Expression of chemokine receptors CCR1 and CCR5 reflects differential activation of mononuclear phagocytes in pattern II and pattern III multiple sclerosis lesions.

abstract：:The brainstem and cervical spinal cord were sampled from 45 cases of sudden infant death syndrome (SIDS), from 17 control cases without neurological disease, and from three negative control cases with abnormal growth of the central nervous system (36-98 postconceptional weeks). Morphometric analyses were performed on ...

journal_title：Journal of neuropathology and experimental neurology

authors： O'Kusky JR,Kozuki DE,Norman MG

更新日期：1995-07-01 00:00:00

abstract：:We previously found that vascular smooth muscle actin (SMA) is reduced in the brains of patients with late stage Alzheimer disease (AD) compared with brains of nondemented, neuropathologically normal subjects. To assess the pathogenetic significance and disease specificity of this finding, we studied 3 additional pati...

journal_title：Journal of neuropathology and experimental neurology

authors： Hulette CM,Ervin JF,Edmonds Y,Antoine S,Stewart N,Szymanski MH,Hayden KM,Pieper CF,Burke JR,Welsh-Bohmer KA

更新日期：2009-04-01 00:00:00

abstract：:Tissue hypoxia and necrosis represent pathophysiologic and histologic hallmarks of glioblastoma (GBM). Although hypoxia inducible factor 1α (HIF-1α) plays crucial roles in the malignant phenotypes of GBM, developing HIF-1α-targeted agents has been hampered by the lack of a suitable preclinical model that recapitulates...

journal_title：Journal of neuropathology and experimental neurology

authors： Nigim F,Cavanaugh J,Patel AP,Curry WT Jr,Esaki S,Kasper EM,Chi AS,Louis DN,Martuza RL,Rabkin SD,Wakimoto H

更新日期：2015-07-01 00:00:00

abstract：:Brain aging is accompanied by increased oxidative stress and what has been termed "neuroinflammation," which might contribute to age-related neurodegenerative diseases. We analyzed expression in the transcription of innate inflammatory response genes in eleven representative regions including frontal, parietal, inferi...

journal_title：Journal of neuropathology and experimental neurology

authors： López-González I,Tebé Cordomí C,Ferrer I

更新日期：2017-02-01 00:00:00

abstract：:Studies dealing with transport of proteins from the oligodendrocyte cell body to the myelin sheath reveal the presence of different transport pathways. Proteolipid protein (PLP) is synthesized at the rough endoplasmic reticulum (ER) and then processed through the Golgi apparatus and transported to the myelin membranes...

journal_title：Journal of neuropathology and experimental neurology

authors： Bauer J,Bradl M,Klein M,Leisser M,Deckwerth TL,Wekerle H,Lassmann H

更新日期：2002-01-01 00:00:00

abstract：:Primary central nervous system lymphomas (PCNSLs) are more resistant to radiotherapy and chemotherapy in AIDS (A-PCNSLs) than in non-AIDS patients (NA-PCNSLs). We investigated 23 A-PCNSLs and 24 NA-PCNSLs. Lymphoma cell kinetics (i.e. proliferation [mitotic index, MIB-1 and PCNA labeling indices], apoptosis and turnov...

journal_title：Journal of neuropathology and experimental neurology

authors： Christov C,Adle-Biassette H,Lechapt E,Poron F,Gray F,Gaulard P,Gherardi RK

更新日期：1999-10-01 00:00:00

abstract：:The microtubule-associated phosphoprotein, tau, is an integral component of paired helical filaments in Alzheimer neurofibrillary tangles (NFT). The mechanism of NFT formation is unknown but aberrant phosphorylation of tau may be contributory. Calcium/calmodulin-dependent protein kinase type II (CaM kinase II), the mo...

