Sango K,Proia RL,Langaman C

更新日期：1997-06-01 00:00:00

abstract：:Werdnig-Hoffmann disease (WHD) is the most severe clinical type of spinal muscular atrophy characterized by loss of lower motor neurons and paralysis. We examined the hypothesis that disease pathogenesis is based on an inappropriate persistence of normally occurring motor neuron programmed cell death. The diagnosis of...

journal_title：Journal of neuropathology and experimental neurology

authors： Simic G,Seso-Simic D,Lucassen PJ,Islam A,Krsnik Z,Cviko A,Jelasic D,Barisic N,Winblad B,Kostovic I,Kruslin B

更新日期：2000-05-01 00:00:00

abstract：:The present study introduces an in vitro model of xenogeneic peripheral nerve rejection to analyze the role of macrophages in this complex immunological situation. Nerve-sensitized mouse peritoneal exudate cells were co-cultured with rat peripheral nerve segments. The cultured rat nerve segments were fulminantly rejec...

journal_title：Journal of neuropathology and experimental neurology

authors： Brück W,Brück Y,Maruschak B,Friede RL

更新日期：1994-01-01 00:00:00

abstract：:Two basic proteins, P1 of molecular weight 14,200 and P2 of molecular weight 12,300, purified from bovine peripheral nerve, were assayed for biological activity. The P1 protein is an exclusively neuritogenic agent, capable of producing clinical signs of experimental allergic neuritis (EAN) and histological abnormaliti...

journal_title：Journal of neuropathology and experimental neurology

authors： Abramsky O,Teitelbaum D,Webb C,Arnon R

更新日期：1975-01-01 00:00:00

abstract：:Localized hypertrophic neuropathy is a rare Schwann cell proliferation that usually affects single nerves from the extremities, and it is of unclear etiology in its pure form. RASopathies are a defined group of genetic diseases with overlapping clinical features, usually secondary to germline mutations in genes encodi...

journal_title：Journal of neuropathology and experimental neurology

authors： Vizcaino MA,Belzberg A,Ahlawat S,Belakhoua S,Chen L,Staedtke V,Rodriguez FJ

更新日期：2020-06-01 00:00:00

abstract：:Nemaline myopathy is the most common congenital myopathy and is caused by mutations in various genes such as ACTA1 (encoding skeletal α-actin). It is associated with limb and respiratory muscle weakness. Despite increasing clinical and scientific interest, the molecular and cellular events leading to such weakness rem...

journal_title：Journal of neuropathology and experimental neurology

authors： Lindqvist J,Cheng AJ,Renaud G,Hardeman EC,Ochala J

更新日期：2013-06-01 00:00:00

abstract：:This study determined if hippocampal AMPA and NMDA subunit immunoreactivity (IR) in temporal lobe epilepsy patients was increased compared with nonseizure autopsies. Hippocampi from hippocampal sclerosis patients (HS; n = 26) and nonsclerosis cases (non-HS: n = 12) were compared with autopsies (n = 6) and studied for ...

journal_title：Journal of neuropathology and experimental neurology

authors： Mathern GW,Pretorius JK,Mendoza D,Lozada A,Leite JP,Chimelli L,Fried I,Sakamoto AC,Assirati JA,Adelson PD

更新日期：1998-06-01 00:00:00