journal_title：Journal of neuropathology and experimental neurology

authors： McKee AC,Kosik KS,Kennedy MB,Kowall NW

更新日期：1990-01-01 00:00:00

abstract：:Intrauterine infection and inflammation have been linked to preterm birth and brain damage. We hypothesized that recombinant human erythropoietin (rhEPO) would ameliorate brain damage in anovine model of fetal inflammation. At 107 +/- 1 day of gestational age (DGA), chronically catheterized fetal sheep received on 3 c...

journal_title：Journal of neuropathology and experimental neurology

authors： Rees S,Hale N,De Matteo R,Cardamone L,Tolcos M,Loeliger M,Mackintosh A,Shields A,Probyn M,Greenwood D,Harding R

更新日期：2010-03-01 00:00:00

abstract：:Experimental cerebral ischemia was produced in gerbils by occlusion of the right common carotid artery in the neck. The evolution of the ischemic lesions was followed from five minutes to six hours by using the immunohistochemical techniques for tubulin and creatine kinase BB-isoenzyme. The earliest lesion was found i...

journal_title：Journal of neuropathology and experimental neurology

authors： Yanagihara T,Yoshimine T,Morimoto K,Yamamoto K,Homburger HA

更新日期：1985-03-01 00:00:00

abstract：:Brainstem Lewy bodies (LB) are neuronal inclusions that are closely related to Parkinson's disease (PD). The filamentous component of LB from patients with PD contains biochemically altered neurofilaments (NF). Herein we have tested the hypothesis that the oxidized products of catechols may covalently crosslink NF. Ne...

journal_title：Journal of neuropathology and experimental neurology

authors： Montine TJ,Farris DB,Graham DG

更新日期：1995-05-01 00:00:00

abstract：:Glial cytoplasmic inclusions (GCIs) are a pathologic hallmark of multiple system atrophy (MSA), but their pathogenetic roles need to be clarified. To determine possible roles of GCIs in individual cells, serial optical sections obtained by confocal microscopy were reconstructed to yield 3-dimensional (3D) images of th...

journal_title：Journal of neuropathology and experimental neurology

authors： Uyama N,Uchihara T,Mochizuki Y,Nakamura A,Takahashi R,Mizutani T

更新日期：2009-10-01 00:00:00

abstract：:The accumulation of misfolded or unfolded proteins in the endoplasmic reticulum (ER) lumen causes a cellular stress response termed the unfolded protein response. Although ER stress has been implicated in various neurodegenerative diseases, the morphological features of aggregated proteins in ER lumina that may cause ...

journal_title：Journal of neuropathology and experimental neurology

authors： Sasaki S

更新日期：2010-04-01 00:00:00

abstract：:Arteriolar tortuousities, consisting of vascular coils, loops, and spirals, appear in white matter in a subset of human cerebral vessels. Computerized morphometry was used to analyze brain sections from a broad age range of subjects to determine whether tortuosity is a phenomenon of aging or is associated with leukoar...

journal_title：Journal of neuropathology and experimental neurology

authors： Thore CR,Anstrom JA,Moody DM,Challa VR,Marion MC,Brown WR

更新日期：2007-05-01 00:00:00

abstract：:How to assess the substantial neuronal loss in a neurodegenerative disease such as Alzheimer disease is still being debated. Recently, stereological procedures have been proposed that claim improved accuracy and statistical power, but the results of some of these investigations have been controversial. In this study w...

journal_title：Journal of neuropathology and experimental neurology

authors： Everall IP,DeTeresa R,Terry R,Masliah E

更新日期：1997-11-01 00:00:00

abstract：:Abnormalities were detected by two-dimensional gel electrophoresis in the protein composition of both the dorsal and ventral roots of three of six patients who succumbed to amyotrophic lateral sclerosis (ALS). The abnormalities consisted of a cascade of acidic protein spots on silver-stained gels which were shown by i...

journal_title：Journal of neuropathology and experimental neurology

authors： Brock TO,McIlwain DL

更新日期：1984-11-01 00:00:00

abstract：:Nicotinic acetylcholine receptors (nAChRs) mediate fast synaptic transmission in autonomic ganglia, which innervate and control the activity of most visceral organs. By combining ultrastructural, immunocytochemical, and pharmacological analyses, we characterized the nAChR subtypes in the rat superior cervical ganglion...

journal_title：Journal of neuropathology and experimental neurology

authors： Del Signore A,Gotti C,Rizzo A,Moretti M,Paggi P

更新日期：2004-02-01 00:00:00

abstract：:Werdnig-Hoffmann disease (WHD) is the most severe clinical type of spinal muscular atrophy characterized by loss of lower motor neurons and paralysis. We examined the hypothesis that disease pathogenesis is based on an inappropriate persistence of normally occurring motor neuron programmed cell death. The diagnosis of...

journal_title：Journal of neuropathology and experimental neurology

authors： Simic G,Seso-Simic D,Lucassen PJ,Islam A,Krsnik Z,Cviko A,Jelasic D,Barisic N,Winblad B,Kostovic I,Kruslin B

更新日期：2000-05-01 00:00:00

abstract：:The oligoastrocytoma, as a mixed glioma, represents a nosologic dilemma with respect to precisely defining the oligodendroglial and astroglial phenotypes that constitute the neoplastic cell lineages of these tumors. In this study, cell image analysis with Feulgen-stained nuclei was used to distinguish between oligoden...

journal_title：Journal of neuropathology and experimental neurology

authors： Decaestecker C,Lopes BS,Gordower L,Camby I,Cras P,Martin JJ,Kiss R,VandenBerg SR,Salmon I

更新日期：1997-04-01 00:00:00

abstract：:This study describes, for the first time, the neuropathy of zinc pyridinethione (ZPT) toxicity in rats. Although hind-limb weakness has been previously reported as a consequence of dietary ZPT ingestion in rats and rabbits, the cause of the paralysis has been unexplained. Sequential morphologic studies in rats fed a d...

journal_title：Journal of neuropathology and experimental neurology

authors： Sahenk Z,Mendell JR

更新日期：1979-09-01 00:00:00

abstract：:The balance between excitatory and inhibitory synaptic inputs is critical for the physiological control of motoneurons. The maintenance of a low-intracellular chloride concentration by the potassium chloride cotransporter 2 (KCC2) is essential for the efficacy of fast synaptic inhibition of mature motoneurons in respo...

journal_title：Journal of neuropathology and experimental neurology

authors： Fuchs A,Ringer C,Bilkei-Gorzo A,Weihe E,Roeper J,Schütz B

更新日期：2010-10-01 00:00:00

abstract：:We investigated the temporal course of blood-nerve barrier (BNB) breakdown during the evolution of tellurium neuropathy, ricin neuropathy, and Wallerian degeneration following nerve transection or nerve crush. Blood-nerve barrier permeability was assessed with a 4,000-molecular weight fluoresceinated dextran from thre...

journal_title：Journal of neuropathology and experimental neurology

authors： Bouldin TW,Earnhardt TS,Goines ND

更新日期：1991-11-01 00:00:00

abstract：:This study examines a radiation-induced invasion and spread of Schwann cells into ventral gray regions of the lumbar spinal cord. The prevalence of these cells within the gray matter and the time course of their appearance in the ventral spinal cord is quite different from the pattern of Schwann cell development in do...

journal_title：Journal of neuropathology and experimental neurology

authors： Sims TJ,Durgun MB,Gilmore SA

更新日期：1998-09-01 00:00:00

abstract：:Growing evidence indicates that alterations within the peripheral nervous system (PNS) are involved at an early stage in the amyotrophic lateral sclerosis (ALS) pathogenetic cascade. In this study, magnetic resonance imaging (MRI), neurophysiologic analyses, and histologic analyses were used to monitor the extent of P...

journal_title：Journal of neuropathology and experimental neurology

authors： Riva N,Chaabane L,Peviani M,Ungaro D,Domi T,Dina G,Bianchi F,Spano G,Cerri F,Podini P,Corbo M,Carro UD,Comi G,Bendotti C,Quattrini A

更新日期：2014-07-01 00:00:00

abstract：:To assess the range of differentiation of the cells comprising dysembryoplastic neuroepithelial tumor (DNT), particularly the oligodendrocyte-like cells (OLC), 14 DNT were immunochemically studied with a spectrum of neuronal and glial markers. Eight tumors were also studied ultrastructurally. Neurofilament protein, cl...

journal_title：Journal of neuropathology and experimental neurology

authors： Hirose T,Scheithauer BW,Lopes MB,VandenBerg SR

更新日期：1994-03-01 00:00:00

abstract：:The diagnosis of Alzheimer disease (AD) according to current criteria is a combined clinical and pathological exercise. The clinical discrimination of AD from other types of dementia may be complicated when the patient suffers from more than one disease. In particular the concomitant presence of other neurological con...

journal_title：Journal of neuropathology and experimental neurology

authors： Nagy Z,Esiri MM,Jobst KA,Morris JH,King EM,McDonald B,Joachim C,Litchfield S,Barnetson L,Smith AD

更新日期：1997-02-01 00:00:00

abstract：:Frontotemporal dementia with inclusion body myopathy and Paget disease of bone is a rare, autosomal-dominant disorder caused by mutations in the gene valosin-containing protein (VCP). The CNS pathology is characterized by a novel pattern of ubiquitin pathology distinct from sporadic and familial frontotemporal lobar d...

journal_title：Journal of neuropathology and experimental neurology

authors： Neumann M,Mackenzie IR,Cairns NJ,Boyer PJ,Markesbery WR,Smith CD,Taylor JP,Kretzschmar HA,Kimonis VE,Forman MS

更新日期：2007-02-01 00:00:00

abstract：:The association of Charcot-Marie-Tooth (CMT) disease with renal dysfunction is uncommon but has long been recognized in several families. Recently, mutations in the INF2 gene, which encodes inverted formin-2, were identified in patients with focal segmental glomerulosclerosis and a dominant intermediate form of CMT (C...

journal_title：Journal of neuropathology and experimental neurology

authors： Mathis S,Funalot B,Boyer O,Lacroix C,Marcorelles P,Magy L,Richard L,Antignac C,Vallat JM

更新日期：2014-03-01 00:00:00

abstract：:This is the fourth recorded patient with extension of syringomyelia into the brain rostral to the mesencephalon verified at autopsy. A syrinx was demonstrated from the low thoracic segments of the spinal cord to the cervico-medullary junction, where a fibrovascular malformation and dural-arachnoid adhesions deformed t...

journal_title：Journal of neuropathology and experimental neurology

authors： Berry RG,Chambers RA,Lublin FD

更新日期：1981-11-01 00:00:00

abstract：:The 2016 WHO classification of brain tumors represents a major step towards the integration of molecular data into pathologic diagnoses. Our institution has included massively parallel sequencing technology in the diagnostic work-up of all gliomas since January 2016. The utilized platform successfully identifies copy ...

journal_title：Journal of neuropathology and experimental neurology

authors： Parilla M,Kadri S,Patil SA,Fitzpatrick C,Ritterhouse L,Segal J,Collins J,Pytel P

更新日期：2019-03-01 00:00:00

abstract：:Mutations in peripheral myelin protein 22 (PMP22) result in the most common form of Charcot-Marie-Tooth (CMT) disease, CMT1A. This hereditary peripheral neuropathy is characterized by dysmyelination of peripheral nerves, reduced nerve conduction velocity, and muscle weakness. APMP22 point mutation in L16P (leucine 16 ...

journal_title：Journal of neuropathology and experimental neurology

authors： Scurry AN,Heredia DJ,Feng CY,Gephart GB,Hennig GW,Gould TW

更新日期：2016-04-01 00:00:00